Prediction of hemodynamic tolerance of intermittent hemodialysis in critically ill patients: a cohort study

The evaluation and management of fluid balance are key challenges when caring for critically ill patients requiring renal replacement therapy. The aim of this study was to assess the ability of clinical judgment and other variables to predict the occurrence of hypotension during intermittent hemodialysis (IHD) in critically ill patients. This was a prospective, observational, single-center study involving critically ill patients undergoing IHD. The clinical judgment of hypervolemia was determined by the managing nephrologists and critical care physicians in charge of the patients on the basis of the clinical data used to calculate the ultrafiltration volume and rate for each dialysis treatment. Seventy-nine (31.9%) patients presented with hypotension during IHD. Patients were perceived as being hypervolemic in 109 (43.9%) of the cases by nephrologists and in 107 (43.1%) by intensivists. The agreement between nephrologists and intensivists was weak (kappa = 0.561). Receiver operating characteristic curve analysis yielded an AUC of 0.81 (95% CI 0.75 to 0.84; P < 0.0001), and a cutoff value of 70 mm for the vascular pedicle width (VPW) had the highest accuracy for the prediction of the absence of hypotension. The clinical judgment of hypervolemia did not predict hypotension during IHD. The high predictive ability of the VPW may assist clinicians with critical thinking.

Pedicle Morphometry of Sub Axial Cervical Spine using Computed Tomography Scans among Adult Ugandan Population

Background: Accurate placement of pedicle screws in the sub axial cervical spine requires precise understanding of vertebrae anatomy. Little is known about the morphometric characteristics of the sub axial cervical pedicle in the Ugandan population. The objective of the study was to determine the morphometric dimensions of pedicles in the sub axial cervical spine among the adult Ugandan population. Methods: We conducted a cross sectional study from March to November 2019 among adult Ugandans with a normal cervical CT scan at Nsambya hospital in Kampala. Eligible participants were consecutively recruited into the study. Data on baseline characteristics and pedicle dimensions from the CT scan findings were collected using a structured questionnaire and analysed using Stata 13.0. Pedicle dimensions for the different levels of sub axial cervical vertebrae were summarised as means and standard deviations, the Mann Whitney test was used to compare pedicle dimensions for the different vertebrae level among females and males on both right and left side and the level of significance was set at 0.05. Results: A total of 700 sub axial cervical pedicles (C3-C7) from 49 males and 21 female participants were studied. Pedicle width diameter showed cephalo-caudal gradual increment from C3 [1.65(0.63) mm] to [3.46(0.75) mm] at C7. Pedicle height also showed an increase caudally with smallest diameter at C3 [1.98(0.76) mm] and largest at C5 in females [3.67(6.42) mm] and at C7in males [3.83(0.76) mm]. The pedicle height was wider than the pedicle width at all levels. The pedicle chord length gradually increased caudally in both sexes ranging from [29.08(1.35) mm] at C3 to [32.53(3.19) mm] at C7. The axial angles were oriented medially and showed no consistent trend ranging between 500 and 530. The sagittal angles decreased as one moved from C3 to C7. The dimensions of females were significantly smaller than in males.Conclusion: Pedicle endosteal width was smaller than pedicle height dimensions at all levels. Pedicle cord length increased caudally. The pedicle dimensions except angulations, were smaller in females than in males.

Spinal Pedicle Morphometry using Multidetector CT—An experience from the Indian Subcontinent

Introduction For safe pedicle screws placement, knowledge of pedicle morphometry is essential, because an inconsistency between pedicle width and the screw diameter may lead to severe complications like nerve, vessel or visceral injuries. Objectives To study the spinal pedicle width and height of lumbar spine, using multidetector CT (MDCT), among the Indian population. To study the spinal pedicle angulation of lumbar spine, using MDCT, among the Indian population. Method The study was conducted at a tertiary care multispecialty hospital. In the present study, a total of 321 patients were included, who underwent MDCT scan without contrast at our institution, over a period of 2 years, from May 2017 to May 2019. The study population (n = 321) was divided into different subgroups on the basis of the age. The data was taken from the workstation. Comparison was made separately between each subgroup. Results In our subset of population, the 10 to 90 years age group, pedicle dimensions are as follow: The pedicle diameter from L1 to L5 is 4.46 to 11.92 mm. The pedicle height from L1 to L5 is 7.38 to 11.01 mm. The pedicle axial angulation from L1 to L5 is 22.27 to 36.08 degree. The pedicle lateral angulation from L1 to L5 is 16.12 to 22.47 degree. Conclusion Knowledge of the pedicle morphometry (pedicle width, height and angulation) of lumbar spine will help the neurosurgeons standardize the size of pedicle screws which is required for spinal fixation surgery at various lumbar vertebra levels.

Prediction of Hemodynamic Tolerance of Intermittent Hemodialysis in Critically Ill Patients: A Cohort Study

Background: The evaluation and management of fluid balance are key challenges when caring for critically ill patients requiring renal replacement therapy (RRT). The aim of this study was to assess the ability of clinical judgment and other variables to predict the occurrence of hypotension during intermittent hemodialysis (IHD) in critically ill patients.Methods: This was a prospective, observational, single-center study involving critically ill patients undergoing IHD. The clinical judgment of hypervolemia was determined by the managing nephrologists and critical care physicians in charge of the patients on the basis of the clinical data used to calculate the ultrafiltration volume and rate for each dialysis treatment.Results: Seventy-nine (31.9%) patients presented with hypotension during IHD. Patients were perceived as being hypervolemic in 109 (43.9%) of the cases by nephrologists and in 107 (43.1%) by intensivists. The agreement between nephrologists and intensivists was weak (kappa =0.561). Receiver operating characteristic (ROC) curve analysis yielded an AUC of 0.81 (95% CI 0.75 to 0.84; P < 0.0001), and a cutoff value of 70 mm for the vascular pedicle width (VPW) had the highest accuracy for the prediction of the absence of hypotension.Conclusions: The clinical judgment of hypervolemia did not predict hypotension during IHD. The high predictive ability of the VPW may assist clinicians with critical thinking.

Prediction of Hemodynamic Tolerance of Intermittent Hemodialysis in Critically Ill Patients: A Cohort Study

Background: The evaluation and management of fluid balance are key challenges when caring for critically ill patients requiring renal replacement therapy (RRT). The aim of this study was to assess the ability of clinical judgment and other variables to predict the occurrence of hypotension during intermittent hemodialysis (IHD) in critically ill patients.Methods: This was a prospective, observational, single-center study involving critically ill patients undergoing IHD. The clinical judgment of hypervolemia was determined by the managing nephrologists and critical care physicians in charge of the patients on the basis of the clinical data used to calculate the ultrafiltration volume and rate for each dialysis treatment.Results: Seventy-nine (31.9%) patients presented with hypotension during IHD. Patients were perceived as being hypervolemic in 109 (43.9%) of the cases by nephrologists and in 107 (43.1%) by intensivists. The agreement between nephrologists and intensivists was weak (kappa =0.561). Receiver operating characteristic (ROC) curve analysis yielded an AUC of 0.81 (95% CI 0.75 to 0.84; P < 0.0001), and a cutoff value of 70 mm for the vascular pedicle width (VPW) had the highest accuracy for the prediction of the absence of hypotension.Conclusions: The clinical judgment of hypervolemia did not predict hypotension during IHD. The high predictive ability of the VPW may assist clinicians with critical thinking.

Assessment of pedicle size in patients with scoliosis using EOS 2D imaging: a validity and reliability study

Purpose Free-hand pedicle screw insertion methods are widely used for screw insertion during scoliosis surgery. Preoperative knowledge about the pedicle size helps to maximize screw containment and minimize the risk of pedicle breach. Radiographs taken by a biplanar low-dose X-ray device (EOS) have no divergence in the vertical plane. The criterion validity and reliability of preoperative EOS images for pedicle size measurements in patients with idiopathic scoliosis (IS) was investigated in this study. Methods Sixteen patients who underwent surgical treatment for IS were prospectively included. Intra- and extracortical pedicle height and width measurements on EOS images were compared with reconstructed intra-operative 3D images of the isthmus of included pedicles. Secondly, intra- and interobserver reliability of pedicle size measurements on EOS images was determined. Results The total number of analyzed pedicles was 203. The correlation between the EOS and 3D scan measurements was very strong for the intra- and extracortical pedicle height and strong for the intra- and extracortical pedicle width. There are, however, significant, but likely clinically irrelevant differences (mean absolute differences < 0.43 mm) between the two measure methods for all four measurements except for extracortical pedicle height. For pedicles classified as Nash–Moe 0, no significant differences in intra- and extracortical pedicle width were observed. Both intra- and interobserver reliability was excellent for all pedicle size measurements on EOS images. Conclusion The results of this study indicate a good validity and reliability for pedicle size measurements on EOS radiographs. Therefore, EOS radiographs may be used for a preoperative estimation of pedicle size and subsequent screw diameter in patients with IS.

Distally based peroneal artery perforator-plus fasciocutaneous flap in the reconstruction of soft tissue defects over the distal forefoot: a retrospectively analyzed clinical trial

Background Distally based peroneal artery perforator-plus fasciocutaneous (DPAPF) flaps are widely used for reconstructing soft-tissue defects of the lower extremity. However, reports on the reconstruction of the defects over the distal forefoot using the DPAPF flaps are scarce. Herein, we describe our experience on the reconstruction of these defects using DPAPF flaps in a considerable sample size. Methods Between February 2005 and August 2019, a total of 56 DPAPF flaps in 56 patients were used to reconstruct soft-tissue defects in the forefoot. In order to reduce the length of fascial pedicle and the total length of the DPAPF flaps, the ankles were fixed in dorsiflexion using a Kirschner wire before designing the flaps. The flaps were elevated by the anterograde–retrograde approach. Patient factors and flap factors were compared between the “survival” and “partial necrosis” groups. Results Overall, 47 flaps had survived completely in one stage. Partial necrosis developed in nine flaps, with only one remnant defect covered using a local flap. By fixing the ankles in dorsiflexion, the length of the fascial pedicle was reduced approximately 2.35 ± 0.58 cm, the total length of the flap was simultaneously shortened by the same amount as the length of the fascial pedicle. The width of the fascia pedicle varied from 3.0 cm to 6.0 cm. The fascial pedicle width > 4 cm was found in 21 flaps. The partial necrosis rate of the DPAPF flaps with the top edge located in the 8th zone was significantly lower than that in the 9th zone (p < 0.05). Conclusions The DPAPF flaps can be effectively used to reconstruct the defects over the distal forefoot because of convenient harvest and reliability. By fixing the ankle in dorsiflexion with Kirschner wire and widening the fascial pedicle appropriately, the top edge and LWR of the flaps will be decreased, and thus the procedures are helpful for the flaps survival.

A Computed Tomographic Study of Vietnamese C1-C2 Morphology for Atlantoaxial Crew Fixation Techniques

Objectives: This study aimed to define variations in radiological C1 and C2 measurements among Vietnamese subjects and to determine the feasibility of implementing C1-2 fixation techniques. Material and Methods: From October 2017 to April 2018, 120 patients underwent thin slide computed tomography (CT) scans of the cervical spine, in our hospital. Various dimensions of the C1 and C2 were analyzed, using axial and sagittal reconstructions of CT images. Differences in characteristics between the two sides and between sexes were investigated, using Student’s t-test, with significance at P < 0.05. Results: The mean anteroposterior dimension and the transverse width of the C1 lateral mass were 19.7 ± 2.1 mm and 12.2 ± 1.7 mm, respectively. The mean angles of the screw, directed to the maximal medial, lateral, cranial, and caudal directions, were 36.6 ± 2.8°, 28.2 ± 3.0°, 49.6 ± 4.1°, and 26.4 ± 5.5°, respectively. The average isthmus height, internal height, and pedicle width of the C2 were 5.8 ± 1.0 mm, 4.8 ± 1.3 mm, and 5.0 ± 1.3 mm, respectively. No significant differences were observed for any parameters, between the left and right side of the C1 or C2 or between the two sexes. Conclusion: This study revealed that the morphology of the C1 and C2 did not differ between genders in the studied subjects, but morphologic variations exist between Vietnamese subjects and other populations. Pre-operative anatomy evaluations based on CT data are essential be performed for screw placement and trajectory planning to avoid neurovascular complications and to enhance the treatment outcome.

Distally based peroneal artery perforator-plus fasciocutaneous flap in the reconstruction of soft tissue defects over the distal forefoot: a retrospectively analyzed clinical trial

Background Distally based peroneal artery perforator-plus fasciocutaneous (DPAPF) flaps are widely used for reconstructing soft-tissue defects of the lower extremity. However, reports on the reconstruction of the defects over the distal forefoot using the DPAPF flaps are scarce. Herein, we describe our experience on the reconstruction of these defects using DPAPF flaps in a considerable sample size. Methods Between February 2005 and August 2019, a total of 56 DPAPF flaps in 56 patients were used to reconstruct soft-tissue defects in the forefoot. In order to reduce the length of fascial pedicle and the total length of the DPAPF flaps, the ankles were fixed in dorsiflexion using a Kirschner wire before designing the flaps. The flaps were elevated by the anterograde–retrograde approach. Patient factors and flap factors were compared between the “survival” and “partial necrosis” groups. Results Overall, 47 flaps had survived completely in one stage. Partial necrosis developed in nine flaps, with only one remnant defect covered using a local flap. By fixing the ankles in dorsiflexion, the length of the fascial pedicle was reduced approximately 2.35 ± 0.58 cm, the total length of the flap was simultaneously shortened by the same amount as the length of the fascial pedicle. The width of the fascia pedicle varied from 3.0 cm to 6.0 cm. The fascial pedicle width > 4 cm was found in 21 flaps. The partial necrosis rate of the DPAPF flaps with the top-edge located in the 8th zone was significantly lower than that in the 9th zone (p < 0.05).Conclusions The DPAPF flaps can be effectively used to reconstruct the defects over the distal forefoot because of convenient harvest and reliability. By fixing ankle in dorsiflexion with Kirschner wire and widening the fascial pedicle appropriately, the top-edge and LWR of the flaps will be decreased, and thus the procedures are helpful for the flaps survival.

Computerized three-dimensional pedicle morphometry from computed tomography images of the thoracic spine

Knowledge of pedicle morphometry is valuable for a safe and reliable pedicle screw placement. In this study, we performed and evaluated computerized pedicle morphometry measurements from preoperative computed tomography (CT) images of the thoracic spine from 26 subjects. Manual measurements of the pedicle width, height and chord length were obtained for 540 thoracic pedicles in selected cross sections of orthogonal and oblique multiplanar reconstructions (MPRs). Computerized measurements of the pedicle width, height, length, chord length, transverse angulation, sagittal angulation and cross-sectional area were obtained for the same pedicles by an automated method that is based on parametric modeling of vertebral structures in three dimensions (3D). Statistical analysis revealed that manual measurements from orthogonal MPRs were significantly different (p ≤ 0.0011) when compared to those from oblique MPRs and computerized measurement in 3D, with the respective mean absolute difference (MAD) ± standard deviation (SD) of 0.77 ± 0.56 mm and 0.74 ± 0.57 mm for the pedicle width, and 1.31 ± 1.08 mm and 1.45 ± 1.10 mm for the pedicle height. No statistically significant differences (p ≥ 0.12) were observed between manual measurements from oblique MPRs and computerized measurements in 3D, with MAD ± SD of 0.44 ± 0.35 mm, 0.56 ± 0.52 mm and 1.72 ± 1.29 mm for the pedicle width, height and chord length, respectively. The advantage of computerized measurements is that they allow the extraction of additional pedicle morphometric parameters, which are important for preoperative planning of pedicle screw placement, or can be used for population and demographic studies using larger pedicle databases.