Primordial Black Holes and a Common Origin of Baryons and Dark Matter

The origin of the baryon asymmetry of the Universe (BAU) and the nature of dark matter are two of the most challenging problems in cosmology. We propose a scenario in which the gravitational collapse of large inhomogeneities at the quark-hadron epoch generates both the baryon asymmetry and most of the dark matter in the form of primordial black holes (PBHs). This is due to the sudden drop in radiation pressure during the transition from a quark-gluon plasma to non-relativistic hadrons. The collapse to a PBH is induced by fluctuations of a light spectator scalar field in rare regions and is accompanied by the violent expulsion of surrounding material, which might be regarded as a sort of “primordial supernova". The acceleration of protons to relativistic speeds provides the ingredients for efficient baryogenesis around the collapsing regions and its subsequent propagation to the rest of the Universe. This scenario naturally explains why the observed BAU is of order the PBH collapse fraction and why the baryons and dark matter have comparable densities. The predicted PBH mass distribution ranges from subsolar to several hundred solar masses. This is compatible with current observational constraints and could explain the rate, mass and low spin of the black hole mergers detected by LIGO-Virgo. Future observations will soon be able to test this scenario.

A Concise Review of Dendrocalamus asper and Related Bamboos: Germplasm Conservation, Propagation and Molecular Biology

Bamboos represent an emerging forest resource of economic significance and provide an avenue for sustainable development of forest resources. The development of the commercial bamboo industry is founded upon efficient molecular and technical approaches for the selection and rapid multiplication of elite germplasm for its subsequent propagation via commercial agro-forestry business enterprises. This review will delve into the micropropagation of Dendrocalamus asper, one of the most widely cultivated commercial varieties of bamboo, and will encompass the selection of germplasm, establishment of explants in vitro and micropropagation techniques. The currently available information pertaining to molecular biology, DNA barcoding and breeding, has been included, and potential areas for future research in the area of genetic engineering and gene regulation have been highlighted. This information will be of relevance to both commercial breeders and molecular biologists who have an interest in establishing bamboo as a crop of the future.

CONNECTING GEOMETRY AND SEMANTICS VIA ARTIFICIAL INTELLIGENCE: FROM 3D CLASSIFICATION OF HERITAGE DATA TO H-BIM REPRESENTATIONS

Cultural heritage information systems, such as H-BIM, are becoming more and more widespread today, thanks to their potential to bring together, around a 3D representation, the wealth of knowledge related to a given object of study. However, the reconstruction of such tools starting from 3D architectural surveying is still largely deemed as a lengthy and time-consuming process, with inherent complexities related to managing and interpreting unstructured and unorganized data derived, e.g., from laser scanning or photogrammetry. Tackling this issue and starting from reality-based surveying, the purpose of this paper is to semi-automatically reconstruct parametric representations for H-BIM-related uses, by means of the most recent 3D data classification techniques that exploit Artificial Intelligence (AI). The presented methodology consists of a first semantic segmentation phase, aiming at the automatic recognition through AI of architectural elements of historic buildings within points clouds; a Random Forest classifier is used for the classification task, evaluating each time the performance of the predictive model. At a second stage, visual programming techniques are applied to the reconstruction of a conceptual mock-up of each detected element and to the subsequent propagation of the 3D information to other objects with similar characteristics. The resulting parametric model can be used for heritage preservation and dissemination purposes, as common practices implemented in modern H-BIM documentation systems. The methodology is tailored to representative case studies related to the typology of the medieval cloister and scattered over the Tuscan territory.

A glacier–ocean interaction model for tsunami genesis due to iceberg calving

Glaciers calving icebergs into the ocean significantly contribute to sea-level rise and can trigger tsunamis, posing severe hazards for coastal regions. Computational modeling of such multiphase processes is a great challenge involving complex solid–fluid interactions. Here, a new continuum damage Material Point Method has been developed to model dynamic glacier fracture under the combined effects of gravity and buoyancy, as well as the subsequent propagation of tsunami-like waves induced by released icebergs. We reproduce the main features of tsunamis obtained in laboratory experiments as well as calving characteristics, the iceberg size, tsunami amplitude and wave speed measured at Eqip Sermia, an ocean-terminating outlet glacier of the Greenland ice sheet. Our hybrid approach constitutes important progress towards the modeling of solid–fluid interactions, and has the potential to contribute to refining empirical calving laws used in large-scale earth-system models as well as to improve hazard assessments and mitigation measures in coastal regions, which is essential in the context of climate change.

Isoflurane-Induced Burst Suppression Is a Thalamus-Modulated, Focal-Onset Rhythm With Persistent Local Asynchrony and Variable Propagation Patterns in Rats

Background: Inhalational anesthetic-induced burst suppression (BS) is classically considered a bilaterally synchronous rhythm. However, local asynchrony has been predicted in theoretical studies and reported in patients with pre-existing focal pathology.Method: We used high-speed widefield calcium imaging to study the spatiotemporal dynamics of isoflurane-induced BS in rats.Results: We found that isoflurane-induced BS is not a globally synchronous rhythm. In the neocortex, neural activity first emerged in a spatially shifting, variably localized focus. Subsequent propagation across the whole cortex was rapid, typically within <100 milliseconds, giving the superficial resemblance to global synchrony. Neural activity remained locally asynchronous during the bursts, forming complex recurrent propagating waves. Despite propagation variability, spatial sequences of burst propagation were largely preserved between the hemispheres, and neural activity was highly correlated between the homotopic areas. The critical role of the thalamus in cortical burst initiation was demonstrated by using unilateral thalamic tetrodotoxin injection.Conclusion: The classical impression that anesthetics-induced BS is a state of global brain synchrony is inaccurate. Bursts are a series of shifting local cortical events facilitated by thalamic projection that unfold as rapid, bilaterally asynchronous propagating waves.

Dynamic degradation of metallic nanowire networks under electrical stress: a comparison between experiments and simulations

We describe the degradation mechanism in a metallic nanowire network subjected to electrical stress. The nanowire network degradation is ascribed, at a very local scale, to hot-spot formation and the subsequent propagation of a spatially correlated disruptive crack.

Snow Avalanches

This work is a critical update of the most recent and innovative developments of the avalanche science. It aims at re-founding it on clear scientific bases, from field observations and experiments up to strong mathematical and physical analysis and modeling. It points out snow peculiarities, regarding both static mechanical properties and flow dynamics, that may strongly differ from those of compact solids for the former, and of Newtonian fluids for the latter. It analyzes the general processes involved in avalanche release, in terms of brittle fracture and ductile plasticity, specific friction laws, flow of healable granular materials, percolation concepts, cellular automata, scale invariance, criticality, theory of dynamical systems, bifurcations, etc. As a result, slab triggering (including remote triggering) can be summarized by the “slab avalanche release in 4 steps” concept, based on weak layer local collapse and subsequent propagation driven by slab weight. The frequent abortion of many incipient avalanches is easily explained in terms of snow grain dynamical healing. Sluffs and full-depth avalanches are also analyzed. Such advances pave the way for significant progress in risk evaluation procedures. In the present context of a speeding-up climate warming, possible evolutions of snow cover extent and stability are also tentatively discussed. We show how, in mountainous areas, the present analysis can be extended to other gravitational failures (rock-falls, landslides) that are likely to take over from avalanches in such circumstances. The text is supported by on-line links to field experiments and lectures on triggering mechanisms, risk management, and decision making.

Integrity of a heterochromatic domain ensured by its boundary elements

In fission yeast, the inverted repeatsIR-LandIR-Rfunction as boundary elements at the edges of a 20-kb silent heterochromatic domain where nucleosomes are methylated at histone H3K9. Each repeat contains a series of B-box motifs physically associated with the architectural TFIIIC complex and with other factors including the replication regulator Sap1 and the Rix1 complex (RIXC). We demonstrate here the activity of these repeats in heterochromatin formation and maintenance. Deletion of the entireIR-Rrepeat or, to a lesser degree, deletion of just the B boxes impaired the de novo establishment of the heterochromatic domain. Nucleation proceeded normally at the RNA interference (RNAi)-dependent elementcenHbut subsequent propagation to the rest of the region occurred at reduced rates in the mutants. Once established, heterochromatin was unstable in the mutants. These defects resulted in bistable populations of cells occupying alternate “on” and “off” epigenetic states. DeletingIR-Lin combination withIR-Rsynergistically tipped the balance toward the derepressed state, revealing a concerted action of the two boundaries at a distance. The nuclear rim protein Amo1 has been proposed to tether the mating-type region and its boundaries to the nuclear envelope, where Amo1 mutants displayed milder phenotypes than boundary mutants. Thus, the boundaries might facilitate heterochromatin propagation and maintenance in ways other than just through Amo1, perhaps by constraining a looped domain through pairing.

Autophagy Driven Extracellular Vesicles in the Leukaemic Microenvironment

The leukaemias are a heterogeneous group of blood cancers, which together, caused 310,000 deaths in 2016. Despite significant research into their biology and therapeutics, leukaemia is predicted to account for an increased 470,000 deaths in 2040. Many subtypes remain without targeted therapy, and therefore the mainstay of treatment remains generic cytotoxic drugs with bone marrow transplant the sole definitive option. In this review, we will focus on cellular mechanisms which have the potential for therapeutic exploitation to specifically target and treat this devastating disease. We will bring together the disciplines of autophagy and extracellular vesicles, exploring how the dysregulation of these mechanisms can lead to changes in the leukaemic microenvironment and the subsequent propagation of disease. The dual effect of these mechanisms in the disease microenvironment is not limited to leukaemia; therefore, we briefly explore their role in autoimmunity, inflammation and degenerative disease.

Optimization of the Trench Dimensions for Bahrain LNG Import Terminal Project

Large deformation finite element analyses were carried out to investigate the optimized trench geometry for 24 inch (610 mm) diameter subsea pipelines and power cables (33 kV; outer diameter = 186 mm) used for transporting gas in shallow water depth (approximately 15 m), with an emphasis being on pipe-soil interaction assessment. An extensive parametric investigation was performed varying the relative density of the backfill sand (35%, 54% and 78%) and buried depth (1.89 and 3.14 diameters). Upward and lateral soil failure mec hanisms around a pipe uplifting in a backfill sand layer were compared. The failure mechanisms were manifested by shear band formation and subsequent propagation. It was shown that the trench dimensions originally designed based on conventional conservative approaches can be reduced by up to 10.6% in loose backfill sand (ID = 35%) and 8.7% in dense backfill sand (ID = 78%), leading to minimize cost and time of trenching and backfilling.