The Influence of Lactobacillus Acidophilus on MUC1, GAL-3, IL-1β and IL-17 Gene Expression in BALB/c Mice Stomach

Background and Objective: Lactobacillus acidophilus has been widely used for the management of gastrointestinal carcinoma owing to its immunomodulation effect; however, the role of L. acidophilus and its specific mechanism of action in the stomach is not fully comprehended. The present study evaluated the expression profile of MUC-1, GAL-3, IL -1β, and IL-17 in the L. acidophilus treated mice stomach. Methods: The study was conducted utilizing three groups of mice, 6 mice for each group, administered with different doses of L. acidophilus and a control group treated with normal saline. The results were analyzed with the Mann-Whitney Test. Results: The results demonstrated that L. acidophilus elevated IL-1β insignificantly and inhibited the expression of IL-17. The MUC-1 expression is influenced by L. acidophilus and inversely proportional to GAL-3 expression. Conclusion: Lactobacillus acidophilus plays a prominent role against inflammatory responses and has a potential in the treatment of gastrointestinal cancer.

Nanoparticle-mediated synergistic chemoimmunotherapy for tailoring cancer therapy: recent advances and perspectives

Nowadays, a potent challenge in cancer treatment is considered the lack of efficacious strategy, which has not been able to significantly reduce mortality. Chemoimmunotherapy (CIT) as a promising approach in both for the first-line and relapsed therapy demonstrated particular benefit from two key gating strategies, including chemotherapy and immunotherapy to cancer therapy; therefore, the discernment of their participation and role of potential synergies in CIT approach is determinant. In this study, in addition to balancing the pros and cons of CIT with the challenges of each of two main strategies, the recent advances in the cancer CIT have been discussed. Additionally, immunotherapeutic strategies and the immunomodulation effect induced by chemotherapy, which boosts CIT have been brought up. Finally, harnessing and development of the nanoparticles, which mediated CIT have expatiated in detail.

Immunomodulation Induced During Interferon-α Therapy Impairs the Anti-HBV Immune Response Through CD24+CD38hi B Cells

Type I interferon is widely used for antiviral therapy, yet has yielded disappointing results toward chronic HBV infection. Here we identify that PEG-IFNα-2b therapy toward persistent infection in humans is a double-edged sword of both immunostimulation and immunomodulation. Our studies of this randomised trial showed persistent PEG-IFNα-2b therapy induced large number of CD24+CD38hi B cells and launched a CD24+CD38hi B cells centered immunosuppressive response, including downregulating functions of T cells and NK cells. Patients with low induced CD24+CD38hi B cells have achieved an improved therapeutic effect. Specifically, using the anti-CD24 antibody to deplete CD24+CD38hi B cells without harming other B cell subsets suggest a promising strategy to improve the therapeutic effects. Our findings show that PEG-IFNα-2b therapy toward persistent infection constitutes an immunomodulation effect, and strategies to identifying the molecular basis for the antiviral versus immunomodulatory effects of PEG-IFNα-2b to selectively manipulate these opposing activities provide an opportunity to ameliorate anti-virus immunity and control viral infection.

A REVIEW OF PANCHAKARMA THERAPIES WITH RESPECT TO BALA (IMMUNITY) FOR PREVENTION AND MANAGEMENT OF COVID-19

Introduction: Worldwide prevalence rate of COVID-19 is increasing day wise, and estimated at 6.6% in the Indian population in August 2020, the curable medicine and immunization for COVID-19 is not availa-ble yet. The disease COVID-19 can be compared with Janapadodhansa Vyadhi (Epidemic) mentioned in Ayurveda. Panchakarma therapies are advised in Janapadodhansa Vyadhi. Virus is very prominent, and it is the common cause mentioned in both. The Ayurved fraternity and people have fear about Panchakarma therapies in the COVID-19 era. Aim: need of current situation is to find applicability effectiveness of Pan-chakarma therapies. Methodology: By critical literary search of Classical Ayurvedic texts, electronic me-dia, PubMed, indexed Journal, Google scholar is carried out and observations were recorded. Observation and Results: Panchakarma helps to increase Bala (Immunity) and improves immunomodulation effect of Rasayana (Rejuvenation) medicine. Fever, Headache, Common cold, Cough, Dyspnea, these are common symptoms found in COVID-19 and Panchakarma therapies are indicated in the same. Conclusion: Pan-chakarma Therapies, are independently advocated for improvement of Bala (Immunity) and as a preopera-tive measure for improving immunomodulation property of Rasayana (Rejuvenation) medicines. These principles of Panchakarma Therapies can be applied in prevention and treatment of COVID- 19 disease.

Immunomodulation Effect of Nypa fruticans Palm Vinegar

Vinegars are aqueous products of fermentation that are composed of acetic acid, water and other trace chemical components. Previous studies have shown that they have several beneficial effects for humans, such as anti-diabetic, anti-bacteria, antioxidant, anti-tumor or the enhancement of immune function. Nypa fruticans palm vinegar (NPV) is 1 of the vinegars that is usually used as a food ingredient. However, there are limited studies that have provided results to support its proposed immunomodulatory properties. This study investigated the immunomodulatory effects of NPV. Locally produced NPV from 3 different planting areas (fresh, brackish and saline water) of the Nakhon Si Thammarat province in Thailand were administered to rats, and the enhancement of the in vitro phagocytic activity was assessed. The results showed that NPV potently enhanced antibody production and the phagocytic activity. Moreover, NPV-treated rats showed a reduction of edema in type 4 hypersensitivity reactions. The results indicated that NPV had immunomodulatory effects, and therefore, NPV could be considered a functional food.