Immunomodulation effect of a hierarchical macropore/nanosurface on osteogenesis and angiogenesis

2017 ◽  
Vol 12 (4) ◽  
pp. 045006 ◽  
Author(s):  
Houhua Pan ◽  
Youtao Xie ◽  
Zequan Zhang ◽  
Kai Li ◽  
Dandan Hu ◽  
...  
Keyword(s):  
Immunomodulation Effect

Immune Enhancing Activity of β-(1,3)-Glucan Isolated from Genus Agrobacterium in Bone-Marrow Derived Macrophages and Mice Splenocytes

2016 ◽  
Vol 44 (05) ◽  
pp. 1009-1026 ◽  
Author(s):  
Eui-Baek Byun ◽  
Beom-Su Jang ◽  
Eui-Hong Byun ◽  
Nak-Yun Sung
Keyword(s):  
Immune Response ◽  
Macrophage Activation ◽  
Transmembrane Protein ◽  
Signaling Mechanism ◽  
Th2 Cytokine ◽  
Mitogen Activated Protein ◽  
Th1 Cytokine ◽  
Th1 Polarization ◽  
Necrosis Factor ◽  
Immunomodulation Effect

An effective method for activating macrophages and deriving a Th1 immune response could be used to improve the defenses of hosts. In this study, we investigated the immunomodulation effect and the related signaling mechanism of [Formula: see text]-(1,3)-glucan, isolated from the Agrobacterium species. Here, we found that [Formula: see text]-(1,3)-glucan predominantly induced the tumor necrosis factor (TNF)-[Formula: see text], interleukin (IL)-1[Formula: see text], IL-6, IL-12p70, and nitric oxide, which was dependent on mitogen-activated protein kinases (MAPK) and nuclear factor (NF)-[Formula: see text]B signaling. Additionally, [Formula: see text]-(1,3)-glucan treatment significantly up-regulated the expression of the co-stimulatory molecules CD80 and CD86, and also significantly increased the expression of iNOS and Dectin-1, which is a transmembrane protein that binds [Formula: see text]-glucan and associates with macrophage activation. Importantly, the splenic T cells co-cultured with [Formula: see text]-(1,3)-glucan-treated macrophages produced the a Th1 cytokine profile that includes high levels of IFN-[Formula: see text], but not IL-4 (Th2 cytokine), indicating that [Formula: see text]-(1,3)-glucan contributes to Th1 polarization of the immune response. Taken together, our results suggest that [Formula: see text]-(1,3)-glucan isolated from Agrobacterium species can induce macrophage activation through the MAPK and NF-[Formula: see text]B signaling pathway, as well as Th1 polarization.

scholarly journals Enhancing immunomodulation on innate immunity by shape transition among RNA triangle, square and pentagon nanovehicles

2014 ◽  
Vol 42 (15) ◽  
pp. 9996-10004 ◽  
Author(s):  
Emil F. Khisamutdinov ◽  
Hui Li ◽  
Daniel L. Jasinski ◽  
Jiao Chen ◽  
Jian Fu ◽  
...  
Keyword(s):  
Immune Response ◽  
Innate Immunity ◽  
Self Assembly ◽  
Vaccine Adjuvant ◽  
Shape Transition ◽  
Immune Disease ◽  
Disease Therapy ◽  
Tnf Α ◽  
Immunomodulation Effect

Abstract Modulation of immune response is important in cancer immunotherapy, vaccine adjuvant development and inflammatory or immune disease therapy. Here we report the development of new immunomodulators via control of shape transition among RNA triangle, square and pentagon. Changing one RNA strand in polygons automatically induced the stretching of the interior angle from 60° to 90° or 108°, resulting in self-assembly of elegant RNA triangles, squares and pentagons. When immunological adjuvants were incorporated, their immunomodulation effect for cytokine TNF-α and IL-6 induction was greatly enhanced in vitro and in animals up to 100-fold, while RNA polygon controls induced unnoticeable effect. The RNA nanoparticles were delivered to macrophages specifically. The degree of immunostimulation greatly depended on the size, shape and number of the payload per nanoparticles. Stronger immune response was observed when the number of adjuvants per polygon was increased, demonstrating the advantage of shape transition from triangle to pentagon.

scholarly journals A REVIEW OF PANCHAKARMA THERAPIES WITH RESPECT TO BALA (IMMUNITY) FOR PREVENTION AND MANAGEMENT OF COVID-19

2020 ◽  
Vol 08 (11) ◽  
pp. 5168-5173
Author(s):  
Vedpathak S ◽  
Bapat V ◽  
Tanwar V
Keyword(s):  
Common Cold ◽  
Prevalence Rate ◽  
Indian Population ◽  
Current Situation ◽  
Google Scholar ◽  
Common Cause ◽  
Prevention And Treatment ◽  
The Common ◽  
Recorded Observation ◽  
Immunomodulation Effect

Introduction: Worldwide prevalence rate of COVID-19 is increasing day wise, and estimated at 6.6% in the Indian population in August 2020, the curable medicine and immunization for COVID-19 is not availa-ble yet. The disease COVID-19 can be compared with Janapadodhansa Vyadhi (Epidemic) mentioned in Ayurveda. Panchakarma therapies are advised in Janapadodhansa Vyadhi. Virus is very prominent, and it is the common cause mentioned in both. The Ayurved fraternity and people have fear about Panchakarma therapies in the COVID-19 era. Aim: need of current situation is to find applicability effectiveness of Pan-chakarma therapies. Methodology: By critical literary search of Classical Ayurvedic texts, electronic me-dia, PubMed, indexed Journal, Google scholar is carried out and observations were recorded. Observation and Results: Panchakarma helps to increase Bala (Immunity) and improves immunomodulation effect of Rasayana (Rejuvenation) medicine. Fever, Headache, Common cold, Cough, Dyspnea, these are common symptoms found in COVID-19 and Panchakarma therapies are indicated in the same. Conclusion: Pan-chakarma Therapies, are independently advocated for improvement of Bala (Immunity) and as a preopera-tive measure for improving immunomodulation property of Rasayana (Rejuvenation) medicines. These principles of Panchakarma Therapies can be applied in prevention and treatment of COVID- 19 disease.

scholarly journals Potential immunomodulation effect of the extract of Nigella sativa on ovalbumin sensitized guinea pigs

2011 ◽  
Vol 12 (3) ◽  
pp. 201-209 ◽  
Author(s):  
Mohammad-Hossein Boskabady ◽  
Rana Keyhanmanesh ◽  
Saeed Khameneh ◽  
Yousef Doostdar ◽  
Mohammad-Reza Khakzad
Keyword(s):  
Guinea Pigs ◽  
Nigella Sativa ◽  
Immunomodulation Effect

scholarly journals Immunomodulation Induced During Interferon-α Therapy Impairs the Anti-HBV Immune Response Through CD24+CD38hi B Cells

2020 ◽  
Vol 11 ◽  
Author(s):  
Binqing Fu ◽  
Dongyao Wang ◽  
Xiaokun Shen ◽  
Chuang Guo ◽  
Yanyan Liu ◽  
...  
Keyword(s):  
B Cells ◽  
Persistent Infection ◽  
Randomised Trial ◽  
Interferon Α ◽  
Therapeutic Effects ◽  
Type I ◽  
Chronic Hbv ◽  
B Cell Subsets ◽  
And Control ◽  
Immunomodulation Effect

Type I interferon is widely used for antiviral therapy, yet has yielded disappointing results toward chronic HBV infection. Here we identify that PEG-IFNα-2b therapy toward persistent infection in humans is a double-edged sword of both immunostimulation and immunomodulation. Our studies of this randomised trial showed persistent PEG-IFNα-2b therapy induced large number of CD24+CD38hi B cells and launched a CD24+CD38hi B cells centered immunosuppressive response, including downregulating functions of T cells and NK cells. Patients with low induced CD24+CD38hi B cells have achieved an improved therapeutic effect. Specifically, using the anti-CD24 antibody to deplete CD24+CD38hi B cells without harming other B cell subsets suggest a promising strategy to improve the therapeutic effects. Our findings show that PEG-IFNα-2b therapy toward persistent infection constitutes an immunomodulation effect, and strategies to identifying the molecular basis for the antiviral versus immunomodulatory effects of PEG-IFNα-2b to selectively manipulate these opposing activities provide an opportunity to ameliorate anti-virus immunity and control viral infection.

scholarly journals Does the Propolis Reinforce the Autoclaved Bone Allograft and Does it Have an Immunomodulation Effect?

2014 ◽  
Vol 1 (2) ◽  
pp. 54-59
Author(s):  
Abdellatif Boudra
Keyword(s):  
Bone Allograft ◽  
Femoral Diaphysis ◽  
Control Group ◽  
Long Bones ◽  
Sterile Condition ◽  
Local Breed ◽  
Osteosynthesis Material ◽  
Group Control Group ◽  
Autoclaved Bone ◽  
Immunomodulation Effect

The loss of bone substance in diaphyseal region of long bones is a common problem faced by veterinarian orthopedic surgeon. In order to recover from cortical bone defect our study proposes to implant an autoclaved orthotopic allograft of one centimeter length and compares effects of covered and uncovered bones with propolis in the femoral diaphysis under general anesthesia and sterile condition. The experiment involved eight adult dogs, from local breed and different sex; split into two groups. An autoclaved allograft without propolis was implanted for the first animals group (control group ) then the same graft has been implanted to the second animals group. The aim of our study is to determine whether the propolis resin can diminish the fragility of autoclaved allografts that was confirmed by the resistance of the graft covered with propolis even once the osteosynthesis material is removed and if the autoclaved grafts covered by the propolis used in our experiments have not suffered resorption despite the intensity of the immune response during the first month.The results show that all grafts covered with propolis remained unbroken and have not suffered of the resorption problems.

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