Heart rate: Activity mismatch as a prognostic marker of survival in metastatic non-small cell lung cancer (NSCLC).

190 Background: Performance status (PS) is the foundation for clinical trial eligibility criteria and the basis for treatment decisions in the treatment of NSCLC, but it is limited by subjectivity and potential miscommunication between patient, physician, and family. Activity trackers use is widespread and offers the potential to collect a broad range of patient generated data (steps, activity, heart rate, calories, sleep, etc.) to supplement the assessment of PS while minimizing subjectivity. Here we evaluated a clinical observation that elevated heart rate at rest is prognostic of survival. Methods: Patients with metastatic NSCLC were asked to participate in a prospective, observational study of potential prognostic survival factors that included wearing a FitBit tracker with a goal to measure HR-Activity mismatch measured by 2 parameters: 1) Heart Rate-Activity Mismatch (HAM) by percent of time when HR is high and activity is moderate or low over a day; 2) inappropriate HR (iHR) is the ratio of time with elevated HR/sedentary minutes average over a week. Correlation and regression analyses were performed for the initial 55 patients enrolled prior to COVID restrictions using data limited to the average of 7 days with wear > 500 minutes closest to date of consent. Results: We enrolled 55 patients with metastatic NSCLC. There were 35 females and 20 males with a median age of 67 years. A majority of patients were never (38%, n = 21) or former smokers (40%, n = 22); adenocarcinoma (83%, n = 83%) was the most common histology. 30% (n = 17) patients were on 2nd or greater line of therapy. 52 were included for survival analysis and 21 expired with median survival 226 days (149, NA). As average daily steps increased by 1000, the hazard of death decreased by a factor of 0.65 (95% CI: 0.45, 0.93, p = 0.018). As daily average distance increased by 1 mile, the hazard of death decreased by 0.55 (95% CI: 0.33, 0.91, p = 0.019). For HAM, the risk of death increased by 1.14 (95% CI: 1, 1.13, p = 0.046) for every 10% increase in HAM. For iHR < 1 (i.e. high HR when sedentary), the risk of death was 2.84 (95% CI: 1.05, 7.67, p = 0.04) compared those with iHR > 1. Steps, Distance, HAM and iHR were not statistically different by gender. Conclusions: Tracker-based measures of steps/distance and HR-Activity are prognostic of survival in NSCLC and may be useful to supplement evaluation of PS in clinical trials and practice.

Structure and mechanism of the γ-glutamyl-γ-aminobutyrate hydrolase SpuA from Pseudomonas aeruginosa

Polyamines are important regulators in all living organisms and are implicated in essential biological processes including cell growth, differentiation and apoptosis. Pseudomonas aeruginosa possesses an spuABCDEFGHI gene cluster that is involved in the metabolism and uptake of two polyamines: spermidine and putrescine. In the proposed γ-glutamylation–putrescine metabolism pathway, SpuA hydrolyzes γ-glutamyl-γ-aminobutyrate (γ-Glu-GABA) to glutamate and γ-aminobutyric acid (GABA). In this study, crystal structures of P. aeruginosa SpuA are reported, confirming it to be a member of the class I glutamine amidotransferase (GAT) family. Activity and substrate-binding assays confirm that SpuA exhibits a preference for γ-Glu-GABA as a substrate. Structures of an inactive H221N mutant were determined with bound glutamate thioester intermediate or glutamate product, thus delineating the active site and substrate-binding pocket and elucidating the catalytic mechanism. The crystal structure of another bacterial member of the class I GAT family from Mycolicibacterium smegmatis (MsGATase) in complex with glutamine was determined for comparison and reveals a binding site for glutamine. Activity assays confirm that MsGATase has activity for glutamine as a substrate but not for γ-Glu-GABA. The work reported here provides a starting point for further investigation of polyamine metabolism in P. aeruginosa.

Pathways to adulthood

Supplies a broad overview of the themes pursued through the different chapters. The overriding theme is structural and cultural change affecting contexts and pathways to adulthood in two European societies that differ in their institutional fabric - England and Germany. Change in family relationships and identity construction, transformations in education, labour markets, politics and media are highlighted. The life course perspective that informs the theoretical framework of the book is introduced. The impact on and over shadowing of all youth and family activity through the COVID-19 virus is also addressed as precursor to the main discussion in Chapter 8

ECONOMIC INDEPENDENCE FAMILY ACTIVITY THROUGH THE SECOND BUSINES IN SOUTH SULAWESI, INDONESIA

This type of qualitative research uses a phenomenological approach, while the results of the research show that side businesses owned by the community in various forms, both engaged in goods and services, are very important in supporting the economy, especially in the aspect of meeting the needs of daily life, alternative side businesses carried out by the community are solutions in facing human needs who always want better, both primary, secondary and tertiary needs.

Storytelling: An alternative home delivery of English vocabulary for preschoolers during COVID-19’s lockdown in southern Thailand

Background: Storytelling, a common family activity for preschool children to develop their literacy, can be used to promote learning of a language other than the mother-tongue, hence a starting point of home education for early childhood.Aim: The study aims to integrate storytelling as a family activity that helps to promote learning of English vocabulary for preschoolers.Setting: Young children aged 3–5 years and their parents living in a small neighbourhood of Muang District, province of Suratthani, in the south of Thailand attended the study during the restriction imposed to curb the coronavirus disease 2019 (COVID-19) pandemic under the ‘Stay at Home’ measures (March–April 2020). Both parents and children were given information about the study before they decided whether or not to participate in the project by parents’ informed consent for their child to be involved.Methods: The data were collected in four stages: pretest, storytelling, post-test and interview. The storytelling material included five stories, particularly composed for the study. These stories were written in Thai (average 423 words), each with three English words inserted, making up 15 English words as the test items. Analyses were conducted on the pre- and post-test scores, observation of children’s learning performance and parents’ reflection.Results: The preschoolers showed vocabulary development from listening to the in-house stories. On average, children obtained 12.2 scores out of 15 words in the post-test versus 8 scores in the pretest. The family’s satisfaction level was high, that is, 3.5 from 4 on children’s learning behaviour and English word development and 3.77 on stories appreciation. The preschoolers requested to hear a story as many as three times in order to be confident. The high frequency of hearing tended to predict individual’s development.Conclusion: Storytelling promoted English vocabulary learning and it could be done at home, provided that parents are equipped with appropriate material. In a story, preschoolers should be introduced to mono-syllabic concrete words and only up to three words at a time. Repetition of at least three times is necessary.

The Influence of Attending Festivals with Children on Family Quality of Life, Subjective Well-Being, and Event Experience

Participants attending a festival(s) with children is a family activity that influences family relationships. This study examines the relationship between attending status (e.g., with or without children), event experience, subjective well-being, and family quality of life (FQOL). A total of 585 festival participants’ data analyzed by structural equation modeling (SEM) revealed that participants attending with children have a higher level of subjective well-being and FQOL compared to those without children. Participants attending with children have a higher level of cognitive engagement and experience novelty in festivals compared to those without children. Event experience results in a significant positive relationship with subjective well-being. This study expands current event literature in terms of FQOL and provides a practical guideline to event organizers to better understand the significance of festivals.

ECONOMIC INDEPENDENCE FAMILY ACTIVITY THROUGH THE SECOND BUSINES IN SOUTH SULAWESI, INDONESIA.

This type of qualitative research uses a phenomenological approach, while the results of the research show that side businesses owned by the community in various forms, both engaged in goods and services, are very important in supporting the economy, especially in the aspect of meeting the needs of daily life, alternative side businesses carried out by the community are solutions in facing human needs who always want better, both primary, secondary and tertiary needs.

Effetti della lettura ad alta voce oltre il linguaggio: l’ autoregolazione come mediatore

Effects of reading aloud beyond language: self-regulation as a mediator Reading aloud is a family activity which, if carried out frequently in the first years of life, supports the child’s linguistic and alphabetic development. Being a social process, shared reading in the family improves the child’s psychosocial development and parenting skills. It has recently been shown that cognitive and linguistic stimulation are associated with an improvement in self-regulation skills. This article describes the most recent findings on the importance of conversation during shared reading and the relationship of this activity with self-regulation and parenting.

Strategic management of horse-related events: the case of the National Championships of the Icelandic horse (Landsmót) 1998-2008.

Horse-related events have been popular in Iceland for many decades, as well as in other countries. Such events attract many people that are both enthusiastic about and involved in horse-related activities. The biggest horse event in Iceland since 1950 has been the National Championships of the Icelandic Horse - Landsmót - which enables the owners of the best horses in Iceland to come together and compete in various categories. Landsmót is organized by the Icelandic Equestrian Association (Landssamband hestamannafélaga [National Association of Equestrian Associations], referred to as LH) and the Farmers Association of Iceland in cooperation with local horse clubs that act as hosts for Landsmót. In this chapter, the Landsmót events held in the years 1998-2008 are studied from a strategic management point of view. The chapter looks into the lessons learnt from the events, based on a four-dimensional approach to strategic management. The main goal of the research, which was completed in 2010, was to bring forward important knowledge and information on the Landsmót events that could be used in the strategy and the development work for upcoming events over the following years. The study of Landsmót 1998-2008 was based on a case study method. Six cases were studied from an illustrative and explorative point of view. The study also made use of focus groups, interviews, questionnaires and document analysis. The study concluded that Landsmót as a biennial event is a celebration of success in breeding and training of the Icelandic horse. Landsmót is also a social gathering, uniting people who are dedicated to the Icelandic horse, both within Iceland and from abroad. The study also concluded that Landsmót is about competition and ranking of the best horses, while at the same time it is an event true to tradition and family activity. Finally, the main conclusions reveal that Landsmót is very important for marketing and communication of the qualities of the Icelandic horse.

ADAPTATION OF MUSLIM FAMILY ACTIVITY IN OCCUPYING MINIMALIST CONTEMPORARY ARCHITECTURAL HOUSING DESIGN

The Muslim family's important criteria that inhabited their house are the needs of his family's privacy, creating an Islamic behavior (modesty) and entertaining guests (hospitality) who came to visit. The perception of these needs included the development of a minimalist contemporary architecture that is now widely grown. Contemporary minimalism is one type of architecture emerged in Indonesia, especially in Medan. The type is simple and small dimensions characterize minimalism. Does every Muslim family in the area of Medan (sample) is easily adaptable to the needs that exist in minimalist contemporary architecture include the need for privacy, modesty, and hospitality?. Therefore, the research purpose is to discover a Muslim family adaptation to the needs of space and performance. The method used was a qualitative method of mapping the behavior by place-centered mapping. Results from this study are the adaptation of living in the house to appropriate their needs and recommending improvements in the design of houses.