The technological development led to the substitution of vegetable and animal oils for the mineral ones. With further development of engine manufacturing, the requirements to the quality of lubricants increased. It was revealed that the mineral oils, as though they are cleaned, do not satisfy the requirements. In this regard, the new method for the improvement of the quality of lubricants is the addition of organic compounds with various functional groups providing the lubricants with set properties into so-called “additives”. In 1945 on the offer of academician U. Mammadaliev a laboratory of the lubricants and additives had been established and leaded by academician A.M. Kuliev under AzNIINP named after V.V. Kuybyshev. Fundamental studies of this staff were considered a basis for the development of industrial production of efficient additives in the former Soviet Union. First developments of the staff related to the depressor and detergent, afterwards to the multi-functional additives. Based on carried out surveys by the laboratory staff the first local additives – depressors AzNII, AzNII-4, AzNII-5, AzNII-TSIATIM etc. have been developed in Azerbaijan. The success of the staff in the studies and developments, as well as the presence of qualified specialists in the chemistry of additives promoted the establishment of the single in our country profiled Institute for the chemistry of additives of the Academy of Sciences of Azerbaijan SSR under the leadership of A.M. Kuliev in 1965. The diapason of fundamental works, enabling to develop the scientific basis of synthesis of efficient additives of optimum structure has been dramatically increased. Numerous efficient additives of various purpose have been obtained. The lubricants are being used in all spheres of the economy.