The system presented in this chapter is mainly destined to offer support and to monitor chronic and elderly patients. In accordance with the new tendencies in the field, it integrates innovative components for data acquisition systems, Web-based virtual instrumentation, personalized user interfaces, and relational data in a complex, modular, flexible, and opened structure. Compared with other similar integrated communication systems, which are based on Wi-Fi technology, the presented one has as distinctive features: small dimensions, low power consumption, and a considerable autonomy. A large set of experiments and the corresponding results illustrates the functionality of the configurable virtual web instrument principle materialized in the E-Health Monitoring and Supervising System (EMSS) that has many possible applications. As an example, a cheap, easy to use, and personalized support destined to improve the quality of life for subjects suffering from chronic diseases or elderly patients was chosen. The implementation of the complete application included a model for gesture recognition, which allows the classification and assessment of the characteristics of the subject’s movement, highlighting even small progresses of the monitored patients.