The experience gained over the last 20 years of working with the Third Sector (in different organizational, sectoral, and territorial areas), as well as the study of literature, invites us to reflect and analyze, in a world which is complex, uncertain, and with plenty of information and knowledge, on the need to produce a new innovation and transformation strategy. This “Great Transformation” will allow NGOs to have a greater global impact thanks to the development of new approaches, new relational models and the creation of value with their environment and stakeholders. To this end, this chapter analyzes and makes a concrete proposal about the role that technology (especially the Internet) and social networks can play in the co-production and distribution of knowledge and the role of participation in communities to learn and innovate, but in order to move forward in this challenge, requires addressing the difficulties and reluctance in the NGOs, which are not only technological, but conceptual, structural, relational, and cultural. As stated in the conclusion of the chapter, the key to success lies in the purpose and vision of what is to be achieved rather than on the technology used.