A Novel pH and Thermo-sensitive N,O-Carboxymethyl Chitosan-graft-Poly(N-isopropylacrylamide) Hydrogel for Controlled Drug Delivery

e-Polymers ◽  
2007 ◽  
Vol 7 (1) ◽  
Author(s):  
M. Prabaharan ◽  
J. F. Mano
Keyword(s):  
Phase Transition ◽  
Drug Delivery ◽  
Controlled Release ◽  
Ph Value ◽  
Drug Loading ◽  
Crosslinking Agent ◽  
Weight Ratio ◽  
Carboxymethyl Chitosan ◽  
Swelling Ratio ◽  
Drug Delivery Carrier

Abstract A novel kind of thermo and pH-responsive hydrogels was prepared by reacting N,O-carboxymethyl chitosan (NOCC) with amino-telechelic poly(Nisopropylacrylamide) (PNIPAAm-NH2) as a drug delivery carrier. The hydrogels were characterized by FT-IR and 1H-NMR techniques. The phase transition behavior of the hydrogels was found to be dependent on the NOCC/PNIPAAm-NH2 weight ratio and pH value of the medium. The hydrogels with a higher content of PNIPAAm showed a definite phase transition at 32 °C as it occurs in pure PNIPAAm. For the release study, NOCC-g-PNIPAAm beads were prepared using glutaraldehyde (GA) as a crosslinking agent. The swelling ratio of the beads was higher in pH 2.1 than pH 7.4. Moreover, the swelling ratio of the beads decreased with the increase in PNIPAAm content of the beads. The release profile of NOCCg- PNIPAAm beads showed a slower and controlled release of the entrapped ketoprofen, and found that the release behaviour was influenced by both the pH and temperature of the medium. It is expected that these smart hydrogels may be useful to develop drug delivery systems with improved drug loading capacity and controlled release behaviour.

A Controlled-Release Nanocarrier with Extracellular pH Value Driven Tumor Targeting and Translocation for Drug Delivery

2013 ◽  
Vol 52 (29) ◽  
pp. 7487-7491 ◽  
Author(s):  
Zilong Zhao ◽  
Hongmin Meng ◽  
Nannan Wang ◽  
Michael J. Donovan ◽  
Ting Fu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Tumor Targeting ◽  
Ph Value ◽  
Extracellular Ph

scholarly journals SYNTHESIS AND CHARACTERIZATION OF THIOLATED JACKFRUIT SEED STARCH AS A COLONIC DRUG DELIVERY CARRIER

2019 ◽  
pp. 53-62 ◽  
Author(s):  
Sanjoy Das ◽  
Malay K. Das
Keyword(s):  
Drug Delivery ◽  
Release Kinetics ◽  
Drug Loading ◽  
Local Treatment ◽  
Entrapment Efficiency ◽  
Esterification Reaction ◽  
Compatibility Study ◽  
Mice Model ◽  
Drug Delivery Carrier

Objective: Site-specific drug delivery into the colonic region is extremely fascinating for local treatment of various colonic diseases like ulcerative colitis, colon cancer but it should be capable of saving the drug from hydrolysis and degradation. The present study reports the application of jackfruit seed starch and its thiol derivative as a drug delivery carrier for the colon. Methods: The starch was extracted from the jackfruit seeds by water extraction method and modified by the esterification reaction with thioglycolic acid. The thiolated starch was characterized for morphology, functional and flow properties. The safety profile of the thiolated starch was confirmed by acute toxicity study in a mice model as per OECD guidelines 423. The microspheres based on thiolated starch were prepared by ionic gelation method incorporating Ibuprofen as a model drug. The prepared microspheres were characterized for particle size, drug entrapment efficiency, drug loading, compatibility study, surface morphology, in vitro drug release and release kinetics. Results: The result attributed that starch was successfully modified by the thiolation with a degree of substitution of 3.30. The size of prepared microspheres ranges from 825.5±4.58 to 857±6.24 µm, the entrapment efficiencies ranges from 69.23±1.19 to 76.15±0.83 % and the drug loading capacity ranges from 17.75±0.30 to 46.05±0.49 %. The FT-IR, DSC and XRD studies confirmed that there is no interaction within drug and excipients. The thiolated starch microspheres show the maximum release of drug at pH 7.4 in the presence of rat caecal content as compared to pH 1.2 and pH 6.8 for up to 24 h and are following first order release kinetics. Conclusion: These results suggest the application of thiolated jackfruit seed starch could be promising as a long-term drug delivery carrier for the colon.

scholarly journals Development of a Layer-by-Layer Assembled Film on Hydrogel for Ocular Drug Delivery

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Pin Chen ◽  
Xin Wang ◽  
Yan Dong ◽  
Xiaohong Hu
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Ph Value ◽  
Drug Loading ◽  
Drug Carriers ◽  
Ocular Drug Delivery ◽  
Layer By Layer ◽  
Uv Spectrum ◽  
Modification Technique ◽  
Assembly Procedure

Hydrogel is a kind of attractive drug carriers because of its good biocompatibility and transparency. But traditional hydrogel showed some restrictions in its application in ocular drug delivery. A simple surface modification technique based on layer-by-layer (LbL) self-assembled multilayer for ocular drug delivery was developed in this work. Polycarboxymethyl-β-cyclodextrin (poly(CM-β-CD))/poly-l-lysine (PLL) multilayer film was designed and constructed for ocular drug delivery, sinceβ-CD showed good drug delivery property. The properties such as the contact angle and transparency varied a little with the deposition of poly(CM-β-CD)/PLL multilayer. Orfloxacin and puerarin were loaded into multilayer during the self-assembly procedure by two methods, which were tracked by the largest drug absorbance of UV spectrum. The loaded drug amount by incorporating drugs into poly(CM-β-CD) solution was larger than that by incorporating drugs into PLL solution. The loaded drug in the multilayer could gradually be released from multilayer in some period either for orfloxacin or for puerarin. The drug release behavior was influenced by drug loading method and pH value of released medium. Moreover, the balanced released drug amount by incorporating drugs into poly(CM-β-CD) solution is much smaller than that by incorporating drugs into PLL solution.

scholarly journals Mesenchymal stem cells-derived exosomes for drug delivery

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yao Sun ◽  
Guoliang Liu ◽  
Kai Zhang ◽  
Qian Cao ◽  
Tongjun Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Lipid Bilayers ◽  
Drug Loading ◽  
The Body ◽  
Existing Problems ◽  
Drug Delivery Carrier ◽  
Purification Methods ◽  
Loading Methods

AbstractExosomes are extracellular vesicles secreted by various cells, mainly composed of lipid bilayers without organelles. In recent years, an increasing number of researchers have focused on the use of exosomes for drug delivery. Targeted drug delivery in the body is a promising method for treating many refractory diseases such as tumors and Alzheimer's disease (AD). Finding a suitable drug delivery carrier in the body has become a popular research today. In various drug delivery studies, the exosomes secreted by mesenchymal stem cells (MSC-EXOs) have been broadly researched due to their immune properties, tumor-homing properties, and elastic properties. While MSC-EXOs have apparent advantages, some unresolved problems also exist. This article reviews the studies on MSC-EXOs for drug delivery, summarizes the characteristics of MSC-EXOs, and introduces the primary production and purification methods and drug loading methods to provide solutions for existing problems and suggestions for future studies.

Antheraea pernyi Silk Fibroin Nanoparticles for Drug Delivery

2014 ◽  
Vol 27 ◽  
pp. 75-81 ◽  
Author(s):  
Shen Zhou Lu ◽  
Juan Wang ◽  
Li Mao ◽  
Gui Jun Li ◽  
Jian Jin
Keyword(s):  
Drug Delivery ◽  
Silk Fibroin ◽  
Molecular Conformation ◽  
Ph Value ◽  
Drug Loading ◽  
Antheraea Pernyi ◽  
Silk Fibroin Nanoparticles ◽  
Loading Ratio ◽  
Α Helix ◽  
Average Size

Silk nanoparticles were easily obtained from regenerated Antheraea Pernyi Silk Fibroin (ASF). The morphology and average size of the silk particles was sensitive to pH value of fibroin solution. The diameter of nanoparticles prepared was in the range of 30 nm to 1000 nm with a narrow size distribution. On this process, the molecular conformation of regenerated ASF changed from α-helix to β-sheet structure. The shape of prepared nanoparticles were regular spherical structure when the pH value was about 4.3 (pI) in ASF solution. Doxorubicin hydrochloride (DOX) was loaded in the ASF particles as drug release model and the drug-loading ratio was 3.4 %. The release rate of DOX from ASF nanoparticles was pH sensitive. After 23 days release, there was still 84% DOX in the ASF nanoparticles. The result suggested that the ASF nanoparticles might be suitable microcarriers for drug delivery.

scholarly journals Live-Cell Imaging of Colloidal Mesoporous Silica Nanoparticles for Drug Delivery: Drug Loading, Pore Sealing and Controlled Release

2011 ◽  
Vol 100 (3) ◽  
pp. 600a
Author(s):  
Anna M. Sauer ◽  
Axel Schlossbauer ◽  
Valentina Cauda ◽  
Hanna Engelke ◽  
Christian Argyo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Live Cell ◽  
Pore Sealing

Preparation and Drug Release Behavior from a Temperature-Sensitive Poly(aspartic Acid) Derivatives Hydrogel

2013 ◽  
Vol 711 ◽  
pp. 18-21
Author(s):  
Kui Lin Deng ◽  
Chun Xiu Li ◽  
Ting Gao ◽  
Xiao Dan Fu ◽  
Wen Hui Jin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Aspartic Acid ◽  
Ph Value ◽  
Phosphate Buffer Solution ◽  
Temperature Sensitive ◽  
Release Behavior ◽  
Buffer Solution ◽  
Drug Release Behavior ◽  
Drug Delivery Carrier ◽  
Increasing Temperature

In this paper, a new pH/temperature-sensitive beads with semi-interpenetrating polymeric network based on sodium alginate(SA) and poly(aspartic acid) derivatives(M-E-PSI) were prepared using as drug delivery carrier. With indomethacin as a drug model，we investigated the release behaviors of indomethacin in different pH value, temperature and ratio of SA/ M-E-PSI. It turned out that the release amount of indomethacin in pH=2.1 phosphate buffer solution(PBS) was evidently higher than that in pH=7.4 PBS. And also, the release amount of indomethacin was also increased with increasing temperature and poly(aspartic acid) derivatives content in the beads.

The Layered Silicate, Montmorillonite (MMT) as a Drug Delivery Carrier

2013 ◽  
Vol 571 ◽  
pp. 111-132 ◽  
Author(s):  
Bhavesh D. Kevadiya ◽  
Hari C. Bajaj
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Clay Minerals ◽  
Organic Molecules ◽  
Clinical Medicine ◽  
Layered Silicate ◽  
Controlled Drug Delivery ◽  
Therapeutic Index ◽  
High Concentration ◽  
Drug Delivery Carrier

Controlled drug delivery system is a protocol to develop nanostructures and materials that can efficiently encapsulate drugs at high concentration, cross the cell membrane, and release the drug at the target site in a controlled manner for a prescribed period of time. This system can reduces the patient expenses, and risks of toxicity, while it can increase the drug efficacy, specificity, tolerability and therapeutic index of corresponding drugs. Therefore, construction of stimuli-responsive controlled-release systems is of crucial importance for the development of both fundamental science and clinical medicine. Both natural and synthetic materials have been tested and proposed as components of controlled drug delivery. Clay minerals, synthetic or natural, are an important, widely abundant, and low-cost class of materials with unique swelling, intercalation, adsorption, and ion-exchange properties. The safety proof data of clay minerals clearly suggest them to be non-toxic for transdermal application and oral administration. To accomplish controlled-release systems based on layered clay minerals, one of the best ways is to intercalate organic molecules into the interlayer gallery of clay minerals. Intercalation of organic molecules within the gallery of layered silicates offers a novel route to prepare organic and inorganic hybrids that contain properties of both the inorganic host and organic guest in a single material. In this article we will highlight the applications of clay in pharmaceutics as controlled drug delivery carrier.

Controlled Release of Doxycycline by Magnetized Microporous MIL53(Fe); Focus on Magnetization and Drug Loading

2018 ◽  
Vol 16 (1) ◽  
pp. 42-50 ◽  
Author(s):  
Shakiba Naeimi ◽  
Hossein Faghihian
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Loading ◽  
In Vitro Release ◽  
Time Intervals ◽  
Drug Content ◽  
Releasing Process ◽  
Phosphate Buffered Saline ◽  
Vitro Release

Background: In this research, MIL-53(Fe) was magnetized and the performance of the magnetized material as a drug delivery system for doxycycline was studied. Objectives: The experiments were designed to load the magnetic delivery compounds with different amount of the drug. Methods: The in vitro release rate of doxycycline from magnetic MIL-53(Fe) with different drug content into saline buffered fluid (SBF, pH=7.4) and phosphate buffered saline (PBS, pH=3) was then studied. Results: The results showed that the releasing process of the drug in PBS media achieved the equilibration within 48h with 98% of releasing efficiency, while the releasing process in SBF media (pH=7.4) was slower and the equilibrium was established within 264 h with the releasing efficiency of 95%. The amount of the released doxycycline from the samples with different drug content was measured at various time intervals. Conclusion: It was concluded that in PBS media after 75 h, 85, 95 and 98% of loaded doxycycline released, respectively, from the sample containing 22, 32 and 35% of the drug. In SBF media, the release was slower and after 350 h, 82, 91 and 95% of loaded doxycycline released from the samples, respectively, containing 22, 32 and 35 % of the drug. The results of this study indicated that by use of drugreleasing profile and selecting appropriate carrier dose, the released amount of the drug into the patient body can be controlled.

scholarly journals Therapeutic Potential of Polymer-Coated Mesoporous Silica Nanoparticles

2019 ◽  
Vol 10 (1) ◽  
pp. 289 ◽  
Author(s):  
Kuldeep K. Bansal ◽  
Deepak K. Mishra ◽  
Ari Rosling ◽  
Jessica M. Rosenholm
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Therapeutic Potential ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Polymer Coatings ◽  
Drug Delivery Carrier ◽  
Great Solution ◽  
Selection Of

Mesoporous silica nanoparticles (MSNs) find tremendous applications in drug delivery due to several advantages such as their easy fabrication process, high drug loading, biodegradability, biocompatibility, and so forth. Nevertheless, despite several advantages, the use of this striking drug delivery carrier is restricted due to premature drug release owing to the porous structure. Coating of the pores using polymers has emerged as a great solution to this problem. Polymer coatings, which act as gatekeepers, avoid the premature release of loaded content from MSNs and offers the opportunity for controlled and targeted drug delivery. Therefore, in this review, we have compiled the polymer-based coating approaches used in recent years for improving the drug delivery capability of MSNs. This manuscript provides an insight into the research about the potential of polymer-coated MSNs, allowing the selection of right polymer for coating purposes according to the desired application.

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