Zeolite reinforced carboxymethyl cellulose-Na+ -g-cl -poly(AAm) hydrogel composites with pH responsive phosphate release behavior

2018 ◽  
Vol 136 (15) ◽  
pp. 47332 ◽  
Author(s):  
Anupama Singh ◽  
Dhruba Jyoti Sarkar ◽  
Shailja Mittal ◽  
Rashmi Dhaka ◽  
Pushkar Maiti ◽  
...  
Keyword(s):  
Carboxymethyl Cellulose ◽  
Release Behavior ◽  
Ph Responsive ◽  
Phosphate Release ◽  
Hydrogel Composites

scholarly journals Preparation and Swelling Behaviors of High-Strength Hemicellulose-g-Polydopamine Composite Hydrogels

Materials ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 186
Author(s):  
Jiayan Ge ◽  
Kaiqi Gu ◽  
Kewen Sun ◽  
Xinyue Wang ◽  
Shuangquan Yao ◽  
...  
Keyword(s):  
Water Retention ◽  
High Strength ◽  
Release Behavior ◽  
Ph Responsive ◽  
Composite Hydrogels ◽  
Hydrogel Network ◽  
Microsphere Size ◽  
Chemical Cross Linking ◽  
Swelling Behaviors ◽  
Good Water Retention

Hemicellulose-based composite hydrogels were successfully prepared by adding polydopamine (PDA) microspheres as reinforcing agents. The effects of PDA microsphere size, dosage, and nitrogen content in hydrogel on the mechanical and rheological properties was studied. The compressive strength of hydrogel was increased from 0.11 to 0.30 MPa. The storage modulus G’ was increased from 7.9 to 22.0 KPa. The gaps in the hemicellulose network are filled with PDA microspheres. There is also chemical cross-linking between them. These gaps increased the density of the hydrogel network structure. It also has good water retention and pH sensitivity. The maximum cumulative release rate of methylene blue was 62.82%. The results showed that the release behavior of hydrogel was pH-responsive, which was beneficial to realizing targeted and controlling drug release.

scholarly journals pH-Responsive Succinoglycan-Carboxymethyl Cellulose Hydrogels with Highly Improved Mechanical Strength for Controlled Drug Delivery Systems

Polymers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 3197
Author(s):  
Younghyun Shin ◽  
Dajung Kim ◽  
Yiluo Hu ◽  
Yohan Kim ◽  
In Ki Hong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mechanical Strength ◽  
Carboxymethyl Cellulose ◽  
Polymer Network ◽  
Controlled Drug Release ◽  
Interpenetrating Polymer Network ◽  
Ph Responsive ◽  
Hek 293 ◽  
Natural Polysaccharide ◽  
293 Cells

Carboxymethyl cellulose (CMC)-based hydrogels are generally superabsorbent and biocompatible, but their low mechanical strength limits their application. To overcome these drawbacks, we used bacterial succinoglycan (SG), a biocompatible natural polysaccharide, as a double crosslinking strategy to produce novel interpenetrating polymer network (IPN) hydrogels in a non-bead form. These new SG/CMC-based IPN hydrogels significantly increased the mechanical strength while maintaining the characteristic superabsorbent property of CMC-based hydrogels. The SG/CMC gels exhibited an 8.5-fold improvement in compressive stress and up to a 6.5-fold higher storage modulus (G′) at the same strain compared to the CMC alone gels. Furthermore, SG/CMC gels not only showed pH-controlled drug release for 5-fluorouracil but also did not show any cytotoxicity to HEK-293 cells. This suggests that SG/CMC hydrogels could be used as future biomedical biomaterials for drug delivery.

Hydrazone-linked soybean protein isolate-carboxymethyl cellulose conjugates for pH-responsive controlled release of pesticides

2019 ◽  
Vol 51 (11) ◽  
pp. 1211-1222 ◽  
Author(s):  
Guanghua Liu ◽  
Guanquan Lin ◽  
Mingyi Tan ◽  
Hongjun Zhou ◽  
Huayao Chen ◽  
...  
Keyword(s):  
Controlled Release ◽  
Carboxymethyl Cellulose ◽  
Soybean Protein ◽  
Protein Isolate ◽  
Ph Responsive ◽  
Soybean Protein Isolate

scholarly journals ENZYMATICALLY SYNTHESIZED pH-RESPONSIVE IPN FOR IN-SITU RELEASE OF PANTOPRAZOLE SODIUM

2019 ◽  
pp. 98-103
Author(s):  
Saruchi Sharma ◽  
VANEET KUMAR
Keyword(s):  
Drug Release ◽  
Polymer Network ◽  
Lateral Diffusion ◽  
Ph Sensitive ◽  
Interpenetrating Polymer Network ◽  
Release Behavior ◽  
Ph Responsive ◽  
Gum Tragacanth ◽  
Swelling Capacity

Objective: This study involves the synthesis of Gum tragacanth (gt) based interpenetrating polymer network (ipn) and its utilization for sustained release of anti-ulcerative drug i.e. pantoprazole sodium. Methods: IPN was synthesized from Gum tragacanth, polyacrylic acid (gt-cl-paa) hydrogel. gt-cl-paa was kept in distilled water. Further, acryamide (aam) and methylmethacrylate (mma) was added and then kept for overnight. Later on, lipase and glutaraldehyde were added. Homopolymers and the unreacted monomers were removed using acetone. Synthesized IPN was dried at 50 °C for further study. Synthesized ipn was swelled in water and the drug was added to it. The drug was entrapped in the pores of the synthesized ipn and then drug release behavior was studied using uv-vis spectrophotometer. Results: Gt, paa and mma based crosslinked IPN were synthesized using lipase-glutaraldehyde as initiator-crosslinker system. The synthesized IPN was pH sensitive and possessed the desired swelling capacity required for the controlled and systematic liberation of pantoprazole sodium at 37 °C. The kinetic of drug release was studied and found that lateral diffusion (DL) of drug was higher as compared to the initial diffusion (DI). The prepared IPN can be used as prospective carrier for prolonged drug delivery. Conclusion: A novel pH sensitive and colon targeted IPN was synthesized. It acts as an effective device for the controlled release of drug pantoprazole sodium.

pH-Responsive Model Drug Release from Silica-Poly(methacrylic acid) Interpenetrating Gel Hybrids

2001 ◽  
Vol 16 (5) ◽  
pp. 409-418 ◽  
Author(s):  
Kazuya Suzuki ◽  
Takeshi Yumura ◽  
Yuko Tanaka ◽  
Mitsuru Akashi
Keyword(s):  
Methacrylic Acid ◽  
Porous Silica ◽  
Silica Particles ◽  
Release Behavior ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
The Core ◽  
Ph Values ◽  
Brilliant Blue Fcf ◽  
Model Drug

Stimuli-responsive gel was hybridized with porous silica particles, by radical polymerization of methacrylic acid (MA) in the presence of a crosslinker. Brilliant Blue FCF (BBFCF) was encapsulated in the core of the particle and its release behavior from the particle under specific stimuli was studied. PMA gel hybridized silica particles showed specific release behavior at different pH values while normal silica particles released BBFCF at the same rate at all pHs.

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