Challenges and Opportunities in the Development of Medical Therapies for Pediatric Populations and the Role of Extrapolation

2018 ◽  
Vol 103 (3) ◽  
pp. 419-433 ◽  
Author(s):  
Jeffrey S. Barrett ◽  
Raafat Bishai ◽  
Christina Bucci-Rechtweg ◽  
Amy Cheung ◽  
Solange Corriol-Rohou ◽  
...  
Keyword(s):  
Challenges And Opportunities ◽  
Pediatric Populations ◽  
Medical Therapies

Emerging Challenges and Opportunities of Mobile Commerce in India: A Study on Societal Perspective

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Utkarsh Kumar ◽  
Anil Kumar Gope ◽  
Shweta Singh
Keyword(s):  
Growth Rate ◽  
Societal Perspective ◽  
Mobile Applications ◽  
Mobile Application ◽  
Mobile Commerce ◽  
Mobile Banking ◽  
Black And White ◽  
The People ◽  
Challenges And Opportunities

In India, the position of mobile banking was in saga and this time, it is in pic position. The speedof reaching the people is going high and high. This is time of wireless world and sense of prestige; no doubt the mobile commerce is contributing to enhance the beauty of life and playing the role of metaphor and has become the part and parcel of our life. This growth has changed people to do business in mobile commerce (М- Commerce). Peoples are transferring to M-Commerce to attain good and fast transaction into market and saving their precious time. M-Commerce has become distinguished in Indian people, quickly during last few years. Due to large number of mobile application, growth rate in mobile penetration in India is increasing with the rapid speed. The mobile users has shifted to use the android phone from simple and black and white phone and taking the service of internet, the role of telecom companies is also important in the being popular of mobile commerce. Although many people have started E-Commerce but still a separate part of the society feel uncomfortable and hesitate to use M-Commerce because of security problems, payment issues and complexity of mobile applications. This paper identifies facts about the feasibility of MCommercein India today its growth and the Strength and opportunity, weakness and threats lying ahead.

RURAL TOURISM IN INDIA CHALLENGES AND OPPORTUNITIES

2018 ◽  
Vol 6 (26) ◽  
Author(s):  
Pankaj Sharma ◽  
Ravi Parkash
Keyword(s):  
Private Sector ◽  
Rural Areas ◽  
Economic Condition ◽  
Rural Tourism ◽  
Rural Location ◽  
Different Types ◽  
Challenges And Opportunities ◽  
Political Background ◽  
The Government

The paper analyze the role of rural tourism for the development of rural areas, The study analyzed how the different types of tourist product diversifications influence the development possibilities of studied rural areas in India. The government should sponsor private Sector to promote tourism in rural areas. For upgrading the rural tourism government requires to understand the rural location, demography, socio-culture, financial and political background of that area. How we can involve the rural citizens to improve their socio-economic condition. The objective of this paper is to present an update on rural tourism expansion and development in India. Rural tourism is rising in terms of number of visitors and the government of India should focus on it as an engine of growth

Revolutionizing Mental Health with Social Media

2019 ◽  
pp. 259-284
Author(s):  
Munmun De Choudhury
Keyword(s):  
Social Media ◽  
Well Being ◽  
Linguistic Expression ◽  
Ethical Considerations ◽  
Self Disclosure ◽  
Vulnerable Communities ◽  
Tailored Interventions ◽  
Challenges And Opportunities ◽  
Social Media Platforms

Social media platforms have emerged as rich repositories of information relating to people’s activities, emotions, and linguistic expression. This chapter highlights how these data may be harnessed to reason about human mental and psychological well-being. It also discusses the emergent role of social media in providing a platform of self-disclosure and support to distressed and vulnerable communities. It reflects on how this new line of research bears potential for informing the design of timely and tailored interventions, provisions for improved personal and societal well-being assessment, privacy and ethical considerations, and the challenges and opportunities of the increasing ubiquity of social media.

scholarly journals The continuum of simulator-based maritime training and education

2021 ◽  
Author(s):  
Tae-eun Kim ◽  
Amit Sharma ◽  
Morten Bustgaard ◽  
William C. Gyldensten ◽  
Ole Kristian Nymoen ◽  
...  
Keyword(s):  
Digital Technologies ◽  
Competency Development ◽  
Training And Education ◽  
Maritime Education ◽  
Training Interventions ◽  
The Future ◽  
Challenges And Opportunities ◽  
Maritime Operations ◽  
Maritime Education And Training

AbstractThe COVID-19 pandemic has brought unprecedented challenges to the maritime supply chain and called for accelerated adoption of digital technologies in various aspects of maritime operations, including the area of maritime education and training (MET). This paper aims to discuss the current maritime simulator-based training and educational practices that forms an integral part in seafarer training and competency development. The study provides a review of the existing simulators in use in MET, and discusses upon the technological and pedagogical advancement of maritime simulator-based training interventions with predictions regarding the future MET practices with use of virtual reality and cloud-based simulators. This study—by focusing on ship’s bridge operations—highlights the characteristics of various types of simulators and also discusses the role of instructors, challenges, and opportunities involving future simulator-based MET due to accelerated adoption of digital technologies and the need to comply with pandemic-related restrictions for MET institutes. The analysis generated in the paper may contribute to the ongoing discussion regarding the future of simulator-based MET and the fulfillment of the UN Sustainable Development Goal (SDG) 4 in the maritime sector.

scholarly journals Kidney organoid systems for studies of immune-mediated kidney diseases: challenges and opportunities

2021 ◽  
Author(s):  
Melissa C. Stein ◽  
Fabian Braun ◽  
Christian F. Krebs ◽  
Madeleine J. Bunders
Keyword(s):  
Kidney Diseases ◽  
Three Dimensional ◽  
Renal Tissue ◽  
Chronic Kidney Diseases ◽  
Immune Mediated ◽  
Primary Epithelial Cell ◽  
Challenges And Opportunities ◽  
Underlying Mechanisms ◽  
Global Population

AbstractAcute and chronic kidney diseases are major contributors to morbidity and mortality in the global population. Many nephropathies are considered to be immune-mediated with dysregulated immune responses playing an important role in the pathogenesis. At present, targeted approaches for many kidney diseases are still lacking, as the underlying mechanisms remain insufficiently understood. With the recent development of organoids—a three-dimensional, multicellular culture system, which recapitulates important aspects of human tissues—new opportunities to investigate interactions between renal cells and immune cells in the pathogenesis of kidney diseases arise. To date, kidney organoid systems, which reflect the structure and closer resemble critical aspects of the organ, have been established. Here, we highlight the recent advances in the development of kidney organoid models, including pluripotent stem cell-derived kidney organoids and primary epithelial cell-based tubuloids. The employment and further required advances of current organoid models are discussed to investigate the role of the immune system in renal tissue development, regeneration, and inflammation to identify targets for the development of novel therapeutic approaches of immune-mediated kidney diseases.

scholarly journals Towards Sustainable Mobility? The Influence of the COVID-19 Pandemic on Romanian Mobile Citizens in Spain

2021 ◽  
Vol 13 (7) ◽  
pp. 4023
Author(s):  
Silvia Marcu
Keyword(s):  
Sustainable Development Goals ◽  
Human Mobility ◽  
Sustainable Mobility ◽  
The Sustainable Development ◽  
New Models ◽  
Challenges And Opportunities ◽  
Development Goals ◽  
Depth Interviews

Using the case study of Romanians in Spain, this article highlights how the COVID-19 crisis presents both challenges and opportunities when it comes to human mobility and sustainability. Drawing on in-depth interviews with mobile people during the period of lockdown and circulation restrictions, and in accordance with the objectives of the Sustainable Development Goals (SDGs), the paper advances and contributes to the relevance of sustainability and its impact on people’s mobility in the context of the COVID-19 pandemic. I argue that even in the midst of the crisis, sustainable ways may be found to promote and protect human mobility. The paper raises the way sustainability acts as a driver, gains relevance and influence, and contributes to the creation of new models of resilient mobility in times of crisis. The conclusions defend the respect for the SDGs regarding human mobility and emphasise the role of people on the move as sustainable actors learning to overcome distance and the barriers to their mobility during the pandemic.

scholarly journals Including the animal standpoint in critical public relations research

2021 ◽  
Vol 10 (2) ◽  
pp. 139-161
Author(s):  
Núria Almiron ◽  
Laura Fernández
Keyword(s):  
Political Economy ◽  
Public Relations ◽  
Animal Studies ◽  
Critical Animal Studies ◽  
Essential Step ◽  
Challenges And Opportunities ◽  
Discourse Studies ◽  
Theoretical Paper ◽  
Short Explanation

In this paper we argue that adopting critical animal studies perspectives in critical public relations can not only be very fruitful, but that it is also a necessity if the aims of the latter are to be achieved. To this end, this text introduces the challenges and opportunities that the field of critical animal studies brings to critical public relations studies. First, a short explanation of what critical animal studies is and why it can contribute to critical public relations studies is provided. Then the main fields of research where this contribution can be most relevant are discussed, including ethics, discourse studies and political economy. The final aim of this theoretical paper is to expand research within the field of critical public relations by including a critical animal studies approach. Eventually, the authors suggest that embracing the animal standpoint in critical public relations is an essential step to furthering the study of power, hegemony, ideology, propaganda or social change and to accomplishing the emancipatory role of research.

scholarly journals Pediatric Antiphospholipid Syndrome: from Pathogenesis to Clinical Management

2021 ◽  
Vol 23 (2) ◽  
Author(s):  
Silvia Rosina ◽  
Cecilia Beatrice Chighizola ◽  
Angelo Ravelli ◽  
Rolando Cimaz
Keyword(s):  
Antiphospholipid Syndrome ◽  
Fluid Phase ◽  
Multiple Organ ◽  
Clinical Settings ◽  
Glycoprotein I ◽  
Long Term Follow Up ◽  
Pediatric Populations ◽  
Cellular Components

Abstract Purpose of Review Elucidating the pathogenic mechanisms mediated by antiphospholipid antibodies (aPL) might exert important clinical implications in pediatric antiphospholipid syndrome (APS). Recent Findings aPL are traditionally regarded as the main pathogenic players in APS, inducing thrombosis via the interaction with fluid-phase and cellular components of coagulation. Recent APS research has focused on the role of β2 glycoprotein I, which bridges innate immunity and coagulation. In pediatric populations, aPL should be screened in appropriate clinical settings, such as thrombosis, multiple-organ dysfunction, or concomitant systemic autoimmune diseases. Children positive for aPL tests often present non-thrombotic non-criteria manifestations or asymptomatic aPL positivity. In utero aPL exposure has been suggested to result in developmental disabilities, warranting long-term follow-up. Summary The knowledge of the multifaceted nature of pediatric APS should be implemented to reduce the risk of underdiagnosing/undertreating this condition. Hopefully, recent pathogenic insights will open new windows of opportunity in the management of pediatric APS.

scholarly journals Using chemical biology to assess and modulate mitochondria: progress and challenges

2017 ◽  
Vol 7 (2) ◽  
pp. 20160151 ◽  
Author(s):  
Angela Logan ◽  
Michael P. Murphy
Keyword(s):  
Mitochondrial Function ◽  
Chemical Biology ◽  
Biomedical Sciences ◽  
Interdisciplinary Approaches ◽  
Wide Range ◽  
Challenges And Opportunities ◽  
Future Challenges ◽  
The Many ◽  
Opening Up

Our understanding of the role of mitochondria in biomedical sciences has expanded considerably over the past decade. In addition to their well-known metabolic roles, mitochondrial are also central to signalling for various processes through the generation of signals such as ROS and metabolites that affect cellular homeostasis, as well as other processes such as cell death and inflammation. Thus, mitochondrial function and dysfunction are central to the health and fate of the cell. Consequently, there is considerable interest in better understanding and assessing the many roles of mitochondria. Furthermore, there is also a growing realization that mitochondrial are a promising drug target in a wide range of pathologies. The application of interdisciplinary approaches at the interface between chemistry and biology are opening up new opportunities to understand mitochondrial function and in assessing the role of the organelle in biology. This work and the experience thus gained are leading to the development of new classes of therapies. Here, we overview the progress that has been made to date on exploring the chemical biology of the organelle and then focus on future challenges and opportunities that face this rapidly developing field.

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