Relationship of the CYBA Gene Polymorphisms with Oxidative Stress and Cardiovascular Risk

Was to conduct a systematic review of data on the relationship between polymorphisms genes of detoxification system and development of preeclampsia (РЕ). Рresents the main genes of detoxification system (GSTPI, GSTМI, GSTТI, GРХI, ЕРНХI, SOD-2, SOD-3, CYPIAL, MTHЕR, MTR) and their functions. Of interest is the possibility of calculating the individual risk of PE based on the results about the presence of a combination of different polymorphisms in the genotype of the female. Question about early diagnosis of РЕ remains controversial and not fully understood. It is necessary to conduct further in-depth, extended study of this problem. Key words: preeclampsia, oxidative stress, genes of the detoxification system.

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Known Hepatoprotectors Act as Antioxidants and Immune Stimulators in Stressed Mice: Perspectives in Animal Health Care

Current Pharmaceutical Design ◽

10.2174/1381612825666190116151628 ◽

2019 ◽

Vol 24 (40) ◽

pp. 4825-4837 ◽

Cited By ~ 2

Author(s):

Gustavo Alberto de la Riva ◽

Francisco Javier López Mendoza ◽

Guillermin Agüero-Chapin

Keyword(s):

Oxidative Stress ◽

Animal Health ◽

Cellular Damage ◽

Farm Animals ◽

Physiological Status ◽

Stress Markers ◽

Glutathione Peroxidases ◽

Transport Chain ◽

Exogenous Compounds ◽

Relationship Of

Background: Oxygen is involved in a variety of physiological reactions in aerobic organisms, such as those produced in the electron transport chain, hydroxylation, and oxygenation. Reactive oxygen species (ROS) are naturally formed as byproducts from these previously reactions involving the O2 molecule; they are made up of superoxide anion (O2−), hydroxyl radical (HO−), hydrogen peroxide (H2O2), nitric oxide (NO), peroxyl (ROO−), and reactive aldehyde (ROCH). Under certain environmental stress conditions, ROS are accumulated causing cellular damage but also triggering the overexpression of several enzyme classes such as superoxide dismutases (SOD), catalases (CAT) and glutathione peroxidases (GPx), which represent an important intrinsic antioxidant defence line. Liver is a key organ in vertebrates including farm animals and human. The oxidative stress plays an important role in systemic malfunctions including hepatic, renal and immunological, disorders. Methods: This review presents a brief update about the relationship of oxidative stress with hepatic, renal and immunological malfunctions in stressed organisms. Cellular and exogenous hepatoprotective compounds share also the ability to scavenge ROS acting as antioxidants and in many cases as stimulators of immune response in stressed organisms. We present the effect of some hepatoprotectors on the hepatic, renal and immunological function in stressed mice by the jointed evaluation of biological and oxidative stress markers. Conclusion: Hepatoprotective effect of several exogenous compounds is very associated with their antioxidant capacity. This fact is relevant for keeping oxidant/antioxidant balance in the respective organs, but also for maintaining the physiological status of the whole organism.

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Increased cardiovascular risk due to systemic inflammatory changes and enhanced oxidative stress in urban Indian women

Air Quality Atmosphere & Health ◽

10.1007/s11869-012-0189-0 ◽

2012 ◽

Vol 6 (2) ◽

pp. 501-508 ◽

Cited By ~ 4

Author(s):

Anindita Dutta ◽

Manas Ranjan Ray

Keyword(s):

Oxidative Stress ◽

Cardiovascular Risk ◽

Indian Women ◽

Urban Indian ◽

Inflammatory Changes

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The Role of Antioxidants Supplementation in Clinical Practice: Focus on Cardiovascular Risk Factors

Antioxidants ◽

10.3390/antiox10020146 ◽

2021 ◽

Vol 10 (2) ◽

pp. 146

Author(s):

Vittoria Cammisotto ◽

Cristina Nocella ◽

Simona Bartimoccia ◽

Valerio Sanguigni ◽

Davide Francomano ◽

...

Keyword(s):

Oxidative Stress ◽

Risk Factors ◽

Cardiovascular Disease ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Antioxidant Supplementation ◽

Oxidative Stress Biomarkers ◽

Increased Risk ◽

Human Disorders ◽

Stress Burden

Oxidative stress may be defined as an imbalance between reactive oxygen species (ROS) and the antioxidant system to counteract or detoxify these potentially damaging molecules. This phenomenon is a common feature of many human disorders, such as cardiovascular disease. Many of the risk factors, including smoking, hypertension, hypercholesterolemia, diabetes, and obesity, are associated with an increased risk of developing cardiovascular disease, involving an elevated oxidative stress burden (either due to enhanced ROS production or decreased antioxidant protection). There are many therapeutic options to treat oxidative stress-associated cardiovascular diseases. Numerous studies have focused on the utility of antioxidant supplementation. However, whether antioxidant supplementation has any preventive and/or therapeutic value in cardiovascular pathology is still a matter of debate. In this review, we provide a detailed description of oxidative stress biomarkers in several cardiovascular risk factors. We also discuss the clinical implications of the supplementation with several classes of antioxidants, and their potential role for protecting against cardiovascular risk factors.

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GTP Cyclohydrolase I Gene Polymorphisms Are Associated with Endothelial Dysfunction and Oxidative Stress in Patients with Type 2 Diabetes Mellitus

PLoS ONE ◽

10.1371/journal.pone.0108587 ◽

2014 ◽

Vol 9 (11) ◽

pp. e108587 ◽

Cited By ~ 8

Author(s):

Pawel P. Wolkow ◽

Wladyslaw Kosiniak-Kamysz ◽

Grzegorz Osmenda ◽

Grzegorz Wilk ◽

Beata Bujak-Gizycka ◽

...

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Endothelial Dysfunction ◽

Gene Polymorphisms ◽

Gtp Cyclohydrolase I ◽

And Oxidative Stress ◽

I Gene

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Anti-inflammatory effects of short-term pioglitazone therapy in men with advanced diabetic nephropathy

AJP Renal Physiology ◽

10.1152/ajprenal.00289.2005 ◽

2006 ◽

Vol 290 (3) ◽

pp. F600-F605 ◽

Cited By ~ 51

Author(s):

Rajiv Agarwal

Keyword(s):

Oxidative Stress ◽

Diabetic Nephropathy ◽

Cardiovascular Risk ◽

High Rate ◽

Protein Carbonyls ◽

Open Label ◽

End Point ◽

Tnf Α ◽

Markers Of Oxidative Stress ◽

Wbc Count

Patients with diabetic nephropathy have a high rate of cardiovascular events and mortality. Nontraditional cardiovascular risk factors such as oxidative stress and inflammation are thought to be particularly important in mediating these events. Studies suggest that thiazolidinediones (TZDs) can reduce the level of nontraditional cardiovascular risk in people with or without diabetes mellitus. Whether this benefit occurs in patients with diabetic nephropathy is unknown. I hypothesized that the TZD pioglitazone will mitigate oxidative stress and inflammation compared with glipizide in patients with overt diabetic nephropathy. Markers of oxidative stress (plasma and urine albumin carbonyl and total protein carbonyls and malondialdehyde), inflammation [white blood cell (WBC) count, C-reactive protein (CRP), plasma IL-6, TNF-α], and plaque stability [matrix metalloproteinase 9 (MMP-9)] were measured in frozen samples obtained from patients with overt diabetic nephropathy participating in a randomized, open-label, blinded end-point, 16-wk trial with glipizide ( n = 22) or pioglitazone ( n = 22). Pioglitazone therapy in men with advanced diabetic nephropathy reduced WBC count by 1,125/μl ( P < 0.001), CRP by 41% ( P = 0.042), IL-6 by 38% ( P = 0.009), and MMP-9 by 29% ( P = 0.016). Specific differential reductions in WBC count of 1,251/μl ( P = 0.009) and reduction in IL-6 of 58% with pioglitazone ( P = 0.001) were seen compared with glipizide. There were no statistically significant changes observed with plasma TNF-α concentrations or markers of oxidative stress with either hypoglycemic agent. In conclusion, pioglitazone reduces proinflammatory markers in patients with overt diabetic nephropathy, which indicates potentially beneficial effects on overall cardiovascular risk. This surrogate end point needs to be confirmed in trials designed to demonstrate cardiovascular protection.

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