Development of Frequency Specific Flow Maps on the Sebaou Watershed in Great Kabylia in Algeria

2019 ◽  
pp. 45-48
Author(s):  
Hocine Hammoum ◽  
Karima Bouzelha ◽  
Mohammed Djemai ◽  
Malik Bouzelha ◽  
Lila Ben Si Said ◽  
...  
Keyword(s):  
Specific Flow ◽  
Flow Maps

Consideration of the temperature factor of atmospheric air when determining standard consumption of fuel and energy resources for train traction

2018 ◽  
Vol 77 (6) ◽  
pp. 375-381
Author(s):  
K. M. Popov
Keyword(s):  
Statistical Processing ◽  
Specific Consumption ◽  
Energy Resources ◽  
Effect Of Temperature ◽  
Influence Coefficient ◽  
Specific Work ◽  
Specific Flow ◽  
Temperature Changes ◽  
Work Area ◽  
Physical Laws

Abstract. Influence of air temperature on the consumption of fuel and energy resources (FER) on train traction is due to a number of physical laws. The extent of this effect is specified in the Rules for Traction Settlement (RTS). At the same time, when rationing FER consumption for train traction, a specialized methodical base is used, which involves a different approach to accounting for the effect of temperature on FER consumption for train traction. At the same time in different documents of this base, the effects of low temperature on the absolute and specific consumption of fuel and energy resources on train traction are taken into account in a different way, which is due to the lack of consensus among specialists on the way this factor is taken into account. Specialists of JSC “VNIIZhT” carried out an analysis of a significant amount of driver’s routes data, results of which showed that the dependence of the specific flow rate on temperature, on the basis of which the corresponding influence coefficient is determined, needs to be periodically updated. In addition, when technically standardizing the consumption of fuel and energy resources (for the locomotive crew work site), the temperature effect coefficients need to be calculated for a specific work area and direction of motion on it, while using the average network coefficient values will lead to errors. When calculating additional flow of fuel and energy from the effect of temperature for electric multiple units (EMU), the equations of regression dependencies should be used, obtained by statistical processing of data on temperature changes and specific consumption of fuel and energy resources for EMU and determined for each series of EMU when working on a particular suburban area.

scholarly journals Synergistic Interaction of MEK Kinase 2, c-Jun N-Terminal Kinase (JNK) Kinase 2, and JNK1 Results in Efficient and Specific JNK1 Activation

2000 ◽  
Vol 20 (7) ◽  
pp. 2334-2342 ◽  
Author(s):  
Jinke Cheng ◽  
Jianhua Yang ◽  
Ying Xia ◽  
Michael Karin ◽  
Bing Su
Keyword(s):  
Complex Formation ◽  
Molecular Basis ◽  
Synergistic Interaction ◽  
Specific Flow ◽  
Mitogen Activated Protein Kinases ◽  
Mapk Kinase ◽  
Signaling Complex ◽  
Mapk Cascades ◽  
Mitogen Activated Protein ◽  
Flow Of Information

ABSTRACT Mitogen-activated protein kinases (MAPKs) are activated through cascades or modules consisting of a MAPK, a MAPK kinase (MAPKK), and a MAPKK kinase (MAPKKK). Investigating the molecular basis of activation of the c-Jun N-terminal kinase (JNK) subgroup of MAPK by the MAPKKK MEKK2, we found that strong and specific JNK1 activation by MEKK2 was mediated by the MAPKK JNK kinase 2 (JNKK2) rather than by JNKK1 through formation of a tripartite complex consisting of MEKK2, JNKK2, and JNK1. No scaffold protein was required for the MEKK2-JNKK2-JNK1 tripartite-complex formation. Expression of JNK1, JNKK2, and MEKK2 significantly augmented the coprecipitation of, respectively, MEKK2-JNKK2, MEKK2-JNK1, and JNKK2-JNK1, indicating that the interaction of MEKK2, JNKK2, and JNK1 is synergistic. Finally, the JNK1 was activated more efficiently in the MEKK2-JNKK2-JNK1 complex than was the JNK1 excluded from the complex. Thus, formation of a signaling complex through synergistic interaction of a MAPKKK, a MAPKK, and a MAPK molecule like MEKK2-JNKK2-JNK1 is likely to be responsible for the efficient, specific flow of information via MAPK cascades.

scholarly journals A Driver’s Visual Attention Prediction Using Optical Flow

Sensors ◽  
2021 ◽  
Vol 21 (11) ◽  
pp. 3722
Author(s):  
Byeongkeun Kang ◽  
Yeejin Lee
Keyword(s):  
Visual Attention ◽  
Optical Flow ◽  
Prediction Models ◽  
Apparent Movement ◽  
Image Sequences ◽  
Motion Information ◽  
Accuracy Improvement ◽  
Flow Maps ◽  
Current State ◽  
Motion Features

Motion in videos refers to the pattern of the apparent movement of objects, surfaces, and edges over image sequences caused by the relative movement between a camera and a scene. Motion, as well as scene appearance, are essential features to estimate a driver’s visual attention allocation in computer vision. However, the fact that motion can be a crucial factor in a driver’s attention estimation has not been thoroughly studied in the literature, although driver’s attention prediction models focusing on scene appearance have been well studied. Therefore, in this work, we investigate the usefulness of motion information in estimating a driver’s visual attention. To analyze the effectiveness of motion information, we develop a deep neural network framework that provides attention locations and attention levels using optical flow maps, which represent the movements of contents in videos. We validate the performance of the proposed motion-based prediction model by comparing it to the performance of the current state-of-art prediction models using RGB frames. The experimental results for a real-world dataset confirm our hypothesis that motion plays a role in prediction accuracy improvement, and there is a margin for accuracy improvement by using motion features.

scholarly journals Combined Perfusion and Permeability Imaging Reveals Different Pathophysiologic Tissue Responses After Successful Thrombectomy

2021 ◽  
Author(s):  
Arne Potreck ◽  
Matthias A. Mutke ◽  
Charlotte S. Weyland ◽  
Johannes A. R. Pfaff ◽  
Peter A. Ringleb ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Blood Brain Barrier ◽  
Hemorrhagic Transformation ◽  
Brain Barrier ◽  
Dynamic Susceptibility ◽  
Blood Brain Barrier Disruption ◽  
Flow Maps ◽  
Blood Brain ◽  
Patients At Risk ◽  
Brain Barrier Disruption

AbstractDespite successful recanalization of large-vessel occlusions in acute ischemic stroke, individual patients profit to a varying degree. Dynamic susceptibility-weighted perfusion and dynamic T1-weighted contrast-enhanced blood-brain barrier permeability imaging may help to determine secondary stroke injury and predict clinical outcome. We prospectively performed perfusion and permeability imaging in 38 patients within 24 h after successful mechanical thrombectomy of an occlusion of the middle cerebral artery M1 segment. Perfusion alterations were evaluated on cerebral blood flow maps, blood-brain barrier disruption (BBBD) visually and quantitatively on ktrans maps and hemorrhagic transformation on susceptibility-weighted images. Visual BBBD within the DWI lesion corresponded to a median ktrans elevation (IQR) of 0.77 (0.41–1.4) min−1 and was found in all 7 cases of hypoperfusion (100%), in 10 of 16 cases of hyperperfusion (63%), and in only three of 13 cases with unaffected perfusion (23%). BBBD was significantly associated with hemorrhagic transformation (p < 0.001). While BBBD alone was not a predictor of clinical outcome at 3 months (positive predictive value (PPV) = 0.8 [0.56–0.94]), hypoperfusion occurred more often in patients with unfavorable clinical outcome (PPV = 0.43 [0.10–0.82]) compared to hyperperfusion (PPV = 0.93 [0.68–1.0]) or unaffected perfusion (PPV = 1.0 [0.75–1.0]). We show that combined perfusion and permeability imaging reveals distinct infarct signatures after recanalization, indicating the severity of prior ischemic damage. It assists in predicting clinical outcome and may identify patients at risk of stroke progression.

3D Micromixer

2012 ◽  
Author(s):  
Bahador Farshchian ◽  
Junseo Choi ◽  
Sunggook Park
Keyword(s):  
Cover Plate ◽  
Bottom Surface ◽  
Mixing Efficiency ◽  
Molding Process ◽  
Specific Flow ◽  
Pdms Stamp ◽  
Fluorescein Dye ◽  
Solvent Bonding ◽  
Peeling Off

This paper presents the fabrication of a 3D microchannel whose sidewalls and bottom surface are patterned with ratchets using a modified 3D molding process. In the modified 3D molding process the surface of poly(methyl methacrylate) (PMMA) is first patterned using a brass mold having ratchet structures. Then PDMS prepolymer was spin coated over the surface of micropatterned PMMA and cured followed by the primary molding using a brass mold having a T-conjunction protrusion. After primary molding demolding was done by first demolding the brass mold and then peeling off PDMS stamp from PMMA substrate. By setting a 45° angle between direction of ratchets patterned on the surface of PMMA and the brass mold protrusion prior to primary molding 45° slanted ratchets were formed on the sidewall and bottom surface of microchannel using the modified 3D molding. The scanning electron microscope (SEM) micrographs show a successful integration of micropatterns inside the microchannel. Holes were drilled in the inlet and outlet area of the 3D channel before bonding. A solvent bonding technique was used for bonding of 3D channel to a plain cover plate. After bonding capillary tubes were inserted into the holes and glued to the chip using an epoxy glue. For characterization of mixing fluorescence intensity was quantified in the 3D microchannel as deionized water and fluorescein dye injected from different inlets of 3D micromixer were mixed along the 3D microchannel and mixing efficiency was calculated. The results were compared with the data obtained for similar microdevice whose surfaces were not patterned. The results demonstrate at a specific flow rate a faster mixing occurs in a microdevice whose sidewall and bottom surface are patterned with slanted 45° ratchets.

scholarly journals Diagnostic performance of four SARS-CoV-2 antibody assays in patients with COVID-19 or with bacterial and non-SARS-CoV-2 viral respiratory infections

2021 ◽  
Author(s):  
Timo Huber ◽  
Philipp Steininger ◽  
Pascal Irrgang ◽  
Klaus Korn ◽  
Matthias Tenbusch ◽  
...  
Keyword(s):  
Legionella Pneumophila ◽  
False Positive ◽  
Bacterial Infections ◽  
Viral Infections ◽  
Respiratory Infections ◽  
Chlamydia Psittaci ◽  
Specific Flow ◽  
Antibody Assays ◽  
Positive Results ◽  
Viral Respiratory

AbstractSARS-CoV-2 antibody assays are used for epidemiological studies and for the assessment of vaccine responses in highly vulnerable patients. So far, data on cross-reactivity of SARS-CoV-2 antibody assays is limited. Here, we compared four enzyme-linked immunosorbent assays (ELISAs; Vircell SARS-CoV-2 IgM/IgA and IgG, Euroimmun SARS-CoV-2 IgA and IgG) for detection of anti-SARS-CoV-2 antibodies in 207 patients with COVID-19, 178 patients with serological evidence of different bacterial infections, 107 patients with confirmed viral respiratory disease, and 80 controls from the pre-COVID-19 era. In COVID-19 patients, the assays showed highest sensitivity in week 3 (Vircell-IgM/A and Euroimmun-IgA: 78.9% each) and after week 7 (Vircell-IgG: 97.9%; Euroimmun-IgG: 92.1%). The antibody indices were higher in patients with fatal disease. In general, IgM/IgA assays had only limited or no benefit over IgG assays. In patients with non-SARS-CoV-2 respiratory infections, IgG assays were more specific than IgM/IgA assays, and bacterial infections were associated with more false-positive results than viral infections. The specificities in bacterial and viral infections were 68.0 and 81.3% (Vircell-IgM/IgA), 84.8 and 96.3% (Euroimmun-IgA), 97.8 and 86.0% (Vircell-IgG), and 97.8 and 99.1% (Euroimmun-IgG), respectively. Sera from patients positive for antibodies against Mycoplasma pneumoniae, Chlamydia psittaci, and Legionella pneumophila yielded particularly high rates of unspecific false-positive results in the IgM/IgA assays, which was revealed by applying a highly specific flow-cytometric assay using HEK 293 T cells expressing the SARS-CoV-2 spike protein. Positive results obtained with anti-SARS-CoV-2 IgM/IgA ELISAs require careful interpretation, especially if there is evidence for prior bacterial respiratory infections.

The Study of Fire-extinguishing Process of Modelled Fire Seats

2021 ◽  
pp. 57-62
Author(s):  
V.N. Bordakov ◽  
Keyword(s):  
Flow Rate ◽  
Experimental Studies ◽  
Physical Modelling ◽  
Specific Flow Rate ◽  
Specific Flow ◽  
Acceptable Error ◽  
Fire Extinguishing ◽  
Fire Zone ◽  
Analysis Of Results ◽  
Fire Extinguishers

Test-fires to determine fire-extinguishers’ efficiency for extinguishing B class fires are conducted by operators equipped with working clothes, which does not comply with the requirements of physical modelling. This is why the ranks of extinguished modelled seats are significantly overestimated. The quantitative results of fire seats’ extinguishing can be comparatively evaluated in accordance with the value of specific flow rate of a fire-extinguishing agent. As it was detected, the specific flow rate of a fire-extinguishing agent does not actually depend on the rank of modelled fire seat when extinguished by an operator wearing thermal-protective clothes. At the same time, it is increasing along with the expansion of the fire zone scale in case the fire is extinguished without special protective clothes. Consequently, to increase the fire-extinguisher’s efficiency data reliability, the certifying tests should be conducted in conditions close to the real application conditions when the first person to firefight is not equipped with such special protective clothes. The experimental studies to determine the specific flow rate of a fire-extinguishing agent used modelled fire seats of various ranks. The analysis of results showed that the fire-extinguishers ensuring generation of drops of prevailing size more than 0,5 mm are required to extinguish the modelled sire seats. The degree of increasing flow rate for the fire-extinguishing agent to eliminate a fire and observation of a safe distance from the flame for an operator are conditioned by the scale of fire zone and affect the specific flow rate of agent required to ensure stable fire-extinguishing. Based on the results of extinguishing the fire seats «34В» or «55В», it is demonstrated that via using a correction factor it is possible, assuming an acceptable error, to evaluate the flow rate of fire-extinguishing agent to extinguish a modelled fire seat of any rank.

Abstract T P41: Determination of Collateral Supply Patterns Using MR or CT Perfusion Imaging

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
Cihat Eldeniz ◽  
Yueh Lee ◽  
Maria Gisele Matheus ◽  
Jeffery Keith Smith ◽  
James Faber ◽  
...  
Keyword(s):  
Perfusion Imaging ◽  
Ct Perfusion ◽  
Mapping Method ◽  
Collateral Flow ◽  
Scoring Method ◽  
Flow Mapping ◽  
Flow Maps ◽  
Ct Perfusion Imaging ◽  
Ischemic Tissue ◽  
Flow Information

Introduction: In this study, we sought to develop a collateral flow mapping method based on MR or CT perfusion imaging and compare this method with the digital subtraction angiography (DSA) method. Methods: Ischemic tissue supplied by collateral flow is likely to have delayed tracer arrival but relatively normal flow. In this study, abnormal Tmax (> 6 sec), MTT (4 sec or greater than unaffected hemisphere) and CBF (<40% of unaffected hemisphere) were labeled with green, red and blue, respectively (Fig. A). Any perfusion patterns can then be represented by a combination of this integrated RGB maps (Integrated Collateral flow Maps, iCMaps). 24 patients were included in this study. DSA images were obtained from all patients, whereas MR and CT perfusion images were acquired from 15 and 9 patients, respectively, within 30 hours after MCA occlusion. iCMaps collateral flow was scored independently as follows. iCMaps without any perfusion abnormality was assigned “1”. iCMaps with white as the dominant perfusion pattern was assigned a “5”; while those with a dominant green and yellow pattern were assigned a “2” or a “3”, depending on the relative green and yellow volume. Finally, iCMaps with a white region surrounded with yellow and green was assigned a “4”. Examples of iCMaps scoring are shown in Fig. B. Using a DSA scoring method in the literature5, a score of 1-5 was given independently based on the degree of retrograde collateralization (5: poor collateralization). Results: Good correlation was found between the MR perfusion iCMaps and DSA (DSA=0.70*MR iCMaps+0.54, R=0.75). Moderate correlation was obtained between the CT perfusion iCMaps and DSA (DSA=0.51*CT iCMaps+1.9, R=0.56). Conclusions: Based on the different characteristics of Tmax, MTT and CBF maps, the proposed MR or CT perfusion based iCMaps method can provide DSA comparable collateral flow information.

European Working Group on Clinical Cell Analysis: Consensus Protocol for the Flow Cytometric Characterisation of Platelet Function

1998 ◽  
Vol 79 (05) ◽  
pp. 885-896 ◽  
Author(s):  
Gerd Schmitz ◽  
Gregor Rothe ◽  
Andreas Ruf ◽  
Stefan Barlage ◽  
Diethelm Tschöpe ◽  
...  
Keyword(s):  
Platelet Function ◽  
Diagnostic Testing ◽  
Consensus Protocol ◽  
Specific Flow ◽  
New Techniques ◽  
Flow Cytometric ◽  
Open Questions ◽  
European Working ◽  
Definition Of

IntroductionAn increased or disturbed activation and aggregation of platelets plays a major role in the pathophysiology of thrombosis and haemostasis and is related to cardiovascular disease processes. In addition to qualitative disturbances of platelet function, changes in thrombopoiesis or an increased elimination of platelets, (e. g., in autoimmune thrombocytopenia), are also of major clinical relevance. Flow cytometry is increasingly used for the specific characterisation of phenotypic alterations of platelets which are related to cellular activation, haemostatic function and to maturation of precursor cells. These new techniques also allow the study of the in vitro response of platelets to stimuli and the modification thereof under platelet-targeted therapy as well as the characterisation of platelet-specific antibodies. In this protocol, specific flow cytometric techniques for platelet analysis are recommended based on a description of the current state of flow cytometric methodology. These recommendations are an attempt to promote the use of these new techniques which are at present broadly evaluated for diagnostic purposes. Furthermore, the definition of the still open questions primarily related to the technical details of the method should help to promote the multi-center evaluation of procedures with the goal to finally develop standardized operation procedures as the basis of interlaboratory reproducibility when applied to diagnostic testing.

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