Topical Delivery of Drugs for Skin Disease Treatment: Prospects and Promises

2020 ◽  
pp. 197-212
Author(s):  
Abinaya Mani ◽  
Gayathri Mahalingam
Keyword(s):  
Skin Disease ◽  
Topical Delivery ◽  
Disease Treatment

scholarly journals Pharmacotherapy: Its impact on morphofunctional characteristics of the epidermal barrier

2019 ◽  
Vol 95 (1) ◽  
pp. 59-76 ◽  
Author(s):  
D. D. Petrunin
Keyword(s):  
Literature Review ◽  
Systemic Therapy ◽  
Skin Disease ◽  
Barrier Properties ◽  
Physiological Characteristics ◽  
Human Epidermis ◽  
Disease Treatment ◽  
Epidermal Barrier ◽  
The Impact

Various pharmaceuticals used for topical and systemic therapy are capable of exerting significant impact on morphological and physiological characteristics of human epidermis, as well as its barrier properties. This may affect the course of dermatologic diseases and the efficacy of their treatment. In this literature review, the author analyzes the impact of various pharmaceutical classes on the morphofunctional characteristics of the epidermal barrier and formulates recommendations for skin disease treatment.

scholarly journals The Study of Cryosurgical Micro-instrument on Biomedicine

2021 ◽  
Vol 233 ◽  
pp. 02005
Author(s):  
Tao Song ◽  
Baolin Liu ◽  
Linhan Jiao ◽  
Wanzhu Zhang
Keyword(s):  
Skin Disease ◽  
Surgical Instruments ◽  
Disease Treatment ◽  
Advantages And Disadvantages ◽  
Disease Research ◽  
New Type ◽  
And Performance ◽  
Development Course ◽  
Application Scope ◽  
Pathological Tissues

This paper introduces the development course of cryosurgery, mechanism, advantages and disadvantages, application scope, the analysis of the current world advanced the development of cryogenic surgical instruments and its principle and performance, found that at present, the development of the cryoablation equipment mainly for the treatment of diseases such as cancer such heavy research, thus ignore the crowd larger quantity of the treatment of skin disease research. cryopen are introduced in this paper to solve small pathological tissues such as skin disease treatment. we study a new type of freezing and melting equipment, named cryopen. at the same time, the simulation of treating abnormal skin is completed effectively. The results show that cryopen is very good for the treatment of abnormal skin. The future development of small cryoablation equipment is also put forward.

scholarly journals Qualitative and Quantitative Ethnobotanical Analysis of Ricinus communis L. and Azadirachta indica A. Juss. in Sonipat District of Haryana, India

2021 ◽  
Vol 21 (1) ◽  
pp. 61
Author(s):  
Preeti Rani ◽  
Neelu Sood
Keyword(s):  
Health Care ◽  
Statistical Analysis ◽  
Quantitative Analysis ◽  
Indigenous Knowledge ◽  
Azadirachta Indica ◽  
Skin Disease ◽  
Ricinus Communis ◽  
Disease Treatment ◽  
Qualitative And Quantitative ◽  
Treatment Documentation

This manuscript contains vital ethnobotanical information and facts about<em> Ricinus communis</em> and <em>Azadirachta indica</em>, generated through extensive interviews and statistical analysis of data from studied site. Collection and documentation of the information was accomplished by surveying of selected area. The data was analyzed qualitatively and quantitatively, using statistical indices. Number of informants for<em> Ricinus communis</em> and <em>Azadirachta indica</em> were found to be 85 and 111 respectively. Number of ailments being treated by these plants have been recorded carefully. Quantitative analysis has revealed that seeds of <em>Ricinus communis</em> are frequently used to treat arthritis while leaves of <em>Azadirachta indica</em> are used for skin disease treatment. Documentation of such ethnobotanical data will help in conservation of studied plants and sustainability of indigenous knowledge which can be instrumental for strengthening health care system.

scholarly journals Strategies to Develop a Suitable Formulation for Inflammatory Skin Disease Treatment

2021 ◽  
Vol 22 (11) ◽  
pp. 6078
Author(s):  
Jiun-Wen Guo ◽  
Shiou-Hwa Jee
Keyword(s):  
Skin Disease ◽  
Seborrheic Dermatitis ◽  
Topical Therapy ◽  
Skin Barrier ◽  
Therapeutic Effects ◽  
Target Area ◽  
Inflammatory Skin Disease ◽  
Disease Treatment ◽  
Inflammatory Skin

Skin barrier functions, environmental insults, and genetic backgrounds are intricately linked and form the basis of common inflammatory skin disorders, such as atopic dermatitis, psoriasis, and seborrheic dermatitis, which may seriously affect one’s quality of life. Topical therapy is usually the first line of management. It is believed that successful topical treatment requires pharmaceutical formulation from a sufficient dosage to exert therapeutic effects by penetrating the stratum corneum and then diffusing to the target area. However, many factors can affect this process including the physicochemical properties of the active compound, the composition of the formulation base, and the limitations and conditions of the skin barrier, especially in inflammatory skin. This article briefly reviews the available data on these issues and provides opinions on strategies to develop a suitable formulation for inflammatory skin disease treatment.

scholarly journals A review on the important phytochemicals and their role in psoriasis

2021 ◽  
Vol 13 (3) ◽  
pp. 880-896
Author(s):  
Ashish Pandey ◽  
Alok Kumar Shukla ◽  
Ramesh Chandra Dubey ◽  
Ravi Pratap
Keyword(s):  
Skin Disease ◽  
Geographic Location ◽  
Inflammatory Skin Disease ◽  
Delivery Methods ◽  
Disease Treatment ◽  
Site Specific ◽  
Target Sites ◽  
Herbal Therapies ◽  
Aloe Emodin ◽  
Environmental Causes

Psoriasis may emerge at any stage of life irrespective of age, sex or geographic location. It is identified as a chronic immune-linked inflammatory skin disease that affects all human races. Psoriasis is often more Caucasian than non-Caucasian groups of human races and in geographic areas, like higher latitudes and Western countries. Therefore, attention should be paid to both genetic and environmental causes of psoriasis. Natural products have significantly contributed and encouraged the advances in skin disease treatment like psoriasis. The maximum number of phytochemicals is now being used worldwide, including various plants, herbs, and formulations. In addition, some phytochemicals like psoralen, aloe-emodin, curcumin etc. have also been isolated in pure form and have also shown their efficacy in the management of psoriasis. The presence of such phytochemicals confirms the effectiveness of few herbal therapies. This paper reviews some of the promising phytochemicals and their potential molecular target sites and mechanism of action, which may aid in designing and producing more precise and selective antipsoriatic agents. Exploring and recognizing phytochemicals as to how they function will facilitate more site-specific delivery methods for psoriasis care.

A Nanocrystals-Based Topical Drug Delivery System with Improved Dermal Penetration and Enhanced Treatment of Skin Diseases

2021 ◽  
Vol 17 (12) ◽  
pp. 2319-2337
Author(s):  
Lin Sun ◽  
Hong Xiang ◽  
Canfeng Ge ◽  
Xingxu Chen ◽  
Qian Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Skin Disease ◽  
Skin Diseases ◽  
Drug Loading ◽  
Clinical Trial Data ◽  
Topical Delivery ◽  
Active Pharmaceutical Ingredient ◽  
Topical Drug Delivery ◽  
Sustained Drug Release ◽  
Drug Nanocrystal

Topical drug delivery methods are important in the treatment of skin diseases. Drug nanocrystals, which are nanometersized particles of active pharmaceutical ingredients, offer efficient topical delivery with high stability, high drug loading capacity, steady dissolution, and sustained drug release profiles. The use of nanocrystals for the topical delivery of skin disease therapies is currently being evaluated; this review focuses on how nanocrystals facilitate active pharmaceutical ingredient transport across skin barriers, exploring the underlying transportation mechanisms of the nanocrystals and active pharmaceutical ingredient molecules to the dermal and epidermal skin cells. In topical delivery, previous skin treatments, choice of excipients and vehicles, and penetration enhancement strategies critically influence the topical delivery of drug nanocrystals. Various research and applications of drug nanocrystals in skin disease therapy are highlighted in this review, and intellectual property protection for drug nanocrystal formulations, clinical trial data, and products with commercial potential are also discussed.

Paracrystalline Aggregates of Psoriatic Keratin and Their Relation to Normal Keratin Structure

1985 ◽  
Vol 43 ◽  
pp. 680-681
Author(s):  
S. Trachtenberg ◽  
P.M. Steinert ◽  
B.L. Trus ◽  
A.C. Steven
Keyword(s):  
Cell Death ◽  
Stratum Corneum ◽  
Intermediate Filament ◽  
Skin Disease ◽  
Amorphous Matrix ◽  
Terminal Differentiation ◽  
Proteolytic Degradation ◽  
Horny Layer ◽  
Chronic Skin ◽  
Chronic Skin Disease

During terminal differentiation of vertebrate epidermis, certain specific keratin intermediate filament (KIF) proteins are produced. Keratinization of the epidermis involves cell death and disruption of the cytoplasm, leaving a network of KIF embedded in an amorphous matrix which forms the outer horny layer known as the stratum corneum. Eventually these cells are shed (desquamation). Normally, the processes of differentiation, keratinization, and desquamation are regulated in an orderly manner. In psoriasis, a chronic skin disease, a hyperkeratotic stratum corneum is produced, resulting in abnormal desquamation of unusually large scales. In this disease, the normal KIF proteins are diminished in amount or absent, and other proteins more typical of proliferative epidermal cells are present. There is also evidence of proteolytic degradation of the KIF.

Changes in CD44 isoform expression during inflammatory skin disease

1997 ◽  
Vol 22 (03) ◽  
pp. 128-133
Author(s):  
A.J. HARRIS ◽  
D. DEAN ◽  
S. BURGE ◽  
F. WOJNAROWSKA
Keyword(s):  
Skin Disease ◽  
Inflammatory Skin Disease ◽  
Inflammatory Skin ◽  
Isoform Expression

The skin disease that cures itself

Nature ◽  
2010 ◽  
Author(s):  
Ewen Callaway
Keyword(s):  
Skin Disease
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