Structural consequences of NF-κB inhibition by natural antioxidants: α-lipoic acid and vitamin E

Type 2 diabetes is a major cause of cardiovascular disease. We have determined whether the metabolic and cardiovascular changes induced by a diet high in fructose in young adult male Wistar rats could be prevented or reversed by chronic intervention with natural antioxidants. We administered a regenerative antioxidant protocol using two natural compounds:α-lipoic acid together with vitamin E (α-tocopherol alone or a tocotrienol-rich fraction), given as either a prevention or reversal protocol in the food. These rats developed glucose intolerance, hypertension, and increased collagen deposition in the heart together with an increased ventricular stiffness. Treatment with a fixed combination of vitamin E (eitherα-tocopherol or tocotrienol-rich fraction, 0.84 g/kg food) andα-lipoic acid (1.6 g/kg food) normalized glucose tolerance, blood pressure, cardiac collagen deposition, and ventricular stiffness in both prevention and reversal protocols in these fructose-fed rats. These results suggest that adequate antioxidant therapy can both prevent and reverse the metabolic and cardiovascular damage in type 2 diabetes.

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Secunder prevention with alpha-lipoic acid and vitamin E in porphyria cutanea tarda patients

Zeitschrift für Gastroenterologie ◽

10.1055/s-2008-1079707 ◽

2008 ◽

Vol 46 (05) ◽

Author(s):

E Székely ◽

K Szentmihályi ◽

M Bor ◽

Á Pusztai ◽

T Kurucz ◽

...

Keyword(s):

Vitamin E ◽

Lipoic Acid ◽

Porphyria Cutanea Tarda ◽

Alpha Lipoic Acid

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Comparison of the Protective Effects of Radix Astragali, α-Lipoic Acid, and Vitamin E on Acute Acoustic Trauma

Clinical Medicine Insights Ear Nose and Throat ◽

10.4137/cment.s10711 ◽

2012 ◽

Vol 5 ◽

pp. CMENT.S10711 ◽

Cited By ~ 8

Author(s):

Min Xiong ◽

Huangwen Lai ◽

Chuanhong Yang ◽

Weiyi Huang ◽

Jian Wang ◽

...

Keyword(s):

Hearing Loss ◽

Vitamin E ◽

Lipoic Acid ◽

Impulse Noise ◽

Cell Damage ◽

Acoustic Trauma ◽

Protective Effects ◽

Radix Astragali ◽

Hair Cell Damage ◽

Acute Acoustic Trauma

Objective Oxidative damage is a critical role which involves hearing loss induced by impulse noise. That exogenous antioxidant agents reduce noise induced hearing loss (NIHL) has been well demonstrated in both animal studies and clinical practices. Choosing a stronger and more effective antioxidant is very important for treatment of NIHL. Vitamin E, α-lipoic acid, and radix astragali are the most commonly used anti-oxidants for cochlear oxidative damage from acoustic trauma. In this study, the protective effects of radix astragali, α-lipoic acid, and vitamin E on acute acoustic trauma are investigated. Methods Guinea pigs in the experimental groups were intragastrically administered vitamin E, α-lipoic acid, and radix astragali. Auditory thresholds were assessed by sound-evoked auditory brainstem response (ABR) at click and tone bursts of 8, 16 and 32 kHz, 24 hours before and 72 hours after exposure to impulse noise. Cochlear malondialdehyde (MDA) concentrations were detected. Hair cell damage was analyzed by scanning electron microscopy. Results Vitamin E, α-lipoic acid, and radix astragali significantly reduced ABR deficits, reduced hair cell damage, and decreased the concentrations of MDA. α-lipoic acid and radix astragali were better than vitamin E, and there were no significant differences between α-lipoic acid and radix astragali. Conclusions α-lipoic acid or radix astragali are recommended for treatment of NIHL.

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