The Quest for an Animal Model of Diabetic Nephropathy and the Role of Taurine Deficiency

2015 ◽  
pp. 217-226 ◽  
Author(s):  
Xiaobin Han ◽  
Takashi Ito ◽  
Junichi Azuma ◽  
Stephen W. Schaffer ◽  
Russell W. Chesney
Keyword(s):  
Animal Model ◽  
Diabetic Nephropathy ◽  
Taurine Deficiency

scholarly journals Role of Endothelial Nitric Oxide Synthase in Diabetic Nephropathy: Lessons from Diabetic eNOS Knockout Mice

2014 ◽  
Vol 2014 ◽  
pp. 1-17 ◽  
Author(s):  
Takamune Takahashi ◽  
Raymond C. Harris
Keyword(s):  
Animal Model ◽  
Diabetic Nephropathy ◽  
Critical Role ◽  
Therapeutic Interventions ◽  
Diabetic Mice ◽  
Model Study ◽  
Animal Model Study ◽  
Stage Renal Disease ◽  
End Stage

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease in many countries. The animal models that recapitulate human DN undoubtedly facilitate our understanding of this disease and promote the development of new diagnostic markers and therapeutic interventions. Based on the clinical evidence showing the association of eNOS dysfunction with advanced DN, we and others have created diabetic mice that lack eNOS expression and shown that eNOS-deficient diabetic mice exhibit advanced nephropathic changes with distinct features of progressive DN, including pronounced albuminuria, nodular glomerulosclerosis, mesangiolysis, and arteriolar hyalinosis. These studies clearly defined a critical role of eNOS in DN and developed a robust animal model of this disease, which enables us to study the pathogenic mechanisms of progressive DN. Further, recent studies with this animal model have explored the novel mechanisms by which eNOS deficiency causes advanced DN and provided many new insights into the pathogenesis of DN. Therefore, here we summarize the findings obtained with this animal model and discuss the roles of eNOS in DN, unresolved issues, and future investigations of this animal model study.

scholarly journals Role of endocannabinoid CB1 receptors in Streptozotocin-induced uninephrectomised Wistar rats in diabetic nephropathy

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Jayarami Reddy Medapati ◽  
Deepthi Rapaka ◽  
Veera Raghavulu Bitra ◽  
Santhosh Kumar Ranajit ◽  
Girija Sankar Guntuku ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Morphological Changes ◽  
Serum Levels ◽  
Cb1 Receptors ◽  
Protective Effects ◽  
Renal Hypertrophy ◽  
Necrosis Factor Alpha

Abstract Background The endocannabinoid CB1 receptor is known to have protective effects in kidney disease. The aim of the present study is to evaluate the potential agonistic and antagonistic actions and to determine the renoprotective potential of CB1 receptors in diabetic nephropathy. The present work investigates the possible role of CB1 receptors in the pathogenesis of diabetes-induced nephropathy. Streptozotocin (STZ) (55 mg/kg, i.p., once) is administered to uninephrectomised rats for induction of experimental diabetes mellitus. The CB1 agonist (oleamide) and CB1 antagonist (AM6545) treatment were initiated in diabetic rats after 1 week of STZ administration and were given for 24 weeks. Results The progress in diabetic nephropathy is estimated biochemically by measuring serum creatinine (1.28±0.03) (p < 0.005), blood urea nitrogen (67.6± 2.10) (p < 0.001), urinary microprotein (74.62± 3.47) (p < 0.005) and urinary albuminuria (28.31±1.17) (p < 0.0001). Renal inflammation was assessed by estimating serum levels of tumor necrosis factor alpha (75.69±1.51) (p < 0.001) and transforming growth factor beta (8.73±0.31) (p < 0.001). Renal morphological changes were assessed by estimating renal hypertrophy (7.38± 0.26) (p < 0.005) and renal collagen content (10.42± 0.48) (p < 0.001). Conclusions From the above findings, it can be said that diabetes-induced nephropathy may be associated with overexpression of CB1 receptors and blockade of CB1 receptors might be beneficial in ameliorating the diabetes-induced nephropathy. Graphical abstract

Gender bias in the genetic vulnerability towards type 2 diabetes and diabetic nephropathy: Role of forkhead box Protein3 transcription factor gene variants

Gene ◽  
2021 ◽  
Vol 774 ◽  
pp. 145426
Author(s):  
Swetha Chikoti ◽  
Umme Najiya Mahwish ◽  
Sree Bhushan Raju ◽  
Sumanlatha Gaddam ◽  
Parveen Jahan
Keyword(s):  
Type 2 Diabetes ◽  
Transcription Factor ◽  
Diabetic Nephropathy ◽  
Gender Bias ◽  
Gene Variants ◽  
Transcription Factor Gene ◽  
Factor Gene ◽  
Forkhead Box

scholarly journals The Role of Pretraining on Skilled Forelimb Use in an Animal Model of Huntington's Disease

2003 ◽  
Vol 12 (3) ◽  
pp. 257-264 ◽  
Author(s):  
R. A. Fricker-Gates ◽  
R. Smith ◽  
J. Muhith ◽  
S. B. Dunnett
Keyword(s):  
Animal Model ◽  
Huntington's Disease ◽  
Huntington’S Disease

scholarly journals Role of patient factors in therapy resistance to antiproteinuric intervention in nondiabetic and diabetic nephropathy

2000 ◽  
Vol 57 ◽  
pp. S32-S37 ◽  
Author(s):  
Hendrik Bos ◽  
Steen Andersen ◽  
Peter Rossing ◽  
Dick de Zeeuw ◽  
Hans-Henrik Parving ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Therapy Resistance ◽  
Patient Factors

The protective effect of Salvia miltiorrhiza in an animal model of early experimentally induced diabetic nephropathy

2011 ◽  
Vol 137 (3) ◽  
pp. 1409-1414 ◽  
Author(s):  
Sang-Hun Lee ◽  
Young-Seok Kim ◽  
Seung-Jin Lee ◽  
Byung-Cheol Lee
Keyword(s):  
Animal Model ◽  
Diabetic Nephropathy ◽  
Protective Effect ◽  
Salvia Miltiorrhiza ◽  
Experimentally Induced
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