Beta Binders for Biological Interactions

2005 ◽  
pp. 20-33 ◽  
Author(s):  
Corrado Priami ◽  
Paola Quaglia
Keyword(s):  
Biological Interactions

Species densities, biological interactions and benthic ecosystem functioning: an in situ experiment

2016 ◽  
Vol 547 ◽  
pp. 149-161 ◽  
Author(s):  
DS Clare ◽  
M Spencer ◽  
LA Robinson ◽  
CLJ Frid
Keyword(s):  
Ecosystem Functioning ◽  
Biological Interactions ◽  
In Situ Experiment

Biotics: Competition, Herbivory, Predation, Parasitism and Symbiosis

2017 ◽  
Author(s):  
Christer Brönmark ◽  
Lars-Anders Hansson
Keyword(s):  
Population Dynamics ◽  
Ecosystem Function ◽  
Theoretical Basis ◽  
Abiotic Factors ◽  
Biological Interactions ◽  
Natural Systems ◽  
The Many

If biological interactions, such as competition and predation, have any effect on population dynamics, or if abiotic factors alone determine which organisms, how many of them do we see in a specific ecosystem, was for long a controversial question. This chapter aims at providing the basis for the understanding of biological interactions, as well as showing ample examples of how important those interactions are in shaping both population dynamics and ecosystem function of natural systems. In addition to the many examples, the reader is introduced to the history and the theoretical basis for biological interactions.

scholarly journals Biological interactions of biocompatible and water-dispersed MoS2 nanosheets with bacteria and human cells

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Jasneet Kaur ◽  
Manjot Singh ◽  
Carmela Dell‘Aversana ◽  
Rosaria Benedetti ◽  
Paola Giardina ◽  
...  
Keyword(s):  
Human Cells ◽  
Biological Interactions ◽  
Mos2 Nanosheets

scholarly journals Strategies for the Development of pH-Responsive Synthetic Polypeptides and Polymer-Peptide Hybrids: Recent Advancements

Polymers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 624
Author(s):  
Cintya Dharmayanti ◽  
Todd A. Gillam ◽  
Manuela Klingler-Hoffmann ◽  
Hugo Albrecht ◽  
Anton Blencowe
Keyword(s):  
Functional Groups ◽  
Hybrid Materials ◽  
Tumour Microenvironment ◽  
The Body ◽  
Supramolecular Interactions ◽  
Biological Interactions ◽  
Ph Responsive ◽  
Form Complex ◽  
Synthetic Polypeptides ◽  
External Stimuli

Synthetic polypeptides and polymer-peptide hybrid materials have been successfully implemented in an array of biomedical applications owing to their biocompatibility, biodegradability and ability to mimic natural proteins. In addition, these materials have the capacity to form complex supramolecular structures, facilitate specific biological interactions, and incorporate a diverse selection of functional groups that can be used as the basis for further synthetic modification. Like conventional synthetic polymers, polypeptide-based materials can be designed to respond to external stimuli (e.g., light and temperature) or changes in the environmental conditions (e.g., redox reactions and pH). In particular, pH-responsive polypeptide-based systems represent an interesting avenue for the preparation of novel drug delivery systems that can exploit physiological or pathological pH variations within the body, such as those that arise in the extracellular tumour microenvironment, intracellularly within endosomes/lysosomes, or during tissue inflammation. Here, we review the significant progress made in advancing pH-responsive polypeptides and polymer-peptide hybrid materials during the last five years, with a particular emphasis on the manipulation of ionisable functional groups, pH-labile linkages, pH-sensitive changes to secondary structure, and supramolecular interactions.

scholarly journals Functionalization of Cellulose-Based Hydrogels with Bi-Functional Fusion Proteins Containing Carbohydrate-Binding Modules

Materials ◽  
2021 ◽  
Vol 14 (12) ◽  
pp. 3175
Author(s):  
Mariana Barbosa ◽  
Hélvio Simões ◽  
Duarte Miguel F. Prazeres
Keyword(s):  
Fusion Proteins ◽  
Fluorescent Protein ◽  
Protein A ◽  
Chemical Properties ◽  
Main Idea ◽  
Bioactive Molecules ◽  
Scaffolding Protein ◽  
Carbohydrate Binding ◽  
Biological Interactions ◽  
Carbohydrate Binding Modules

Materials with novel and enhanced functionalities can be obtained by modifying cellulose with a range of biomolecules. This functionalization can deliver tailored cellulose-based materials with enhanced physical and chemical properties and control of biological interactions that match specific applications. One of the foundations for the success of such biomaterials is to efficiently control the capacity to combine relevant biomolecules into cellulose materials in such a way that the desired functionality is attained. In this context, our main goal was to develop bi-functional biomolecular constructs for the precise modification of cellulose hydrogels with bioactive molecules of interest. The main idea was to use biomolecular engineering techniques to generate and purify different recombinant fusions of carbohydrate binding modules (CBMs) with significant biological entities. Specifically, CBM-based fusions were designed to enable the bridging of proteins or oligonucleotides with cellulose hydrogels. The work focused on constructs that combine a family 3 CBM derived from the cellulosomal-scaffolding protein A from Clostridium thermocellum (CBM3) with the following: (i) an N-terminal green fluorescent protein (GFP) domain (GFP-CBM3); (ii) a double Z domain that recognizes IgG antibodies; and (iii) a C-terminal cysteine (CBM3C). The ability of the CBM fusions to bind and/or anchor their counterparts onto the surface of cellulose hydrogels was evaluated with pull-down assays. Capture of GFP-CBM3 by cellulose was first demonstrated qualitatively by fluorescence microscopy. The binding of the fusion proteins, the capture of antibodies (by ZZ-CBM3), and the grafting of an oligonucleotide (to CBM3C) were successfully demonstrated. The bioactive cellulose platform described here enables the precise anchoring of different biomolecules onto cellulose hydrogels and could contribute significatively to the development of advanced medical diagnostic sensors or specialized biomaterials, among others.

scholarly journals Small RNAs and their targets are associated with the transgenerational effects of water-deficit stress in durum wheat

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Haipei Liu ◽  
Amanda J. Able ◽  
Jason A. Able
Keyword(s):  
Durum Wheat ◽  
Water Deficit ◽  
Small Rna ◽  
Wheat Yield ◽  
Water Deficit Stress ◽  
Integrated Analysis ◽  
Sequencing Analysis ◽  
Biological Interactions ◽  
Transgenerational Effects ◽  
Nutrient Metabolism

AbstractWater-deficit stress negatively affects wheat yield and quality. Abiotic stress on parental plants during reproduction may have transgenerational effects on progeny. Here we investigated the transgenerational influence of pre-anthesis water-deficit stress by detailed analysis of the yield components, grain quality traits, and physiological traits in durum wheat. Next-generation sequencing analysis profiled the small RNA-omics, mRNA transcriptomics, and mRNA degradomics in first generation progeny. Parental water-deficit stress had positive impacts on the progeny for traits including harvest index and protein content in the less stress-tolerant variety. Small RNA-seq identified 1739 conserved and 774 novel microRNAs (miRNAs). Transcriptome-seq characterised the expression of 66,559 genes while degradome-seq profiled the miRNA-guided mRNA cleavage dynamics. Differentially expressed miRNAs and genes were identified, with significant regulatory patterns subject to trans- and inter-generational stress. Integrated analysis using three omics platforms revealed significant biological interactions between stress-responsive miRNA and targets, with transgenerational stress tolerance potentially contributed via pathways such as hormone signalling and nutrient metabolism. Our study provides the first confirmation of the transgenerational effects of water-deficit stress in durum wheat. New insights gained at the molecular level indicate that key miRNA-mRNA modules are candidates for transgenerational stress improvement.

Evolution of the grapevine (Vitis vinifera L.) imprinted by natural and human factorsThis review is one of a selection of papers presented at the symposium on Vitis at the XVII International Botanical Congress held in Vienna, Austria, in 2005.

2007 ◽  
Vol 85 (8) ◽  
pp. 679-690 ◽  
Author(s):  
Roger Bessis
Keyword(s):  
Vegetative Reproduction ◽  
Molecular Characteristics ◽  
Vitis Vinifera L ◽  
Biological Interactions ◽  
Direct Effects ◽  
Parasitic Fungi ◽  
International Botanical ◽  
International Botanical Congress ◽  
Environmental Agents ◽  
Selection Of

This paper is concerned with vegetative reproduction, which is the only mode of propagation in cultivated grapevines. After a brief summary of the systematics of the Vitaceae the question of the nomenclature of cultivated grapevines is discussed. Intra-varietal variability is discussed using morphological and molecular characteristics. The origins of variation are presented: mutations, foreign nucleic acids, and memory of previous environmental conditions. Grapevines provide characteristic products, leading viticulturalists to make selections among the diversity observed in the vineyard, thus decreasing diversity. Grapevines interact with various environmental agents. One example, the natural defence provided by resveratrol, is analysed, showing its direct effects against parasitic fungi and its indirect effects, both metabolic and genetic, on other organisms. Thus, the grapevine, viticulturalists, and their environment form a web of biological interactions.

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