Homing by Systematic Search

Abstract We analyse the flux-induced scalar potential for type IIA orientifolds in the presence of p-form, geometric and non-geometric fluxes. Just like in the Calabi-Yau case, the potential presents a bilinear structure, with a factorised dependence on axions and saxions. This feature allows one to perform a systematic search for vacua, which we implement for the case of geometric backgrounds. Guided by stability criteria, we consider configurations with a particular on-shell F-term pattern, and show that no de Sitter extrema are allowed for them. We classify branches of supersymmetric and non-supersymmetric vacua, and argue that the latter are perturbatively stable for a large subset of them. Our solutions reproduce and generalise previous results in the literature, obtained either from the 4d or 10d viewpoint.

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Investigator Initiated Clinical Trials (IICTs): A Systematic Search in Registries to Compare the Czech Republic and Portugal in Terms of Funding Policies and Scientific Outcomes

Therapeutic Innovation & Regulatory Science ◽

10.1007/s43441-021-00293-w ◽

2021 ◽

Author(s):

C. Madeira ◽

L. Hořavová ◽

F. dos Santos ◽

J. R. Batuca ◽

K. Nebeska ◽

...

Keyword(s):

Clinical Trials ◽

Czech Republic ◽

Clinical Research ◽

Systematic Search ◽

European Countries ◽

The Czech Republic ◽

Research Outcomes ◽

Funding Policies ◽

Funding Agencies ◽

First Time

Abstract Objectives Clinical trials provide one of the highest levels of evidence to support medical practice. Investigator initiated clinical trials (IICTs) answer relevant questions in clinical practice that may not be addressed by industry. For the first time, two European Countries are compared in terms of IICTs, respective funders and publications, envisaging to inspire others to use similar indicators to assess clinical research outcomes. Methods A retrospective systematic search of registered IICTs from 2004 to 2017, using four clinical trials registries was carried out in two European countries with similar population, GDP, HDI and medical schools but with different governmental models to fund clinical research. Each IICT was screened for sponsors, funders, type of intervention and associated publications, once completed. Results IICTs involving the Czech Republic and Portugal were n = 439 (42% with hospitals as sponsors) and n = 328 (47% with universities as sponsors), respectively. The Czech Republic and Portuguese funding agencies supported respectively 61 and 27 IICTs. Among these, trials with medicinal products represent 52% in Czech Republic and 4% in Portugal. In the first, a higher percentage of IICTs’ publications in high impact factor journals with national investigators as authors was observed, when compared to Portugal (75% vs 15%). Conclusion The better performance in clinical research by Czech Republic might be related to the existence of specific and periodic funding for clinical research, although further data are still needed to confirm this relationship. In upcoming years, the indicators used herein might be useful to tracking clinical research outcomes in these and other European countries.

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Telemedicine curriculum in undergraduate medical education: a systematic search and review

Health and Technology ◽

10.1007/s12553-021-00559-1 ◽

2021 ◽

Author(s):

Işıl İrem Budakoğlu ◽

Mustafa Ünal Sayılır ◽

Yavuz Selim Kıyak ◽

Özlem Coşkun ◽

Serdar Kula

Keyword(s):

Medical Education ◽

Undergraduate Medical Education ◽

Systematic Search

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Neonatal Uterine Bleedings: An Ignored Sign but a Possible Cause of Early-Onset Endometriosis – A Systematic Review

Biomedicine Hub ◽

10.1159/000512663 ◽

2021 ◽

pp. 6-16

Author(s):

Judith Dekker ◽

Isabelle Hooijer ◽

Johannes C.F. Ket ◽

Aleksandra Vejnović ◽

Giuseppe Benagiano ◽

...

Keyword(s):

Systematic Review ◽

Full Text ◽

Early Onset ◽

Cochrane Collaboration ◽

Systematic Search ◽

Future Research ◽

Screening Techniques ◽

Screening Strategies ◽

The Cochrane Collaboration ◽

Possible Cause

Objective: Based on the hypothesis that neonatal uterine bleedings (NUB), occurring mostly in the first week after birth, could represent a pathogenetic mechanism for early-onset endometriosis, this systematic review (SR) was undertaken to evaluate the prevalence and screening strategies used to assess and quantify NUB. Design: Both a SR and a sample literature search in PubMed and Embase were conducted to gather information on NUB prevalence and screening techniques. This was performed by an information specialist. Only full-text articles regarding the assessment of NUB in neonates in the first 2 weeks after birth were included. No limit on language or publication data was used. Materials and Methods: The SR was registered in PROSPERO (CRD42019138121). Data was first assessed for eligibility on title and abstract by 2 blinded review authors. Any disagreements were discussed with a third reviewer if necessary. Subsequently, full-text articles were read and assessed for quality using the Cochrane Collaboration Handbook. Results: Out of 1,988 articles in the systematic search, 10 relevant articles were selected, of which 8 were identified through the systematic search and 2 were found through other sources. The sample search of 4,445 articles did not bring up relevant articles. Results were not comparable due to the heterogeneity of screening techniques, although data showed consensus. The prevalence of visible bleeding ranged from 3.3 to 53.8% and the prevalence of occult bleeding from 25.4 to 96.7%. The occurrence was the highest between the 3rd and 7th day postpartum (PP) and the bleeding lasted for 3–4 days on average. Various screening techniques for detecting NUB were found in the literature, including the use of hemoglobin detection devices (such as Hemastix) in the vaginal vestibulum, comparison of diapers with stains of known volume, colposcopy, and ultrasonography. Conclusion: The reported prevalence of NUB varies considerably, with a consistent occurrence between the 3rd and the 7th day PP. Literature to assess NUB is dated. The techniques are poorly described and heterogeneous. Future research should focus on prospective cohort studies in order to attempt to correlate NUB cases to (early-onset) endometriosis.

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A Critical Review on Mathematical Descriptions to Study Flux Processes and Environmental-Related Interactions of Mangroves

Sustainability ◽

10.3390/su13126970 ◽

2021 ◽

Vol 13 (12) ◽

pp. 6970

Author(s):

Jefferson Brooks ◽

Miguel Chen Chen Austin ◽

Dafni Mora ◽

Nathalia Tejedor-Flores

Keyword(s):

Systematic Review ◽

Mathematical Model ◽

Global Warming ◽

Process Modeling ◽

Critical Review ◽

Systematic Search ◽

Raw Material ◽

Mangrove Forests ◽

Recent Information ◽

Modeling Studies

Trees are resources that provide multiple benefits, such as the conservation of fauna, both terrestrial and marine, a source of food and raw material, and offering protection in storms, which makes it practical to understand their behavior against different phenomena. Such understanding may be possible through process modeling. Studies confirm that mangrove forests can store more carbon than other forests, influencing the fight against global warming. Thus, a critical and systematic review was carried out regarding studies focusing on mangroves to collect information on the models that have been applied and the most influential variables highlighted by other authors. Applying a systematic search for the most relevant topics related to mangroves (basic as well as recent information), it is possible to group models and methods carried out by other authors to respond to certain behaviors presented by mangroves. Moreover, possible structuring of a mathematical model applied to a species of interest thanks to the analyzed references could provide justified information to the authorities on the importance of these forests and the benefits of their preservation and regeneration-recovery.

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Construction of symmetric Hadamard matrices of order 4v for v = 47, 73, 113

Special Matrices ◽

10.1515/spma-2018-0002 ◽

2018 ◽

Vol 6 (1) ◽

pp. 11-22 ◽

Cited By ~ 5

Author(s):

N. A. Balonin ◽

D. Ž. Ðokovic ◽

D. A. Karbovskiy

Keyword(s):

Hadamard Matrices ◽

Systematic Search

Abstract We continue our systematic search for symmetric Hadamard matrices based on the so called propus construction. In a previous paper this search covered the orders 4v with odd v ≤ 41. In this paper we cover the cases v = 43, 45, 47, 49, 51. The odd integers v < 120 for which no symmetric Hadamard matrices of order 4v are known are the following: 47, 59, 65, 67, 73, 81, 89, 93, 101, 103, 107, 109, 113, 119. By using the propus construction, we found several symmetric Hadamard matrices of order 4v for v = 47, 73, 113.

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Quality assessment of the guidelines for the management of malignant pleural effusions and ascites

World Journal of Surgical Oncology ◽

10.1186/s12957-020-02097-y ◽

2020 ◽

Vol 18 (1) ◽

Author(s):

Jia-Xi Li ◽

Yan-Mei Shi ◽

Li-Ya An ◽

Jin-Xu Yang ◽

Yu-Xing Qi ◽

...

Keyword(s):

Quality Assessment ◽

Malignant Ascites ◽

Systematic Search ◽

Measurement Scale ◽

Pleural Effusions ◽

Management Guidelines ◽

Malignant Pleural Effusions

Abstract Objectives To fully assess the quality of the guidelines for the management of malignant pleural effusions (MPE) and ascites and reveal the heterogeneity of recommendations and possible reasons among guidelines. Methods A systematic search was performed in the database to obtain guidelines for the management of MPE and ascites. The AGREE IIGtool was used to assess the quality of these guidelines. The Measurement Scale of Rate of Agreement (MSRA) was introduced to assess the scientific agreement of formulated recommendations for the management of MPE and ascites among guidelines, and evidence supporting these recommendations was extracted and analyzed. Results Nine guidelines were identified. Only 4 guidelines scored more than 60% and are worth recommending. Recommendations were also heterogeneous among guidelines for the management of MPE, and the main reasons were the different emphases of the recommendations for the treatment of MPE, the contradictions in recommendations, and the unreasonably cited evidence for MPE. Conclusions The quality of the management guidelines for patients with MPE and malignant ascites was highly variable. Specific improvement of the factors leading to the heterogeneity of recommendations will be a reasonable and effective way for developers to upgrade the recommendations in the guidelines for MPE.

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The COVID-19 Pandemic and nursing challenges: A review of the early literature

Work ◽

10.3233/wor-213458 ◽

2021 ◽

pp. 1-14

Author(s):

Mojtaba K. Danesh ◽

Ehsan Garosi ◽

Hamedeh Golmohamadpour

Keyword(s):

Health Systems ◽

Personal Protective Equipment ◽

Qualitative Studies ◽

Systematic Search ◽

Current Paper ◽

Protective Equipment ◽

Early Literature ◽

The Face ◽

Physical Distress ◽

The Impact

BACKGROUND: The COVID-19 pandemic has put health systems under unprecedented pressure, challenging their workforce, especially nurses. OBJECTIVE: The current paper presented a review of the early literature concerning emerging nursing challenges during the early stages of the COVID-19 pandemic. METHODS: A systematic search of the published literature between January and May 2020 was carried out in Medline, Science Direct, and Google Scholar to identify relevant quantitative and qualitative studies. RESULTS: Twenty-two original articles were retrieved, the majority of which were survey studies from China. Synthesis of the evidence resulted in four overarching themes including “being physically and mentally drained in the face of fear and uncertainty,” “shortage of personal protective equipment and usability issues,” “psychosomatic disturbances among nurses,” and “moderators to mitigate nurses’ challenges.” CONCLUSIONS: Providing care for demanding COVID-19 patients, nurses experienced a gruelling situation, during which a significant amount of psychological and physical distress was inflicted to them. However, receiving proper support from their organization and society could improve the condition substantially. Further research is required to explore the impact of the COVID-19 pandemic on nurses, especially from Western countries.

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