Principles for Designing Scientific Investigations of Orthopedic Malignancies

1992 ◽  
pp. 68-73
Author(s):  
Masanori Fukushima
Keyword(s):  
Scientific Investigations

Using Systems Mapping to Plan Scientific Investigations

Science Scope ◽  
2017 ◽  
Vol 040 (05) ◽  
Author(s):  
Eleanor Abrams ◽  
Michael Middleton ◽  
Sameer Honwad ◽  
Erica Jablonski ◽  
Marlena Koper ◽  
...  
Keyword(s):  
Scientific Investigations ◽  
Systems Mapping

Antipyretic activity of the root extracts of Desmodium Gangeticum

2018 ◽  
Vol 8 (2) ◽  
pp. 20-23
Author(s):  
Raja Sheker K ◽  
Naveen B ◽  
Anil kumar A ◽  
Abhilash G
Keyword(s):  
Gastric Ulcers ◽  
Plant Leaves ◽  
Medical Systems ◽  
Human Race ◽  
Standard Drug ◽  
Root Extracts ◽  
Antipyretic Activity ◽  
Scientific Investigations ◽  
And Control ◽  
Effective Drugs

Fevers are considered as the most important parameters to evaluate and diagnose most of the disease conditions like inflammations, wounds and other infections. There are effective drugs that treat and control the fevers out of which NSAID's are most important ones. They cause notable side effects like gastric ulcers, gastric mucosal perforations etc. which make the use of those drugs limited. Herbs are used to treat various diseases, starting from the evolution of the human race. During this, herbs had been introduced to many types of tests and scientific investigations to prove the activities that herbs possess. The diseases that the herbs are used for are notable in the medical systems like Ayurveda and other systems. The need for the validation of the activities of the herbs and medicinal plants is utmost important these days. The extracts of the plant leaves of Desmodium gangeticum were extracted with ethanol and then investigated for the antipyretic activity in yeast induced pyretic method. The extract was tested in two doses 200 and 400mg/kg. This was found significant when compared to the standard drug.

An ayurvedic tablet formulation for ulcer protection

2020 ◽  
Vol 10 (4) ◽  
pp. 35-38
Author(s):  
Shiva Kumar K ◽  
Purushothaman M ◽  
Soujanya H ◽  
Jagadeeshwari S
Keyword(s):  
Pharmacological Activity ◽  
The Body ◽  
Gastric Ulcers ◽  
Antiulcer Activity ◽  
Herbal Drugs ◽  
Human Beings ◽  
Synthetic Drugs ◽  
Scientific Investigations ◽  
System A ◽  
The World

Gastric ulcers or the peptic ulcer is the primary disease that affects the gastrointestinal system. A large extent of the population in the world are suffering from the disease, and the age group of people those who suffer from ulcers are 20-55years. Herbs are known to the human beings that are useful in the treatment of diseases, and there are a lot of scientific investigations that prove the pharmacological activity of herbal drugs. Practitioners have been using the herbal material to treat the ulcers successfully, and the same had been reported scientifically. Numerous publications have been made that proves the antiulcer activity of the plants around the world. The tablets were investigated for the antiulcer activity in two doses 200 and 400mg/kg in albino Wistar rats in the artificial ulcer those are induced by the ethanol. The prepared tablets showed a better activity compared to the standard synthetic drug and the marketed ayurvedic formulation. The tablets showed a dose-dependent activity in ulcer prevention and treatment. Many synthetic drugs are available for the ulcer treatment, and the drugs pose the other problems in the body by showing the side effects and some other reactions. This limits the use of synthetic drugs to treat ulcers effectively. Herbs are known to the human beings that are useful in the treatment of diseases, and there are a lot of scientific investigations that prove the pharmacological activity of herbal drugs.

scholarly journals Brazilian Portuguese version of the Amsterdam infant stool scale: a valid and reliable scale for evaluation of stool from children up to 120 days old

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Laura Cantisano de Deus Silva ◽  
Priscila Monaro Bianchini ◽  
Erika Veruska Paiva Ortolan ◽  
Juliana Fattori Hamamoto ◽  
Rosemary Fermiano ◽  
...  
Keyword(s):  
Psychometric Properties ◽  
Cultural Adaptation ◽  
Age Groups ◽  
Kappa Statistic ◽  
Brazilian Portuguese ◽  
Cross Cultural ◽  
Cross Cultural Adaptation ◽  
Final Version ◽  
Scientific Investigations ◽  
Examiner Agreement

Abstract Background For newborns and infants wearing diapers the difficulties in characterizing the appearance of the stool are significant, since the changes in consistency, quantity, and color of the stool are higher than in other age groups. The Amsterdam Infant Stool Scale (AISS) was created and validated in 2009, providing a specific tool for the evaluation of the stool of children up to 120 days old. However, to be used in clinical practice and scientific investigations in Brazil, it is mandatory to perform the translation and cross-cultural adaptation process for Brazilian Portuguese language. Thus, we aim to perform the translation and cross-cultural adaptation of AISS into Brazilian Portuguese and to evaluate the psychometric properties of the translated version. Methods The process of translation and cross-cultural adaptation was performed according to the internationally accepted methodology, including: translation, summary of translations, backtranslation, preparation of the pre-final version, application of the pre-test and determination of the final version. The evaluation of the psychometric properties was performed through the application of Brazilian Portuguese AISS, by five examiners (including child health field specialists and a literate adult lay on the subject), analyzing 238 stool photographs of children under 120 days old. The intra and inter-examiner agreement values were determined using kappa statistic. The validity of the criterion was investigated through correlation analysis (Kendall’s coefficient) between the classifications determined by the non-specialist examiner and the expert examiners. Results In all 30 tests performed between different examiners, there was an agreement considered as at least moderate (kappa values above 0.40). The intra-examiner reliability was considered as substantial (kappa> 0.6). There was a statistically significant correlation (p <  0.05) between the classifications determined by the examiners considered as specialists and the examiner considered as non-specialist. Conclusion The Brazilian Portuguese AISS version proved to be valid and reliable to be used by healthcare professionals and the general public in the evaluation of stool from children up to 120 days old.

scholarly journals What Do Meditators Do When They Meditate? Proposing a Novel Basis for Future Meditation Research

Mindfulness ◽  
2021 ◽  
Author(s):  
Karin Matko ◽  
Ulrich Ott ◽  
Peter Sedlmeier
Keyword(s):  
Qualitative Study ◽  
Quantitative Study ◽  
Literature Search ◽  
Comprehensive Overview ◽  
Contemplative Practices ◽  
Comprehensive List ◽  
Scientific Investigations ◽  
Wide Range ◽  
Vast Range ◽  
Selection Of

Abstract Objectives Meditation is an umbrella term for a vast range of contemplative practices. Former proposals have struggled to do justice to this variety. To our knowledge, there is to date no comprehensive overview of meditation techniques spanning all major traditions. The present studies aimed at providing such a comprehensive list of meditation techniques. Methods In a qualitative study, we compiled a collection of 309 meditation techniques through a literature search and interviews with 20 expert meditators. Then, we reduced this collection to 50 basic meditation techniques. In a second, quantitative study, 635 experienced meditators from a wide range of meditative backgrounds indicated how much experience they had with each of these 50 meditation techniques. Results Meditators’ responses indicated that our choice of techniques had been adequate and only two techniques had to be added. Our additional statistical and cluster analyses illustrated preferences for specific techniques across and within diverse traditions as well as sets of techniques commonly practiced together. Body-centered techniques stood out in being of exceptional importance to all meditators. Conclusions In conclusion, we found an amazing variety of meditation techniques, which considerably surpasses previous collections. Our selection of basic meditation techniques might be of value for future scientific investigations and we encourage researchers to use this set.

Voyaging towards the future: the brig Rurik in the North Pacific and the emerging science of the sea

2020 ◽  
pp. 1-27
Author(s):  
ALEXANDRA BEKASOVA
Keyword(s):  
North Pacific ◽  
Bering Strait ◽  
Journal Articles ◽  
Complex Interplay ◽  
Global Networks ◽  
Scientific Investigations ◽  
Knowledge Based ◽  
The North ◽  
Private Correspondence ◽  
The North Pacific

Abstract This article explores the networking activities of Count Nikolai Rumiantsev and Adam von Krusenstern, his close collaborator. The visionary Russian statesman and the celebrated navigator were deeply involved in northern exploration. They funded and organized a circumnavigating voyage by the brig Rurik in 1815–18, with the explicit goals of searching for a northern passage between Eurasia and North America and conducting a series of scientific investigations in the Bering Strait region. This private exploratory enterprise profoundly influenced the exchange of information and reconfigured both local and global networks of knowledge. Based on an analysis of private correspondence, printed accounts and journal articles related to the Rurik's expedition, this study sheds light on how this transnational network of actors emerged and functioned, and how it promoted a lively circulation of information about exploration in the Bering Strait region in the 1810s–1820s. I argue that a complex interplay of geopolitical and intellectual competition, with exchanges, collaborations and coordination among various actors (e.g. patrons, navigators, scholars, entrepreneurs and publishers), stimulated further research on the global ocean's northern spaces and laid the foundations of marine science.

scholarly journals “Green” Prussian Blue Analogues as Peroxidase Mimetics for Amperometric Sensing and Biosensing

Biosensors ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 193
Author(s):  
Galina Z. Gayda ◽  
Olha M. Demkiv ◽  
Yanna Gurianov ◽  
Roman Ya. Serkiz ◽  
Halyna M. Klepach ◽  
...  
Keyword(s):  
Prussian Blue ◽  
Noble Metals ◽  
High Sensitivity ◽  
Graphite Electrodes ◽  
Flavocytochrome B2 ◽  
Prussian Blue Analogues ◽  
Scientific Investigations ◽  
Electrochemically Active ◽  
Amperometric Sensing ◽  
Prussian Blue Analogs

Prussian blue analogs (PBAs) are well-known artificial enzymes with peroxidase (PO)-like activity. PBAs have a high potential for applications in scientific investigations, industry, ecology and medicine. Being stable and both catalytically and electrochemically active, PBAs are promising in the construction of biosensors and biofuel cells. The “green” synthesis of PO-like PBAs using oxido-reductase flavocytochrome b2 is described in this study. When immobilized on graphite electrodes (GEs), the obtained green-synthesized PBAs or hexacyanoferrates (gHCFs) of transition and noble metals produced amperometric signals in response to H2O2. HCFs of copper, iron, palladium and other metals were synthesized and characterized by structure, size, catalytic properties and electro-mediator activities. The gCuHCF, as the most effective PO mimetic with a flower-like micro/nano superstructure, was used as an H2O2-sensitive platform for the development of a glucose oxidase (GO)-based biosensor. The GO/gCuHCF/GE biosensor exhibited high sensitivity (710 A M−1m−2), a broad linear range and good selectivity when tested on real samples of fruit juices. We propose that the gCuHCF and other gHCFs synthesized via enzymes may be used as artificial POs in amperometric oxidase-based (bio)sensors.

Precision measurement of vacuum in scientific investigations

1964 ◽  
Vol 7 (6) ◽  
pp. 482-485 ◽  
Author(s):  
M. A. Gulyaev ◽  
A. V. Eryukhin
Keyword(s):  
Precision Measurement ◽  
Scientific Investigations

The Small Mammal Project: Engaging Students as Scientists

2017 ◽  
Vol 79 (3) ◽  
pp. 200-206
Author(s):  
Erika V. Iyengar ◽  
Paul T. Meier ◽  
Rachel E. Hamelers
Keyword(s):  
College Courses ◽  
Scientific Process ◽  
Scientific Creativity ◽  
Scientific Investigations ◽  
Hands On ◽  
Upper Level ◽  
Multiple Species ◽  
Dissemination Of Results ◽  
Scientific Questions

This article describes a sustained, student-driven, inquiry-based set of activities meant to illuminate the scientific process from the initial scientific questions to oral dissemination of results. It is appropriate for science majors and nonmajors, advanced high school through upper-level college courses. Involving students in hands-on, self-driven investigations will allow them to see the challenges of quantitative scientific investigations, and the role of scientific creativity in experimental design and interpretation. This project allows a large group of students to engage in the type of research project often only available to students working one-on-one with instructors or in research labs. This activity requires skeletons of multiple species of small mammals, but there are many ways to alter the project to suit available resources. We expect that students involved in hands-on, self-directed scientific investigations early in their academic careers are less likely to view science as a mere accumulation of facts and more likely to be empowered to participate later in more sustained scientific investigations.

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