Plant Natural Products as a Potential Source of Antimicrobial Agents: An Overview and a Glimpse on Recent Developments

2013 ◽  
pp. 93-107 ◽  
Author(s):  
Mohd. Shahid ◽  
Fazal K. Dar ◽  
Abdulrahman Y. Ismaeel ◽  
Ali Al-Mahmeed ◽  
Khalid Al Sindi ◽  
...  
Keyword(s):  
Natural Products ◽  
Antimicrobial Agents ◽  
Plant Natural Products ◽  
Potential Source ◽  
Recent Developments

Plant Natural Products as a Potential Source for Antibacterial Agents: Recent Trends

2009 ◽  
Vol 8 (3) ◽  
pp. 211-225 ◽  
Author(s):  
M. Shahid ◽  
A. Shahzad ◽  
F. Sobia ◽  
A. Sahai ◽  
T. Tripathi ◽  
...  
Keyword(s):  
Natural Products ◽  
Antibacterial Agents ◽  
Plant Natural Products ◽  
Potential Source ◽  
Recent Trends

scholarly journals Chemical Diversity of Plant Cyanogenic Glycosides: An Overview of Reported Natural Products

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 719
Author(s):  
Meri Yulvianti ◽  
Christian Zidorn
Keyword(s):  
Natural Products ◽  
Plant Species ◽  
Chemical Diversity ◽  
Cyanogenic Glycosides ◽  
Sugar Moiety ◽  
Plant Natural Products ◽  
Naturally Occurring

Cyanogenic glycosides are an important and widespread class of plant natural products, which are however structurally less diverse than many other classes of natural products. So far, 112 naturally occurring cyanogenic glycosides have been described in the phytochemical literature. Currently, these unique compounds have been reported from more than 2500 plant species. Natural cyanogenic glycosides show variations regarding both the aglycone and the sugar part of the molecules. The predominant sugar moiety is glucose but many substitution patterns of this glucose moiety exist in nature. Regarding the aglycone moiety, four different basic classes can be distinguished, aliphatic, cyclic, aromatic, and heterocyclic aglycones. Our overview covers all cyanogenic glycosides isolated from plants and includes 33 compounds with a non-cyclic aglycone, 20 cyclopentane derivatives, 55 natural products with an aromatic aglycone, and four dihydropyridone derivatives. In the following sections, we will provide an overview about the chemical diversity known so far and mention the first source from which the respective compounds had been isolated. This review will serve as a first reference for researchers trying to find new cyanogenic glycosides and highlights some gaps in the knowledge about the exact structures of already described compounds.

scholarly journals Antiviral Natural Products for Arbovirus Infections

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2796 ◽  
Author(s):  
Vanessa Shi Li Goh ◽  
Chee-Keng Mok ◽  
Justin Jang Hann Chu
Keyword(s):  
Natural Products ◽  
Side Effects ◽  
Plant Extracts ◽  
Antiviral Drug ◽  
Good Tolerability ◽  
Antiviral Compounds ◽  
Potential Source ◽  
Herbal Plants ◽  
Antiviral Activities ◽  
Arboviral Diseases

Over the course of the last 50 years, the emergence of several arboviruses have resulted in countless outbreaks globally. With a high proportion of infections occurring in tropical and subtropical regions where arthropods tend to be abundant, Asia in particular is a region that is heavily affected by arboviral diseases caused by dengue, Japanese encephalitis, West Nile, Zika, and chikungunya viruses. Major gaps in protection against the most significant emerging arboviruses remains as there are currently no antivirals available, and vaccines are only available for some. A potential source of antiviral compounds could be discovered in natural products—such as vegetables, fruits, flowers, herbal plants, marine organisms and microorganisms—from which various compounds have been documented to exhibit antiviral activities and are expected to have good tolerability and minimal side effects. Polyphenols and plant extracts have been extensively studied for their antiviral properties against arboviruses and have demonstrated promising results. With an abundance of natural products to screen for new antiviral compounds, it is highly optimistic that natural products will continue to play an important role in contributing to antiviral drug development and in reducing the global infection burden of arboviruses.

scholarly journals Synthetic biology of plant natural products: from pathway elucidation to engineered biosynthesis in plant cells

2021 ◽  
pp. 100229
Author(s):  
Xiaoxi Zhu ◽  
Xiaonan Liu ◽  
Tian Liu ◽  
Yina Wang ◽  
Nida Ahmed ◽  
...  
Keyword(s):  
Natural Products ◽  
Synthetic Biology ◽  
Plant Cells ◽  
Plant Natural Products

Metabolon formation and metabolic channeling in the biosynthesis of plant natural products

2005 ◽  
Vol 8 (3) ◽  
pp. 280-291 ◽  
Author(s):  
Kirsten Jørgensen ◽  
Anne Vinther Rasmussen ◽  
Marc Morant ◽  
Allan Holm Nielsen ◽  
Nanna Bjarnholt ◽  
...  
Keyword(s):  
Natural Products ◽  
Metabolic Channeling ◽  
Plant Natural Products

scholarly journals Antimicrobial Activity of Leaves and Flowers of Cassia auriculata linn

1970 ◽  
Vol 46 (4) ◽  
pp. 513-518 ◽  
Author(s):  
V Subhadradevi ◽  
K Asokkumar ◽  
M Umamaheswari ◽  
AT Sivashanmugam ◽  
JR Ushanandhini ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Agents ◽  
Inhibitory Concentration ◽  
Dominant Role ◽  
Ethanolic Extract ◽  
Diffusion Method ◽  
Cassia Auriculata ◽  
Potential Source ◽  
Wide Range ◽  
Ancient Times

Since ancient times plant as sources of medicinal compounds have continued to play a dominant role in the maintenance of human health. To treat chronic and infectious diseases plants used in traditional medicine contain a wide range of ingredients. In this regard, Cassia auriculata L. (Caesalpiniaceae) is widely used in Ayurvedic medicine as a tonic, astringent and as a remedy for diabetes, conjunctivitis, ulcers, leprosy, skin and liver diseases. The aim of present study was to evaluate the antimicrobial activity of ethanolic extract of Cassia auriculata leaves and flowers (CALE & CAFE). CALE and CAFE exhibited broad spectrum antimicrobial activity against standard strains of Staphylococcus aureus, Escherichia coli and Bacillus subtilis and exhibited no antifungal activity against standard strains of Candida albicans and Aspergillus niger. Minimum inhibitory concentration (MIC) and Minimum bactericidal concentration (MBC) was carried out for CALE and CAFE. The results obtained in the present study indicate that the CALE and CAFE can be a potential source of natural antimicrobial agents. Key words: Cassia auriculata; Antimicrobial activity; Agar well diffusion method. DOI: http://dx.doi.org/10.3329/bjsir.v46i4.9600 BJSIR 2011; 46(4): 513-518

ChemInform Abstract: Recent Developments in the Total Synthesis of Fungicidal Natural Products - A Crop Protection Perspective

ChemInform ◽  
2011 ◽  
Vol 42 (32) ◽  
pp. no-no
Author(s):  
Carl F. Nising ◽  
Stefan Hillebrand ◽  
Lars Rodefeld
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Crop Protection ◽  
Recent Developments

scholarly journals Multiple Myeloma Inhibitory Activity of Plant Natural Products

Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2678
Author(s):  
Karin Jöhrer ◽  
Serhat Sezai Ҫiҫek
Keyword(s):  
Multiple Myeloma ◽  
Natural Products ◽  
Myeloma Cell ◽  
Myeloma Cell Line ◽  
Antiproliferative Effects ◽  
Plant Natural Products ◽  
Starting Point ◽  
Human Myeloma Cell Line ◽  
Group A ◽  
Good Starting Point

A literature search on plant natural products with antimyeloma activity until the end of 2020 resulted in 92 compounds with effects on at least one human myeloma cell line. Compounds were divided in different compound classes and both their structure–activity-relationships as well as eventual correlations with the pathways described for Multiple Myeloma were discussed. Each of the major compound classes in this review (alkaloids, phenolics, terpenes) revealed interesting candidates, such as dioncophyllines, a group of naphtylisoquinoline alkaloids, which showed pronounced and selective induction of apoptosis when substituted in position 7 of the isoquinoline moiety. Interestingly, out of the phenolic compound class, two of the most noteworthy constituents belong to the relatively small subclass of xanthones, rendering this group a good starting point for possible further drug development. The class of terpenoids also provides noteworthy constituents, such as the highly oxygenated diterpenoid oridonin, which exhibited antiproliferative effects equal to those of bortezomib on RPMI8226 cells. Moreover, triterpenoids containing a lactone ring and/or quinone-like substructures, e.g., bruceantin, whitaferin A, withanolide F, celastrol, and pristimerin, displayed remarkable activity, with the latter two compounds acting as inhibitors of both NF-κB and proteasome chymotrypsin-like activity.

scholarly journals Metabolomic-Guided Isolation of Bioactive Natural Products from Curvularia sp., an Endophytic Fungus of Terminalia laxiflora

Planta Medica ◽  
2017 ◽  
Vol 84 (03) ◽  
pp. 182-190 ◽  
Author(s):  
Ahmed Tawfike ◽  
Grainne Abbott ◽  
Louise Young ◽  
RuAngelie Edrada-Ebel
Keyword(s):  
Natural Products ◽  
Leukemia Cell ◽  
Myelogenous Leukemia ◽  
Leukemia Cell Line ◽  
Ionization Mass ◽  
Bioactive Components ◽  
Bioactive Natural Products ◽  
Linear Peptide ◽  
Potential Source ◽  
Fungal Extracts

AbstractEndophytic fungi associated with medicinal plants are a potential source of novel chemistry and biology. Metabolomic tools were successfully employed to compare the metabolite fingerprints of solid and liquid culture extracts of endophyte Curvularia sp. isolated from the leaves of Terminalia laxiflora. Natural product databases were used to dereplicate metabolites in order to determine known compounds and the presence of new natural products. Multivariate analysis highlighted the putative metabolites responsible for the bioactivity of the fungal extract and its fractions on NF-κB and the myelogenous leukemia cell line K562. Metabolomic tools and dereplication studies using high-resolution electrospray ionization mass spectrometry directed the fractionation and isolation of the bioactive components from the fungal extracts. This resulted in the isolation of N-acetylphenylalanine (1) and two linear peptide congeners of 1: dipeptide N-acetylphenylalanyl-L-phenylalanine (2) and tripeptide N-acetylphenylalanyl-L-phenylalanyl-L-leucine (3).

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