Cytokine expression in B-CLL in relation to disease progression andin vitro activation

1999 ◽  
Vol 16 (4) ◽  
pp. 289-295 ◽  
Author(s):  
M Aguilar-Santelises ◽  
D Gigliotti ◽  
LM Osorio ◽  
A Santiago ◽  
H Mellstedt ◽  
...  
Keyword(s):  
Disease Progression ◽  
Cytokine Expression

scholarly journals MAPK Usage in Periodontal Disease Progression

2012 ◽  
Vol 2012 ◽  
pp. 1-17 ◽  
Author(s):  
Qiyan Li ◽  
Michael S. Valerio ◽  
Keith L. Kirkwood
Keyword(s):  
Bone Loss ◽  
Periodontal Disease ◽  
Disease Progression ◽  
P38 Mapk ◽  
Rna Binding ◽  
Cytokine Expression ◽  
Negative Regulator ◽  
Host Recognition ◽  
Mapk Activation ◽  
Periodontal Inflammation

In periodontal disease, host recognition of bacterial constituents, including lipopolysaccharide (LPS), induces p38 MAPK activation and subsequent inflammatory cytokine expression, favoring osteoclastogenesis and increased net bone resorption in the local periodontal environment. In this paper, we discuss evidence that the p38/MAPK-activated protein kinase-2 (MK2) signaling axis is needed for periodontal disease progression: an orally administered p38α inhibitor reduced the progression of experimental periodontal bone loss by reducing inflammation and cytokine expression. Subsequently, the significance of p38 signaling was confirmed with RNA interference to attenuate MK2-reduced cytokine expression and LPS-induced alveolar bone loss. MAPK phosphatase-1 (MKP-1), a negative regulator of MAPK activation, was also critical for periodontal disease progression. In MPK-1-deficient mice, p38-sustained activation increased osteoclast formation and bone loss, whereas MKP-1 overexpression dampened p38 signaling and subsequent cytokine expression. Finally, overexpression of the p38/MK2 target RNA-binding tristetraprolin (TTP) decreased mRNA stability of key inflammatory cytokines at the posttranscriptional level, thereby protecting against periodontal inflammation. Collectively, these studies highlight the importance of p38 MAPK signaling in immune cytokine production and periodontal disease progression.

Reduced-size liver ischemia and reperfusion in mice: Effects of gender on cytokine expression and liver injury

2001 ◽  
Vol 120 (5) ◽  
pp. A25-A25
Author(s):  
H HARADA ◽  
K PAVLICK ◽  
L GRAY ◽  
M GRISHAM
Keyword(s):  
Liver Injury ◽  
Cytokine Expression ◽  
Ischemia And Reperfusion ◽  
Liver Ischemia
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