Experimental studies on the metabolism of glucose and pyridine nucleotides in liver injuries

1967 ◽  
Vol 2 (2) ◽  
pp. 136-137
Author(s):  
K. Kuzuya ◽  
K. Mori ◽  
S. Tabuchi ◽  
K. Hamana ◽  
H. Inoue ◽  
...  
Keyword(s):  
Experimental Studies ◽  
Pyridine Nucleotides ◽  
Liver Injuries

scholarly journals Efficiency of ademethionine in oxidative stress in tissues of irradiated rats

2021 ◽  
Vol 11 (6) ◽  
pp. 192-198
Author(s):  
G. F. Stepanov ◽  
L. O. Tereshchenko ◽  
E. V. Oleinik ◽  
G. S. Maryniuk ◽  
O. I. Budalenko ◽  
...  
Keyword(s):  
Total Dose ◽  
Control Level ◽  
Experimental Studies ◽  
Living Organism ◽  
Reduction Factor ◽  
Low Doses ◽  
Pyridine Nucleotides ◽  
Γ Irradiation ◽  
Low Intensity ◽  
Reduced Forms

Introduction. Ionizing radiation in low doses of low intensity causes prolonged activation of lipid per oxidation and depletion of the antioxidant system in a living organism. Moreover, Ademethionine is currently being considered as a promising antioxidant.Method. Experimental studies were carried out on 60 sexually mature male Wistar rats. The animals were irradiated in a total dose of 1Gy on a γ-therapeutic device AGAT-R No. 83 (isotope 60Co). At the end of the total dose, the rats were injected intraperitoneally with Heptral (ademethionine) after 15 minutes, 12, 24, 36, 48, 60, 72, 84, 96, 108, 120, 132, 144, 156 hours after radiation exposure at the rate of 10 mg / kg mass. After the introduction of Heptral, the animals were taken into the experiment after 24 hours, 3, 7, 15 days. In homogenates of the spleen and thymus of animals, the amount of oxidized and reduced forms of pyridine nucleotides was determined.Results. Chronic γ-irradiation in a total dose of 1Gy leads to a significant decrease in the content of reduced forms of pyridine nucleotides in the spleen and thymus of rats. Administration of Heptral to irradiated animals normalized oxidative homeostasis. So, on the 7th day of the experiment, the amount of oxidized forms of pyridine nucleotides in the spleen was 47.3% lower, and reduced - 36.3% higher than in animals that did not receive treatment. At the end of the observation period, the reduction coefficient of pyridine nucleotides in the spleen slightly differed from the control level. In comparison with irradiated animals, which were not injected with Heptral, the NADP content was lower by 70.3%, and NADPH2 - higher by 48.8%.Conclusion. The course administration of Heptral to irradiated animals leads to the normalization of the reduction factor of pyridine nucleotides. According to its mechanism of action, Heptral can be used in the complex treatment of low- intensity radiation injuries in low doses.

scholarly journals Protective roles of adiponectin in obesity-related fatty liver diseases: mechanisms and therapeutic implications

2009 ◽  
Vol 53 (2) ◽  
pp. 201-212 ◽  
Author(s):  
Yu Wang ◽  
Mingyan Zhou ◽  
Karen S. L. Lam ◽  
Aimin Xu
Keyword(s):  
Fatty Liver ◽  
Liver Diseases ◽  
Experimental Studies ◽  
Biological Properties ◽  
Cellular Mechanisms ◽  
Nonalcoholic Fatty Liver ◽  
Therapeutic Implications ◽  
Beneficial Effects ◽  
Liver Injuries ◽  
Oligomeric Complex

Adiponectin is an insulin-sensitizing adipokine possessing multiple beneficial effects on obesity-related medical complications. This adipokine is secreted from adipocytes into the circulation as three oligomeric isoforms, including trimer, hexamer and the high molecular weight (HMW) oligomeric complex. Each oligomeric isoform of adiponectin possesses distinct biological properties and activates different signaling pathways in various target tissues. The hepato-protective activities have been demonstrated by many clinical and experimental studies. The decreased level of serum adiponectin represents an independent risk factor for nonalcoholic fatty liver disease (NAFLD) and liver dysfunctions in humans. In animals, elevation of circulating adiponectin by either pharmacological or genetic approaches leads to a significant alleviation of hepatomegaly, steatosis and necro-inflammation associated with various liver diseases. In adiponectin knockout mice, there is a pre-existing condition of hepatic steatosis and mitochondria dysfunction, which might contribute to the increased vulnerabilities of these mice to the secondary liver injuries induced by obesity and other conditions. This review aims to summarize recent advances on delination of the structural, molecular and cellular mechanisms underlying the hepato-protective properties of adiponectin.

3-D reconstruction and analysis of mammalian mitotic spindle structure

1992 ◽  
Vol 50 (1) ◽  
pp. 578-579
Author(s):  
Kent McDonald ◽  
David Mastronarde ◽  
Rubai Ding ◽  
Eileen O'Toole ◽  
J. Richard McIntosh
Keyword(s):  
Cross Sections ◽  
Mitotic Spindle ◽  
Experimental Studies ◽  
Video Camera ◽  
Three Dimensions ◽  
Mitotic Spindles ◽  
Black And White ◽  
Reconstruction Methods ◽  
Spindle Structure ◽  
Tissue Culture Line

Mammalian spindles are generally large and may contain over a thousand microtubules (MTs). For this reason they are difficult to reconstruct in three dimensions and many researchers have chosen to study the smaller and simpler spindles of lower eukaryotes. Nevertheless, the mammalian spindle is used for many experimental studies and it would be useful to know its detailed structure.We have been using serial cross sections and computer reconstruction methods to analyze MT distributions in mitotic spindles of PtK cells, a mammalian tissue culture line. Images from EM negatives are digtized on a light box by a Dage MTI video camera containing a black and white Saticon tube. The signal is digitized by a Parallax 1280 graphics device in a MicroVax III computer. Microtubules are digitized at a magnification such that each is 10-12 pixels in diameter.

Effects of Attachment Styles on the Experience of Equity in Heterosexual Couples Relationships

2003 ◽  
Vol 50 (4) ◽  
pp. 298-310 ◽  
Author(s):  
Ina Grau ◽  
Jörg Doll
Keyword(s):  
Attachment Theory ◽  
Attachment Style ◽  
Intimate Relationships ◽  
Attachment Styles ◽  
Experimental Studies ◽  
The Other ◽  
Heterosexual Couples ◽  
Secure Attachment ◽  
Dependent Variables ◽  
Equity Ratio

Abstract. Employing one correlational and two experimental studies, this paper examines the influence of attachment styles (secure, anxious, avoidant) on a person’s experience of equity in intimate relationships. While one experimental study employed a priming technique to stimulate the different attachment styles, the other involved vignettes describing fictitious characters with typical attachment styles. As the specific hypotheses about the single equity components have been developed on the basis of the attachment theory, the equity ratio itself and the four equity components (own outcome, own input, partner’s outcome, partner’s input) are analyzed as dependent variables. While partners with a secure attachment style tend to describe their relationship as equitable (i.e., they give and take extensively), partners who feel anxious about their relationship generally see themselves as being in an inequitable, disadvantaged position (i.e., they receive little from their partner). The hypothesis that avoidant partners would feel advantaged as they were less committed was only supported by the correlational study. Against expectations, the results of both experiments indicate that avoidant partners generally see themselves (or see avoidant vignettes) as being treated equitably, but that there is less emotional exchange than is the case with secure partners. Avoidant partners give and take less than secure ones.

Exneriana – II – The Scientific Legacy of John E. Exner, Jr. 1Part of this paper was presented at the XIXth International Congress of Rorschach and Projective Methods, July 22–26, 2008, Louvain, Belgium.

2008 ◽  
Vol 29 (2) ◽  
pp. 81-107 ◽  
Author(s):  
Anne Andronikof
Keyword(s):  
Clinical Studies ◽  
Experimental Studies ◽  
Scientific Work ◽  
International Congress ◽  
Response Process ◽  
Scientific Legacy ◽  
Projective Test ◽  
Projective Methods ◽  
Comprehensive Picture ◽  
Complex Mechanisms

Based on an analysis of John Exner’s peer-reviewed published work from 1959 to 2007, plus a brief comment for an editorial in Rorschachiana, the author draws a comprehensive picture of the scientific work of this outstanding personality. The article is divided into three sections: (1) the experimental studies on the Rorschach, (2) the clinical studies using the Rorschach, and (3) Exner’s “testament,” which we draw from the last paper he saw published before his death (Exner, 2001/2002). The experimental studies were aimed at better understanding the nature of the test, in particular the respective roles of perception and projection in the response process. These fundamental studies led to a deeper understanding of the complex mechanisms involved in the Rorschach responses and introduced some hypotheses about the intentions of the author of the test. The latter were subsequently confirmed by the preparatory sketches and documents of Hermann Rorschach, which today can be seen at the H. Rorschach Archives and Museum in Bern (Switzerland). Exner’s research has evidenced the notion that the Rorschach is a perceptive-cognitive-projective test.

The “Big Two” in Political Communication

2013 ◽  
Vol 44 (2) ◽  
pp. 117-128 ◽  
Author(s):  
Mauro Bertolotti ◽  
Patrizia Catellani ◽  
Karen M. Douglas ◽  
Robbie M. Sutton
Keyword(s):  
Political Communication ◽  
Experimental Studies ◽  
Two Dimensions ◽  
Political Sophistication

In two experimental studies (conducted in Britain and Italy), participants read about a politician answering to leadership- versus morality-related allegations using either downward counterfactuals (“things could have been worse, if ...”) or upward counterfactuals (“things could have been better, if ...”). Downward messages increased the perception of the politician’s leadership, while both downward and upward messages increased morality perception. Political sophistication moderated the effect of message direction, with downward messages increasing perceived morality in low sophisticates and upward messages increasing perceived morality in high sophisticates. In the latter group, the acknowledgment of an intent to take responsibility mediated morality judgment. Results were consistent across different countries, highlighting previously unexplored effects of communication on the perception of the “Big Two” dimensions.

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