Estimating the burden of psychiatric disorders in adolescence: the impact of subthreshold disorders

2014 ◽  
Vol 50 (3) ◽  
pp. 397-406 ◽  
Author(s):  
Robert E. Roberts ◽  
Prudence W. Fisher ◽  
J. Blake Turner ◽  
Min Tang
Keyword(s):  
Psychiatric Disorders ◽  
The Impact

Depression and its Somatic Consequences: Allostatic Load as the Connecting Link

2017 ◽  
Vol 41 (S1) ◽  
pp. S62-S62
Author(s):  
B. Penninx
Keyword(s):  
Health Outcomes ◽  
Psychiatric Disorders ◽  
Allostatic Load ◽  
Cellular Aging ◽  
Health Consequences ◽  
Somatic Health ◽  
Depressed Patients ◽  
Physiological Dysregulation ◽  
Increased Risk ◽  
The Impact

Stress-related psychiatric disorders, such as depressive and anxiety disorders, have been associated with increased risk of overall mortality as well as with the onset of various aging-related somatic diseases. In addition to unhealthy lifestyles and poorer (self) care, various stress-related physiological processes likely contribute to these detrimental health consequences of psychiatric disorders. Considering the fact that the impact of stress-related disorders is visible on many different somatic health outcomes, it is unlikely that contributing biological systems are very specific. In fact, it is likely that multiple dysregulations of stress systems, including the immune, HPA-axis and autonomic nervous systems, but also various general proteomic or metabolomic pathways are involved. The concept of Allostatic Load (AL) emphasizes the presence of a multi-system physiological dysregulation.In this talk I will summarize what the evidence is for somatic health consequences of psychiatric conditions, with depression as an important example. Subsequently, I will provide an overview of the various stress systems that are dysregulated in depressed patients. In addition, I will provide empirical data from the Netherlands Study of Depression and Anxiety (n = 2981) that illustrate that there is evidence that depressed patients are especially at risk for a dysregulation in multiple physiological stress systems. I will also illustrate how such a state of AL can impact on basis cellular aging indicators like telomere length and epigenetic age.In sum, this talk will highlight the current state-of-evidence for an association between depressions with the onset of many adverse somatic health outcomes, and will provide insight into the contributing role of a multisystem physiological dysregulation.Disclosure of interestThe author has not supplied his declaration of competing interest.

scholarly journals Mental health among young adults in prison: The importance of childhood-onset conduct disorder

BJPsych Open ◽  
2017 ◽  
Vol 3 (2) ◽  
pp. 78-84 ◽  
Author(s):  
Björn Hofvander ◽  
Henrik Anckarsäter ◽  
Märta Wallinius ◽  
Eva Billstedt
Keyword(s):  
Mental Health ◽  
Young Adults ◽  
Conduct Disorder ◽  
Psychiatric Disorders ◽  
Violent Offenders ◽  
Childhood Onset ◽  
Important Indicator ◽  
Health Burden ◽  
Axis I ◽  
The Impact

BackgroundThe psychiatric health burden of prisoners is substantial. However, there is a lack of high-quality studies of psychiatric disorders among young adults with a high risk of reoffending.AimsTo investigate the lifetime prevalence of psychiatric disorders and use of mental health services among young male violent offenders and the impact of childhood-onset conduct disorder (COCD).MethodA nationally representative cohort (n = 270, age 18–25) of male offenders was followed back in medical records and clinically assessed by gold standard methods. Lifetime prevalences are presented together with odds ratios (ORs) as risk estimates in relation to COCD.ResultsPrevious use of psychiatric services among the participants was high but their lifetime psychiatric morbidity was even higher, with 93% meeting criteria for at least one Axis I disorder. The COCD group was overrepresented in most clinical categories and carried five times higher odds (OR = 5.1, 95% CI 2.0–12.8) of a psychotic disorder, three times higher odds (OR = 3.2, 95% CI 1.2–8.5) of a substance use disorder and two times higher odds of a mood disorder (OR = 2.3, 95% CI 1.3–4.0) or anxiety disorder (OR = 2.0, 95% CI 1.1–3.5).ConclusionsThe mental health burden is substantial among young violent offenders, and COCD is an important indicator of future mental health problems which must be a priority for public health efforts.

scholarly journals Multiple-time measurements of multidimensional psychiatric states from immediately before the COVID-19 pandemic to one year later: A longitudinal online survey of the Japanese population

2021 ◽  
Author(s):  
Taiki Oka ◽  
Takatomi Kubo ◽  
Nao Kobayashi ◽  
Fumiya Nakai ◽  
Yuka Miyake ◽  
...  
Keyword(s):  
Psychiatric Disorders ◽  
Principal Components ◽  
Japanese Population ◽  
Online Survey ◽  
Psychiatric Symptoms ◽  
Social Withdrawal ◽  
Mitigation Strategies ◽  
Series Data ◽  
Multiple Time ◽  
The Impact

ABSTRACTThe coronavirus disease 2019 (COVID-19) pandemic has profoundly affected the mental health of both infected and uninfected people. Although most psychiatric disorders have highly overlapping genetic and pathogenic backgrounds, most studies investigating the impact of the pandemic have examined only single psychiatric disorders. It is necessary to examine longitudinal trajectories of factors that modulate psychiatric states across multiple dimensions. 2274 Japanese citizens participated in online surveys presented in December 2019 (before the pandemic), August 2020, Dec 2020, and April 2021. These surveys included nine questionnaires on psychiatric symptoms, such as depression and anxiety. Multi-dimensional psychiatric time series data were then decomposed into four principal components. We used generalized linear models to identify modulating factors for effects of the pandemic on these components. The four principal components can be interpreted as general psychiatric burden, social withdrawal, alcohol-related problems, and depression/anxiety. Principal components associated with general psychiatric burden and depression/anxiety peaked during the initial phase of the pandemic. They were further exacerbated by the economic burden of the pandemic. In contrast, principal components associated with social withdrawal showed a delayed peak, with human relationships as an important risk modulating factor. In addition, being elderly and female were risk factors shared across all components. Our results show that COVID-19 has imposed a large and varied burden on the Japanese population since the commencement of the pandemic. Although components related to the general psychiatric burden remained elevated, peak intensities differed between components related to depression/anxiety and those related to social anxiety. These results underline the importance of using flexible monitoring and mitigation strategies for mental problems, according to the phase of the pandemic.

The Impact of the Internet in Twenty-First Century Addictions

2019 ◽  
pp. 436-454
Author(s):  
Shilpa Suresh Bisen ◽  
Yogesh Deshpande
Keyword(s):  
Psychiatric Disorders ◽  
Illicit Drugs ◽  
Cost Effective ◽  
First Century ◽  
Online Gambling ◽  
The Internet ◽  
Web Based ◽  
Positive Side ◽  
User Friendly ◽  
The Impact

In the era of digital technology, the internet has its significant role in sprouting vulnerability toward the different form of addictions and psychiatric disorders as well as providing the platform to manage them effectively. The internet provides ready access to illicit drugs, nonprescription medications which facilitate a sale of controlled substances over the Internet without a valid prescription which contributed to the rise of several forms of addictions. Studies have linked the severity of Problematic Internet Use to increase chances of substance Use disorder. Utilization of internet for longer durations serves as a booster for behavioral addictions like online gambling. Web based interventions on the positive side provides a cost effective, readily accessible and user-friendly platform to reach out majority of patients to help them in seeking treatment of Addictions and various psychiatric disorders. The aim of this chapter is to discuss the contribution of the internet in a positive and negative way to develop as well as resolve Psychiatric disorder.

Epigenetics in Psychiatry

2018 ◽  
pp. 165-183
Author(s):  
Subha Subramanian ◽  
James B. Potash
Keyword(s):  
Dna Methylation ◽  
Human Brain ◽  
Psychiatric Disorders ◽  
Drugs Of Abuse ◽  
Future Directions ◽  
Peripheral Tissues ◽  
Risk Genes ◽  
Epigenetic Biomarkers ◽  
Ongoing Work ◽  
The Impact

Epigenetic modifications such as DNA methylation (DNAm), histone acetylation and methylation, and those directed by small RNAs, are widely studied in psychiatry and may play a role in the etiology and pathophysiology of psychiatric disorders. This chapter provides a brief overview of the mechanisms regulating these epigenetic marks and the challenges in obtaining biologically meaningful epigenetic data, given the inaccessibility of the living human brain. Significant results to date from studies on the epigenetics of psychiatric disorders are presented, including the impact of stress on DNAm in psychiatric risk genes such as FKBP5, and the impact of drugs of abuse and of psychiatric medications on histone modifications. Future directions are discussed, including the study of newly discovered aspects of DNAm: 5-hydroxymethylcytosine and non-CpG methylation. Ongoing work aims to uncover neurobiological mechanisms of illness and to find epigenetic biomarkers in peripheral tissues that inform diagnosis, prognosis, and therapeutic response.

Psychiatry, folk psychology, and the impact of neuroscience—a response to Steven Hyman’s Loebel Lectures

2020 ◽  
pp. 304-319
Author(s):  
Jonathan Glover
Keyword(s):  
Fine Structure ◽  
Psychiatric Disorders ◽  
Folk Psychology ◽  
The Status ◽  
The Impact ◽  
The Brain

This chapter reflects on Steven Hyman's Loebel Lectures, which revolve around a contrast between folk psychology and what neuroscience is starting to reveal. Folk psychology is the unscientific picture of what goes on in people’s minds when they perceive, remember, think, feel, decide, and act. It is based on introspection and on intuitive ‘reading’ of other people. In contrast to folk psychology is the fine structure neuroscience is starting to reveal: the brain mechanisms underlying perception, memory, thought, emotion, decision, and action. Hyman says that mapping out this fine structure has the promise of changing the understanding and treatment of psychiatric disorders. Out of this emerges Hyman’s philosophical claim that neuroscience radically challenges the status of folk psychology. Folk psychology, being in conflict with neuroscience, is largely false.

scholarly journals Racism, racial life events and mental ill health

2001 ◽  
Vol 7 (5) ◽  
pp. 343-349 ◽  
Author(s):  
Dinesh Bhugra ◽  
Oyedeji Ayonrinde
Keyword(s):  
Psychiatric Disorders ◽  
Life Events ◽  
Common Mental Disorders ◽  
The Body ◽  
Mental Illnesses ◽  
Positive Life Events ◽  
Minority Ethnic Groups ◽  
Different Cultures ◽  
The Impact

The association of life events with the onset of various psychiatric disorders is well-known. The body of evidence has highlighted the impact of negative or positive life events on the genesis of common mental disorders, especially depression. These findings have been replicated across different cultures, although the impact of different life events varies between cultures. In addition, the roles of chronic difficulties (defined in Life events and psychiatric disorders, below) and resulting ongoing chronic stress have been shown to contribute to vulnerability to certain mental illnesses. However, data on the impact of life events, especially those perceived as racial, on members of minority ethnic groups are rather sparse. The questions that need to be addressed concern the perception of life events as racial, the role of pervasive and perceived institutional and individual racism, and chronic difficulties.

scholarly journals The Impact of Alexithymia on Treatment Response in Psychiatric Disorders: A Systematic Review

2020 ◽  
Vol 11 ◽  
Author(s):  
Federica Pinna ◽  
Mirko Manchia ◽  
Pasquale Paribello ◽  
Bernardo Carpiniello
Keyword(s):  
Systematic Review ◽  
Psychiatric Disorders ◽  
Treatment Response ◽  
The Impact

scholarly journals The association between the serotonin and dopamine neurotransmitters and personality traits

2016 ◽  
Vol 25 (2) ◽  
pp. 109-112 ◽  
Author(s):  
G. Delvecchio ◽  
M. Bellani ◽  
A. C. Altamura ◽  
P. Brambilla
Keyword(s):  
Personality Traits ◽  
Psychiatric Disorders ◽  
Candidate Genes ◽  
Genetic Polymorphisms ◽  
Complex Traits ◽  
Healthy Subjects ◽  
Mental Illnesses ◽  
Biological Mechanisms ◽  
Normal Personality ◽  
The Impact

Evidence from previous studies has reported that complex traits, including psychiatric disorders, are moderately to highly heritable. Moreover, it has also been shown that specific personality traits may increase the risk to develop mental illnesses. Therefore the focus of the research shifted towards the identification of the biological mechanisms underpinning these traits by exploring the effects of a constellation of genetic polymorphisms in healthy subjects. Indeed, studying the effect of genetic variants in normal personality provides a unique means for identifying candidate genes which may increase the risk for psychiatric disorders. In this review, we discuss the impact of two of the most frequently studied genetic polymorphisms on personality in healthy subjects, the 5-HTT polymorphism of the serotonin transporter and the DRD2/DRD4 polymorphisms of the D2/D4 dopamine's receptors. The main aims are: (a) to highlight that the study of candidate genes provides a fruitful ground for the identification of the biological underpinnings of personality without, though, reaching a general consensus about the strength of this relationship; and (b) to outline that the research in personality genetics should be expanded to provide a clearer picture of the heritability of personality traits.

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