Septic cardiomyopathy in rat LPS-induced endotoxemia: relative contribution of cellular diastolic Ca2+ removal pathways, myofibrillar biomechanics properties and action of the cardiotonic drug levosimendan

2015 ◽  
Vol 110 (5) ◽  
Author(s):  
S. Wagner ◽  
S. Schürmann ◽  
S. Hein ◽  
J. Schüttler ◽  
O. Friedrich
2003 ◽  
Vol 8 (4) ◽  
pp. 252-265 ◽  
Author(s):  
Manuel G. Calvo ◽  
P. Avero ◽  
M. Dolores Castillo ◽  
Juan J. Miguel-Tobal

We examined the relative contribution of specific components of multidimensional anxiety to cognitive biases in the processing of threat-related information in three experiments. Attentional bias was assessed by the emotional Stroop word color-naming task, interpretative bias by an on-line inference processing task, and explicit memory bias by sensitivity (d') and response criterion (β) from word-recognition scores. Multiple regression analyses revealed, first, that phobic anxiety and evaluative anxiety predicted selective attention to physical- and ego-threat information, respectively; cognitive anxiety predicted selective attention to both types of threat. Second, phobic anxiety predicted inhibition of inferences related to physically threatening outcomes of ambiguous situations. And, third, evaluative anxiety predicted a response bias, rather than a genuine memory bias, in the reporting of presented and nonpresented ego-threat information. Other anxiety components, such as motor and physiological anxiety, or interpersonal and daily-routines anxiety made no specific contribution to any cognitive bias. Multidimensional anxiety measures are useful for detecting content-specificity effects in cognitive biases.


Diabetes ◽  
1993 ◽  
Vol 42 (5) ◽  
pp. 720-731 ◽  
Author(s):  
G. M. Steil ◽  
M. A. Meador ◽  
R. N. Bergman

2019 ◽  
Author(s):  
Krisztina Sára Lukics ◽  
Ágnes Lukács

First language acquisition is facilitated by several characteristics of infant-directed speech, but we know little about their relative contribution to learning different aspects of language. We investigated infant-directed speech effects on the acquisition of a linear artificial grammar in two experiments. We examined the effect of incremental presentation of strings (starting small) and prosody (comparing monotonous, arbitrary and phrase prosody). Presenting shorter strings before longer ones led to higher learning rates compared to random presentation. Prosody marking phrases had a similar effect, yet, prosody without marking syntactic units did not facilitate learning. These studies were the first to test the starting small effect with a linear artificial grammar, and also the first to investigate the combined effect of starting small and prosody. Our results suggest that starting small and prosody facilitate the extraction of regularities from artificial linguistic stimuli, indicating they may play an important role in natural language acquisition.


Author(s):  
Z.B. Baktybaeva ◽  
R.A. Suleymanov ◽  
T.K. Valeev ◽  
N.R. Rakhmatullin

Carried out ecological and hygienic assessment of pollution of surface and groundwater of mining areas in the Republic of Bashkortostan. Revealed exceeding standards for fishery water bodies and drinking and cultural and community water use, which indicates the potential danger of surface water for the health of the region's population. The greatest relative contribution to the overall pollution of surface water bodies are making manganese (33,0–66,6 %), iron (9,1–15,6 %), calcium (6,5–11,7 %), lead (5,8– 7,2 %). The quality of water used for drinking purposes from decentralized water sources (boreholes, wells, springs), do not always correspond to the hygienic and sanitary-epidemiological requirements. In this case, the highest priority performance of drinking water contamination are increased stiffness, high content of iron, calcium, nitrate, presence cadmium, and hexavalent chromium.


2000 ◽  
Vol 31 (4-5) ◽  
pp. 411-422 ◽  
Author(s):  
Gísli Már Gíslason ◽  
Jón S. Ólafsson ◽  
Hákon Adalsteinsson

The characteristics of stream and river ecosystems in arctic and alpine areas are determined mainly by the relative contribution of glacial meltwater, snowmelt, rainfall and groundwater. Each source generates a particular seasonal hydrological signature, affecting physical and chemical properties, and hence biological communities. The relative contribution of each source is sensitive to climate change. The study was concentrated on the glacial River W-Jökulsá and some non-glacial rivers in the central highlands of Iceland. The water in the glacial river was entirely glacial meltwater at the glacier margin, but the glacial contribution was about 20% 40 km downstream. However, its tributaries and non-glacial reference rivers were mainly springfed. The invertebrate fauna was confined to Chironomidae of the genus Diamesa close to the glacier, but other taxa (species and groups of species) occupied the river further downstream, where their diversity was close to that found in the reference rivers.


Author(s):  
Elisa M. Trucco ◽  
Gabriel L. Schlomer ◽  
Brian M. Hicks

Approximately 48–66% of the variation in alcohol use disorders is heritable. This chapter provides an overview of the genetic influences that contribute to alcohol use disorder within a developmental perspective. Namely, risk for problematic alcohol use is framed as a function of age-related changes in the relative contribution of genetic and environmental factors and an end state of developmental processes. This chapter discusses the role of development in the association between genes and the environment on risk for alcohol use disorder. Designs used to identify genetic factors relevant to problematic alcohol use are discussed. Studies examining developmental pathways to alcohol use disorder with a focus on endophenotypes and intermediate phenotypes are reviewed. Finally, areas for further investigation are offered.


2019 ◽  
Vol 69 (Supplement_6) ◽  
pp. S466-S473 ◽  
Author(s):  
Oluwafemi Popoola ◽  
Aderemi Kehinde ◽  
Veronica Ogunleye ◽  
Oluwafemi J Adewusi ◽  
Trevor Toy ◽  
...  

Abstract Background The relative contribution of bacterial infections to febrile disease is poorly understood in many African countries due to diagnostic limitations. This study screened pediatric and adult patients attending 4 healthcare facilities in Ibadan, Nigeria, for bacteremia and malaria parasitemia. Methods Febrile patients underwent clinical diagnosis, malaria parasite testing, and blood culture. Bacteria from positive blood cultures were isolated and speciated using biochemical and serological methods, and Salmonella subtyping was performed by polymerase chain reaction. Antimicrobial susceptibility was tested by disk diffusion. Results A total of 682 patients were recruited between 16 June and 16 October 2017; 467 (68.5%) were <18 years of age. Bacterial pathogens were cultured from the blood of 117 (17.2%) patients, with Staphylococcus aureus (69 [59.0%]) and Salmonella enterica (34 [29.1%]) being the most common species recovered. Twenty-seven (79.4%) of the Salmonella isolates were serovar Typhi and the other 7 belonged to nontyphoidal Salmonella serovarieties. Thirty-four individuals were found to be coinfected with Plasmodium falciparum and bacteria. Five (14.7%) of these coinfections were with Salmonella, all in children aged <5 years. Antimicrobial susceptibility testing revealed that most of the Salmonella and Staphylococcus isolates were multidrug resistant. Conclusions The study demonstrates that bacteria were commonly recovered from febrile patients with or without malaria in this location. Focused and extended epidemiological studies are needed for the introduction of typhoid conjugate vaccines that have the potential to prevent a major cause of severe community-acquired febrile diseases in our locality.


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