Different skeletal muscle HSP70 responses to high-intensity strength training and low-intensity endurance training

2004 ◽  
Vol 91 (2-3) ◽  
pp. 330-335 ◽  
Author(s):  
Yuefei Liu ◽  
Werner Lormes ◽  
Liangli Wang ◽  
Susanne Reissnecker ◽  
J�rgen M. Steinacker
Keyword(s):  
Skeletal Muscle ◽  
Strength Training ◽  
Endurance Training ◽  
High Intensity ◽  
Low Intensity

scholarly journals Defining the contribution of skeletal muscle pyruvate dehydrogenase α1 to exercise performance and insulin action

2018 ◽  
Vol 315 (5) ◽  
pp. E1034-E1045 ◽  
Author(s):  
Kristoffer Svensson ◽  
Jessica R. Dent ◽  
Shahriar Tahvilian ◽  
Vitor F. Martins ◽  
Abha Sathe ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Insulin Sensitivity ◽  
Energy Expenditure ◽  
Exercise Performance ◽  
Pyruvate Dehydrogenase ◽  
High Intensity ◽  
High Intensity Exercise ◽  
Low Intensity ◽  
Low Intensity Exercise ◽  
Muscle Contractile

The pyruvate dehydrogenase complex (PDC) converts pyruvate to acetyl-CoA and is an important control point for carbohydrate (CHO) oxidation. However, the importance of the PDC and CHO oxidation to muscle metabolism and exercise performance, particularly during prolonged or high-intensity exercise, has not been fully defined especially in mature skeletal muscle. To this end, we determined whether skeletal muscle-specific loss of pyruvate dehydrogenase alpha 1 ( Pdha1), which is a critical subunit of the PDC, impacts resting energy metabolism, exercise performance, or metabolic adaptation to high-fat diet (HFD) feeding. For this, we generated a tamoxifen (TMX)-inducible Pdha1 knockout (PDHmKO) mouse, in which PDC activity is temporally and specifically ablated in adult skeletal muscle. We assessed energy expenditure, ex vivo muscle contractile performance, and endurance exercise capacity in PDHmKO mice and wild-type (WT) littermates. Additionally, we studied glucose homeostasis and insulin sensitivity in muscle after 12 wk of HFD feeding. TMX administration largely ablated PDHα in skeletal muscle of adult PDHmKO mice but did not impact energy expenditure, muscle contractile function, or low-intensity exercise performance. Additionally, there were no differences in muscle insulin sensitivity or body composition in PDHmKO mice fed a control or HFD, as compared with WT mice. However, exercise capacity during high-intensity exercise was severely impaired in PDHmKO mice, in parallel with a large increase in plasma lactate concentration. In conclusion, although skeletal muscle PDC is not a major contributor to resting energy expenditure or long-duration, low-intensity exercise performance, it is necessary for optimal performance during high-intensity exercise.

scholarly journals The Effect of Endurance Training Intensity on the Expression of Perlipin a Protein of Subcutaneous Adipose Tissue and Pancreatic B cells Function in Diabetic Rats

2020 ◽  
Author(s):  
Hadi Ghaedi
Keyword(s):  
B Cells ◽  
Endurance Training ◽  
High Intensity ◽  
Subcutaneous Adipose Tissue ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
P Value ◽  
Low Intensity ◽  
Pancreatic B Cells ◽  
Subcutaneous Adipose

Objective: The aim of this study was to compare the three endurance training intensities on the expression of Perlipin A protein in subcutaneous adipose tissue and pancreatic B-cells function in male diabetic rats. Materials and Methods: In this study, 40 healthy male wistar rats were divided into five groups, including diabetic with low intensity endurance training, diabetic with moderate intensity endurance training, diabetic with high intensity endurance training, diabetic control and healthy control. After diabetic induction with streptozotocin, endurance training was performed with low intensity, moderate and severe for eight weeks, three sessions per week. The relative expression of Perilipin A was measured by western blot technique. Results: The results indicated a significant effect of endurance training with three intensities on serum levels of insulin and glucose and pancreatic B-cells function ( P -value: 0.001). Also the results showed that there was no significant difference between Perlipin A expression in healthy and diabetic control groups with endurance training groups (with low, moderate and high intensity) ( P -value: 0.07). Conclusion: However, Moderate and high intensity endurance training compared to low-intensity training can compensate for the loss caused by diabetes in the expression of the Perlipin A protein but the difference was not significant. It seems that more intensity endurance training lead to more increase in Perlipin A expression in diabetic rats.

High-intensity strength training in nonagenarians. Effects on skeletal muscle

JAMA ◽  
1990 ◽  
Vol 263 (22) ◽  
pp. 3029-3034 ◽  
Author(s):  
M. A. Fiatarone
Keyword(s):  
Skeletal Muscle ◽  
Strength Training ◽  
High Intensity

Effects of Increased Load of Low- Versus High-Intensity Endurance Training on Performance and Physiological Adaptations in Endurance Athletes

2021 ◽  
pp. 1-10
Author(s):  
Rune K. Talsnes ◽  
Roland van den Tillaar ◽  
Øyvind Sandbakk
Keyword(s):  
Oxygen Uptake ◽  
Endurance Training ◽  
Maximal Oxygen Uptake ◽  
High Intensity ◽  
Time Trial ◽  
Endurance Athletes ◽  
High Intensity Training ◽  
Low Intensity ◽  
Physiological Adaptations ◽  
Intensity Training

Purpose: To compare the effects of increased load of low- versus high-intensity endurance training on performance and physiological adaptations in well-trained endurance athletes. Methods: Following an 8-week preintervention period, 51 (36 men and 15 women) junior cross-country skiers and biathletes were randomly allocated into a low-intensity (LIG, n = 26) or high-intensity training group (HIG, n = 25) for an 8-week intervention period, load balanced using the overall training impulse score. Both groups performed an uphill running time trial and were assessed for laboratory performance and physiological profiling in treadmill running and roller-ski skating preintervention and postintervention. Results: Preintervention to postintervention changes in running time trial did not differ between groups (P = .44), with significant improvements in HIG (−2.3% [3.2%], P = .01) but not in LIG (−1.5% [2.9%], P = .20). There were no differences between groups in peak speed changes when incremental running and roller-ski skating to exhaustion (P = .30 and P = .20, respectively), with both modes being significantly improved in HIG (2.2% [3.1%] and 2.5% [3.4%], both P < .01) and in roller-ski skating for LIG (1.5% [2.4%], P < .01). There was a between-group difference in running maximal oxygen uptake changes (P = .04), tending to improve in HIG (3.0% [6.4%], P = .09) but not in LIG (−0.7% [4.6%], P = .25). Changes in roller-ski skating peak oxygen uptake differed between groups (P = .02), with significant improvements in HIG (3.6% [5.4%], P = .01) but not in LIG (−0.1% [0.17%], P = .62). Conclusion: There was no significant difference in performance adaptations between increased load of low- versus high-intensity training in well-trained endurance athletes, although both methods improved performance. However, increased load of high-intensity training elicited better maximal oxygen uptake adaptations compared to increased load of low-intensity training.

Does Polarized Training Improve Performance in Recreational Runners?

2014 ◽  
Vol 9 (2) ◽  
pp. 265-272 ◽  
Author(s):  
Iker Muñoz ◽  
Stephen Seiler ◽  
Javier Bautista ◽  
Javier España ◽  
Eneko Larumbe ◽  
...  
Keyword(s):  
Training Program ◽  
Endurance Training ◽  
High Intensity ◽  
Ventilatory Threshold ◽  
Training Session ◽  
Moderate Intensity ◽  
Intervention Period ◽  
Low Intensity ◽  
Recreational Runners ◽  
The Impact

Purpose:To quantify the impact of training-intensity distribution on 10K performance in recreational athletes.Methods:30 endurance runners were randomly assigned to a training program emphasizing low-intensity, sub-ventilatory-threshold (VT), polarized endurance-training distribution (PET) or a moderately high-intensity (between-thresholds) endurance-training program (BThET). Before the study, the subjects performed a maximal exercise test to determine VT and respiratory-compensation threshold (RCT), which allowed training to be controlled based on heart rate during each training session over the 10-wk intervention period. Subjects performed a 10-km race on the same course before and after the intervention period. Training was quantified based on the cumulative time spent in 3 intensity zones: zone 1 (low intensity, <VT), zone 2 (moderate intensity, between VT and RCT), and zone 3 (high intensity, >RCT). The contribution of total training time in each zone was controlled to have more low-intensity training in PET (±77/3/20), whereas for BThET the distribution was higher in zone 2 and lower in zone 1 (±46/35/19).Results:Both groups significantly improved their 10K time (39min18s ± 4min54s vs 37min19s ± 4min42s, P < .0001 for PET; 39min24s ± 3min54s vs 38min0s ± 4min24s, P < .001 for BThET). Improvements were 5.0% vs 3.6%, ~41 s difference at post-training-intervention. This difference was not significant. However, a subset analysis comparing the 12 runners who actually performed the most PET (n = 6) and BThET (n = 16) distributions showed greater improvement in PET by 1.29 standardized Cohen effect-size units (90% CI 0.31–2.27, P = .038).Conclusions:Polarized training can stimulate greater training effects than between-thresholds training in recreational runners.

Reversal of the Energy Metabolism Responses to Endurance Training by Weight Loading

1974 ◽  
Vol 39 (2) ◽  
pp. 847-852
Author(s):  
Crawford Kennedy ◽  
Wayne D. Van Huss ◽  
William W. Heusner
Keyword(s):  
Energy Metabolism ◽  
Endurance Training ◽  
Energy Cost ◽  
High Intensity ◽  
Anaerobic Metabolism ◽  
Distance Runners ◽  
Control Groups ◽  
Low Intensity ◽  
And Control ◽  
Weight Loading

6 university team distance runners were randomly placed into experimental and control groups to determine the effect of progressive overloading with weights upon selected training responses. Both groups received identical training for 8 wk. with the exception that three days each week the experimental Ss wore weighted wristlets, anklets, and belts. Pre- and posttest energy metabolism measures were taken during and following both a low-intensity 15-min. run (9.7 km/hr, 0% grade) and a high-intensity run to exhaustion (16.1 km/hr, 9% grade). The energy metabolism responses to endurance training were significantly reversed by the progressive overloading with weights. The energy cost of the low-intensity run was increased and an unexpected shift toward greater anaerobic metabolism was observed.

The effect of rowing ergometry and resistive exercise on skeletal muscle structure and function during bed rest

2014 ◽  
Vol 116 (12) ◽  
pp. 1569-1581 ◽  
Author(s):  
Felix Krainski ◽  
Jeffrey L. Hastings ◽  
Katja Heinicke ◽  
Nadine Romain ◽  
Eric L. Pacini ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Strength Training ◽  
Short Duration ◽  
High Intensity ◽  
Bed Rest ◽  
Muscle Volume ◽  
Muscle Fiber Types ◽  
Resonance Spectroscopy ◽  
Fiber Types ◽  
Rowing Ergometry

Exposure to microgravity causes functional and structural impairment of skeletal muscle. Current exercise regimens are time-consuming and insufficiently effective; an integrated countermeasure is needed that addresses musculoskeletal along with cardiovascular health. High-intensity, short-duration rowing ergometry and supplemental resistive strength exercise may achieve these goals. Twenty-seven healthy volunteers completed 5 wk of head-down-tilt bed rest (HDBR): 18 were randomized to exercise, 9 remained sedentary. Exercise consisted of rowing ergometry 6 days/wk, including interval training, and supplemental strength training 2 days/wk. Measurements before and after HDBR and following reambulation included assessment of strength, skeletal muscle volume (MRI), and muscle metabolism (magnetic resonance spectroscopy); quadriceps muscle biopsies were obtained to assess muscle fiber types, capillarization, and oxidative capacity. Sedentary bed rest (BR) led to decreased muscle volume (quadriceps: −9 ± 4%, P < 0.001; plantar flexors: −19 ± 6%, P < 0.001). Exercise (ExBR) reduced atrophy in the quadriceps (−5 ± 4%, interaction P = 0.018) and calf muscle, although to a lesser degree (−14 ± 6%, interaction P = 0.076). Knee extensor and plantar flexor strength was impaired by BR (−14 ± 15%, P = 0.014 and −22 ± 7%, P = 0.001) but preserved by ExBR (−4 ± 13%, P = 0.238 and +13 ± 28%, P = 0.011). Metabolic capacity, as assessed by maximal O2 consumption, 31P-MRS, and oxidative chain enzyme activity, was impaired in BR but stable or improved in ExBR. Reambulation reversed the negative impact of BR. High-intensity, short-duration rowing and supplemental strength training effectively preserved skeletal muscle function and structure while partially preventing atrophy in key antigravity muscles. Due to its integrated cardiovascular benefits, rowing ergometry could be a primary component of exercise prescriptions for astronauts or patients suffering from severe deconditioning.

The Annual Periodization of Training Volumes of International-Level Cross-Country Skiers and Biathletes

2020 ◽  
Vol 15 (8) ◽  
pp. 1181-1188
Author(s):  
Evgeny B. Myakinchenko ◽  
Andrey S. Kriuchkov ◽  
Nikita V. Adodin ◽  
Victor Feofilaktov
Keyword(s):  
Strength Training ◽  
Endurance Training ◽  
High Intensity ◽  
Upper Body ◽  
Moderate Intensity ◽  
International Level ◽  
Strength Exercises ◽  
Pyramid Model ◽  
Competition Period ◽  
Cross Country

Purpose: To compare the training-volume (TrV) distribution of Russian international-level male biathletes, female biathletes, and cross-country skiers (XC) during an annual cycle. Methods: Day-to-day TrVs were recorded and averaged for a 5-year period for male biathletes (n = 6), female biathletes (n = 8), and XC (n = 14) with VO2max values of 77.7 (3.8), 64.6 (1.9), and 79.4 (3.5) mL·min−1·kg−1, respectively. Results: The volumes of low- and moderate-intensity endurance training and all types of nonspecific endurance and strength training gradually decreased toward the competition period. However, the volumes and proportions of high-intensity endurance training and specific exercises (roller skiing, skiing, and shooting during high-intensity endurance training) increased by the time of the competition period. The total volume of training, volumes of low- and moderate-intensity endurance training, moderate- and high-load strength training (70%–95% 1RM), and power/speed loads did not increase gradually but reached their maximum immediately after a short stage of initial training. All teams employed the “pyramid” model of intensity distribution. Compared with the biathletes, XC demonstrated a larger (P < .01) annual volume of endurance training (~190 h), low-intensity endurance training (~183 h), and strength training (~818 sets). They also engaged in more upper-body and core-strength exercises (~769 sets), and they reached their maximum aerobic TrVs in June, while the biathletes reached theirs in July. Conclusions: In recent decades, the traditional model of periodization has been altered. The Russian XC and biathletes had significant differences in TrVs.

scholarly journals Dynamic strength training intensity in cardiovascular rehabilitation: is it time to reconsider clinical practice? A systematic review

2019 ◽  
Vol 26 (14) ◽  
pp. 1483-1492 ◽  
Author(s):  
Dominique Hansen ◽  
Ana Abreu ◽  
Patrick Doherty ◽  
Heinz Völler
Keyword(s):  
Systematic Review ◽  
Clinical Practice ◽  
Muscle Strength ◽  
Strength Training ◽  
High Intensity ◽  
Dynamic Strength ◽  
Training Intensity ◽  
Low Intensity ◽  
Peripheral Muscle ◽  
Dynamic Strength Training

When added to endurance training, dynamic strength training leads to significantly greater improvements in peripheral muscle strength and power output in patients with cardiovascular disease, which may be relevant to enhance the patient’s prognosis. As a result, dynamic strength training is recommended in the rehabilitative treatment of many different cardiovascular diseases. However, what strength training intensity should be selected remains under intense debate. Evidence is nonetheless emerging that high-intensity strength training (≥70% of one-repetition maximum) is more effective to increase acutely myofibrillar protein synthesis, cause neural adaptations and, in the long term, increase muscle strength, when compared to low-intensity strength training. Moreover, multiple studies report that high-intensity strength training causes fewer increments in (intra-)arterial blood pressure and cardiac output, as opposed to low-intensity strength training, thus potentially pointing towards sufficient medical safety for the cardiovascular system. The aim of this systematic review is therefore to discuss this line of evidence, which is in contrast to current clinical practice, and to re-open the debate as to what dynamic strength training intensities should actually be applied.

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