Effects of dietary myo-inositol on growth, antioxidative capacity, and nonspecific immunity in skin mucus of taimen Hucho taimen fry

2020 ◽  
Vol 46 (3) ◽  
pp. 1011-1018 ◽  
Author(s):  
Chang’an Wang ◽  
Shaoxia Lu ◽  
Jinnan Li ◽  
Liansheng Wang ◽  
Haibo Jiang ◽  
...  
2021 ◽  
Author(s):  
Chang'an Wang ◽  
Shaoxia Lu ◽  
Ze Fan ◽  
Di Wu ◽  
Jinnan Li ◽  
...  

Abstract The effects of dietary glutathione on growth performance, skin antioxidant capacity, and immune responses and of juvenile taimen (Hucho taimen) were investigated. The experimental fish had a mean initial weight of 5.36 ± 0.13 g and were fed for eight weeks on diets containing graduated amounts of glutathione (0, 100, 200, 400, and 800 mg kg−1). After the 7 d lipopolysaccharide challenge, the immune parameters of the skin mucus, and antioxidant ability were determined. The treatment groups (400 – 800 mg kg−1) showed a higher survival rate and weight gain rate (P < 0.05). There were higher levels of skin mucus protein, lysozyme activity, and alkaline phosphate activity associated with dietary glutathione supplementation (P < 0.05). Dietary glutathione supplementation improved the minimal inhibitory concentration and antimicrobial activity of the skin mucus (P < 0.05). Fish in the treatment groups showed higher superoxide dismutase, glutathione peroxidase, and catalase activity (P < 0.05), whereas the malondialdehyde content was lower (P < 0.05) than those in the control group. Supplementary glutathione decreased the expression levels of TNF-α, IL1β, IL6, IL8 in the skin and ensured the relatively high expression levels of IκBα after lipopolysaccharide challenge. In conclusion, dietary glutathione (400 – 800 mg kg−1) improved the growth performance, decreased lipopolysaccharide-induced skin inflammatory response, indicating that glutathione has the potential anti-inflammatory effects for preventing inflammation diseases in juvenile taimen.


2014 ◽  
Vol 42 (05) ◽  
pp. 261-270
Author(s):  
D. Bäuml ◽  
M. Fürll ◽  
M. Heilig

Zusammenfassung Gegenstand und Ziel: Häufiges Auftreten der Gebärparese (GP) sowie zum Teil unbefriedigende Behandlungserfolge zwingen zur Frage, inwieweit neben den bekannten Ursachen weitere Faktoren Inzidenz und Therapieerfolg bei GP beeinflussen. Spurenelemente, wie Selen (Se), sind in den Knochenstoffwechsel involviert, doch gibt es wenige Kenntnisse über fördernde Einflüsse von Se bei der Entstehung der GP. Ziel der Studie war deshalb, die Konzentration von Se und statistische Beziehungen zu unter Se-Einflüssen stehenden Parametern bei festliegenden Kühen zu analysieren. Material und Methoden: Festliegende und klinisch gesunde Fleckviehkühe wurden in fünf Gruppen eingeteilt: a) Kontrollgruppe (KG, n = 21) b) GP-Kühe gesamt (n = 174), c) GP-Kühe ohne Zusatzkrankheiten (n = 145), d) GP-Kühe mit Mastitis (n = 10) sowie e) GP-Kühe mit Retentio secundinarum oder puerperaler Metritis (n = 19). Die Blutserumanalysen umfassten Selen (Se), Kalzium (Ca), anorganisches Phosphat (Pi), Tumornekrosefaktor α (TNFα), Haptoglobin (Hp), Antioxidanzien (Trolox Equivalent Antioxidative Capacity) sowie weitere metabolische Parameter. Ergebnisse: Die Serumkonzentrationen von Se, Ca, Pi und TEAC waren in den Gruppen b) bis e) signifikant niedriger bzw. Hp höher als in der KG (p 0,05). Se korrelierte in der KG positiv mit Pi, in den Gruppen b) und c) mit Ca, Pi, K, Mg und in Gruppe c) mit Hp (p 0,05). Die Ca- und Pi-Konzentrationen lagen in Gruppe c) signifikant niedriger als in Gruppe d) (p 0,05). Die TNFα-Konzentration zeigte sich in den Gruppen b) und c) gegenüber a) erhöht und korrelierte in der Gruppe e) mit Se (p 0,05). Die Aktivität der alkalischen Phosphatase war in den Gruppen b) und e) niedriger als in der KG und korrelierte in der Gruppe a) mit Se (p 0,05). Schlussfolgerung: In Übereinstimmung mit Literaturangaben unterstützen die Resultate die Hypothese, dass Se unmittelbar in den Knochenstoffwechsel eingreift und damit in der Pathogenese der GP involviert sein könnte. Se wirkt über Zytokine auf die Ca-Mobilisierbarkeit aus dem Knochen. Die gemessenen Konzentrationen von Hp und TEAC unterstützen diese Interpretation. Die Kontrolle des Se-Status und die Se-Supplementation der Kühe sollten bei der Prävention und erweiterten Therapie der GP berücksichtigt werden.


2020 ◽  
Vol 3 (1) ◽  
pp. 58-76 ◽  
Author(s):  
Bohan Rong ◽  
Qiong Wu ◽  
Chao Sun

Melatonin is a well-known molecule for its involvement in circadian rhythm regulation and its contribution to protection against oxidative stress in organisms including unicellular alga, animals and plants. Currently, the bio-regulatory effects of melatonin on the physiology of various peripheral tissues have drawn a great attention of scientists. Although melatonin was previously defined as a neurohormone secreted from pineal gland, recently it has been identified that virtually, every cell has the capacity to synthesize melatonin and the locally generated melatonin has multiple pathophysiological functions, including regulations of obesity and metabolic syndromes. Herein, we focus on the effects of melatonin on fat deposition in various peripheral organs/tissues. The two important regulatory mechanisms related to the topic, i.e., the improvements of circadian rhythms and antioxidative capacity will be thoroughly discussed since they are linked to several biomarkers involved in obesity and energy imbalance, including metabolism and immunity. Furthermore, several other functions of melatonin which may serve to prevent or promote obesity and energy dysmetabolism-induced pathological states are also addressed. The organs of special interest include liver, pancreas, skeletal muscle, adipose tissue and the gut microbiota.


2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Roghieh Safari ◽  
Seyed Hossein Hoseinifar ◽  
Maryam Dadar ◽  
Hien Van Doan

AbstractThe present study investigated possible effects of dietary malic acid on the expression of immunity, antioxidant and growth related genes expression as well as skin mucus immune parameters in common carp. Common carp (Cyprinus carpio) fingerlings were fed diets supplemented with different levels (0 [control], 0.5%, 1%, 2%) of malic acid (MA) for 60 days. The results revealed highest expression levels of immune-related genes (tnf-alpha, il1b, il8 and lyz) in skin of common carp fed 2% MA (P < 0.05). Regarding 1% MA treatment comparison with control group, significant difference was noticed just in case of lyz (P < 0.05). Evaluation of growth related genes expression revealed no significant difference between treatments (P > 0.05). The study of antioxidant related genes (gsta and gpx) in common carp skin fed with MA, showed significant difference between treated groups and control (P < 0.05). Carps fed with 2% MA had highest alkaline phosphatase activity in skin mucus compared other treated groups and control (P < 0.05). There were no significant difference between 0.5% and 1% and control (P > 0.05). The study of total protein and total immunoglobulin (Ig) in common carp skin musus revealed no alteration following MA treatment (P > 0.05). The present data demonstrated that feeding with MA altered immune and antioxidant genes expression in skin mucus of common carp.


Author(s):  
L.L. Fomina ◽  
◽  
Yu.L. Oshurkova ◽  
O.A. Junina ◽  
T.S. Kulakova ◽  
...  

2010 ◽  
Vol 33 (5) ◽  
pp. 945-950
Author(s):  
Yong-Quan ZHANG ◽  
Jia-Sheng YIN ◽  
Jia DU ◽  
Zhong-He JIA ◽  
Guang-Xiang TONG

2013 ◽  
Vol 20 (5) ◽  
pp. 1023-1031
Author(s):  
Guifang LIN ◽  
Qingpi YAN ◽  
Wenbo CHEN ◽  
Yongquan SU ◽  
Yingxue QIN

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