scholarly journals Greater mastery is associated with lower depression risk in a large international cohort of people with multiple sclerosis over 2.5 years

2021 ◽  
Author(s):  
Sandra Neate ◽  
Afaf Humam ◽  
Nupur Nag ◽  
George A. Jelinek ◽  
Steve Simpson-Yap
Keyword(s):  
Multiple Sclerosis ◽  
Cross Sectional ◽  
Depression Risk ◽  
Patient Health ◽  
Fatigue Severity ◽  
Clinically Significant ◽  
Relationship Of ◽  
The Relationship ◽  
Subsequent Risk

Abstract Background Mastery is the extent to which an individual perceives their life circumstances as being under their control and not predominantly influenced by external factors. The relationship of mastery with clinical outcomes in people with multiple sclerosis (pwMS) has not been well-researched. We assessed the relationships of mastery with fatigue, disability, relapse number, and depression risk among pwMS over 2.5 years’ follow-up. Methods Data from the Health Outcomes and Lifestyle in a Sample of people with Multiple sclerosis study, among 839 participants who completed the 2.5 and 5-year reviews, were analysed. Mastery was measured by the Pearlin Mastery Scale, fatigue by Fatigue Severity Scale, depression risk by Patient Health Questionnaire-9, and disability by Patient-Determined Disease Steps, and diagnosed relapse number in the previous 12 months was queried. Cross-sectional and prospective analyses were undertaken by log-binomial, log-multinomial, and Poisson regression, as appropriate, adjusted for relevant confounders. Results Cross-sectionally, pwMS with the highest quartile mastery (> 25/28) had 90% lower frequency of depression risk, 60% lower frequency of clinically significant fatigue, and 77% fewer had severe disability, all largely robust to adjustment. Prospectively, those in the top two quartiles of mastery (> 21–25, > 25/28) had 66% and 74% lower subsequent depression risk, robust to adjustment. No significant associations were seen prospectively for change in fatigue, disability, or relapse number, however, and no robust associations of mastery with relapse number were evident. Conclusions Prospectively, a protective relationship of mastery with subsequent risk of depression was observed, suggesting this may be a point of intervention to improve wellbeing in pwMS.

scholarly journals Greater mastery is associated with lower depression risk in a large international cohort of people with multiple sclerosis over 2.5 years

2021 ◽  
Author(s):  
Sandra Neate ◽  
Afaf Humam ◽  
Nupur Nag ◽  
George Jelinek ◽  
Steve Simpson-Yap
Keyword(s):  
Multiple Sclerosis ◽  
Cross Sectional ◽  
Depression Risk ◽  
Patient Health ◽  
Fatigue Severity ◽  
Clinically Significant ◽  
Relationship Of ◽  
The Relationship ◽  
Subsequent Risk

Abstract Background: Mastery is the extent to which an individual perceives their life circumstances as being under their control and not predominantly influenced by external factors. The relationship of mastery with clinical outcomes in people with multiple sclerosis (pwMS) has not been well-researched. We assessed the relationships of mastery with fatigue, disability, relapse number, and depression risk among pwMS over 2.5 years’ follow-up. Methods: Data from the Health Outcomes and Lifestyle in a Sample of people with Multiple sclerosis (HOLISM) study, among 839 participants who completed the 2.5 and 5-year reviews, were analysed. Mastery was measured by the Pearlin Mastery Scale, fatigue by Fatigue Severity Scale, depression risk by Patient Health Questionnaire-9, and disability by Patient-Determined Disease Steps, and diagnosed relapse number in the previous 12 months was queried. Cross-sectional and prospective analyses were undertaken by log-binomial, log-multinomial, and Poisson regression, as appropriate, adjusted for relevant confounders. Results: Cross-sectionally, pwMS with the highest quartile mastery (>25/28) had 90% lower depression risk, 60% lower frequency of clinically significant fatigue, and 77% fewer with severe disability, all largely robust to adjustment. Prospectively, those in the top two quartiles of mastery (>21-25, >25) had 66% and 74% lower depression risk, robust to adjustment. No significant associations were seen prospectively for change in fatigue, disability, or relapse number, however, and no robust associations of mastery with relapse number. Conclusions: Prospectively, a protective relationship of mastery with subsequent risk of depression was observed, suggesting this may be a point of intervention to improve wellbeing in pwMS.

scholarly journals ANAlISIS FAKTOR YANG BERHUBUNGAN DENGAN TERJADINYA KELELAHAN KERJA PADA PENGUMPUl TOL DI PERUSAHAAN PENGEMBANG JALAN TOL SURABAYA

2017 ◽  
Vol 4 (2) ◽  
pp. 113
Author(s):  
Shintia Yunita Arini ◽  
Endang Dwiyanti
Keyword(s):  
Simple Random Sampling ◽  
Work Climate ◽  
Cross Sectional ◽  
Exercise Habits ◽  
Toll Road ◽  
Contingency Coefficient ◽  
Cross Sectional Design ◽  
Relationship Of ◽  
The Relationship

ABSTRACTFatigue is one of the problems experienced often by workers. Feeling of fatigue is subjective because every person is influenced by several factors deserve and need special attention as a follow-up in order to avoid problems in the health of workers. Toll collector is one of the employees at toll road developer that has an important task in the operation of toll roads. The objective of this research to determine the relationship of several independent variables included age, gender, exercise habits, monotonous circumstances and workload, work climate and noise toward to the dependent variable, fatigue. This research was analytic observational methods of data collection and cross sectional design.. The sample in this study was a toll collector at one of toll road developer taken from the population using simple random sampling. Variable testing performed using spearman correlation analysis and contingency coefficient. Variables studied had a relationship with fatigue if p < 0.05. There are 34 workers (50.7%) had mild fatigue. Statistical analysis showed weak correlation to the variables gender (p = 0.004), exercise habits (p = 0.033), state of monotony (p = 0.008), work climate perception (p = 0.011) , and the noise perception (p = 0.033) of the relationship with the occurrence of fatigue. So fatigue was influenced by several factors such as individual factors, job factors, and work environmental factors.Keywords: fatigue, toll collector, subjective

The relationship between problemsolving ability and fatigue severity in people with multiple sclerosis

2020 ◽  
Author(s):  
Seyed Alireza Derakhshanrad ◽  
Emily Piven
Keyword(s):  
Multiple Sclerosis ◽  
Problem Solving ◽  
Correlation Coefficient ◽  
Descriptive Study ◽  
Severity Scale ◽  
Ongoing Debate ◽  
Cross Sectional ◽  
Fatigue Severity ◽  
The Relationship ◽  
The City

Background: The literature speculates that there may be a relationship between cognitive capacities and levels of fatigue in people with multiple sclerosis (MS), which has been under reported. This study has investigated one aspect of cognition by evaluating the association between problem-solving ability and the severity of fatigue. Methods: A cross-sectional, descriptive study was used to investigate the association between levels of problem-solving ability and degrees of fatigue severity. Eighty-five participants living in the city of Shiraz, Iran, completed Cassidy Problem-Solving Inventory (PSI) and the Fatigue Severity Scale (FSS). Pearson’s Product Moment Correlation Coefficient was used to analyze the data. Results: Problem-solving was inversely associated with fatigue (r = -0.381, P = 0.009), whereby higher levels of problem-solving ability were associated with lower degrees of fatigue. Conclusion: The results of this study contributed to the ongoing debate about the linkage between cognition and fatigue in people with MS, suggesting an association between problem-solving ability and fatigue severity. A possible implication would be the importance of problem-solving training for people with MS.

scholarly journals Association Between Pain and Mindfulness in Multiple Sclerosis

2018 ◽  
Vol 20 (1) ◽  
pp. 28-34 ◽  
Author(s):  
Angela Senders ◽  
Alena Borgatti ◽  
Douglas Hanes ◽  
Lynne Shinto
Keyword(s):  
Multiple Sclerosis ◽  
Pain Interference ◽  
Measurement Information ◽  
Common Symptom ◽  
Five Facet Mindfulness Questionnaire ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Patient Reported ◽  
Clinically Significant ◽  
The Relationship

Abstract Background: Chronic pain is a common symptom in people with multiple sclerosis (MS) and often requires a multimodal approach to care. The practice of mindfulness has been shown to decrease the experience of pain in other conditions, yet little is known about the relationship between mindfulness and pain in people with MS. The objective of this study was to evaluate the association between pain interference and trait mindfulness in people with MS. Methods: In this cross-sectional survey, 132 people with any type of MS completed the Patient-Reported Outcomes Measurement Information System Pain Interference scale and the Five Facet Mindfulness Questionnaire. Linear regression was used to test the association between pain and mindfulness while adjusting for demographic and MS-related characteristics. Results: The relationship between pain and mindfulness was clinically meaningful and highly significant (t = −5.52, P &lt; .0001). For every 18-point increase in mindfulness scores, pain interference scores are expected to decrease by 3.96 (95% CI, −2.52 to −5.40) points (β = −0.22, P &lt; .0001). The adjusted model, including age, type of MS, the interaction between mindfulness and age, and the interaction between mindfulness and MS type, explains 26% of the variability in pain interference scores (R2 = 0.26). Conclusions: These results suggest a clinically significant association between mindfulness and pain interference in MS and support further exploration of mindfulness-based interventions in the management of MS-related pain.

scholarly journals Hypertension Related Knowledge and Its Relationship with Control of High Blood Pressure in Pakistan

2021 ◽  
pp. 183-186
Author(s):  
Bilal Younas ◽  
Muhammad Fahad ◽  
Muhammad Arslan
Keyword(s):  
Blood Pressure ◽  
High Blood Pressure ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Compliance Level ◽  
Significant Difference ◽  
Level Of Knowledge ◽  
Relationship Of ◽  
The Relationship

Introduction: High blood pressure (HBP) is a leading major risk factor for chronic diseases such as CKD, CADx, and deaths. The prevalence of patients with hypertension (HT) has risen from 600 million in 1980 to one billion in 2008. Aims and Objectives: The basic aim of the study is to find the relationship of knowledge about hypertension with the control of blood pressure. Methodology of the Study: This cross sectional study was conducted in Mayo hospital Lahore from January 2021 to July 2021. The data was collected from 100 patients with high blood pressure who visited the OPD of our hospital. A questionnaire was prepared by the researchers in accordance with the literature to measure the level of knowledge about HT. Results: The data was collected from 100 patients of both genders. On comparison of questions related to knowledge, there was a statistically significant difference in; meaning of hypertension (p <0.001), target SBP (p0.001), target DBP (p 0.001), importance of SBP versus DBP, improvement of health with lowering of blood pressure (p 0.002), high blood pressure being asymptomatic (p <0.001), changing lifestyle improves blood pressure (p 0.003), hypertension being a lifelong disease (<0.001), lifelong treatment with anti-hypertensives (<0.001) and high blood pressure being part of aging (<0.001). Conclusion: It is concluded that patients who were aware that elevated BP levels lead to reductions in life expectancy had a higher compliance level with medication use and follow-up visits than patients without this awareness.

Retinal migraine

2020 ◽  
pp. 92-97
Author(s):  
Brian M. Grosberg ◽  
C. Mark Sollars
Keyword(s):  
Multiple Sclerosis ◽  
Bipolar Disorder ◽  
Abdominal Pain ◽  
Low Back Pain ◽  
Sleep Disorders ◽  
Population Based ◽  
Sleep Apnoea ◽  
Cross Sectional ◽  
Relationship Of ◽  
The Relationship

The relationship between migraine and a large number of other diseases has been studied to varying degrees. Both clinical and population-based studies, cross-sectional and longitudinal, have been performed, indicating a relationship of migraine with ischaemic stroke, epilepsy, vertigo, psychiatric disorders, sleep disorders, pain disorders, and others. The association of migraine with depression is one of the most extensively studied comorbidities. The bidirectional nature of this comorbidity indicates possible shared genetic factors. Furthermore, the risk of migraine chronification is increased in migraine patients with a depression. Also, anxiety and bipolar disorder show clear associations with migraine. Sleep disorders have been reported to occur more often in migraineurs than in persons without migraine. A clear association was found for restless legs syndrome and familial advanced sleep phase syndrome. Furthermore, associations have been described with insomnia, daytime sleepiness, sleep apnoea, and narcolepsy. Among pain disorders associated with migraine are low back pain, fibromyalgia, and abdominal pain. The magnitude and the background of these comorbidities remain unclear, and should be further investigated. Other described comorbidities of migraine include syncope, movement disorders, asthma and allergies, gynaecological disturbances, obesity, diabetes, multiple sclerosis, and cancer.

scholarly journals Dynamics of transmission of Trypanosoma cruzi in a rural area of Argentina: III. Persistence of T. cruzi parasitemia among canine reservoirs in a two-year follow-up

1986 ◽  
Vol 28 (4) ◽  
pp. 213-219 ◽  
Author(s):  
Ricardo E. Gurtler ◽  
Nora D. Solard ◽  
Marta A. Lauricela ◽  
Ana S. Haedo ◽  
Silvia M. Pietrokovski ◽  
...  
Keyword(s):  
Rural Area ◽  
Rural Areas ◽  
Cross Sectional Survey ◽  
Present Survey ◽  
Cross Sectional ◽  
The One ◽  
Relationship Of ◽  
The Relationship ◽  
Insight Into

A new cross-sectional survey of household- associated mongrel dogs as well as follow-up of previously parasitemic individuals was carried out in 1984 toy means of xenodiagnosis and serologic techniques to get a deeper insight into the relationship of T. cruzi parasitemia and age among canine hosts in a rural area of Argentina. Persistence of detectable parasitemia was age-independent, or at most, loosely related to age, confirming the pattern observed in 1982. Similarly no significant age-decreasing effect was recorded among seropositive dogs in: a) the probability of detecting parasites in a 2-year follow-up; b) their intensity of infectiousness (=infective force) for T. infestans 3rd-4th instar nymphs, as measured by the percentage of infected bugs observed in each dog xenodiagnosis. Moreover, not only was the infective force of seropositive dogs for bugs approximately constant through lifetime, but it was significantly higher than the one recorded for children in the present survey, and for human people by other researchers. Therefore, and since T. infestans field populations show high feeding frequencies on dogs, the latter are expected to make the greatest contribution to the pool of infected vectors in the rural household of Argentina. This characteristic should be sufficient to involve canine reservoirs definitely as a risk factor for human people residing in the same house. The increased severity of parasitemia observed among dogs in this survey may be related to the acute undernutrition characteristic of canine populations of poor rural areas in our country, which is expected to affect the ability of the host to manage the infection.

scholarly journals 509Healthy-lifestyle-scores associated with lower subsequent fatigue risk in multiple sclerosis using inverse probability treatment weighting

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Tracey Weiland ◽  
Steve Simpson-Yap ◽  
Nupur Nag ◽  
George Jelinek ◽  
Keryn Taylor ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Lower Risk ◽  
Healthy Lifestyle ◽  
Medication Use ◽  
Lifestyle Factors ◽  
Inverse Probability ◽  
Fatigue Severity ◽  
Clinically Significant ◽  
Doubly Robust

Abstract Background Several lifestyle factors have been associated with the onset and progression of multiple sclerosis (MS). Combining these lifestyle factors into scoring indices is an efficient way to assess their collective relationship with clinical outcomes. We examined the association of two lifestyle scores with clinically significant fatigue and change thereof over two years’ follow-up. Methods Data on sociodemographic, lifestyle and clinical characteristics surveyed from the international HOLISM cohort of people with MS at baseline and 2.5-year follow-up. Fatigue was defined by Fatigue Severity Scale (FSS), and healthy lifestyle by the Healthy Lifestyle Index Score (HLIS), and SNAP (Smoking, Nutrition, Alcohol, Physical Activity) score. Analyses by standard logistic and inverse probability treatment weighting (IPTW) models adjusted for age, sex, MS type, disability, comorbidity number, immunomodulatory medication use, prescription antifatigue medication use, and ongoing relapse symptoms; change in fatigue models also adjusted for baseline fatigue. Results 1,160 participants completed the FSS questionnaire at both timepoints, and roughly 62% had fatigue at each timepoint. By logistic regression, baseline HLIS and SNAP were each associated with lower risk of being fatigued at follow-up, persisting on adjustment. Using doubly-robust IPTW these associations were attenuated but high HLIS (OR = 0.89, 95% CI = 0.81-0.97) and SNAP (OR = 0.82, 95% CI = 0.73-0.90) were each associated with lower risk of fatigue at follow-up. Evaluating change in fatigue, however, there was no consistent association of either HLIS or SNAP score by either statistical method. Conclusions In this sample of people with MS, healthy lifestyle scores were associated with less fatigue 2.5 years later, though not with change in fatigue over this interval.

Side effect profile and adherence to in the treatment of Multiple Sclerosis with interferon beta-la

1998 ◽  
Vol 4 (6) ◽  
pp. 487-489 ◽  
Author(s):  
David C Mohr ◽  
William Likosky ◽  
Arne C Boudewyn ◽  
Peter Marietta ◽  
Pat Dwyer ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Side Effects ◽  
Side Effect ◽  
Interferon Beta ◽  
Side Effect Profile ◽  
Patient Reported ◽  
Relationship Of ◽  
The Relationship

This study examines the course of patient-reported side effect during the first 4 months of treatment for multiple sclerosis (MS) with interferon beta-Ia (IFNβ-Ia), and the relationship of those side effects to discontinuation of medication. Flu-like symptoms, muscle aches and chills decreased over the first 2 months of treatment but did not change over the second 2 months. Loss of feeling or numbness, tingling and depression increased over 4 months, however these side effects were generally mild. Loss of feeling or numbness and tingling at 2 month follow-up were significantly related to discontinuation of IFNβ-Ia by 4 month follow-up.

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