Study of Characteristics of the Cold Atmospheric Plasma Source Based on a Piezo Transformer

2020 ◽  
Vol 62 (11) ◽  
pp. 2073-2080 ◽  
Author(s):  
K. V. Artem’ev ◽  
N. N. Bogachev ◽  
N. G. Gusein-zade ◽  
T. V. Dolmatov ◽  
L. V. Kolik ◽  
...  
Keyword(s):  
Plasma Source ◽  
Atmospheric Plasma ◽  
Cold Atmospheric Plasma

scholarly journals Micro-Sized Cold Atmospheric Plasma Source for Brain and Breast Cancer Treatment

2018 ◽  
Vol 8 (2) ◽  
pp. 203-215 ◽  
Author(s):  
Zhitong Chen ◽  
Li Lin ◽  
Qinmin Zheng ◽  
Jonathan H. Sherman ◽  
Jerome Canady ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Treatment ◽  
Plasma Source ◽  
Breast Cancer Treatment ◽  
Atmospheric Plasma ◽  
Cold Atmospheric Plasma

scholarly journals Mismatch of frequencies of ac voltage and streamers propagation in cold atmospheric plasma jet for typical regimes of cancer cell treatment

2021 ◽  
Vol 2100 (1) ◽  
pp. 012020
Author(s):  
I Schweigert ◽  
A Alexandrov ◽  
D Zakrevsky ◽  
E Milakhina ◽  
E Patrakova ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cancer Cell ◽  
Plasma Jet ◽  
Plasma Source ◽  
Atmospheric Plasma ◽  
Modes Of Operation ◽  
Cold Atmospheric Plasma ◽  
Mode Of Operation ◽  
Voltage Frequency

Abstract Cold atmospheric plasma (CAP) jet generated by the plasma source at 2-6 kV ac voltages with frequencies of 10-50 kHz demonstrate the different modes of operation. Depending on the voltage frequency and amplitude, some streamers in the plasma jet are short and decay before they approach the treated surface. In this case, the effect on the viability of cancer cells when exposed to CAP jet strongly depends on the mode of operation of the discharge or, in other words, on how many times the streamers hit the bio-target during the treatment. The effect on different modes on cancer cells A549 viability is reported.

scholarly journals Investigation of a cold atmospheric plasma jet generation in single and multichannel planar devices

2021 ◽  
Vol 2064 (1) ◽  
pp. 012127
Author(s):  
P P Gugin ◽  
D E Zakrevsky ◽  
E V Milakhina
Keyword(s):  
Applied Voltage ◽  
Atmospheric Pressure ◽  
Plasma Jet ◽  
Plasma Source ◽  
Atmospheric Plasma ◽  
Planar Geometry ◽  
Collector Current ◽  
Cold Atmospheric Plasma

Abstract A plasma source of atmospheric pressure with a planar geometry of the device and an adjustable number of planar discharge channels has been developed. The dependence of the recorded collector current on the amplitude of the applied voltage is investigated. It was found that the current in each of the channels consists of a set of independent current channels whose propagation does not depend on each other.

scholarly journals Food container employing a cold atmospheric plasma source for prolonged preservation of plant and animal origin food products

MethodsX ◽  
2021 ◽  
Vol 8 ◽  
pp. 101177
Author(s):  
Panagiotis Dimitrakellis ◽  
Marianna Giannoglou ◽  
Angelos Zeniou ◽  
Evangelos Gogolides ◽  
George Katsaros
Keyword(s):  
Food Products ◽  
Plasma Source ◽  
Atmospheric Plasma ◽  
Animal Origin ◽  
Cold Atmospheric Plasma ◽  
Food Container ◽  
Animal Origin Food

Targeting Protective Catalase of Tumor Cells with Cold Atmospheric Plasma- Activated Medium (PAM)

2018 ◽  
Vol 18 (6) ◽  
pp. 784-804 ◽  
Author(s):  
Georg Bauer
Keyword(s):  
Control System ◽  
Singlet Oxygen ◽  
Tumor Cells ◽  
Plasma Potential ◽  
Atmospheric Plasma ◽  
Antitumor Action ◽  
Active Principle ◽  
Reaction Products ◽  
Cold Atmospheric Plasma

Background: Application of cold atmospheric plasma to medium generates “plasma-activated medium” that induces apoptosis selectively in tumor cells and that has an antitumor effect in vivo. The underlying mechanisms are not well understood. Objective: Elucidation of potential chemical interactions within plasma-activated medium and of reactions of medium components with specific target structures of tumor cells should allow to define the active principle in plasma activated medium. Methods: Established knowledge of intercellular apoptosis-inducing reactive oxygen/nitrogen species-dependent signaling and its control by membrane-associated catalase and SOD was reviewed. Model experiments using extracellular singlet oxygen were analyzed with respect to catalase inactivation and their relevance for the antitumor action of cold atmospheric plasma. Potential interactions of this tumor cell-specific control system with components of plasma-activated medium or its reaction products were discussed within the scope of the reviewed signaling principles. Results: None of the long-lived species found in plasma-activated medium, such as nitrite and H2O2, nor OCl- or .NO seemed to have the potential to interfere with catalase-dependent control of apoptosis-inducing signaling of tumor cells when acting alone. However, the combination of H2O2 and nitrite might generate peroxynitrite. The protonation of peroxnitrite to peroxynitrous acid allows for the generation of hydroxyl radicals that react with H2O2, leading to the formation of hydroperoxide radicals. These allow for singlet oxygen generation and inactivation of membrane-associated catalase through an autoamplificatory mechanism, followed by intercellular apoptosis-inducing signaling. Conclusion: Nitrite and H2O2 in plasma-activated medium establish singlet oxygen-dependent interference selectively with the control system of tumor cells.

The Application of the Cold Atmospheric Plasma-Activated Solutions in Cancer Treatment

2018 ◽  
Vol 18 (6) ◽  
pp. 769-775 ◽  
Author(s):  
Dayun Yan ◽  
Jonathan H. Sherman ◽  
Michael Keidar
Keyword(s):  
Cancer Treatment ◽  
Atmospheric Plasma ◽  
Current Status ◽  
Cold Atmospheric Plasma ◽  
Anti Cancer ◽  
Long Time ◽  
Key Topics ◽  
The Common

Background: Over the past five years, the cold atmospheric plasma-activated solutions (PAS) have shown their promissing application in cancer treatment. Similar as the common direct cold plasma treatment, PAS shows a selective anti-cancer capacity in vitro and in vivo. However, different from the direct cold atmospheric plasma (CAP) treatment, PAS can be stored for a long time and can be used without dependence on a CAP device. The research on PAS is gradually becoming a hot topic in plasma medicine. Objectives: In this review, we gave a concise but comprehensive summary on key topics about PAS including the development, current status, as well as the main conclusions about the anti-cancer mechanism achieved in past years. The approaches to make strong and stable PAS are also summarized.

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