The Relationship Between Embryotoxicity and Oxidative Stress Produced by Aluminum, Iron, Mercury, and Their Mixture on Cyprinus carpio

Objective The present study aimed to assess the global oxidant and antioxidant status in infants born to preeclamptic mothers and their correlation with cardiac functions. Study Design We compared 40 infants born to preeclamptic mothers with 40 premature infants born to normotensive mothers. We assessed the relationship between echocardiographic measurements and total antioxidant capacity (TAC) and total oxidant status (TOS) values. Results In the study group, TAC, TOS, and oxidative stress index (OSI) levels were significantly higher in the cord blood (p = 0.03, 0.04, and 0.039, respectively) than in the control group. We did not observe any correlation between echocardiographic measurements and TAC, TOS, and OSI levels in infants born to preeclamptic mothers. Conclusion Compared with the control group, despite higher TAC levels in infants born to preeclamptic mothers, concurrent elevated OSI levels reveal that the oxidant–antioxidant balance is disturbed in favor of oxidants. Furthermore, the findings of this study suggest that echocardiographic parameters are unaffected by the oxidant status.

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Relationship between aldose reductase enzyme and the signaling pathway of protein kinase C in an in vitro diabetic retinopathy model

Canadian Journal of Physiology and Pharmacology ◽

10.1139/cjpp-2019-0211 ◽

2020 ◽

Vol 98 (4) ◽

pp. 243-251

Author(s):

Mutlu Sarikaya ◽

Nuray Yazihan ◽

Net Daş Evcimen

Keyword(s):

Oxidative Stress ◽

Protein Kinase C ◽

Protein Kinase ◽

Molecular Mechanisms ◽

Signaling Molecules ◽

Protein Levels ◽

Kinase C ◽

The Relationship ◽

And Oxidative Stress ◽

Expression And Activity

Protein kinase C (PKC) and aldose reductase (AR) enzyme activities are increased in diabetes and complications are include retinopathy, nephropathy, and neuropathy. However, the relationship between PKC and AR and the underlying molecular mechanisms is still unclear. We aimed to evaluate the relationship between these two enzymes and clarify the underlying molecular mechanisms by the related signaling molecules. The effects of hyperglycemia and oxidative stress on AR and PKC enzymes and the signaling molecules such as nuclear factor-kappa B (NF-κB), inhibitor kappa B-alpha (IkB-α), total c-Jun, phospho c-Jun, and stress-activated protein kinases (SAPK)/Jun amino-terminal kinases (JNK) were evaluated in human retinal pigment epithelial cells (ARPE-19). AR, PKC protein levels, and related signaling molecules increased with hyperglycemia and oxidative stress. The AR inhibitor sorbinil decreased PKC expression and activity and all signaling molecule protein levels. Increased AR expression during hyperglycemia and oxidative stress was found to be correlated with the increase in PKC expression and activity in both conditions. Decreased expression and activity of PKC and the protein levels of related signaling molecules with the AR inhibitor sorbinil showed that AR enzyme may play a key role in the expression of PKC enzyme and oxidative stress during diabetes.

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Ameliorative effects of Moringa oleifera on copper nanoparticle induced toxicity in Cyprinus carpio assessed by histology and oxidative stress markers

Nanotechnology ◽

10.1088/1361-6528/aade23 ◽

2018 ◽

Vol 29 (46) ◽

pp. 464003 ◽

Cited By ~ 3

Author(s):

Aasma Noureen ◽

Farhat Jabeen ◽

Tanveer A Tabish ◽

Muhammad Kashif Zahoor ◽

Muhammad Ali ◽

...

Keyword(s):

Oxidative Stress ◽

Cyprinus Carpio ◽

Moringa Oleifera ◽

Copper Nanoparticle ◽

Oxidative Stress Markers ◽

Stress Markers ◽

And Oxidative Stress

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Bioaccumulation and oxidative stress caused by aluminium nanoparticles and the integrated biomarker responses in the common carp (Cyprinus carpio)

Chemosphere ◽

10.1016/j.chemosphere.2021.132462 ◽

2021 ◽

pp. 132462

Author(s):

Sandra García-Medina ◽

Marcela Galar-Martínez ◽

Selene Cano-Viveros ◽

Karina Ruiz-Lara ◽

Leobardo Manuel Gómez-Oliván ◽

...

Keyword(s):

Oxidative Stress ◽

Common Carp ◽

Cyprinus Carpio ◽

Common Carp Cyprinus Carpio ◽

Carp Cyprinus Carpio ◽

The Common ◽

And Oxidative Stress

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The Relationship between Alcohol–induced Apoptosis and Oxidative Stress in the Liver

Comprehensive Handbook of Alcohol Related Pathology ◽

10.1016/b978-012564370-2/50064-7 ◽

2005 ◽

pp. 785-797

Author(s):

J Sastre ◽

JB Miñana ◽

FV Pallardó ◽

J Viña

Keyword(s):

Oxidative Stress ◽

Induced Apoptosis ◽

The Relationship ◽

And Oxidative Stress

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Relationship Between Oxidative Stress, ER Stress, and Inflammation in Type 2 Diabetes: The Battle Continues

Journal of Clinical Medicine ◽

10.3390/jcm8091385 ◽

2019 ◽

Vol 8 (9) ◽

pp. 1385 ◽

Cited By ~ 48

Author(s):

Burgos-Morón ◽

Abad-Jiménez ◽

Marañón ◽

Iannantuoni ◽

Escribano-López ◽

...

Keyword(s):

Oxidative Stress ◽

Insulin Resistance ◽

Type 2 Diabetes ◽

Er Stress ◽

Mitochondrial Dysfunction ◽

Current Knowledge ◽

Β Cells ◽

The Relationship ◽

And Oxidative Stress

Type 2 diabetes (T2D) is a metabolic disorder characterized by hyperglycemia and insulin resistance in which oxidative stress is thought to be a primary cause. Considering that mitochondria are the main source of ROS, we have set out to provide a general overview on how oxidative stress is generated and related to T2D. Enhanced generation of reactive oxygen species (ROS) and oxidative stress occurs in mitochondria as a consequence of an overload of glucose and oxidative phosphorylation. Endoplasmic reticulum (ER) stress plays an important role in oxidative stress, as it is also a source of ROS. The tight interconnection between both organelles through mitochondrial-associated membranes (MAMs) means that the ROS generated in mitochondria promote ER stress. Therefore, a state of stress and mitochondrial dysfunction are consequences of this vicious cycle. The implication of mitochondria in insulin release and the exposure of pancreatic β-cells to hyperglycemia make them especially susceptible to oxidative stress and mitochondrial dysfunction. In fact, crosstalk between both mechanisms is related with alterations in glucose homeostasis and can lead to the diabetes-associated insulin-resistance status. In the present review, we discuss the current knowledge of the relationship between oxidative stress, mitochondria, ER stress, inflammation, and lipotoxicity in T2D.

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Susceptibility to weathering damage and oxidative stress on soybean seeds with different lignin contents in the seed coat

Journal of Seed Science ◽

10.1590/2317-1545v38n4162115 ◽

2016 ◽

Vol 38 (4) ◽

pp. 296-304 ◽

Cited By ~ 4

Author(s):

Caroline Huth ◽

Liliane Marcia Mertz-Henning ◽

Sidnei Jose Lopes ◽

Luciane Almeri Tabaldi ◽

Liana Veronica Rossato ◽

...

Keyword(s):

Oxidative Stress ◽

Seed Coat ◽

Lignin Content ◽

Accelerated Aging ◽

Guaiacol Peroxidase ◽

Soybean Seeds ◽

Soybean Cultivars ◽

Activity Of Enzymes ◽

The Relationship ◽

And Oxidative Stress

Abstract: This study aimed at evaluating the relationship among lignin content in the seed coat of soybean seeds with tolerance to weathering damage and oxidative stress. Four soybean cultivars (CD 208, CD 215, CD 202 and BRS 184), with lignin contents in the seed coat of 4.2, 2.6, 2.0 and 1.7%, respectively, were used. Seeds were subjected to deterioration by moisture, through artificially simulated rains. Pods of all cultivars were subjected to irrigation by constant sprinkling during 4 hours, and then dried in oven, set at 35 °C, for 37 hours; repeating twice such procedure. After these treatments seeds were subjected to tests and then compared to the control. Tests performed were: germination, accelerated aging and tetrazolium test; thereby quantifying the occurrence of damages by weathering damage. The activity of enzymes superoxide dismutase and guaiacol peroxidase was measured; and the lipid peroxidation was assessed. Soybean cultivars CD 208 and CD 215, with higher lignin content in the seed coat, were less susceptible to weathering damage. Seeds of cultivar CD 208 have also presented lower oxidative stress, when subjected to weathering damage stress.

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