Antimutagenic Activity as a Criterion of Potential Probiotic Properties

Background: Cancer is a disease characterized by the invasion and uncontrolled growth of cells. One of the best ways to minimize the harmful effects of mutagens is through the use of natural antimutagens. In this regard, the search for new antimutagens that act in the chemoprevention could represent a promising field in this area. Objective: In this study biological potential of 11 fractions from Coccoloba uvifera L. leaf hexane extract was evaluated by several in vitro tests. Methods: Leaves were lyophilized and hexane extraction was performed. The extract was fractionated by column chromatography with hexane, ethyl acetate, and methanol. The antimutagenic (Ames test), antiproliferative (MTT test), and antioxidant capacity (DPPH, ABTS, and ferrous ion chelation) of the fractions were evaluated. Results: Fractions 4, 6, 8, and 9 have antimutagenic activity (against sodium azide in strain TA100), fraction 11 showed antiproliferative capacity (IC50 of 24 ± 9 μg/mL in cells of HCT 116). The fractions with the highest activity were analyzed by HPLC-MS and lupeol, acacetin, and β-sitosterol were identified. Conclusion: This study demonstrates, for the first time, the bioactivity of C. uvifera leaf as a new source of high biological value compounds (HBVC), which can be of interest to the food and pharmaceutical industries.

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Antimutagenic Activity of Lutein –An Oxycarotenoid Present in the Macula and its Inhibition of Cytochrome P 450 Enzymes in vitro

Drug Metabolism Letters ◽

10.2174/1872312811206030009 ◽

2013 ◽

Vol 6 (3) ◽

pp. 213-220 ◽

Cited By ~ 1

Author(s):

Edakkadath Sindhu ◽

Alikkunjhi Firdous ◽

Ramnath Viswanathan ◽

Ramadasan Kuttan

Keyword(s):

Antimutagenic Activity ◽

Cytochrome P 450

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Phytochemical Investigation and Antimutagenic Potential of Ethanolic Extracts of Emblica officinalis, Terminalia chebula and Terminalia bellirica

The Natural Products Journal ◽

10.2174/2210315509666190618101140 ◽

2020 ◽

Vol 10 (4) ◽

pp. 488-494 ◽

Cited By ~ 1

Author(s):

Venugopal Singamaneni ◽

Sudheer Kumar Dokuparthi ◽

Nilanjana Banerjee ◽

Ashish Kumar ◽

Tulika Chakrabarti

Keyword(s):

Ethyl Acetate ◽

Gallic Acid ◽

Ellagic Acid ◽

Antimutagenic Activity ◽

Dependent Manner ◽

Terminalia Chebula ◽

Emblica Officinalis ◽

Dried Fruits ◽

Terminalia Bellerica ◽

The Family

Background: Emblica officinalis Gaertn. which belongs to the family Euphorbiaceae, Terminalia chebula Retz. and Terminalia bellerica Roxb. belong to the family Combretaceae. These are well known medicinal plants with phytochemical reservoir of great medicinal values and possess a vast ethnomedical history. Objective: The aim of the present study is to isolation of major compounds and to evaluate antimutagenic potential of the ethanol extracts of these plants. Methods: The dried fruits of E. officinalis, T. bellirica and T. chebula were powdered and extracted with 95% ethanol. The ethyl acetate portions were chromatographed over silica gel to isolate major compounds. Antimutagenic activity was determined by Ames test using TA98 and TA100 strains of Salmonella typhimurium. Results: Two major known compounds, gallic acid and ellagic acid were isolated from the dried fruits of Emblica officinalis, Terminalia chebula and T. bellirica. All the three extracts counteracted the mutagenicity induced by different genotoxic compounds in a dose dependent manner. Conclusion: This study showed that ethyl acetate portion of three extracts contain two major compounds, gallic acid and ellagic acid which might be responsible for potent antimutagenic activity of these extracts.

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Probiotic Properties of Lactobacillus Strains Isolated from Table Olive Biofilms

Probiotics and Antimicrobial Proteins ◽

10.1007/s12602-019-09604-y ◽

2019 ◽

Vol 12 (3) ◽

pp. 1071-1082 ◽

Cited By ~ 2

Author(s):

Antonio Benítez-Cabello ◽

Edgar Torres-Maravilla ◽

Luis Bermúdez-Humarán ◽

Philippe Langella ◽

Rebeca Martín ◽

...

Keyword(s):

Probiotic Properties ◽

Table Olive

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Antimutagenic activity of green tea polyphenols

Mutation Research/Genetic Toxicology ◽

10.1016/0165-1218(89)90120-1 ◽

1989 ◽

Vol 223 (3) ◽

pp. 273-285 ◽

Cited By ~ 172

Author(s):

Zhi Y. Wang ◽

Shu J. Cheng ◽

Zong C. Zhou ◽

Mohammad Athar ◽

Wasiuddin A. Khan ◽

...

Keyword(s):

Green Tea ◽

Tea Polyphenols ◽

Green Tea Polyphenols ◽

Antimutagenic Activity

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Reducing antigenicity of β-lactoglobulin, probiotic properties and safety evaluation of Lactobacillus plantarum AHQ-14 and Lactobacillus bulgaricus BD0390

Food Bioscience ◽

10.1016/j.fbio.2021.101137 ◽

2021 ◽

pp. 101137

Author(s):

Lingying Meng ◽

Xuemei Zhu ◽

Shujuan Jiang ◽

Yanfeng Tuo ◽

Heping Zhang ◽

...

Keyword(s):

Lactobacillus Plantarum ◽

Safety Evaluation ◽

Lactobacillus Bulgaricus ◽

Probiotic Properties ◽

Β Lactoglobulin

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Probiotic and Functional Properties of Limosilactobacillus reuteri INIA P572

Nutrients ◽

10.3390/nu13061860 ◽

2021 ◽

Vol 13 (6) ◽

pp. 1860

Author(s):

Patricia Diez-Echave ◽

Izaskun Martín-Cabrejas ◽

José Garrido-Mesa ◽

Susana Langa ◽

Teresa Vezza ◽

...

Keyword(s):

In Vitro Assays ◽

Immunomodulatory Activity ◽

Probiotic Properties ◽

Protective Effects ◽

Mice Model ◽

In Vivo Models ◽

Food Borne ◽

Gastrointestinal Conditions

Limosilactobacillus reuteri INIA P572 is a strain able to produce the antimicrobial compound reuterin in dairy products, exhibiting a protective effect against some food-borne pathogens. In this study, we investigated some probiotic properties of this strain such as resistance to gastrointestinal passage or to colonic conditions, reuterin production in a colonic environment, and immunomodulatory activity, using different in vitro and in vivo models. The results showed a high resistance of this strain to gastrointestinal conditions, as well as capacity to grow and produce reuterin in a human colonic model. Although the in vitro assays using the RAW 264.7 macrophage cell line did not demonstrate direct immunomodulatory properties, the in vivo assays using a Dextran Sulphate Sodium (DSS)-induced colitic mice model showed clear immunomodulatory and protective effects of this strain.

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