scholarly journals Recent advances in porous microneedles: materials, fabrication, and transdermal applications

2021 ◽  
Author(s):  
Leilei Bao ◽  
Jongho Park ◽  
Gwenaël Bonfante ◽  
Beomjoon Kim
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Biomedical Applications ◽  
Interstitial Fluid ◽  
Material Selection ◽  
Fluid Flows ◽  
Porous Structures ◽  
The Past ◽  
Portable Detection ◽  
Wide Range

AbstractIn the past two decades, microneedles (MNs), as a painless and simple drug delivery system, have received increasing attention for various biomedical applications such as transdermal drug delivery, interstitial fluid (ISF) extraction, and biosensing. Among the various types of MNs, porous MNs have been recently researched owing to their distinctive and unique characteristics, where porous structures inside MNs with continuous nano- or micro-sized pores can transport drugs or biofluids by capillary action. In addition, a wide range of materials, including non-polymers and polymers, were researched and used to form the porous structures of porous MNs. Adjustable porosity by different fabrication methods enables the achievement of sufficient mechanical strength by optimising fluid flows inside MNs. Moreover, biocompatible porous MNs integrated with biosensors can offer portable detection and rapid measurement of biomarkers in a minimally invasive manner. This review focuses on several aspects of current porous MN technology, including material selection, fabrication processes, biomedical applications, primarily covering transdermal drug delivery, ISF extraction, and biosensing, along with future prospects as well as challenges. Graphical abstract

Recent advances in the design of inorganic and nano-clay particles for the treatment of brain disorders

2021 ◽  
Author(s):  
Francesca Persano ◽  
Svetlana Batasheva ◽  
Gölnur Fakhrullina ◽  
Giuseppe Gigli ◽  
Stefano Leporatti ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Silica Nanoparticles ◽  
Biomedical Applications ◽  
Inorganic Materials ◽  
Brain Disorders ◽  
Clay Particles ◽  
Recent Advances ◽  
Wide Range ◽  
Nano Clay

Inorganic materials, in particular nanoclays and silica nanoparticles, have attracted enormous attention due to their versatile and tuneable properties, making them ideal candidates for a wide range of biomedical applications, such as drug delivery.

scholarly journals Green Synthesis of Magnetic Iron Oxide Nanoparticle for Antibacterial Activity: A Review

2021 ◽  
Vol 64 (2) ◽  
pp. 202-210
Author(s):  
Muhammad Isa Khan ◽  
Aliza Zahoor ◽  
Tahir Iqbal ◽  
Abdul Majid ◽  
Mohsin Ijaz
Keyword(s):  
Iron Oxide ◽  
Green Synthesis ◽  
Biomedical Applications ◽  
Synthesis Method ◽  
Antibacterial Activities ◽  
Magnetic Characteristics ◽  
Iron Oxide Nanoparticle ◽  
The Past ◽  
Wide Range ◽  
Oxide Nanoparticle

  Recently, different researchers find nanoparticles as an auspicious alternative to antibacterial agents due to their antibacterial behaviour. This antibacterial behaviour contributes in many biomedical applications including; tissue engineering, drug and gene delivery and, imaging. Furthermore, iron oxide nanoparticle gains much importance due to their magnetic characteristics and wide range of application. Iron oxide nanoparticle (IONPs) have exhibits great potential against bacteria. During the past decade, various routes were developed to synthesize iron oxide nanoparticle with suitable size and composition. This article reviews the recent iron oxide nanoparticle obtained by green synthesis with a focus on their response to antibacterial activities. The iron nanoparticles synthesized by green synthesis method has accumulated a vital attention over the last couple of years due to their unique characteristic as it makes sure environmental friendly, nontoxic and safe reagents.

A Review on Application of Novel Solid Nanostructures in Drug Delivery

2018 ◽  
Vol 53 ◽  
pp. 22-36 ◽  
Author(s):  
Habibollah Faraji ◽  
Reza Nedaeinia ◽  
Esmaeil Nourmohammadi ◽  
Bizan Malaekeh-Nikouei ◽  
Hamid Reza Sadeghnia ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Therapy ◽  
Biomedical Applications ◽  
Imaging Biomarkers ◽  
Cellular Functions ◽  
Scientific Innovation ◽  
Wide Range ◽  
Targeted Drug

Nanotechnology as a multidisciplinary and scientific innovation plays an important role in numerous biomedical applications, such as molecular imaging, biomarkers and biosensors and also drug delivery. A wide range of studies have been conducted on using of nanoparticles for early diagnosis and targeted drug therapy of various diseases. In fact, the small size, customized surface, upgraded solubility, or multi-functionality of nanoparticles enabled them to interact with complex cellular functions in new ways which opened many doors and created new biomedical applications. These studies demonstrated that nanotechnology vehicles can formulate biological products effectively, and this nano-formulated products with a potent ability against different diseases, were represented to have better biocompatibility, bioaccessibility and efficacy, under in vitro and in vivo conditions.

Biomedical Applications of Nanoparticles

2022 ◽  
pp. 289-311
Author(s):  
Raghavv Raghavender Suresh ◽  
Shruthee Sankarlinkam ◽  
Sai Rakshana Karuppusami ◽  
Niraimathi Pandiyan ◽  
Suwetha Bharathirengan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Medical Diagnostics ◽  
Engineered Nanoparticles ◽  
Biological Molecules ◽  
Toxicological Evaluation ◽  
Nanodrug Delivery ◽  
Novel Drugs ◽  
Wide Range ◽  
Targeted Drug

In recent years, there has been significant growth and burgeoning interest in utilizing nanoparticles for various biomedical applications, including medical diagnostics, targeted drug delivery, tissue engineering, regenerative medicine, and biomedical textiles. In particular, nanoparticles functionalized with biological molecules have unique properties and are very effective in medical diagnostics. Besides that, nanoparticles have a wide range of therapeutic applications, including the development of nanodrug delivery systems, the design of novel drugs, as well as their contribution to the design of therapeutic materials. This chapter provides an overview of recent advancements in the biomedical applications of nanoparticles. Finally, this chapter discusses the challenges of the toxicological evaluation of engineered nanoparticles and the importance of conducting detailed studies on the synthesis of future nanomaterials to develop cutting-edge technologies for addressing a wide range of biomedical issues.

scholarly journals Marine Polysaccharides in Pharmaceutical Applications: Fucoidan and Chitosan as Key Players in the Drug Delivery Match Field

Marine Drugs ◽  
2019 ◽  
Vol 17 (12) ◽  
pp. 654 ◽  
Author(s):  
Ana Isabel Barbosa ◽  
Ana Joyce Coutinho ◽  
Sofia A. Costa Lima ◽  
Salette Reis
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Biomedical Applications ◽  
Chemical Structure ◽  
Final Section ◽  
Biological Properties ◽  
Production Methods ◽  
Bioactive Properties ◽  
Wide Range ◽  
Per Se

The use of marine-origin polysaccharides has increased in recent research because they are abundant, cheap, biocompatible, and biodegradable. These features motivate their application in nanotechnology as drug delivery systems; in tissue engineering, cancer therapy, or wound dressing; in biosensors; and even water treatment. Given the physicochemical and bioactive properties of fucoidan and chitosan, a wide range of nanostructures has been developed with these polysaccharides per se and in combination. This review provides an outline of these marine polysaccharides, including their sources, chemical structure, biological properties, and nanomedicine applications; their combination as nanoparticles with descriptions of the most commonly used production methods; and their physicochemical and biological properties applied to the design of nanoparticles to deliver several classes of compounds. A final section gives a brief overview of some biomedical applications of fucoidan and chitosan for tissue engineering and wound healing.

scholarly journals Microneedle System for Transdermal Drug and Vaccine Delivery: Devices, Safety, and Prospects

Dose-Response ◽  
2019 ◽  
Vol 17 (4) ◽  
pp. 155932581987858 ◽  
Author(s):  
Xiaoxiang He ◽  
Jingyao Sun ◽  
Jian Zhuang ◽  
Hong Xu ◽  
Ying Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Research And Development ◽  
Drug Delivery System ◽  
Delivery System ◽  
Future Development ◽  
Transdermal Drug Delivery ◽  
Delivery Methods ◽  
Separate Part ◽  
The Past ◽  
Manufacturing Techniques

Microneedle (MN) delivery system has been greatly developed to deliver drugs into the skin painlessly, noninvasively, and safety. In the past several decades, various types of MNs have been developed by the newer producing techniques. Briefly, as for the morphologically, MNs can be classified into solid, coated, dissolved, and hollow MN, based on the transdermal drug delivery methods of “poke and patch,” “coat and poke,” “poke and release,” and “poke and flow,” respectively. Microneedles also have other characteristics based on the materials and structures. In addition, various manufacturing techniques have been well-developed based on the materials. In this review, the materials, structures, morphologies, and fabricating methods of MNs are summarized. A separate part of the review is used to illustrate the application of MNs to deliver vaccine, insulin, lidocaine, aspirin, and other drugs. Finally, the review ends up with a perspective on the challenges in research and development of MNs, envisioning the future development of MNs as the next generation of drug delivery system.

Atmospheric corrosion modeling

2014 ◽  
Vol 32 (3-4) ◽  
pp. 73-100 ◽  
Author(s):  
Hans Simillion ◽  
Olga Dolgikh ◽  
Herman Terryn ◽  
Johan Deconinck
Keyword(s):  
Structural Design ◽  
Atmospheric Corrosion ◽  
Historical Data ◽  
Material Selection ◽  
Environmental Parameters ◽  
Atmospheric Conditions ◽  
Porous Layers ◽  
The Past ◽  
Microscopic Models ◽  
Wide Range

AbstractA better understanding of corrosion processes during the last years is leading to an increased demand for numerical corrosion models. Corrosion models become increasingly relevant toward simulations, lifetime predictions, and the optimization of corrosion prevention. Also, the improvements in computational power and capacity give rise to an increased number of research projects in this field. Totally different modeling approaches are applied to a wide range of different corrosion processes. This leads to a dispersion of information in the literature. The aim of this paper is to give an overview of the present approaches in atmospheric corrosion modeling. In the past, atmospheric corrosion has been modeled based on empirical, historical data. These models provide fitted functions of the corrosion rate or damage as a function of time for different environmental parameters. These methods give no or little information about the underlying physicochemical phenomena that determine the corrosion processes. During the last decade, more and more work has been done on causal approaches. Therefore, the focus will be on these recent advances in atmospheric corrosion modeling. The links will be made to the microscopic models of isolated corrosion phenomena. The examples are crevice corrosion, corrosion under porous layers, and the modeling of local electrochemical methods. Also, some more general, macroscopic approaches will be discussed. These macroscopic approaches will be compared to each other and positioned into the scope of multiscale modeling. The first goal of atmospheric corrosion modeling is to provide tools in the understanding and quantification of the processes under the influence of external atmospheric conditions. These models could reduce the current corrosion assessment methods that essentially rely on empirical models. On a longer term, modeling would aid in optimizing the material selection, structural design, and maintenance management.

scholarly journals Past Decade Work Done on Cubosomes and its Factorial Design: A Fast Track Information for Researchers

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Y Shravani ◽  
Ahad Hindustan Abdul ◽  
Haranath Chinthaginjala ◽  
Poojitha Bhumireddy gari ◽  
Rahamathulla Syed
Keyword(s):  
Drug Delivery ◽  
Factorial Design ◽  
Rational Design ◽  
Prolonged Release ◽  
Past Work ◽  
The Past ◽  
Wide Range ◽  
Current Scenario ◽  
Work Done ◽  
Nanoparticulate Systems

The objective of this review is to explore the past work done on Cubosomes as drug delivery systems by factorial design. Cubosomes are Nanoparticulate systems made of amphiphilic lipids at a certain percentage, known as liquid crystals. They have tightly packed honeycomb structures twisted into 3D bilayers. Cubosomes can capture all categories of the lipophilic, hydrophilic, and amphiphilic substances irrespective of their affinity, by that they fit for delivering all range of drugs with ease. Many works in recent days are concentrating on Cubosomes for drug delivery, as it suits all ranges of drugs without much difficulty. Cubosomes acts as a carrier in drug delivery for a wide range of drugs and protects them from degradation issues like hydrolysis, oxidation, and others. Moreover, numerous studies have established the benefits of Cubosomes in nanotechnology, prolonged-release, and also enhanced bioavailability. This article reviews about the past work done on Cubosomes using factorial design. Additionally, many studies need to be performed for the optimization of Cubosomes for artificial cells, and biosensors, etc. Moreover, the rational design of Cubosomes for biomedical applications need to be developed. A widespread literature assessment revealed that many reviews and research attempts were made on Cubosomes, but no review article is still available in bringing the attempts made on Cubosomes by factorial design on a single platform. The factorial approach is used to optimize the formulation, which is acceptable and used in the current scenario in optimizing the formulations. So, the authors made widespread work by referring to peer-review journals, periodicals, magazines, and succeeded in bringing work done on Cubosomes in the last ten years by using factorial design. The study concludes and gives a quick reference to the young researchers to get literature on earlier successive attempts done on Cubosomes by factorial design.

scholarly journals THE THE MICROEMULSION AS A KEY PLAYER IN CONQUERING THE SKIN BARRIER FOR THE AIM OF TRANSDERMAL DELIVERY OF DRUGS: REVIEWING A SUCCESSFUL DECADE

2019 ◽  
pp. 34-48
Author(s):  
RANIA YEHIA ◽  
DALIA A ATTIA
Keyword(s):  
Drug Delivery ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Skin Barrier ◽  
The Other ◽  
Penetration Enhancers ◽  
The Past ◽  
Transdermal Drug Delivery Systems ◽  
The One

Microemulsion (ME) systems are now considered of the most successful transdermal drug delivery systems. This is due to their nanodroplets size in the one hand and to their composition that enables the use of several mechanistically penetration enhancers in the same formulation on the other hand. This work summarizes the types, properties, and the merits of the use of MEs for transdermal delivery and reviews the successful studies that were performed to deliver several drugs through this important route during the past 10–12 years.

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