scholarly journals Marine Polysaccharides in Pharmaceutical Applications: Fucoidan and Chitosan as Key Players in the Drug Delivery Match Field

Marine Drugs ◽  
2019 ◽  
Vol 17 (12) ◽  
pp. 654 ◽  
Author(s):  
Ana Isabel Barbosa ◽  
Ana Joyce Coutinho ◽  
Sofia A. Costa Lima ◽  
Salette Reis
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Biomedical Applications ◽  
Chemical Structure ◽  
Final Section ◽  
Biological Properties ◽  
Production Methods ◽  
Bioactive Properties ◽  
Wide Range ◽  
Per Se

The use of marine-origin polysaccharides has increased in recent research because they are abundant, cheap, biocompatible, and biodegradable. These features motivate their application in nanotechnology as drug delivery systems; in tissue engineering, cancer therapy, or wound dressing; in biosensors; and even water treatment. Given the physicochemical and bioactive properties of fucoidan and chitosan, a wide range of nanostructures has been developed with these polysaccharides per se and in combination. This review provides an outline of these marine polysaccharides, including their sources, chemical structure, biological properties, and nanomedicine applications; their combination as nanoparticles with descriptions of the most commonly used production methods; and their physicochemical and biological properties applied to the design of nanoparticles to deliver several classes of compounds. A final section gives a brief overview of some biomedical applications of fucoidan and chitosan for tissue engineering and wound healing.

scholarly journals Recent Trends in Chitosan Nanofibers: From Tissue-Engineering to Environmental Importance: A Review

2017 ◽  
Vol 14 (2) ◽  
pp. 89-99 ◽  
Author(s):  
Saima Wani ◽  
HashAm S Sofi ◽  
Shafquatat Majeed ◽  
Faheem A. Sheikh
Keyword(s):  
Tissue Engineering ◽  
Biomedical Applications ◽  
Biological Properties ◽  
Electrospinning Process ◽  
High Porosity ◽  
Suitable Candidate ◽  
Controlled Drug Delivery System ◽  
Wide Range ◽  
Recent Trends ◽  
Environmental Importance

Chitosan is a biodegradable, biocompatible and extracellular matrix mimicking polymer. These tunable biological properties make chitosan highly useful in a wide range of applications like tissue-engineering, wound dressing material, controlled drug delivery system, biosensors and membrane separators, and as antibacterial coatings etc. Moreover, its similarity with glycosaminoglycans makes its suitable candidate for tissue-engineering. Electrospinning is a novel technique to manufacture nanofibers of chitosan and these nanofibers possess high porosity and surface area, making them excellent candidates for biomedical applications. However, lack of mechanical strength and water insolubility make it difficult to fabricate chitosan nanofibers scaffolds. This often requires blending with other polymers and use of harsh solvents. Also, the functionalization of chitosan with different chemical moieties provides a solution to these limitations. This article reviews the recent trends and sphere of application of chitosan nanofibers produced by electrospinning process. Further, we present the latest developments in the functionalization of this polymer to produce materials of biological and environmental importance.

Advances in nano-biomaterials and their applications in biomedicine

2021 ◽  
Author(s):  
Yogita Patil-Sen
Keyword(s):  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Biomedical Applications ◽  
Materials Science ◽  
Disease Diagnosis ◽  
Biological Properties ◽  
The Past ◽  
Physico Chemical ◽  
Wide Range ◽  
Biomolecules Detection

Nano0technology has received considerable attention and interest over the past few decades in the field of biomedicine due to the wide range of applications it provides in disease diagnosis, drug design and delivery, biomolecules detection, tissue engineering and regenerative medicine. Ultra-small size and large surface area of nanomaterials prove to be greatly advantageous for their biomedical applications. Moreover, the physico-chemical and thus, the biological properties of nanomaterials can be manipulated depending on the application. However, stability, efficacy and toxicity of nanoparticles remain challenge for researchers working in this area. This mini-review highlights the recent advances of various types of nanoparticles in biomedicine and will be of great value to researchers in the field of materials science, chemistry, biology and medicine.

scholarly journals Biomedical Applications of Carbon Nanomaterials: Fullerenes, Quantum Dots, Nanotubes, Nanofibers, and Graphene

Materials ◽  
2021 ◽  
Vol 14 (20) ◽  
pp. 5978
Author(s):  
Manish Gaur ◽  
Charu Misra ◽  
Awadh Bihari Yadav ◽  
Shiv Swaroop ◽  
Fionn Ó. Maolmhuaidh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Quantum Dots ◽  
Biomedical Applications ◽  
Carbon Nanomaterials ◽  
Drug Loading ◽  
Biological Properties ◽  
Dimensional Structure ◽  
Target Drug Delivery ◽  
Target Drug

Carbon nanomaterials (CNMs) have received tremendous interest in the area of nanotechnology due to their unique properties and flexible dimensional structure. CNMs have excellent electrical, thermal, and optical properties that make them promising materials for drug delivery, bioimaging, biosensing, and tissue engineering applications. Currently, there are many types of CNMs, such as quantum dots, nanotubes, nanosheets, and nanoribbons; and there are many others in development that promise exciting applications in the future. The surface functionalization of CNMs modifies their chemical and physical properties, which enhances their drug loading/release capacity, their ability to target drug delivery to specific sites, and their dispersibility and suitability in biological systems. Thus, CNMs have been effectively used in different biomedical systems. This review explores the unique physical, chemical, and biological properties that allow CNMs to improve on the state of the art materials currently used in different biomedical applications. The discussion also embraces the emerging biomedical applications of CNMs, including targeted drug delivery, medical implants, tissue engineering, wound healing, biosensing, bioimaging, vaccination, and photodynamic therapy.

scholarly journals Sputtering of Electrospun Polymer-Based Nanofibers for Biomedical Applications: A Perspective

Nanomaterials ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 77 ◽  
Author(s):  
Hana Kadavil ◽  
Moustafa Zagho ◽  
Ahmed Elzatahry ◽  
Talal Altahtamouni
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Surface Modification ◽  
Wound Dressing ◽  
Biomedical Applications ◽  
Fiber Composites ◽  
Metal Particles ◽  
Electrospun Fibers ◽  
Electrospinning Technique ◽  
Wide Range

Electrospinning has gained wide attention recently in biomedical applications. Electrospun biocompatible scaffolds are well-known for biomedical applications such as drug delivery, wound dressing, and tissue engineering applications. In this review, the synthesis of polymer-based fiber composites using an electrospinning technique is discussed. Formerly, metal particles were then deposited on the surface of electrospun fibers using sputtering technology. Key nanometals for biomedical applications including silver and copper nanoparticles are discussed throughout this review. The formulated scaffolds were found to be suitable candidates for biomedical uses such as antibacterial coatings, surface modification for improving biocompatibility, and tissue engineering. This review briefly mentions the characteristics of the nanostructures while focusing on how nanostructures hold potential for a wide range of biomedical applications.

A Review on Cellulose-based Materials for Biomedicine

2022 ◽  
Author(s):  
Hani Nasser Abdelhamid ◽  
Aji P. Mathew
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Wound Healing ◽  
Biomedical Applications ◽  
Chemical Structure ◽  
Antibacterial Agents ◽  
State Of The Art ◽  
Market Demand ◽  
Mechanical And Physical Properties ◽  
Research Findings

There are various biomaterials in nature, but none fulfills all the requirements. Cellulose, eco-friendly material-based biopolymers, have been advanced biomedicine to satisfy most market demand and circumvent many ecological concerns. This review aims to present an overview of the state of the art in cellulose's knowledge and technical biomedical applications. It included an extensive bibliography of recent research findings for fundamental and applied investigations. The chemical structure of cellulose allows modifications and simple conjugation with several materials, including nanoparticles, without tedious efforts. Cellulose-based materials were used for biomedicine applications such as antibacterial agents, antifouling, wound healing, drug delivery, tissue engineering, and bone regeneration. They advanced the applications to be cheap, biocompatible, biodegradable, easy for shaping and processing into different forms, with suitable chemical, mechanical and physical properties.

NANO AND MICRO-STRUCTURES OF ELASTIN-LIKE POLYPEPTIDE-BASED MATERIALS AND THEIR APPLICATIONS: RECENT DEVELOPMENTS

Nano LIFE ◽  
2013 ◽  
Vol 03 (04) ◽  
pp. 1343002 ◽  
Author(s):  
PAUL A. TURNER ◽  
GAURAV V. JOSHI ◽  
C. ANDREW WEEKS ◽  
R. SCOTT WILLIAMSON ◽  
AARON D. PUCKETT ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Genetic Engineering ◽  
Biomedical Applications ◽  
Chemical Structure ◽  
Biological Properties ◽  
Precise Control ◽  
The Past ◽  
Significant Research ◽  
Recent Developments ◽  
Micro Structures

Elastin-like polypeptide (ELP) containing materials have spurred significant research interest for biomedical applications exploiting their biocompatible, biodegradable and nonimmunogenic nature while maintaining precise control over their chemical structure and functionality through genetic engineering. Physical, mechanical and biological properties of ELPs could be further manipulated using genetic engineering or through conjugation with a variety of chemical moieties. These chemical and physical modifications also achieve interesting micro- and nanostructured ELP-based materials. Here, we review the recent developments during the past decade in the methods to engineer elastin-like materials, available genetic and chemical modification methods and applications of ELP micro and nanostructures in tissue engineering and drug delivery.

scholarly journals Crosslinking method of hyaluronic-based hydrogel for biomedical applications

2017 ◽  
Vol 8 ◽  
pp. 204173141772646 ◽  
Author(s):  
Sureerat Khunmanee ◽  
Younghyen Jeong ◽  
Hansoo Park
Keyword(s):  
Tissue Engineering ◽  
Hyaluronic Acid ◽  
Biomedical Applications ◽  
Biological Properties ◽  
Minimally Invasive Surgical ◽  
Cell Scaffolds ◽  
Wide Range ◽  
Defect Area ◽  
Bioactive Agents ◽  
Injectable Gels

In the field of tissue engineering, there is a need for advancement beyond conventional scaffolds and preformed hydrogels. Injectable hydrogels have gained wider admiration among researchers as they can be used in minimally invasive surgical procedures. Injectable gels completely fill the defect area and have good permeability and hence are promising biomaterials. The technique can be effectively applied to deliver a wide range of bioactive agents, such as drugs, proteins, growth factors, and even living cells. Hyaluronic acid is a promising candidate for the tissue engineering field because of its unique physicochemical and biological properties. Thus, this review provides an overview of various methods of chemical and physical crosslinking using different linkers that have been investigated to develop the mechanical properties, biodegradation, and biocompatibility of hyaluronic acid as an injectable hydrogel in cell scaffolds, drug delivery systems, and wound healing applications.

scholarly journals Design and Assessment of Biodegradable Macroporous Cryogels as Advanced Tissue Engineering and Drug Carrying Materials

Gels ◽  
2021 ◽  
Vol 7 (3) ◽  
pp. 79
Author(s):  
Irina N. Savina ◽  
Mohamed Zoughaib ◽  
Abdulla A. Yergeshov
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Biomedical Applications ◽  
Biological Properties ◽  
Gelation Process ◽  
Biological Environment ◽  
Advanced Biomaterials ◽  
The Relationship ◽  
Interconnected Pores ◽  
Selection Of

Cryogels obtained by the cryotropic gelation process are macroporous hydrogels with a well-developed system of interconnected pores and shape memory. There have been significant recent advancements in our understanding of the cryotropic gelation process, and in the relationship between components, their structure and the application of the cryogels obtained. As cryogels are one of the most promising hydrogel-based biomaterials, and this field has been advancing rapidly, this review focuses on the design of biodegradable cryogels as advanced biomaterials for drug delivery and tissue engineering. The selection of a biodegradable polymer is key to the development of modern biomaterials that mimic the biological environment and the properties of artificial tissue, and are at the same time capable of being safely degraded/metabolized without any side effects. The range of biodegradable polymers utilized for cryogel formation is overviewed, including biopolymers, synthetic polymers, polymer blends, and composites. The paper discusses a cryotropic gelation method as a tool for synthesis of hydrogel materials with large, interconnected pores and mechanical, physical, chemical and biological properties, adapted for targeted biomedical applications. The effect of the composition, cross-linker, freezing conditions, and the nature of the polymer on the morphology, mechanical properties and biodegradation of cryogels is discussed. The biodegradation of cryogels and its dependence on their production and composition is overviewed. Selected representative biomedical applications demonstrate how cryogel-based materials have been used in drug delivery, tissue engineering, regenerative medicine, cancer research, and sensing.

scholarly journals The effects of cononsolvents on the synthesis of responsive particles via polymerisation-induced thermal self-assembly

2021 ◽  
Author(s):  
Marissa Morales-Moctezuma ◽  
Sebastian G Spain
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Self Assembly ◽  
Biomedical Applications

Nanogels have emerged as innovative platforms for numerous biomedical applications including gene and drug delivery, biosensors, imaging, and tissue engineering. Polymerisation-induced thermal self-assembly (PITSA) has been shown to be suitable...

scholarly journals Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Kieran Joyce ◽  
Georgina Targa Fabra ◽  
Yagmur Bozkurt ◽  
Abhay Pandit
Keyword(s):  
Tissue Engineering ◽  
Therapeutic Potential ◽  
Biological Properties ◽  
Biological Assessment ◽  
Cross Linking ◽  
Natural Polymers ◽  
Drug Delivery Device ◽  
Biomedical Device ◽  
Wide Range ◽  
Bioactive Potential

AbstractBiomaterials have had an increasingly important role in recent decades, in biomedical device design and the development of tissue engineering solutions for cell delivery, drug delivery, device integration, tissue replacement, and more. There is an increasing trend in tissue engineering to use natural substrates, such as macromolecules native to plants and animals to improve the biocompatibility and biodegradability of delivered materials. At the same time, these materials have favourable mechanical properties and often considered to be biologically inert. More importantly, these macromolecules possess innate functions and properties due to their unique chemical composition and structure, which increase their bioactivity and therapeutic potential in a wide range of applications. While much focus has been on integrating these materials into these devices via a spectrum of cross-linking mechanisms, little attention is drawn to residual bioactivity that is often hampered during isolation, purification, and production processes. Herein, we discuss methods of initial material characterisation to determine innate bioactivity, means of material processing including cross-linking, decellularisation, and purification techniques and finally, a biological assessment of retained bioactivity of a final product. This review aims to address considerations for biomaterials design from natural polymers, through the optimisation and preservation of bioactive components that maximise the inherent bioactive potency of the substrate to promote tissue regeneration.

Sign in / Sign up

Export Citation Format

Share Document