Recent advances in the design of inorganic and nano-clay particles for the treatment of brain disorders

2021 ◽  
Author(s):  
Francesca Persano ◽  
Svetlana Batasheva ◽  
Gölnur Fakhrullina ◽  
Giuseppe Gigli ◽  
Stefano Leporatti ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Silica Nanoparticles ◽  
Biomedical Applications ◽  
Inorganic Materials ◽  
Brain Disorders ◽  
Clay Particles ◽  
Recent Advances ◽  
Wide Range ◽  
Nano Clay

Inorganic materials, in particular nanoclays and silica nanoparticles, have attracted enormous attention due to their versatile and tuneable properties, making them ideal candidates for a wide range of biomedical applications, such as drug delivery.

scholarly journals Mesoporous silica nanoparticles for drug delivery—Recent advances

2019 ◽  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Targeted Delivery ◽  
Biomedical Applications ◽  
Mesoporous Silica Nanoparticles ◽  
Mesoporous Structure ◽  
Pharmaceutical Ingredients ◽  
Recent Advances ◽  
Controllable Release

Mesoporous silica nanoparticles (MSNs) have been attracting great attention for the potential biomedical applications in the last decades. Due to the unique properties, such as tunable mesoporous structure, huge surface area, large pore volume, as well as the functional ability of surface, MSNs exhibit high loading capacity for therapeutic active pharmaceutical ingredients (APIs) and controllable release behavior. In this review, the applications of MSNs in pharmaceutics improving the bioavailability, reducing toxicity of loaded drugs, increasing cellular targeted delivery ability and recent advances in drug delivery are summarized.

Multifunctional silica nanoparticles as a promising theranostic platform for biomedical applications

2017 ◽  
Vol 1 (7) ◽  
pp. 1257-1272 ◽  
Author(s):  
Zhigang Xu ◽  
Xiaoqian Ma ◽  
Yong-E. Gao ◽  
Meili Hou ◽  
Peng Xue ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Silica Nanoparticles ◽  
Biomedical Applications ◽  
Recent Advances

Recent advances in the use of nonporous silica nanoparticles as theranostic platforms for various biomedical applications, particularly in drug delivery, bioimaging and bio-adhesives.

scholarly journals Biomedical Applications of Metal−Organic Frameworks for Disease Diagnosis and Drug Delivery: A Review

Nanomaterials ◽  
2022 ◽  
Vol 12 (2) ◽  
pp. 277
Author(s):  
Miral Al Sharabati ◽  
Rana Sabouni ◽  
Ghaleb A. Husseini
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Chemical Engineering ◽  
Metal Organic Frameworks ◽  
Disease Diagnosis ◽  
Inorganic Materials ◽  
Synthesis Methods ◽  
High Porosity ◽  
Wide Range ◽  
Metal Organic

Metal−organic frameworks (MOFs) are a novel class of porous hybrid organic−inorganic materials that have attracted increasing attention over the past decade. MOFs can be used in chemical engineering, materials science, and chemistry applications. Recently, these structures have been thoroughly studied as promising platforms for biomedical applications. Due to their unique physical and chemical properties, they are regarded as promising candidates for disease diagnosis and drug delivery. Their well-defined structure, high porosity, tunable frameworks, wide range of pore shapes, ultrahigh surface area, relatively low toxicity, and easy chemical functionalization have made them the focus of extensive research. This review highlights the up-to-date progress of MOFs as potential platforms for disease diagnosis and drug delivery for a wide range of diseases such as cancer, diabetes, neurological disorders, and ocular diseases. A brief description of the synthesis methods of MOFs is first presented. Various examples of MOF-based sensors and DDSs are introduced for the different diseases. Finally, the challenges and perspectives are discussed to provide context for the future development of MOFs as efficient platforms for disease diagnosis and drug delivery systems.

Recent Advances in Application of Azobenzenes Grafted on Mesoporous Silica Nanoparticles in Controlled Drug Delivery Systems Using Light as External Stimulus

2020 ◽  
Vol 20 (11) ◽  
pp. 1001-1016
Author(s):  
Sandra Ramírez-Rave ◽  
María Josefa Bernad-Bernad ◽  
Jesús Gracia-Mora ◽  
Anatoly K. Yatsimirsky
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
Delivery Systems ◽  
Surface Reactivity ◽  
External Stimulus ◽  
Recent Advances

Hybrid materials based on Mesoporous Silica Nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of Drug Delivery Systems (DDS) is not an exception. MSN present desirable biocompatibility, high surface area values, and a well-studied surface reactivity for tailoring a vast diversity of chemical moieties. Particularly important for DDS applications is the use of external stimuli for drug release. In this context, light is an exceptional alternative due to its high degree of spatiotemporal precision and non-invasive character, and a large number of promising DDS based on photoswitchable properties of azobenzenes have been recently reported. This review covers the recent advances in design of DDS using light as an external stimulus mostly based on literature published within last years with an emphasis on usually overlooked underlying chemistry, photophysical properties, and supramolecular complexation of azobenzenes.

scholarly journals Stimuli-responsive nanobubbles for biomedical applications

2021 ◽  
Author(s):  
Ranhua Xiong ◽  
Ronald X. Xu ◽  
Chaobo Huang ◽  
Stefaan De Smedt ◽  
Kevin Braeckmans
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Stimuli Responsive ◽  
Recent Advances ◽  
Tumor Tissues ◽  
Bio Imaging

This review presents an overview of the recent advances in the development of stimuli-responsive nanobubbles and their novel biomedical applications including bio-imaging, drug delivery and ablation of tumor tissues.

A Review on Application of Novel Solid Nanostructures in Drug Delivery

2018 ◽  
Vol 53 ◽  
pp. 22-36 ◽  
Author(s):  
Habibollah Faraji ◽  
Reza Nedaeinia ◽  
Esmaeil Nourmohammadi ◽  
Bizan Malaekeh-Nikouei ◽  
Hamid Reza Sadeghnia ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Therapy ◽  
Biomedical Applications ◽  
Imaging Biomarkers ◽  
Cellular Functions ◽  
Scientific Innovation ◽  
Wide Range ◽  
Targeted Drug

Nanotechnology as a multidisciplinary and scientific innovation plays an important role in numerous biomedical applications, such as molecular imaging, biomarkers and biosensors and also drug delivery. A wide range of studies have been conducted on using of nanoparticles for early diagnosis and targeted drug therapy of various diseases. In fact, the small size, customized surface, upgraded solubility, or multi-functionality of nanoparticles enabled them to interact with complex cellular functions in new ways which opened many doors and created new biomedical applications. These studies demonstrated that nanotechnology vehicles can formulate biological products effectively, and this nano-formulated products with a potent ability against different diseases, were represented to have better biocompatibility, bioaccessibility and efficacy, under in vitro and in vivo conditions.

Impacts of nano-clay addition to soils: a meta-analysis

2021 ◽  
Author(s):  
Grace Maddox ◽  
Stephen Bell ◽  
Carles Barriocanal
Keyword(s):  
Soil Amendment ◽  
Water Retention ◽  
Meta Analysis ◽  
Soil Health ◽  
Biological Properties ◽  
Clay Particles ◽  
Lab Experiments ◽  
Wide Range ◽  
Nano Clay ◽  
Positive Effect

<p>Nano-sized clay particles exhibit unique physicochemical properties within soil matrices relevant to several areas of applied environmental sciences. The amendment of soils with nano-clays in field, lab, and greenhouse settings has been increasingly studied over recent decades from various disciplinary perspectives. In general, nano-clay as a soil amendment is seen as a potentially effective and economically feasible method for managing soil resources. However, no comprehensive review and quantification of the impacts of nano-clay amendment on soil physical, chemical, and biological properties has been undertaken, which limits its uptake and application. Here, we provide a review of the impacts of nano-clay addition in soil, using a meta-analytical approach considering soil health parameters (e.g., organic carbon, water retention, cation exchange, pH, pollutant concentration). Preliminary results synthesizing field and lab experiments indicate a wide range of positive effect sizes across key soil properties, with only limited benefits occurring in specific cases. Our results highlight the significant potential of nano-clay as a soil amendment in diverse applications, especially when coupled with the economic and logistical suitability of nano-clay amendment globally.</p>

Biomedical Applications of Nanoparticles

2022 ◽  
pp. 289-311
Author(s):  
Raghavv Raghavender Suresh ◽  
Shruthee Sankarlinkam ◽  
Sai Rakshana Karuppusami ◽  
Niraimathi Pandiyan ◽  
Suwetha Bharathirengan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Medical Diagnostics ◽  
Engineered Nanoparticles ◽  
Biological Molecules ◽  
Toxicological Evaluation ◽  
Nanodrug Delivery ◽  
Novel Drugs ◽  
Wide Range ◽  
Targeted Drug

In recent years, there has been significant growth and burgeoning interest in utilizing nanoparticles for various biomedical applications, including medical diagnostics, targeted drug delivery, tissue engineering, regenerative medicine, and biomedical textiles. In particular, nanoparticles functionalized with biological molecules have unique properties and are very effective in medical diagnostics. Besides that, nanoparticles have a wide range of therapeutic applications, including the development of nanodrug delivery systems, the design of novel drugs, as well as their contribution to the design of therapeutic materials. This chapter provides an overview of recent advancements in the biomedical applications of nanoparticles. Finally, this chapter discusses the challenges of the toxicological evaluation of engineered nanoparticles and the importance of conducting detailed studies on the synthesis of future nanomaterials to develop cutting-edge technologies for addressing a wide range of biomedical issues.

scholarly journals Marine Polysaccharides in Pharmaceutical Applications: Fucoidan and Chitosan as Key Players in the Drug Delivery Match Field

Marine Drugs ◽  
2019 ◽  
Vol 17 (12) ◽  
pp. 654 ◽  
Author(s):  
Ana Isabel Barbosa ◽  
Ana Joyce Coutinho ◽  
Sofia A. Costa Lima ◽  
Salette Reis
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Biomedical Applications ◽  
Chemical Structure ◽  
Final Section ◽  
Biological Properties ◽  
Production Methods ◽  
Bioactive Properties ◽  
Wide Range ◽  
Per Se

The use of marine-origin polysaccharides has increased in recent research because they are abundant, cheap, biocompatible, and biodegradable. These features motivate their application in nanotechnology as drug delivery systems; in tissue engineering, cancer therapy, or wound dressing; in biosensors; and even water treatment. Given the physicochemical and bioactive properties of fucoidan and chitosan, a wide range of nanostructures has been developed with these polysaccharides per se and in combination. This review provides an outline of these marine polysaccharides, including their sources, chemical structure, biological properties, and nanomedicine applications; their combination as nanoparticles with descriptions of the most commonly used production methods; and their physicochemical and biological properties applied to the design of nanoparticles to deliver several classes of compounds. A final section gives a brief overview of some biomedical applications of fucoidan and chitosan for tissue engineering and wound healing.

scholarly journals Recent advances on polydiacetylene-based smart materials for biomedical applications

2020 ◽  
Vol 4 (4) ◽  
pp. 1089-1104 ◽  
Author(s):  
Fang Fang ◽  
Fanling Meng ◽  
Liang Luo
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Smart Materials ◽  
Biomedical Applications ◽  
Recent Advances ◽  
Smart Biomaterials

This review summarized most recent advances of designing strategies of polydiacetylene-based smart biomaterials with unique colorimetric and mechanical properties, as well as their applications in biosensing, drug delivery, and tissue engineering.

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