Virgin Coconut Oil (VCO) Ameliorates High Fat Diet (HFD)-Induced Obesity, Dyslipidemia and Bestows Cardiovascular Protection in Rats

Background and Aim: Both virgin coconut oil (VCO) and tocotrienol-rich fraction (TRF) are rich in antioxidants and may protect the bone against bone loss induced by ovariectomy and high-fat diet. The study aimed to determine the protective effects of combined therapy of VCO and TRF on osteoporosis in ovariectomized (OVX) rat fed with high-fat diet. Materials and Methods: Thirty-six female Sprague-Dawley rats were divided into six groups: Sham-operated (SHAM), OVX control, OVX and given Premarin at 64.5 μg/kg (OVX+E2), OVX and given VCO at 4.29 ml/kg (OVX+V), OVX and given TRF at 30 mg/kg (OVX+T), and OVX and given a combination of VCO at 4.29 ml/kg and TRF at 30 mg/kg (OVX+VT). Following 24 weeks of treatments, blood and femora samples were taken for analyses. Results: There were no significant differences in serum osteocalcin levels between the groups (p>0.05), while serum C-terminal telopeptide of Type I collagen levels of the OVX+VT group were significantly lower than the other groups (p<0.05). The dynamic bone histomorphometry analysis of the femur showed that the double-labeled surface/bone surface (dLS/BS), mineral apposition rate, and bone formation rate/BS of the OVX+E2, OVX+T, and OVX+VT groups were significantly higher than the rest of the groups (p<0.05). Conclusion: A combination of VCO and TRF has the potential as a therapeutic agent to restore bone loss induced by ovariectomy and high-fat diet.

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Virgin coconut oil (VCO) by normalizing NLRP3 inflammasome showed potential neuroprotective effects in Amyloid-β induced toxicity and high-fat diet fed rat

Food and Chemical Toxicology ◽

10.1016/j.fct.2018.04.064 ◽

2018 ◽

Vol 118 ◽

pp. 68-83 ◽

Cited By ~ 19

Author(s):

Fatemeh Mirzaei ◽

Mozafar Khazaei ◽

Alireza Komaki ◽

Iraj Amiri ◽

Cyrus Jalili

Keyword(s):

Nlrp3 Inflammasome ◽

High Fat Diet ◽

Amyloid Β ◽

Coconut Oil ◽

High Fat ◽

Virgin Coconut Oil ◽

Neuroprotective Effects

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Virgin Coconut Oil Associated with High-Fat Diet Induces Metabolic Dysfunctions, Adipose Inflammation, and Hepatic Lipid Accumulation

Journal of Medicinal Food ◽

10.1089/jmf.2019.0172 ◽

2020 ◽

Vol 23 (7) ◽

pp. 689-698 ◽

Cited By ~ 3

Author(s):

Deise Jaqueline Ströher ◽

Micaela Federizzi de Oliveira ◽

Patrícia Martinez-Oliveira ◽

Bruna Cocco Pilar ◽

Márcia Denise Pavanelo Cattelan ◽

...

Keyword(s):

Lipid Accumulation ◽

High Fat Diet ◽

Coconut Oil ◽

High Fat ◽

Virgin Coconut Oil ◽

Hepatic Lipid ◽

Hepatic Lipid Accumulation ◽

Adipose Inflammation ◽

Metabolic Dysfunctions

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The effects of dietary fatty acids in the physiological outcomes of maternal high-fat diet on offspring energy homeostasis in mice

Journal of Developmental Origins of Health and Disease ◽

10.1017/s2040174419000540 ◽

2019 ◽

Vol 11 (3) ◽

pp. 273-284

Author(s):

Kyle J. Mamounis ◽

Naomi R. Shvedov ◽

Nicholas Margolies ◽

Ali Yasrebi ◽

Troy A. Roepke

Keyword(s):

Glucose Metabolism ◽

High Fat Diet ◽

Energy Homeostasis ◽

Maternal Diet ◽

Coconut Oil ◽

Dietary Fatty Acids ◽

Receptor Expression ◽

Glucose Disposal ◽

High Fat ◽

High Linoleic Acid

AbstractThe early-life origins of disease hypothesis has been applied to obesity research and modeled through overnutrition, usually with a high-fat diet (HFD). Since the obesity epidemic coincided with societal change in dietary fat consumption, rather than amount, manipulation of fatty acid (FA) profile is an under-investigated area of study. Additionally, the binding of FAs to nuclear receptors may have persistent intergenerational, extranutritive endocrinological effects that interact with the actions of reproductive steroids causing sex-dependent effects. To determine the role of FA type in the effects underlying maternal HFD, we fed wild-type C57BL6/J mating pairs, from preconception through lactation, a HFD with high saturated fat levels from coconut oil or high linoleic acid (LA) levels from vegetable oil. Male and female offspring body weight and food intake were measured weekly for 25 weeks. Assays for glucose metabolism, body composition, and calorimetry were performed at 25 weeks. Plasma metabolic peptides and liver mRNA were measured terminally. Obesity was primarily affected by adult rather than maternal diet in males, yet in females, maternal HFD potentiated the effects of adult HFD. Maternal HFD high in LA impaired glucose disposal in males weaned onto HFD and insulin sensitivity of females. Plasma leptin correlated with adiposity, but insulin and insulin receptor expression in the liver were altered by maternal LA in males. Our results suggest that maternal FA profile is most influential on offspring glucose metabolism and that adult diet is more important than maternal diet for obesity and other parameters of metabolic syndrome.

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Thermally Oxidized Coconut Oil as Fat Source in High-Fat Diet Induces Hepatic Fibrosis in Diabetic Rat Model

Cell Biochemistry and Biophysics ◽

10.1007/s12013-021-01009-5 ◽

2021 ◽

Author(s):

Veena Gopinath ◽

Mullam Kunnathu A. Shamsitha ◽

Vaishak Penarveettil Nair ◽

Punnakkal Seena ◽

Rao M. Uppu ◽

...

Keyword(s):

Hepatic Fibrosis ◽

Rat Model ◽

High Fat Diet ◽

Coconut Oil ◽

Diabetic Rat ◽

High Fat ◽

Diabetic Rat Model

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Antihyperlipidemic and hypolipidemic properties of Tacca leontopetaloides (L.) Kuntze (Dioscoreales: Dioscoreaceae) tuber’s aqueous extracts in the rats

Brazilian Journal of Biological Sciences ◽

10.21472/bjbs.040708 ◽

2017 ◽

Vol 4 (7) ◽

pp. 67-80 ◽

Cited By ~ 1

Author(s):

Doubla Sali Aissatou ◽

Josiane Thérèse Ngatchic Metsagang ◽

Celestin Dongmo Sokeng ◽

Nicolas Yanou Njintang

Keyword(s):

Lipid Profile ◽

Aqueous Extract ◽

High Fat Diet ◽

Biochemical Parameters ◽

Coconut Oil ◽

Hdl Cholesterol ◽

Normal Diet ◽

Histopathological Study ◽

Aqueous Extracts ◽

High Fat

Tubers of Tacca leontopetaloides (L.) Kuntze (Dioscoreales: Dioscoreaceae) play an important role in food substitution during the periods of food shortage in occidental and central Africa. It is also used in traditional medicine for the treatment of the diarrhea, dysentery, stomach evil, viral hepatitis and the infection of guinea worn. This study attempted to evaluate the antihyperlipidemic and hypolipidemic properties of aqueous extracts of the tubers of T. leontopetaloides in rats. For this experimentation, two tests were done: antihyperlipidemic and hypolipidemic tests. Hyperlipidemia was induced in rats with High Fat Diet containing 300 g of egg yolk, 2 g of cholesterol, 250 g of coconut oil and 50 g of soya oil. The group of rats on which the antihyperlipidemic test was done was fed with High Fat Diet and supplemented with T. leontopetaloides aqueous extract at 27.34 mg/kg, and 54.68 mg/kg; after 21 days of experimentation, the different groups of rats were sacrificed. The lipid profile and some biochemical parameters were evaluated. Organs like kidneys, liver and stomach were taken for histopathological evaluation. For the hypolipidemic test, after three weeks of induction of hyperlipidemia, the diet was changed to normal diet and aqueous extract of tubers was given to rats during 21 days at doses of 3.41 mg/kg and 13.67 mg/kg. The animals were sacrificed after 21 days of experimentation. The lipid profile, some biochemical parameters and histopathology of organs were evaluated. The antihyperlipidemic and hypolipidemic tests of aqueous extract of the tubers of T. leontopetaloides induced reduction in total cholesterol, triglyceride, LDL-cholesterol and an increase in HDL-cholesterol significantly (p < 0.05); decreasing activities of ALAT and ASAT enzymes, levels of creatinin remained no changed. Histopathological study revealed that extracts did not repair the destructions of liver cells and glomerules of kidneys caused by High Fat Diet. Aqueous extract of tubers of T. leontopetaloides exhibits antihyperlipidemic and hypolipidemic activities; hence it could be important in the management of cardiovascular diseases.

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Energy restriction with high-fat diet enriched with coconut oil gives higher UCP1 and lower white fat in rats

International Journal of Obesity ◽

10.1038/sj.ijo.0800706 ◽

1998 ◽

Vol 22 (10) ◽

pp. 974-979 ◽

Cited By ~ 29

Author(s):

MP Portillo ◽

F Serra ◽

E Simon ◽

AS del Barrio ◽

A Palou

Keyword(s):

High Fat Diet ◽

Coconut Oil ◽

Energy Restriction ◽

High Fat ◽

White Fat

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High-Fat Diet Induces Oxidative Stress and MPK2 and HSP83 Gene Expression inDrosophila melanogaster

Oxidative Medicine and Cellular Longevity ◽

10.1155/2016/4018157 ◽

2016 ◽

Vol 2016 ◽

pp. 1-12 ◽

Cited By ~ 16

Author(s):

Mariane Trindade de Paula ◽

Márcia Rósula Poetini Silva ◽

Stífani Machado Araujo ◽

Vandreza Cardoso Bortolotto ◽

Luana Barreto Meichtry ◽

...

Keyword(s):

Oxidative Stress ◽

Lipid Peroxidation ◽

Antioxidant Enzymes ◽

High Fat Diet ◽

Saturated Fatty Acids ◽

Coconut Oil ◽

Damage Effect ◽

High Fat ◽

Normal Metabolism ◽

Hsp83 Gene

The consumption of a high-fat diet (HFD) causes alteration in normal metabolism affecting lifespan of flies; however molecular mechanism associated with this damage in flies is not well known. This study evaluates the effects of ingestion of a diet supplemented with 10% and 20% of coconut oil, which is rich in saturated fatty acids, on oxidative stress and cells stress signaling pathways. After exposure to the diet for seven days, cellular and mitochondrial viability, lipid peroxidation and antioxidant enzymes SOD and CAT activity, and mRNA expression of antioxidant enzymes HSP83 and MPK2 were analyzed. To confirm the damage effect of diet on flies, survival and lifespan were investigated. The results revealed that the HFD augmented the rate of lipid peroxidation and SOD and CAT activity and induced a higher expression of HSP83 and MPK2 mRNA. In parallel, levels of enzymes involved in lipid metabolism (ACSL1 and ACeCS1) were increased. Our data demonstrate that association among metabolic changes, oxidative stress, and protein signalization might be involved in shortening the lifespan of flies fed with a HFD.

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Effect of repeated stress on body weight and body composition of rats fed low- and high-fat diets

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.1998.275.6.r1928 ◽

1998 ◽

Vol 275 (6) ◽

pp. R1928-R1938 ◽

Cited By ~ 34

Author(s):

Ruth B. S. Harris ◽

Jun Zhou ◽

Bradley D. Youngblood ◽

Igor I. Rybkin ◽

Gennady N. Smagin ◽

...

Keyword(s):

Weight Loss ◽

Body Weight ◽

Food Intake ◽

High Fat Diet ◽

Corn Oil ◽

Coconut Oil ◽

High Fat ◽

Adult Rats ◽

Reduced Body ◽

Fat Diets

Exposure to the moderate stressor of 3-h restraint for 3 consecutive days causes a temporary drop in food intake but a permanent reduction in body weight in adult rats. Young rats did not show the same response. Food intake of adult rats exposed to repeated restraint was significantly lower than that of controls for 4 days after the end of stress, and there was no rebound hyperphagia. Body weight remained significantly lower for at least 40 days after stress. When the rats were fed a high-fat diet of 80% chow and 20% vegetable shortening (48% kcal fat, 16% protein), lean body mass accounted for all of the weight loss in stressed rats. When the experiment was repeated with a purified high-fat diet containing corn oil and coconut oil as the source of fat (41% kcal fat, 16% protein), weight loss consisted of both lean and fat tissue. There were no sustained changes in single time point measures of corticosterone, insulin, or leptin that could account for the reduced body weight in these rats.

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