Relationship of thyroid dysfunction with cardiovascular diseases: updated review on heart failure progression

HORMONES ◽  
2020 ◽  
Vol 19 (3) ◽  
pp. 301-309
Author(s):  
Adel Abdel-Moneim ◽  
Asmaa M. Gaber ◽  
Sherouk Gouda ◽  
Aya Osama ◽  
Sarah I. Othman ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cardiovascular Diseases ◽  
Thyroid Dysfunction ◽  
Heart Failure Progression ◽  
Relationship Of

Adiponectin in heart failure

2020 ◽  
Author(s):  
Hubert Mado ◽  
Wioletta Szczurek ◽  
Mariusz Gąsior ◽  
Bożena Szyguła-Jurkiewicz
Keyword(s):  
Heart Failure ◽  
Adipose Tissue ◽  
Cardiovascular Diseases ◽  
Connective Tissue ◽  
Poor Prognosis ◽  
Adiponectin Level ◽  
Endocrine Organ ◽  
Heart Failure Progression ◽  
Severity Of The Disease

The adipose tissue, apart from storing energy, plays a role of an endocrine organ. One of the most important adipokines secreted by adipose tissue is adiponectin, which is also produced by cardiomyocytes and connective tissue cells within the heart. Adiponectin is known for its beneficial effect on the metabolism and cardiovascular system and its low level is a factor of development of many cardiovascular diseases. Paradoxically, in the course of heart failure, adiponectin level gradually increases with the severity of the disease and higher adiponectin level is a factor of poor prognosis. As a result, there is a growing interest in adiponectin as a marker of heart failure progression and a predictor of prognosis in the course of this disease.

ASSESSMENT OF THE PROBABLE RELATIONSHIP OF EXACERBATIONS OF CARDIOVASCULAR DISEASES WITH THE METEOROLOGICAL SITUATION

2021 ◽  
pp. 63-69
Author(s):  
Berezhnova T.A. ◽  
Kulintsova Ya.V. ◽  
Maslov O.V. ◽  
Kolyagina N.M. ◽  
Ponomaryova E.Yu.
Keyword(s):  
Heart Failure ◽  
Cardiovascular Diseases ◽  
Medical Care ◽  
Cardiovascular System ◽  
Atmospheric Pressure ◽  
Vascular Lesions ◽  
Scientific Publications ◽  
Probable Relationship ◽  
Meteorological Situation ◽  
Relationship Of

Relevance. The analysis of these scientific publications has shown the relevance of studying the problem of the influence of sudden changes in meteorological factors on the functioning of the cardiovascular system, exacerbation of its leading diseases – arterial hypertension, brain vascular lesions, cerebrovascular diseases, angina. Aim: to identify the probable relationship of exacerbations of diseases of the cardiovascular system with the meteorological situation. Material and methods. A sample of data on the daily number of cases of patients 'requests for medical care to the registry of the Voronezh City Polyclinic No. 18 for 2018 was conducted. Results. At a temperature below-200C, which was registered on 27.02.2018, the number of requests for medical care due to hypertension without heart failure is 88 cases, with a diagnosis of brain vascular damage (specified) – 15, with a diagnosis of cerebrovascular disease-16, hypertension with heart failure-2, angina-0. The difference in the average daily temperature of more than 8 0C was recorded in 204 of 365 days. Out of 365 days, the atmospheric pressure drop of more than 6 mm Hg per day was recorded 52 times. Conclusions. The most informative characteristic of the six meteorological indicators taken into account in the study is a sharp drop in atmospheric pressure during the day, with which the number of cases of patients with cardiovascular diseases seeking medical care is statistically significantly correlated.

NT-PROBNP AND THE CUT-OFF VALUE IN CARDIOVASCULAR DISEASES

2011 ◽  
pp. 5-12
Author(s):  
Anh Tien Hoang ◽  
Van Minh Huynh ◽  
Khanh Hoang ◽  
Huu Dang Tran ◽  
Viet An Tran
Keyword(s):  
Heart Failure ◽  
Cardiovascular Disease ◽  
Pilot Study ◽  
Cardiovascular Diseases ◽  
Clinical Application ◽  
European Society ◽  
The Other ◽  
Cardiac Marker ◽  
Cardiac Biomarker ◽  
European Society Of Cardiology

NT-ProBNP is a high value cardiac biomarker and widely applies in many cardiovascular diseases. The evaluation of concentration of NT-ProBNP needs the concern about age, gender, obesity and especially we need each cut-off point for each cause of cardiovascular disease in evaluation and clinical application. Because NT-ProBNP is a new cardiac marker and has been researched in 5 recent years, the cut-off of NT-ProBNP is still being studied for the clinical application in cardiovascular diseases. Only the cut-off of NT-ProBNP in diagnosis heart failure was guided by European Society of Cardiology. The meaning of introduce cut-off value of value plays an role as pilot study for the other relate study and brings the NT-ProBNP closely approach to clinical application.

RELATIONSHIP BETWEEN CARDIOVASCULAR DISEASES AND ANATOMOSIS OF ARTERIOVENOUS FISTULAR IN PATIENTS WITH REGULARLY HEMODIALYSIS

2017 ◽  
pp. 88-92
Author(s):  
Van Hien Pham ◽  
Huu Vu Quang Nguyen ◽  
Tam Vo
Keyword(s):  
Heart Failure ◽  
Blood Pressure ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Cardiovascular Diseases ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Negative Correlation ◽  
Mean Value ◽  
The Mean

Background: Cardiovascular diseases are the leading cause of death in patients with chronic renal failure. When a patient undergoes dialysis, making AVF or AVG causes cardiovascular events. Understanding the relationship between complications: hypertension, heart failure, AVF or AVG (formation time, position, diameter) helps us monitor, detect, prevent and treatment of complications to limit the risk of death in patients with dialysis. Objective: Relationship between cardiovascular diseases and anatomosis of arteriovenous fistular in patients with regularly hemodialysis at Cho Ray Hospital. Methods: A cross-sectional study was conducted at Cho Ray Hospital from 2015 to 2016. The survey some cardiovascular diseases are done by clinical examination, tests for diagnostic imaging such as X-ray, electrocardiogram and echocardiogram: heart and diameter of anastomosis AVF, AVG. Results: The study population included 303 patients with chronic renal failure who were dialysis. Of which, patients aged 25-45 accounted for the highest proportion (43.9%). The proportion of male and female patients was similar (48.5% and 51.5% respectively). The mean value of systolic blood pressure on patients made AVF, AVG less than 12 months is higher than patients made AVF, AVG over 12 months, and there is negative correlation (r = -0.43) between AVF, AVG and systolic blood pressure (p <0.05). The mean value of diastolic blood pressure on patients made AVF, AVG less than 12 months is lower than patients made AVF, AVG over 12 months, and and there is positive correlation (r = -0.43) between AVF, AVG and diastolic blood pressure (p <0.05) (p <0.05). The prevalence of patients with heart failure made AVF, AVG over 12 months is higher than that of the under 12 months group, there is a negative correlation (r = - 0.43) between AVF, AVG diameter and EF index (p <0.05). Conclusion: It is important to note the diameter of anastomosis AVF, AVG in patients with chronic renal failure dialysis to limit cardiovascular complications, especially heart failure. Key words: Chronic kidney disease, hemodialysis.

scholarly journals Relationship of anemia and clinical outcome in heart failure patients with preserved versus reduced ejection fraction in a rural area of Thailand

2020 ◽  
Vol 30 ◽  
pp. 100597
Author(s):  
Kittayaporn Chairat ◽  
Wipharak Rattanavipanon ◽  
Krittika Tanyasaensook ◽  
Busba Chindavijak ◽  
Suvatna Chulavatnatol ◽  
...  
Keyword(s):  
Heart Failure ◽  
Clinical Outcome ◽  
Ejection Fraction ◽  
Rural Area ◽  
Reduced Ejection Fraction ◽  
Heart Failure Patients ◽  
Relationship Of

scholarly journals Heart failure—emerging roles for the mitochondrial pyruvate carrier

2021 ◽  
Author(s):  
Mariana Fernandez-Caggiano ◽  
Philip Eaton
Keyword(s):  
Heart Failure ◽  
Warburg Effect ◽  
Translational Regulation ◽  
Hypertrophic Growth ◽  
Metabolic Adaptations ◽  
Mitochondrial Pyruvate Carrier ◽  
Heart Failure Progression ◽  
Mitochondrial Oxidation ◽  
Human And Mouse ◽  
The Warburg Effect

AbstractThe mitochondrial pyruvate carrier (MPC) is the entry point for the glycolytic end-product pyruvate to the mitochondria. MPC activity, which is controlled by its abundance and post-translational regulation, determines whether pyruvate is oxidised in the mitochondria or metabolised in the cytosol. MPC serves as a crucial metabolic branch point that determines the fate of pyruvate in the cell, enabling metabolic adaptations during health, such as exercise, or as a result of disease. Decreased MPC expression in several cancers limits the mitochondrial oxidation of pyruvate and contributes to lactate accumulation in the cytosol, highlighting its role as a contributing, causal mediator of the Warburg effect. Pyruvate is handled similarly in the failing heart where a large proportion of it is reduced to lactate in the cytosol instead of being fully oxidised in the mitochondria. Several recent studies have found that the MPC abundance was also reduced in failing human and mouse hearts that were characterised by maladaptive hypertrophic growth, emulating the anabolic scenario observed in some cancer cells. In this review we discuss the evidence implicating the MPC as an important, perhaps causal, mediator of heart failure progression.

scholarly journals Osteoprotegerin and RANKL-RANK-OPG-TRAIL signalling axis in heart failure and other cardiovascular diseases

2021 ◽  
Author(s):  
Mieczysław Dutka ◽  
Rafał Bobiński ◽  
Wojciech Wojakowski ◽  
Tomasz Francuz ◽  
Celina Pająk ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Cardiovascular Diseases ◽  
Vascular Endothelial Cells ◽  
Circulatory System ◽  
Prognostic Indicator ◽  
High Plasma ◽  
Mechanisms Of Action ◽  
Left Ventricular ◽  
High Ratio

AbstractOsteoprotegerin (OPG) is a glycoprotein involved in the regulation of bone remodelling. OPG regulates osteoclast activity by blocking the interaction between the receptor activator of nuclear factor kappa B (RANK) and its ligand (RANKL). More and more studies confirm the relationship between OPG and cardiovascular diseases. Numerous studies have confirmed that a high plasma concentration of OPG and a low concentration of tumour necrosis factor–related apoptosis inducing ligand (TRAIL) together with a high OPG/TRAIL ratio are predictors of poor prognosis in patients with myocardial infarction. A high plasma OPG concentration and a high ratio of OPG/TRAIL in the acute myocardial infarction are a prognostic indicator of adverse left ventricular remodelling and of the development of heart failure. Ever more data indicates the participation of OPG in the regulation of the function of vascular endothelial cells and the initiation of the atherosclerotic process in the arteries. Additionally, it has been shown that TRAIL has a protective effect on blood vessels and exerts an anti-atherosclerotic effect. The mechanisms of action of both OPG and TRAIL within the cells of the vascular wall are complex and remain largely unclear. However, these mechanisms of action as well as their interaction in the local vascular environment are of great interest to researchers. This article presents the current state of knowledge on the mechanisms of action of OPG and TRAIL in the circulatory system and their role in cardiovascular diseases. Understanding these mechanisms may allow their use as a therapeutic target in cardiovascular diseases in the future.

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