scholarly journals From the past to the future: what we learn from China’s 2020 Census

2021 ◽  
Author(s):  
Zhenzhen Zheng
Keyword(s):  
Growth Rate ◽  
Institutional Change ◽  
Population Change ◽  
Population Aging ◽  
Low Fertility ◽  
Future Trends ◽  
Population Changes ◽  
The Past ◽  
Near Future ◽  
Proper Response

AbstractThe population of China has entered an era of low fertility and aging, with a slower growth rate in the last decade. This commentary briefly reviews demographic changes in China in the last seven decades with some important years of change in mortality, fertility and urbanization, and discusses future trends according to the information provided by the 2020 Census. China has experienced “compressed” population change, and population aging will continue to advance, meanwhile the size of the population is expected to reach its peak in the near future. To prepare proper response to the challenges proactively, institutional change which adapts to population changes is necessary.

scholarly journals Molecular Epidemiology of blaCMY-1, blaCMY-2, blaFOX Genes in K. pneumoniae From Elderly Patients in Tehran, Iran

2021 ◽  
Author(s):  
Ali Badamchi ◽  
Alireza Namazi Shabestari ◽  
Mohammad Reza Etemadi ◽  
Azardokht Tabatabaei
Keyword(s):  
Growth Rate ◽  
Susceptibility Testing ◽  
Population Aging ◽  
Clinical Samples ◽  
Antibiotic Susceptibility Testing ◽  
Esbl Production ◽  
First Line ◽  
Fox Genes ◽  
Lactam Antibiotic ◽  
Near Future

The growth rate of the population aging is increasing worldwide. To assess antimicrobial susceptibility of extended-spectrum β-lactamase- (ESBL-) producing Klebsiella pneumoniae Isolated from Patients aging in Rasool Akram, Hospital, as well as to identify AmpC genes. 100 K. pneumoniae strain isolated from different clinical samples. Isolates resistant to oxyimino-cephalosporins and to cefoxitin evaluated to phenotypic ESBL production and to phenotypic AmpC production, respectively. Detection of resistance genes was then performed using primers specific for AmpC genes. Piperacillin/tazobactam and carbapenems remained the active β-lactam antibiotic against K. pneumoniae. ESBLs were detected among 40 (40%) of K. pneumoniae isolates. CMY-1 gene was detected in 34.3% of all AmpC-positive isolates, whereas CMY-2 and FOX genes were 14.2% and 28.6%, respectively. The consumption of Carbapenem family drugs is high in Iranian hospitals which are used as a first line of treatment without antibiotic susceptibility testing. Therefore, increase in antibiotic resistance to this family drugs is unavoidable in the near future. Therefore, it is necessary to take the necessary measures to modify the administration and use of antibiotics.

Understanding Molecular Process and Chemotherapeutics for the Management of Breast Cancer.

2020 ◽  
Vol 14 ◽  
Author(s):  
Abhishek Kumar ◽  
Neeraj Masand ◽  
Vaishali M. Patil
Keyword(s):  
Breast Cancer ◽  
Molecular Mechanisms ◽  
Molecular Targets ◽  
Molecular Classification ◽  
Neoplastic Disease ◽  
Molecular Process ◽  
The Past ◽  
Anti Cancer ◽  
Molecular Etiology ◽  
Near Future

Abstract: Breast cancer is the most common and highly heterogeneous neoplastic disease comprised of several subtypes with distinct molecular etiology and clinical behaviours. The mortality observed over the past few decades and the failure in eradicating the disease is due to the lack of specific etiology, molecular mechanisms involved in initiation and progression of breast cancer. Understanding of the molecular classes of breast cancer may also lead to new biological insights and eventually to better therapies. The promising therapeutic targets and novel anti-cancer approaches emerging from these molecular targets that could be applied clinically in the near future are being highlighted. In addition, this review discusses some of the details of current molecular classification and available chemotherapeutics

Introduction

2018 ◽  
Author(s):  
Telesca Giuseppe
Keyword(s):  
Structural Analysis ◽  
Institutional Change ◽  
Cultural Context ◽  
The Past ◽  
Final Goal ◽  
Social Structural ◽  
Country Analysis ◽  
Cross Country ◽  
Over Time

The ambition of this book is to combine different bodies of scholarship that in the past have been interested in (1) providing social/structural analysis of financial elites, (2) measuring their influence, or (3) exploring their degree of persistence/circulation. The final goal of the volume is to investigate the adjustment of financial elites to institutional change, and to assess financial elites’ contribution to institutional change. To reach this goal, the nine chapters of the book introduced here look at financial elites’ role in different European societies and markets over time, and provide historical comparisons and country and cross-country analysis of their adaptation and contribution to the transformation of the national and international regulatory/cultural context in the wake of a crisis or in a longer term perspective.

scholarly journals Mandatory annuitization and money's worth: evidence from Singapore

2021 ◽  
pp. 1-20
Author(s):  
Joelle H. Fong ◽  
Jackie Li
Keyword(s):  
Expected Value ◽  
Longevity Risk ◽  
Future Trends ◽  
The Past ◽  
The Future ◽  
Population Mortality ◽  
Mortality Improvement ◽  
Life Annuities ◽  
Compulsory Purchase ◽  
The Impact

Abstract This paper examines the impact of uncertainties in the future trends of mortality on annuity values in Singapore's compulsory purchase market. We document persistent population mortality improvement trends over the past few decades, which underscores the importance of longevity risk in this market. Using the money's worth framework, we find that the life annuities delivered expected payouts valued at 1.019–1.185 (0.973–1.170) per dollar of annuity premium for males (females). Even in a low mortality improvement scenario, the annuities provide an expected value exceeding 0.950. This suggests that participants in the national annuity pool have access to attractively priced annuities, regardless of sex, product, and premium invested.

scholarly journals Pro-Environmental Behavior in an Aging World: Evidence from 31 Countries

2021 ◽  
Vol 18 (4) ◽  
pp. 1748
Author(s):  
Yan Wang ◽  
Feng Hao ◽  
Yunxia Liu
Keyword(s):  
Linear Models ◽  
Population Change ◽  
Population Aging ◽  
Environmental Behavior ◽  
National Level ◽  
The Elderly ◽  
Human Beings ◽  
Individual Level ◽  
Contemporary World ◽  
The Individual

Population change and environmental degradation have become two of the most pressing issues for sustainable development in the contemporary world, while the effect of population aging on pro-environmental behavior remains controversial. In this paper, we examine the effects of individual and population aging on pro-environmental behavior through multilevel analyses of cross-national data from 31 countries. Hierarchical linear models with random intercepts are employed to analyze the data. The findings reveal a positive relationship between aging and pro-environmental behavior. At the individual level, older people are more likely to participate in environmental behavior (b = 0.052, p < 0.001), and at the national level, living in a country with a greater share of older persons encourages individuals to behave sustainably (b = 0.023, p < 0.01). We also found that the elderly are more environmentally active in an aging society. The findings imply that the longevity of human beings may offer opportunities for the improvement of the natural environment.

scholarly journals Extending the Scope of ALM to Social Investment: Investing in Population Growth to Enhance Sustainability of the Korean National Pension Service

2021 ◽  
Vol 13 (1) ◽  
pp. 401
Author(s):  
Woong Bee Choi ◽  
Dongyeol Lee ◽  
Woo Chang Kim
Keyword(s):  
Fertility Rate ◽  
Low Fertility ◽  
Multistage Stochastic Programming ◽  
Defined Benefit ◽  
Social Investment ◽  
New Approach ◽  
Liability Management ◽  
Good Investment ◽  
Near Future ◽  
Benefit System

The Korean National Pension Service (NPS) is a partially funded and defined-benefit system. Although the accumulated Fund of the NPS has been increased gradually, this large fund is concerned about depletion in the near future due to the unprecedented aging population and the low fertility rate. In this study, we have developed an asset-liability management (ALM) model that endogenizes variables which were regarded as being exogenous by including them in investable assets. We present the multistage stochastic programming (MSP) formulation incorporating the population structure as a variable that is new to ALM. The optimal portfolio encompassing the investment in raising the fertility rate is obtained. Extending the scope of ALM to social investment is a new approach that has not been attempted in other ALM studies. We demonstrate that socially driven investments can also be a good investment asset in which the NPS should consider to invest.

Patents for Critical Pharmaceuticals: The AZT Case

1991 ◽  
Vol 17 (1-2) ◽  
pp. 145-180
Author(s):  
Evan Ackiron
Keyword(s):  
The United States ◽  
Incentive System ◽  
The Public ◽  
Incentive Programs ◽  
The Past ◽  
Research And Innovation ◽  
Monopoly Pricing ◽  
Conflicting Interests ◽  
Necessary Evil ◽  
Near Future

Patents and other statutory types of market protections are used in the United States to promote scientific research and innovation. This incentive is especially important in research intensive fields such as the pharmaceutical industry. Unfortunately, these same protections often result in higher monopoly pricing once a successful product is brought to market. Usually this consequence is viewed as the necessary evil of an incentive system that encourages costly research and development by promising large rewards to the successful inventor. However, in the case of the AIDS drug Zidovudine (AZT), the high prices charged by the pharmaceutical company owning the drug have led to public outcry and a re-examination of government incentive systems.This Note traces the evolution of these incentive programs — the patent system, and, to a lesser extent, the orphan drug program — and details the conflicting interests involved in their development. It then demonstrates how the AZT problem brings the interest of providing inventors with incentives for risky innovative efforts into a sharp collision with the ultimate goal of such systems: ensuring that the public has access to the resulting products at a reasonable price. Finally, the Note describes how Congress and the courts have attempted to resolve these problems in the past, and how they might best try to solve the AZT problem in the near future.

scholarly journals Denitrifying pathways dominate nitrous oxide emissions from managed grassland during drought and rewetting

2021 ◽  
Vol 7 (6) ◽  
pp. eabb7118
Author(s):  
E. Harris ◽  
E. Diaz-Pines ◽  
E. Stoll ◽  
M. Schloter ◽  
S. Schulz ◽  
...  
Keyword(s):  
Growth Rate ◽  
Nitrous Oxide ◽  
N Fertilization ◽  
High Variability ◽  
Nitrous Oxide Emissions ◽  
Severe Drought ◽  
Total N ◽  
The Past ◽  
Precipitation Changes ◽  
Isotopic Measurements

Nitrous oxide is a powerful greenhouse gas whose atmospheric growth rate has accelerated over the past decade. Most anthropogenic N2O emissions result from soil N fertilization, which is converted to N2O via oxic nitrification and anoxic denitrification pathways. Drought-affected soils are expected to be well oxygenated; however, using high-resolution isotopic measurements, we found that denitrifying pathways dominated N2O emissions during a severe drought applied to managed grassland. This was due to a reversible, drought-induced enrichment in nitrogen-bearing organic matter on soil microaggregates and suggested a strong role for chemo- or codenitrification. Throughout rewetting, denitrification dominated emissions, despite high variability in fluxes. Total N2O flux and denitrification contribution were significantly higher during rewetting than for control plots at the same soil moisture range. The observed feedbacks between precipitation changes induced by climate change and N2O emission pathways are sufficient to account for the accelerating N2O growth rate observed over the past decade.

Future Costs of Long-term Care in Japan and Sweden

2017 ◽  
Vol 48 (1) ◽  
pp. 128-147 ◽  
Author(s):  
Mårten Lagergren ◽  
Noriko Kurube ◽  
Yasuhiko Saito
Keyword(s):  
Long Term Care ◽  
Population Change ◽  
Population Aging ◽  
Population Data ◽  
Epidemiological Data ◽  
The Other ◽  
Age Group ◽  
Term Care ◽  
And Gender

Population aging is expected to increase long-term care (LTC) costs in both Japan and Sweden. This study projected LTC costs for 2010 through 2040 for different assumptions of population change, LTC need by age group and gender, and LTC provided per level of need and cost in Japan and Sweden. Population data were taken from the official national forecasts. Needs projections were based on epidemiological data from the Nihon University Japanese Longitudinal Study of Aging and the Swedish Survey of Living Conditions. Data on LTC provision by need and cost were taken from nine Japanese municipalities collected by assessments in the LTC insurance system and from surveys in eight Swedish municipalities. Total initial costs were calibrated to official national figures. Two projections based on two different scenarios were made for each country from 2010 to 2040. The first scenario assumed a constant level of need for LTC by age group and gender, and the other assumed a continuation of the present LTC need trends until 2025. For Japan, this resulted in a projected cost increase of 93% for the one and 80% for the other; for Sweden it was 52% and 24%, respectively. The results reflected differences in population aging and health development.

scholarly journals Acute graft-versus-host disease: a bench-to-bedside update

Blood ◽  
2014 ◽  
Vol 124 (3) ◽  
pp. 363-373 ◽  
Author(s):  
Shernan G. Holtan ◽  
Marcelo Pasquini ◽  
Daniel J. Weisdorf
Keyword(s):  
Small Molecules ◽  
Graft Versus Host Disease ◽  
Host Disease ◽  
Multiple Modalities ◽  
Graft Versus Host ◽  
The Past ◽  
Prevention And Treatment ◽  
Near Future ◽  
Acute Graft

Abstract Over the past 5 years, many novel approaches to early diagnosis, prevention, and treatment of acute graft-versus-host disease (aGVHD) have been translated from the bench to the bedside. In this review, we highlight recent discoveries in the context of current aGVHD care. The most significant innovations that have already reached the clinic are prophylaxis strategies based upon a refinement of our understanding of key sensors, effectors, suppressors of the immune alloreactive response, and the resultant tissue damage from the aGVHD inflammatory cascade. In the near future, aGVHD prevention and treatment will likely involve multiple modalities, including small molecules regulating immunologic checkpoints, enhancement of suppressor cytokines and cellular subsets, modulation of the microbiota, graft manipulation, and other donor-based prophylaxis strategies. Despite long-term efforts, major challenges in treatment of established aGVHD still remain. Resolution of inflammation and facilitation of rapid immune reconstitution in those with only a limited response to corticosteroids is a research arena that remains rife with opportunity and urgent clinical need.

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