scholarly journals Free radicals, aging and degenerative diseases modern aging research, volume 8

FEBS Letters ◽  
1987 ◽  
Vol 212 (1) ◽  
pp. 185-185
Author(s):  
J.V. Bannister
Keyword(s):  
Free Radicals ◽  
Degenerative Diseases ◽  
Aging Research

scholarly journals DETERMINATION OF FLAVONOID LEVELS OF AlCl3 METHODE IN THE EXTRACT OF METANOL FLOWERS (Clitoria ternatea L.)

2020 ◽  
Vol 6 (2) ◽  
pp. 134-141
Author(s):  
Anita Agustina Styawan ◽  
Gandis Rohmanti
Keyword(s):  
Free Radicals ◽  
Immune System ◽  
Medicinal Plants ◽  
Lipid Oxidation ◽  
Secondary Metabolite ◽  
Methanol Extract ◽  
Degenerative Diseases ◽  
Clitoria Ternatea ◽  
Red Color

Telang flowers is one of the medicinal plants that can grow well in Indonesia, but have not been widely used. Previous research stated that methanol extract of telang flowers had secondary metabolite compounds such as tannin, saponin, flavonoid and alkaloid. Flavonoid are natural compounds that have the potential as antioxidants that can capture free radicals that play a role in the emergence of degenerative diseases throught the mechanisme of damage to the body’s immune system, lipid oxidation and protein.The purpose of this study was to determine whether telang flowers content was determined whether by the AlCl3 method and measured by using UV-Vis Spektrophotometry from the methanol extract of telang flowers.The results of this study indicate that the methanol extract of telang flowers contains flavonoid with red color. The level of flavonoids intended is 4.65%.  

scholarly journals Identifying Plant-Based Natural Medicine against Oxidative Stress and Neurodegenerative Disorders

2020 ◽  
Vol 2020 ◽  
pp. 1-9 ◽  
Author(s):  
Rahul Chandran ◽  
Heidi Abrahamse
Keyword(s):  
Oxidative Stress ◽  
Free Radicals ◽  
Therapeutic Potential ◽  
World Population ◽  
Degenerative Diseases ◽  
Plant Polyphenols ◽  
Natural Medicine ◽  
Major Class ◽  
Wide Range ◽  
And Oxidative Stress

Free radicals and oxidative stress are among the most studied factors leading to the imbalance in mental health. With no exception, free radicals also damage neuronal cells, leading to various degenerative diseases. With existing modern medications, around 80% of the world population relies on herbal medicine for various ailments. Phytochemicals in plants have a wide range of pharmacological properties, the major being their ability to scavenge free radicals. Plant polyphenols are among the major class of antioxidants identified in plants. This antioxidative property of plant compounds and their ability to downgrade the process of oxidative stress can be used to treat neurodegenerative diseases. However, selecting plants and their active compounds is a crucial step in framing the mechanism of action underlying their therapeutic potential.

Free Radicals, Exercise, and Antioxidant Supplementation

1994 ◽  
Vol 4 (3) ◽  
pp. 205-220 ◽  
Author(s):  
Mitchell M. Kanter
Keyword(s):  
Lipid Peroxidation ◽  
Free Radicals ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Antioxidant Properties ◽  
Beta Carotene ◽  
Protective Role ◽  
Antioxidant Supplementation ◽  
Aging Research ◽  
Exercise Induced

Free radicals have been implicated in the development of diverse diseases such as cancer, diabetes, and cataracts, and recent epidemic-logical data suggest an inverse relationship between antioxidant intake and cardiovascular disease risk. Data also suggest that antioxidants may delay aging, Research has indicated that free radical production and subsequent lipid peroxidation are normal sequelae to the rise in oxygen consumption with exercise. Consequently, antioxidant supplementation may detoxify the peroxides produced during exercise and diminish muscle damage and soreness. Vitamin E, beta carotene, and vitamin C have shown promise as protective antioxidants. Other ingestible products with antioxidant properties include selenium and coenzyme. The role (if any) that free radicals play in the development of exercise-induced tissue damage, or the protective role that antioxidants may play, remains to be elucidated. Current methods used to assess exercise-induced lipid peroxidation are not extremely specific or sensitive; research that utilizes more sophisticated methodologies should help to answer many questions regarding dietary antioxidants.

Gallic acid: a versatile antioxidant with promising therapeutic and industrial applications

RSC Advances ◽  
2015 ◽  
Vol 5 (35) ◽  
pp. 27540-27557 ◽  
Author(s):  
Bharti Badhani ◽  
Neha Sharma ◽  
Rita Kakkar
Keyword(s):  
Oxidative Stress ◽  
Free Radicals ◽  
Cardiovascular Diseases ◽  
Gallic Acid ◽  
Inflammatory Diseases ◽  
Industrial Applications ◽  
Degenerative Diseases

Oxidative stress, a result of an overproduction and accumulation of free radicals, is the leading cause of several degenerative diseases such as cancer, atherosclerosis, cardiovascular diseases, ageing and inflammatory diseases.

scholarly journals Web evaluation of maceration length period on antioxidant potency of Sonneratia caseolaris leaf

2020 ◽  
Vol 153 ◽  
pp. 01010
Author(s):  
Feni Iranawati ◽  
Rizqi Narulitai ◽  
Citra Satrya Utami Dewi ◽  
Sunanto Arifin
Keyword(s):  
Antioxidant Activity ◽  
Free Radicals ◽  
Bioactive Compounds ◽  
Extraction Method ◽  
Degenerative Diseases ◽  
Strong Potential ◽  
Sonneratia Caseolaris ◽  
Inhibition Concentration ◽  
Antioxidant Potency

Diabetic and cancer, as an examples of degenerative diseases in human may arise as consequences of free radicals, i.e. highly reactive molecules. The reactiveness of free radicals can be constrained by a substance, known as antioxidant. Mangroves that inhabitant of highly dynamic waters of estuary is likely have defend activity by produce some substances those known as bioactive compounds that may have potency of antioxidant. The quality and quantity of bioactive compounds may affected by extraction method. This study aims to evaluate antioxidant potency of Sonneratia caseolaris leaf with three diferent length time (24, 48 and 72 hours) of maceration by applying of DPPD (1,1-diphenyl-β-picryl hydrazyl) method. Result based on 50% of inhibition concentration (IC50) value suggest that the best maceration time is 24 hours (IC50 was 6.35 ppm), following by 72 and 48 hours (IC50 were 11.5 and 17.4 ppm, respectively). In addition, overall of different maceration time show IC value lowe than 50 ppm, indicate that Sonneatia caseolaris leaf have very strong potential of antioxidant activity.

scholarly journals Bats Oxidative Stress Defense

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Desrayni Hanadhita ◽  
Aryani Sismin Satyaningtijas ◽  
Srihadi Agungpriyono
Keyword(s):  
Oxidative Stress ◽  
Free Radicals ◽  
Oxygen Species ◽  
Degenerative Diseases ◽  
Experimental Animals ◽  
Oxidative Stress Defense ◽  
Endogenous Antioxidants ◽  
Main Factors ◽  
Extreme Longevity ◽  
Stress Oxidative

Antioxidants and free radicals have long been known to be the main factors in the occurrence of degenerative diseases. Various studies related to antioxidants and free radicals which have implications for oxidative stress have increased in the last decade. Knowledge of stress oxidative physiology in various animals help in understanding the pathophysiology of diseases associated with oxidative stress. Bats are claimed to be the best known animals in term of survival compared to other mammals. Bats are reported to produce low reactive oxygen species (ROS) but high endogenous antioxidants that can prevent oxidative stress. Bats high defense against oxidative stress has implications for their extreme longevity, the role as a reservoir of viruses, and the potential as experimental animals.

scholarly journals Aging: A Theory Based on Free Radical and Radiation Chemistry

2002 ◽  
Vol 2002 (37) ◽  
Author(s):  
Denham Harman
Keyword(s):  
Free Radicals ◽  
Free Radical ◽  
Molecular Oxygen ◽  
Radiation Chemistry ◽  
Oxidative Enzymes ◽  
Degenerative Diseases ◽  
Connective Tissues ◽  
Iron Cobalt ◽  
Gerontological Society ◽  
Free Radical Chemistry

This 1956 paper describes a theory about mechanisms of aging that is based on free radical chemistry: "Aging and the degenerative diseases associated with it are attributed basically to the deleterious side attacks of free radicals on cell constituents and on the connective tissues. The free radicals probably arise largely through reactions involving molecular oxygen catalyzed in the cell by oxidative enzymes and in the connective tissues by traces of metals such as iron, cobalt, and manganese." Copyright (c) The Gerontological Society of America. Reproduced by permission of the publisher. Denham Harman, Aging: A Theory Based on Free Radical and Radiation Chemistry. J. Gerontol. 11 , 298-300 (1956).

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