266 Diagnostic criteria in the early diagnosis of infantile broncial asthma (BA)

1985 ◽  
Vol 75 (1) ◽  
pp. 171
Author(s):  
M EBORIADOU ◽  
C CHRYSSANTHOPOULOS ◽  
G SEDMAK ◽  
B SOUBASI ◽  
T PAPASTAVROU
Keyword(s):  
Early Diagnosis ◽  
Diagnostic Criteria

scholarly journals Hyperimmunoglobulin E syndrome presenting as osteogenesis imperfecta in a 3 year old child

2013 ◽  
Vol 5 (1) ◽  
pp. 6
Author(s):  
Stephen Gorgas ◽  
Walid Abuhammour ◽  
R. Alexander Blackwood
Keyword(s):  
Early Diagnosis ◽  
Osteogenesis Imperfecta ◽  
Diagnostic Criteria ◽  
Medical Cost ◽  
Diagnostic Tests ◽  
Medical System ◽  
Young Population ◽  
Medical Providers ◽  
Hyper Ige Syndrome ◽  
Serious Infections

We present a case of hyperimmunoglobulin E (hyper-IgE) syndrome in a three year old boy. There are many pitfalls in diagnosing this disease in the very young population, mainly due to the ambiguity of some diagnostic criteria in this population. Recognizing this syndrome early in life can potentially be very beneficial to the patients involved and the medical system as a whole. Early diagnosis can lead to fewer diagnostic tests, fewer referrals, and more focused exams, thus potentially reducing medical cost while also reducing the number of serious infections later in life, including those which are potentially fatal. Additionally, a well-known association between lymphoma and hyper-IgE syndrome has been established; while no recommendations are currently in place for screening, early diagnosis could help medical providers have a higher threshold for diagnosis of this disease.

scholarly journals The Significance of Routine Biochemical Markers in Patients With Sepsis

2020 ◽  
Author(s):  
Yan Meng ◽  
Yue Wang ◽  
Wenbin Qiao ◽  
Yumei LIU ◽  
Liang Wang ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Early Diagnosis ◽  
Diagnostic Criteria ◽  
Assessment Tool ◽  
Diagnostic Value ◽  
Sepsis Group ◽  
Control Group ◽  
Diagnostic Efficiency ◽  
Infection Group ◽  
D Dimer

Abstract Background: Sepsis is a highly complex and fatal syndrome. It is the main cause of death in the intensive care unit. Early diagnosis is beneficial to reduce the mortality of sepsis and improve the prognosis of patients. Therefore, we look forward to finding cheap and fast diagnostic criteria to quickly assess the patient's condition.Methods: This is a retrospective study. The study enrolled 499 patients in the First Affiliated Hospital of Xinjiang Medical University from January 1, 2018 to June 22, 2020, and 96 healthy cases in the same period. Using the diagnostic criteria of bacterial infection, SIRS criteria and Sepsis-2 consensus criteria, 499 patients and 96 healthy cases were divided into 4 groups: sepsis group (n=300), SIRS group (n=151), infection group (n= 48), the control group (n=96). We collected the results of routine laboratory tests, inflammation indicators and blood culture results of these patients. Results: The sepsis group compared with the control group, MCV, NE, WBC, PLT, HB, D-Dimer, PT, CRP, PCT, IL-6, ALB, TBIL, Cr, LAC, CysC and BNP were statistically significant. D-dimer, CRP and PCT have higher diagnostic efficiency. Compared with the difference between the infection group and the SIRS group, PLT and IL-6 are statistically significant, and have a certain diagnostic value. Sepsis group VS infection group, WBC, IL-6, NE and TBIL showed statistical differences in the comparison. The AUC of NE was 67.6, which was the largest among the three. The specificity (95.8%) was the highest, but the sensitivity (49%) was low.Conclusions: This retrospective study shows that NE, WBC, and D-dimer can help in the early diagnosis of sepsis. D-dimer performs best. WBC and NE may have a differential diagnosis significance between the sepsis group and the infection group. This result can provide a timely and convenient assessment tool for early diagnosis of sepsis.

Early Diagnosis and Treatment of the Patients with Acquired Hemophagocytic Lymphohistiocytosis

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 3552-3552
Author(s):  
Zhao Wang ◽  
Yini Wang ◽  
Cuicui Feng ◽  
Liping Tian
Keyword(s):  
Early Diagnosis ◽  
Diagnostic Criteria ◽  
Peripheral Blood ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Nk Cell ◽  
Clinical Symptoms ◽  
Interleukin 2 ◽  
Cell Activity ◽  
Final Diagnosis ◽  
Nk Cell Activity

Abstract Acquired hemophagocytic lymphohistiocytosis (HLH) is a life threatening condition characterized by uncontroling hyperinflammation on the basis of various infection, tumor and inherited immune deficiency. Awareness of the clinical symptoms and of the diagnostic criteria of HLH is crucial in order not to overlook HLH and to start life-saving therapy in time. In this study, we reviewed 57 suspected HLH patients from March 2006 to June 2008. 25 healthy subjects were enrolled in the study as control. NK cell activity in peripheral blood was tested by a released LDH assay. Meanwhile, solution interleukin-2 receptor (sCD25) was examined with ELISA double antibody sandwich assay. The level of glycosylated ferritin was also detected and the ratio of glycosylated ferritin to ferritin was determined. 41 out of 57 patients were definitely diagnosed according to HLH-2004 diagnostic criteria in this study and 16 patients were excluded. We found that the level of NK cell activity and the ratio of glycosylated ferritin in the all 41 final diagnozed HLH patients were significantly lower than those in the 16 excluded patients and 25 healthy control subjects (p<0.01). Meanwhile, the level of sCD25 in peripheral blood was much higher in all the 41 HLH patients than that in the excluded and healthy people (p<0.05). We compared the coincidence of each diagnostic index in the 41 HLH patients before and after final diagnosis. It was found that 100% patients had abnormal expression on NK cell activity, sCD25 and glycosylated ferritin in the early disease. The three diagnostic indexes were more sensitive and specific than other indexes, such as fever, hepatosplenomegaly, cytopenia, hyper-triglyceridemia, hypo-fibrinogenemia. 41 diagnosed patients received the regimen containing methylprednisolone and immunoglobulin, with or without fludarabine, 26 out of 41 were markedly improved after treatment, 10 out of 41 were exacerbated, and other 5 patients gave up treatment. It is concluded that detection of NK cell activity, sCD25 and glycosylated ferritin may play a very important role in the early diagnosis of HLH. Our data also suggest that fludarabine combined with methylprednisolone and immunoglobulin (FDIg) may provide a new viewpoint for HLH therapy.

scholarly journals Updates in Diagnosis and Treatment of Acromegaly

2018 ◽  
Vol 14 (2) ◽  
pp. 57 ◽  
Author(s):  
Roula Zahr ◽  
Maria Fleseriu
Keyword(s):  
Growth Hormone ◽  
Pituitary Adenoma ◽  
Early Diagnosis ◽  
Rare Disease ◽  
Diagnostic Criteria ◽  
Clinical Features ◽  
Morbidity And Mortality ◽  
Diagnosis And Treatment ◽  
Personalised Therapy ◽  
Gh Excess

Acromegaly is a rare disease, caused largely by a growth hormone (GH) pituitary adenoma. Incidence is higher than previously thought. Due to increased morbidity and mortality, if not appropriately treated, early diagnosis efforts are essential. Screening is recommended for all patients with clinical features of GH excess. There is increased knowledge that classical diagnostic criteria no longer apply to all, and some patients can have GH excess with normal GH response to glucose. Treatment is multifactorial and personalised therapy is advised.

P3-063: Revised diagnostic criteria for Alzheimer's disease: impact of different supportive biomarkers on early diagnosis

2011 ◽  
Vol 7 ◽  
pp. S533-S534
Author(s):  
Andreas Fellgiebel ◽  
Martin Gartenschläger ◽  
Martin Schreckenberger ◽  
Harald Hampel ◽  
Igor Yakushev
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Early Diagnosis ◽  
Diagnostic Criteria ◽  
Disease Impact

Diagnosis, classification, and differential diagnosis of schizophrenia

2012 ◽  
pp. 534-540
Author(s):  
Anthony S. David
Keyword(s):  
Differential Diagnosis ◽  
Early Diagnosis ◽  
Diagnostic Criteria ◽  
Diagnostic Process ◽  
Diagnostic Specificity ◽  
International Effort ◽  
Current State ◽  
Diagnosis Classification

Until the early 1970s, the diagnosis of schizophrenia was one of the most contentious and fraught issues in the whole of psychiatry. Since then a massive international effort has been put in motion out of which explicit diagnostic criteria emerged. Some achieved widespread and even multinational agreement, allowing the painstaking process of calculating diagnostic specificity, sensitivity, reliability, and (perhaps) validity to begin. Although criticism of the diagnosis of schizophrenia continues, mostly from outside psychiatrists, the vast majority of psychiatrists look upon the major sets of diagnostic criteria with weary acceptance, seeing them as flawed but useful and possibly ‘as good as it gets’ given our current state of knowledge/ignorance. This chapter covers diagnostic criteria, basis of classification, early diagnosis, differential diagnosis, and finally the diagnostic process.

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