A common component involved in the induction of hepatic tyrosine transaminase by hydrocortisone and glucagon

1973 ◽  
Vol 313 (2) ◽  
pp. 356-362 ◽  
Author(s):  
Donald J. McNamara ◽  
Thomas E. Webb
Keyword(s):  
Common Component ◽  
Tyrosine Transaminase

DEGRADATION OF MESSENGER RNA IN MAMMALIAN CELLS

1972 ◽  
Vol 71 (2_Suppla) ◽  
pp. S369-S380 ◽  
Author(s):  
Francis T. Kenney ◽  
Kai-Lin Lee ◽  
Charles D. Stiles
Keyword(s):  
Messenger Rna ◽  
Mammalian Cells ◽  
Messenger Rnas ◽  
Tyrosine Transaminase

ABSTRACT Analyses of the response of hydrocortisone-induced tyrosine transaminase in cultured H-35 cells to inhibitors of translation (cycloheximide, puromycin) suggest: (1) that bound ribosomes stabilize messenger RNA in vivo; (2) that messenger is degraded at a rate determined by the rate of translation. Since specific messenger RNAs of mammalian cells are degraded at quite different rates, there may be extensive heterogeneity either in the rate at which ribosomes traverse different messengers or in the number of ribosomes which translate specific messenger RNAs.

A new volcanic province: evidence from glacial erratics in western North Greenland

2000 ◽  
pp. 35-41 ◽  
Author(s):  
Peter R. Dawes ◽  
Bjørn Thomassen ◽  
T.I. Hauge Andersson
Keyword(s):  
Volcanic Rocks ◽  
Iron Formation ◽  
Banded Iron Formation ◽  
Common Component ◽  
Volcanic Province ◽  
North West ◽  
North East ◽  
The North ◽  
Surficial Deposits ◽  
North Greenland

NOTE: This article was published in a former series of GEUS Bulletin. Please use the original series name when citing this article, for example: Dawes, P. R., Thomassen, B., & Andersson, T. H. (2000). A new volcanic province: evidence from glacial erratics in western North Greenland. Geology of Greenland Survey Bulletin, 186, 35-41. https://doi.org/10.34194/ggub.v186.5213 _______________ Mapping and regional geological studies in northern Greenland were carried out during the project Kane Basin 1999 (see Dawes et al. 2000, this volume). During ore geological studies in Washington Land by one of us (B.T.), finds of erratics of banded iron formation (BIF) directed special attention to the till, glaciofluvial and fluvial sediments. This led to the discovery that in certain parts of Daugaard-Jensen Land and Washington Land volcanic rocks form a common component of the surficial deposits, with particularly colourful, red porphyries catching the eye. The presence of BIF is interesting but not altogether unexpected since BIF erratics have been reported from southern Hall Land just to the north-east (Kelly & Bennike 1992) and such rocks crop out in the Precambrian shield of North-West Greenland to the south (Fig. 1; Dawes 1991). On the other hand, the presence of volcanic erratics was unexpected and stimulated the work reported on here.

The Greatest Common Component in Science

1942 ◽  
Vol 9 (1) ◽  
pp. 30-36
Author(s):  
Mapheus Smith
Keyword(s):  
Common Component

scholarly journals Fishing during the early human occupations of the Atacama Desert coast: what if we standardize the data?

2021 ◽  
Vol 13 (9) ◽  
Author(s):  
Sandra Rebolledo ◽  
Philippe Béarez ◽  
Débora Zurro
Keyword(s):  
Regional Analysis ◽  
Atacama Desert ◽  
Coastal Communities ◽  
Archaeological Sites ◽  
Common Component ◽  
Exploratory Approach ◽  
Data Heterogeneity ◽  
Terminal Pleistocene ◽  
Methodological Approaches ◽  
Early Human

Abstract The Atacama Desert coast (18–30° S) presents one of the earliest chronologies in the South America region, whose first occupations date from ~ 13,000 cal BP. Since that time, coastal and marine resources have been a common component at sites along the littoral zone. Fish species have been particularly important, as have the fishing technologies developed and used by the coastal communities. However, even though several archaeological sites have been studied, there is no systematic macro-regional analysis of early fisheries along the Atacama Desert coast. Furthermore, differences in theoretical and methodological approaches, as well as research objectives, hinder comparisons between ichthyoarchaeological assemblages. Here, we present a comparative analysis of the Atacama Desert fish data obtained from publications and gray literature from ten archaeological sites dating from the Terminal Pleistocene to the Early Holocene. Through the standardization of contextual and ichthyoarchaeological information, we compared data using NISP, MNI, and weight to calculate fish density, richness, and ubiquity, in order to identify similarities and differences between assemblages. This exploratory approach aims to contribute to studies of fish consumption in the area, as well as proposing new methodological questions and solutions regarding data heterogeneity in archaeozoology.

scholarly journals The Biological Effects of Forsythia Leaves Containing the Cyclic AMP Phosphodiesterase 4 Inhibitor Phillyrin

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2362
Author(s):  
Sansei Nishibe ◽  
Kumiko Mitsui-Saitoh ◽  
Junichi Sakai ◽  
Takahiko Fujikawa
Keyword(s):  
Cyclic Amp ◽  
Influenza A ◽  
Biological Effects ◽  
Polyphenolic Compounds ◽  
Pde4 Inhibitor ◽  
Food Material ◽  
Common Component ◽  
Phosphodiesterase 4 ◽  
Cyclic Amp Phosphodiesterase ◽  
Forsythia Suspensa

Forsythia fruit (Forsythia suspensa Vahl (Oleaceae)) is a common component of Kampo medicines for treating the common cold, influenza, and allergies. The main polyphenolic compounds in the leaves of F. suspensa are pinoresinol β-d-glucoside, phillyrin and forsythiaside, and their levels are higher in the leaves of the plant than in the fruit. It is known that polyphenolic compounds stimulate lipid catabolism in the liver and suppress dyslipidemia, thereby attenuating diet-induced obesity and polyphenolic anti-oxidants might attenuate obesity in animals consuming high-fat diets. Recently, phillyrin was reported as a novel cyclic AMP phosphodiesterase 4 (PDE4) inhibitor derived from forsythia fruit. It was expected that the leaves of F. suspensa might display anti-obesity effects and serve as a health food material. In this review, we summarized our studies on the biological effects of forsythia leaves containing phillyrin and other polyphenolic compounds, particularly against obesity, atopic dermatitis, and influenza A virus infection, and its potential as a phytoestrogen.

scholarly journals Epigenetic Modulation of Radiation-Induced Diacylglycerol Kinase Alpha Expression Prevents Pro-Fibrotic Fibroblast Response

Cancers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 2455
Author(s):  
Chun-Shan Liu ◽  
Reka Toth ◽  
Ali Bakr ◽  
Ashish Goyal ◽  
Md Saiful Islam ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Drug Effects ◽  
Diacylglycerol Kinase ◽  
Dna Demethylation ◽  
Dermal Fibroblasts ◽  
Common Component ◽  
Radiation Induced ◽  
Marker Expression ◽  
Epigenetic Modulation ◽  
Genomic Editing

Radiotherapy, a common component in cancer treatment, can induce adverse effects including fibrosis in co-irradiated tissues. We previously showed that differential DNA methylation at an enhancer of diacylglycerol kinase alpha (DGKA) in normal dermal fibroblasts is associated with radiation-induced fibrosis. After irradiation, the transcription factor EGR1 is induced and binds to the hypomethylated enhancer, leading to increased DGKA and pro-fibrotic marker expression. We now modulated this DGKA induction by targeted epigenomic and genomic editing of the DGKA enhancer and administering epigenetic drugs. Targeted DNA demethylation of the DGKA enhancer in HEK293T cells resulted in enrichment of enhancer-related histone activation marks and radiation-induced DGKA expression. Mutations of the EGR1-binding motifs decreased radiation-induced DGKA expression in BJ fibroblasts and caused dysregulation of multiple fibrosis-related pathways. EZH2 inhibitors (GSK126, EPZ6438) did not change radiation-induced DGKA increase. Bromodomain inhibitors (CBP30, JQ1) suppressed radiation-induced DGKA and pro-fibrotic marker expression. Similar drug effects were observed in donor-derived fibroblasts with low DNA methylation. Overall, epigenomic manipulation of DGKA expression may offer novel options for a personalized treatment to prevent or attenuate radiotherapy-induced fibrosis.

Investigation of the prevalence of cardiovascular risk factors in obese patients diagnosed with metabolic syndrome in childhood and examination of left ventricular function by echocardiography

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Güzin Özden ◽  
Ayşe Esin Kibar Gül ◽  
Eda Mengen ◽  
Ahmet Ucaktürk ◽  
Hazım Alper Gürsu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Left Ventricular ◽  
Atherogenic Index ◽  
Volume Index ◽  
Common Component

Abstract Objectives The objective of this study is to investigate the cardiovascular risk factors associated with metabolic syndrome (MetS), which is increasingly becoming prevalent in childhood obesity. Methods A total of 113 patients, 76 of whom were between the ages of 10 and 17 (mean age: 14.5 ± 1.8 years) and diagnosed with obesity (30 non-MetS and 46 MetS using IDF) and 37 of whom constituted the control group, participated in the study. Echocardiographic examination and atherogenicity parameters (Atherogenic index of plasma [AIP: logTG/HDL], total cholesterol/HDL, and TG/HDL ratio and non-HDL) were evaluated. Results The most common component accompanying obese MetS was found to be hypertension and low HDL. While obesity duration, body mass index (BMI), blood pressure, fasting insulin, insulin resistance, atherogenicity parameters were determined to be significantly higher in the obese-MetS group. Echocardiography showed that while the thickness, volume, and diameter of LV end-diastolic wall, left ventricular mass (LVM), LVM index (LVMI g/m2) and relative wall thickness (RWT) were significantly high in the MetS group, however, mitral E/A ratio was significantly lower (p<0.05). Change in LV geometry consistent with concentric remodeling (increased RWT, normal LVMI) was visible in obese groups. LVM were positively significantly related to BMI, waist circumference, insulin resistance, blood pressure, LDL level, and negative to mitral E/A ratio. In the obese-MetS group, LVMI was positively correlated to office systolic BP, left atrium end-diastolic volume/index. Conclusions LVMI and atherogenicity parameters that were found to be significantly higher in obese MetS exhibit increased cardiovascular risk in childhood.

scholarly journals A Dynamic Factor and Neural Networks Analysis of the Co-movement of Public Revenues in the EMU

2021 ◽  
Author(s):  
Cosimo Magazzino ◽  
Marco Mele
Keyword(s):  
Neural Networks ◽  
Factor Model ◽  
Common Factor ◽  
Back Propagation ◽  
Dynamic Factor ◽  
Common Component ◽  
Economic Cycles ◽  
Composite Nature ◽  
Empirical Demonstration ◽  
Public Revenues

AbstractThis paper shows that the co-movement of public revenues in the European Monetary Union (EMU) is driven by an unobserved common factor. Our empirical analysis uses yearly data covering the period 1970–2014 for 12 selected EMU member countries. We have found that this common component has a significant impact on public revenues in the majority of the countries. We highlight this common pattern in a dynamic factor model (DFM). Since this factor is unobservable, it is difficult to agree on what it represents. We argue that the latent factor that emerges from the two different empirical approaches used might have a composite nature, being the result of both the more general convergence of the economic cycles of the countries in the area and the increasingly better tuned tax structure. However, the original aspect of our paper is the use of a back-propagation neural networks (BPNN)-DF model to test the results of the time-series. At the level of computer programming, the results obtained represent the first empirical demonstration of the latent factor’s presence.

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