Oxidation resistance, oxidation rate, and extent of oxidation of human low-density lipoprotein depend on the ration of oleic acid content to linoleic acid content studies in vitamin E deficient subjects

1993 ◽  
Vol 15 (3) ◽  
pp. 273-280 ◽  
Author(s):  
Henne A. Kleinveld ◽  
Anton H.J. Naber ◽  
AntonF.H. Stalenhoef ◽  
Pierre N.M. Demacker
Keyword(s):  
Oleic Acid ◽  
Linoleic Acid ◽  
Vitamin E ◽  
Acid Content ◽  
Oxidation Rate ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Linoleic Acid Content ◽  
Low Density ◽  
Oleic Acid Content

scholarly journals Construction and Analysis of GmFAD2-1A and GmFAD2-2A Soybean Fatty Acid Desaturase Mutants Based on CRISPR/Cas9 Technology

2020 ◽  
Vol 21 (3) ◽  
pp. 1104 ◽  
Author(s):  
Nan Wu ◽  
Qiang Lu ◽  
Piwu Wang ◽  
Qi Zhang ◽  
Jun Zhang ◽  
...  
Keyword(s):  
Oleic Acid ◽  
Fatty Acid ◽  
Linoleic Acid ◽  
Protein Content ◽  
Acid Content ◽  
Double Mutant ◽  
Fatty Acid Desaturase ◽  
Linoleic Acid Content ◽  
Oleic Acid Content ◽  
Editing Efficiency

The soybean fatty acid desaturase family is composed of seven genes, but the function of each gene has not been reported. Bioinformatics was used to analyse the structure of genes in this family, as well as the correlation between Δ12-fatty acid desaturase II (FAD2) expression and oleic acid content on different days after flowering of soybean. In the present study, CRISPR/Cas9 technology was used to construct single and double mutant knockout vectors of functional genes in the FAD2 family. Analysis of the molecular biology and expression patterns of genes in the FAD2 family, namely, GmFAD2-1A (Glyma.10G278000) and GmFAD2-2A (Glyma.19G147300), showed that they had little homology with other soybean FAD2 genes, and that their function was slightly changed. Sequencing of the target showed that the editing efficiency of the GmFAD2-1A and GmFAD2-2A genes was 95% and 55.56%, respectively, and that the double mutant editing efficiency was 66.67%. The mutations were divided into two main types, as follows: base deletion and insertion. A near-infrared grain analyser determined the following results: In the T2 generation, the oleic acid content increased from 17.10% to 73.50%; the linoleic acid content decreased from 62.91% to 12.23%; the protein content increased from 37.69% to 41.16%; in the T3 generation, the oleic acid content increased from 19.15% to 72.02%; the linoleic acid content decreased from 56.58% to 17.27%. In addition, the protein content increased from 37.52% to 40.58% compared to that of the JN38 control variety.

scholarly journals THE INFLUENCE OF YIELD ON FATTY ACID COMPOSITION OF PECAN NUTS

HortScience ◽  
1995 ◽  
Vol 30 (3) ◽  
pp. 432d-432
Author(s):  
J.B. Storey ◽  
L.J. Grauke ◽  
Laurence Sistrunk ◽  
Tommy E. Thompson
Keyword(s):  
Fatty Acid Composition ◽  
Oleic Acid ◽  
Fatty Acid ◽  
Linoleic Acid ◽  
Acid Composition ◽  
Acid Content ◽  
Linoleic Acid Content ◽  
Oleic Acid Content ◽  
High Quality ◽  
Kernel Color

Four cultivars of pecan [Carya illinoinensis (Wangenh.) K. Koch] were studied for 3 years to determine if variations in yield influence fatty acid composition of kernels. Trees used in the study are part of the U.S. Dept. of Agriculture, Agricultural Research Service Historical Block, a test orchard planted in randomized block design with four blocks, having one single-tree replication per block and containing 36 cultivars. Four trees of each of four cultivars (`Cheyenne', `Mohawk', `Pawnee', and `Osage') were used in this test. Trees were in their 5th to 7th leaf from grafting and showed patterns of increasing yield over time for each cultivar. `Osage' was earliest to mature nuts each year and produced nuts with the lowest linoleic acid content. `Cheyenne' was latest to mature nuts and had nuts with the highest linoleic acid content. Oleic acid composition varied with yield in `Osage' and `Pawnee': as yield (kilogram/square decimeter trunk area) increased, oleic acid content decreased. Kernel color, as determined by a Hunter LabScan 5100 Spectrocolorimeter, varied in relation to fatty acid composition for `Osage' and `Pawnee': as oleic acid content increased, kernel lightness decreased. High oleic acid content and light kernel color are associated with high-quality pecans. The pattern of decreasing oleic acid content associated with increasing kernel lightness raises questions concerning the role kernel color evaluation should play in selecting high-quality pecan cultivars.

Vitamin E reduces cholesterol esterification and uptake of acetylated low density lipoprotein in macrophages

Lipids ◽  
1998 ◽  
Vol 33 (12) ◽  
pp. 1169-1175 ◽  
Author(s):  
Hideki Shige ◽  
Toshitsugu Ishikawa ◽  
Michio Suzukawa ◽  
Masato Nishiwaki ◽  
Takeshi Yamashita ◽  
...  
Keyword(s):  
Vitamin E ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cholesterol Esterification ◽  
Low Density

scholarly journals POTENSI BUAH MERAH (Pandanus conoideus Lam.) DALAM MENURUNKAN KADAR LDL DARAH TIKUS PUTIH

2017 ◽  
Vol 3 (1) ◽  
pp. 48 ◽  
Author(s):  
Oki Sandra Agnesa ◽  
Joko Waluyo ◽  
Jekti Prihatin ◽  
Sri Rahayu Lestari
Keyword(s):  
Reactive Oxygen Species ◽  
Vitamin E ◽  
Rattus Norvegicus ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Reactive Oxygen ◽  
Low Density ◽  
Oxygen Species ◽  
One Way Anova

Penyakit jantung koroner (PJK) terutama disebabkan oleh aterosklerosis karena hiperkolesterolimia. Oksidasi low density lipoprotein (LDL) oleh reactive oxygen species (ROS) sebagai penyebab utama proses aterogenik dapat dicegah dengan kehadiran antioksidan seperti vitamin E. Buah dan sayuran banyak mengandung vitamin. Salah satu buah yang mengandung vitamin E adalah buah merah (Pandanus conoideus Lam.). Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak buah merah terhadap kadar LDL darah pada tikus putih (Rattus norvegicus L.). Jenis penelitian ini adalah penelitian eksperimental laboratorium yang didesain mengikuti Rancangan Acak Lengkap (RAL) dengan 6 perlakuan dan 4 kali ulangan dengan parameter penelitian adalah kadar LDL darah tikus putih. Data dianalisis menggunakan one way anova dilanjutkan dengan uji Duncan 95%. Berdasarkan hasil penelitian, minyak buah merah memiliki kemampuan untuk menurunkan kadar LDL darah tikus putih.

scholarly journals Comparative study between the prophylactics Effects of aqueous extract of Black Currant (Vitis vinferia.L) and vitamin E on some biological parameters related with heart diseases in oxidative Stressed rats

2008 ◽  
Vol 32 (2) ◽  
pp. 227-252
Author(s):  
Abdul-Katum A. H.
Keyword(s):  
Drinking Water ◽  
Platelet Count ◽  
Vitamin E ◽  
Prothrombin Time ◽  
Aqueous Extract ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Black Currant ◽  
Oral Intubation

This study was designed to investigate the prophylactic effect of aqueousextract of black currant concentrate on some biological markers related withheart disease in male rat treated H2O2. It also aimed at comparing theprophylactic effect of black currant concentrate to that of vit E.Forty adult male rats were divided randomly into equal groups (tenrat/group) & were treated as follows for 42 days. Rats in the first group (G І)were received normal water with oral intubation of sun flower oil 1ml /rat andconsider as control group. Animals of the second group (G Π) were received0.5% H2O2 in drinking water, while rats of the third group (G Ш) were received0.5% H2O2 in drinking water with oral intubation of vit E 400 I.U/Kg.B.Wdiluting in sun flower oil for each rat daily .While animals in the fourth group (GІV) were intubated daily 60mg/kg body weight of aqueous extract of blackcurrant concentrate plus 0.5% H2O2 in drinking water.Fasting blood samples were collected at 0, 21, and 42 days of experimentto study the following parameters:A - Platelet count (PC) and prothrombin time (PT).B- Serum concentration of total cholesterol TC, triacylglycerol TAG, Highdensity lipoprotein-cholesterol HDL-C, Low density lipoprotein-cholesterolLDL-C and Very low density lipoprotein- cholesterol VLDL-C of each groupwere measured. These parameters were regarded as biomarkers ofatherosclerosis and coronary heart disease (CHD). Furthermore section of heart& aorta were assessed for histopathogical studies.The result revealed that administration of 0.5% H2O2 in drinking water for sixweeks (42days) caused significant increase (p<0.05) in platelet count & in serumTC,TAG,LDL-C, and VLDL-C concentration with significant decrease(p<0.05)in prothrombin time and HDL-C concentration as compared to other groups, onother hand oral intubation of vitamin E or aqueous extract of black currantconcentrate in addition to H2O2 (groups Ш and ІV respectively) decreased theserum concentration of TC, TAG, LDL-C, VLDL-C, and platelet countIraqi Journal of Veterinary Medicine Vol. 32, No. 2, 2008228

Sialic acid content of low-density lipoprotein in women with coronary artery disease

2000 ◽  
Vol 136 (2) ◽  
pp. 110-115 ◽  
Author(s):  
Nina Lindbohm ◽  
Helena Gylling ◽  
Radhakrishnan A. Rajaratnam ◽  
Tatu A. Miettinen
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Sialic Acid ◽  
Acid Content ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Sialic Acid Content ◽  
Artery Disease

scholarly journals A Prospective Study of Trans Fatty Acids in Erythrocytes and Risk of Coronary Heart Disease

Circulation ◽  
2007 ◽  
Vol 115 (14) ◽  
pp. 1858-1865 ◽  
Author(s):  
Qi Sun ◽  
Jing Ma ◽  
Hannia Campos ◽  
Susan E. Hankinson ◽  
JoAnn E. Manson ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Fatty Acid ◽  
Acid Content ◽  
Low Density Lipoprotein ◽  
Fatty Acid Content ◽  
Density Lipoprotein ◽  
Elevated Risk ◽  
Low Density ◽  
Relative Risks

Background— High consumption of trans fat has been linked to the risk of coronary heart disease (CHD). We assessed the hypothesis that higher trans fatty acid contents in erythrocytes were associated with an elevated risk of CHD in a nested case-control study among US women. Methods and Results— Blood samples were collected from 32 826 participants of the Nurses’ Health Study from 1989 to 1990. During 6 years of follow-up, 166 incident cases of CHD were ascertained and matched with 327 controls. Total trans fatty acid content in erythrocytes was significantly correlated with dietary intake of trans fat (correlation coefficient=0.44, P <0.01) and was associated with increased plasma low-density lipoprotein cholesterol ( P for trend =0.06), decreased plasma high-density lipoprotein cholesterol concentrations ( P for trend <0.01), and increased plasma low-density lipoprotein to high-density lipoprotein ratio ( P for trend <0.01). After adjustment for age, smoking status, and other dietary and lifestyle cardiovascular risk factors, higher total trans fatty acid content in erythrocytes was associated with an elevated risk of CHD. The multivariable relative risks (95% confidence intervals) of CHD from the lowest to highest quartiles of total trans fatty acid content in erythrocytes were 1.0 (reference), 1.6 (0.7 to 3.6), 1.6 (0.7 to 3.4), and 3.3 (1.5 to 7.2) ( P for trend <0.01). The corresponding relative risks were 1.0, 1.1, 1.3, and 3.1 ( P for trend <0.01) for a total of 18:1 trans isomers and 1.0, 1.5, 2.5, and 2.8 ( P for trend <0.01) for a total of 18:2 trans isomers. Conclusions— These biomarker data provide further evidence that high trans fat consumption remains a significant risk factor for CHD after adjustment for covariates.

Sign in / Sign up

Export Citation Format

Share Document