Immunological challenges of the “new” infections: corona viruses

2022 ◽  
pp. 395-450
Author(s):  
Anthony R. Rees
Keyword(s):  
2020 ◽  
Vol 11 (SPL1) ◽  
pp. 259-261
Author(s):  
Aamir Khan ◽  
Rajni K. Gurmule

Vasavaleha is one of the best medicine given for respiratory diseases. Corona viruses typically affect the respiratory system, causing symptoms such as coughing, fever and shortness of breath. It also affects host immune system of human body. Spreading rate of this disease is very high. Whole world is seeking for the treatment which can uproots this diseases. There in no vaccine available till date against this pandemic disease. Ayurveda mainly focuses on prevention of diseases alongwith its total cure. Rajyakshma Vyadhi is MadhyamMarga Roga as per Ayurveda. It shows many symptoms such as Kasa, Shwasa etc. By overall view of Covid 19, shows its resemblance with Rajyakshma Vyadhi described in Ayurveda. Vasavaleha is a Kalpa which is described in Rogadhikara of Rajyakshma. It shows Kasahara, Shwashara properties. It consists of Vasa, Pipalli, Madhu and Goghrita. These components shows actions like bronchodilation, antitussive effect and many more other actions. Pipalli shows important Rasayana effect. So in present review, we have tried to focus on role of Vasavaleha in the management of Covid 19. This can be used as preventive as well as adjuvant medication in treating Covid 19. There is need of further clinical research to rule of exact action of Vasavaleha against Covid 19.


Coronaviruses ◽  
2020 ◽  
Vol 01 ◽  
Author(s):  
Viney Chawla ◽  
Pooja A Chawla

Background: Corona virus disease (COVID-19) is spreading rapidly at an unprecedented scale across continents and has emerged as the single biggest risk the world has faced in modern times. Some scientists are comparing it to Spanish flu that created havoc around a century ago. The fear of death by COVID-19 looms large at the world today. The disease has reached devastating proportions since its first reports in December 2019. Doctors are having a difficult time dealing with this challenge and the microbiologists are having sleepless nights to bring about an effective vaccine for this disease. Methods: A number of research and review articles have been exhaustively reviewed. The collected data was meticulously analysed and documented. Conclusion: This paper reviews the different types of corona viruses, the structure of SARS-CoV-2 responsible for COVID19, its transmission, virulence. Further, the article discusses the diagnosis, signs and symptoms like fever, breathlessness, cough, potential loss of taste or smell, sneezing, runny nose, fatigue, headache, sore throat and different treatment approaches including drug repurposing being tried by doctors around the globe that may come handy in the management of disease symptoms. The article describes the use of remdesivir, ribavarin, lopinavir, favipiravir, hydoxychloroquine, chloroquine, tocilizumab among others in treating COVID-19.


Author(s):  
Preeti Suman Saxena ◽  
Kirti Singh ◽  
Poonam Jangir ◽  
Manish Nath Tripathi ◽  
Vimal Singh ◽  
...  

The current pandemic, novel corona virus 19 disease (COVID-19), has created havoc across the world. Now a third wave is possible, and we have already crossed two waves. The current review article presents recent reports about the COVID-19, the ways of treatments, and prevention. In view of the potential threats of a pandemic, various scientists have been trying to understand the pathophysiology of this disease to uncover possible treatment regimens and discover effective therapeutic agents and vaccines. To add further information to support the ongoing current research and development against SARS-CoV-2, the authors have provided the basics of pathophysiology, possible targets, and current treatment strategy for corona viruses. The current review highlights the antiviral strategies involving small molecules and different biological targets involved in corona virus infection and replication. The information included in this article provides a strong intellectual foundation for the ongoing development of therapeutic agents and vaccines.


2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Muhammad Farhan Jahangir Chughtai ◽  
Saira Tanweer ◽  
Samreen Ahsan ◽  
Tariq Mehmood ◽  
Atif Liaqat ◽  
...  

Purpose Corona viruses have spiked structure and enveloped glycoproteins in their structure, along with specific proteins in membranes. The mode of action of COVID-19 consists of three phases, i.e. viral replication, immune hyperactivity and pulmonary destruction. However, angiotensin-converting enzyme is an essential receptor that causes COVID-19. After infecting any individual, COVID-19 develops in specific pattern with the following stages: replication stage and adaptive immunity stage. After adaptive immunity stage, the clinical symptoms of patient include cough, fever, runny nose, shortness of breath and many more. To cope with this COVID-19, food and nutrition played an important role. The purpose of this review article is to emphasize the significance of food and immunity to reduce COVID-19 attack among susceptibles. Design/methodology/approach In the present era, corona virus, a member of crown-shaped type, created a pandemic situation around the globe owing to its capability to move from human to animals and vice versa. This virus can transfer its 35% infection to the individuals. Contemporarily, this outbreak was observed in Wuhan, China in December 2019 and affected a huge number of communities by spreading like common flu. However, after investigation, it was revealed that COVID-19 is different from common flu regarding respiratory illness created by this novel coronavirus along with its taxonomy. Findings Over and above to all the aforementioned food safety concerns, it is suggested to use sufficient supply of green leafy vegetables along with fiber-rich foods such as legumes, beans, whole grains and vegetables. It is further good for health to get all these varieties whole and organic. The individuals should use probiotics (lactobacillus) on daily basis as a source of diary probiotic that can further bind to the virus directly and then can inhibit the viral attachment with body cells; also the probiotics are claimed to enhance the immune system of the body. Research limitations/implications In the case of fruits and vegetables purchased, it must be thoroughly washed with water and then disinfected; after pat drying, these fruits and vegetables can be moved to the refrigerator and stored along with other foods. During the outbreak of COVID-19, the partially cooked or ready-to-eat foods should be avoided, especially eggs, meat, meat products, milk and milk-related products. On the other side, nuts should not be consumed; if required, then it must be properly roasted at home before consumption. Practical implications The baked product right after coming out of oven is completely safe; however, these are contaminated during handling such as crumb in case of bread and with knives; so in the breakout of any viral attack, the individuals should avoid slicing of the bread. Moreover, it is recommended to place the baked products in personal bags instead of bulk quantity. Before the consumption, the baked products should be toasted, microwaved or heated with the help of pan (traditional) to reduce the amount of viral load. Social implications Dietary supplements are taken by most of the people on daily basis or sporadically especially when they are suffering from inflammation or cold. They have options while selecting these types of supplements such as probiotics, Echinacea, omega-3 fatty acids, vitamins D and E, calcium glucosamine, garlic and iron. These supplements are beneficial for the group of population who do not eat diversity of food as sufficient amount of essential nutrients is provided through this pathway. Originality/value This work is original in its novelty.


1980 ◽  
Vol 14 (4) ◽  
pp. 309-311 ◽  
Author(s):  
J. Gannon ◽  
P. Carthew

Compared with the results of the previous serological survey of 1976-1977, it can be seen that mouse hepatitis virus is still prevalent in the mouse colonies and that corona viruses of rats are also common. The prevalence of Sendai virus has increased considerably. However, the prevalence of Reo 3 virus appeared to have decreased, although this may be the result of the different test used.


2020 ◽  
Vol 12 (2) ◽  
pp. 163
Author(s):  
S. D. Mankar ◽  
R. S. Jadhav ◽  
Kapil Gaikwad

Author(s):  
Kanamala Arun Chand Roby ◽  
Singamala Lakshmi Bhargavi ◽  
Gali Devi Sri ◽  
Avula Madhuri ◽  
Sannadi Kamakshi ◽  
...  

Coronavirus are coming under a broad family of virus that can cause respiratory illnesses such as the common cold, according to the centers for disease control and prevention (CDC). They are usual in many different species of animals, including camels and bats. Unusually, these corona viruses can evolve and infect humans and then spread between humans. Recent examples of this include SARS-CoV and MERS-CoV. 2019 Novel Corona virus (2019-nCoV) is a virus identified as the cause of an outbreak of respiratory illness first detected in Wuhan, China. In some cases, the viruses can cause lower-respiratory tract illnesses such as pneumonia and bronchitis. In human corona viruses are currently classified into seven types that are HCoV-229E, HCoV-OC43, HCoV-NL63, SARS-CoV, HKU1, MERS-CoV and 2019-nCoV. These two types of corona virus (MERS-CoV and SARS-CoV) are more dangerous. Some of corona viruses like HCoV-229E, HCo-OC43, HCoNL63 and HKU1 that are continuously circulate in the population of human and cause respiratory infections in human either may children and adults world-wide. They are generally transmitted between animals and humans through sneezing, coughing, touching or shaking hands and making contact with a surface or object. The symptoms of corona virus are sneezing, cough, fatigue, runny nose, sore throat, breathing difficulty and exacerbated. In more severe cases SARS, kidney failure, pneumonia and even death. Diagnosis can be carried out by healthcare provider in laboratory test on respiratory specimens and serum to detect human corona virus. For this virus no specific treatment like vaccines and antiviral drugs but symptoms can be treated.


Author(s):  
Ramesh Verma ◽  
Vinod Chayal ◽  
Meenakshi Kalhan ◽  
Rohit Dhaka ◽  
Ginni Agrawal ◽  
...  

Coronavirus disease is caused by a novel virus belonging to the family of corona viruses similar to severe acute respiratory syndrome (SARS) and  name given to the novel virus as SARS Coronavirus- 2 (SARS-CoV-2) and the disease was named as COVID-19 on 11th February 2020 by World Health Organization (WHO). First case of this infection was reported in December 2019 in Wuhan city of China and after that it spread globally.3 On 30th January 2020, WHO declared this disease as Public Health Emergency of International Concern (PHEIC) and on 11th March 2020, WHO declared it as a pandemic when the infection was reported from all six WHO regions.


Author(s):  
Shalini H. Moon ◽  
Manjusha Mahakarkar

Corona viruses are a large family of viruses that exist in many different species of animals including camels, bovine animals, and bats. The new strain of corona virus identified as the cause of outbreaks of respiratory disease in people first detected in Wuhan, China, was COVID-19.WHO has published a new guide on how to eat healthily during the COVID-19 COVID pandemic and self-quarantine.The guideline contains valuable information about nutrition to help keep the immune system strong. It also has tips for a diet that supports good health while advised to stay at home and may have less opportunity to consume fresh foods and be physically active.The FDA continues important research to protect public health during the COVID-19 pandemic along with other federal, state , and local agencies and public health officials around the country [1,2,3]. 


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