A preventive effect of the combination of albendazole and pomegranate peel aqueous extract treatment in cystic echinococcosis mice model: An alternative approach

Acta Tropica ◽  
2019 ◽  
Vol 197 ◽  
pp. 105050 ◽  
Author(s):  
Moussa Labsi ◽  
Imene Soufli ◽  
Lila Khelifi ◽  
Zine-Charaf Amir ◽  
Chafia Touil-Boukoffa
Keyword(s):  
Aqueous Extract ◽  
Cystic Echinococcosis ◽  
Preventive Effect ◽  
Mice Model ◽  
Pomegranate Peel ◽  
Alternative Approach

In vitro evaluation of antimicrobial activity and measuring its antigenic specific immune response in mice model studies: Allium cepa

2021 ◽  
pp. 2563-2568
Author(s):  
Amit Gupta ◽  
Karishma Ghosh ◽  
Dakshita Snud Sharma ◽  
Shubham Tyagi
Keyword(s):  
Cell Proliferation ◽  
Antimicrobial Activity ◽  
T Cell ◽  
Allium Cepa ◽  
Aqueous Extract ◽  
Hemolytic Activity ◽  
Cell Culture Supernatant ◽  
T Cell Proliferation ◽  
Mice Model ◽  
Model Studies

Allium cepa (onion; Liliaceae family), herbaceous annual plant and reported Sulphur based amino acids with many minerals including vitamins. Inspite of various medicinal uses of this plant as food and also showed various beneficial effects. The antimicrobial activity of aqueous extract from Allium cepa (onion bulb) was evaluated against bacterial strains using disc diffusion method. In contrast, inflammatory response or inhibition of T cell antigenic response was evaluated using typhoid vaccine and swine flu vaccine in Swiss mice. These studies were conducted according to ethical guidelines and determining T cell proliferation including estimation of cytokines from cell culture supernatant and also measuring its hemolytic activity. The results showed that aqueous extract show the highest inhibition rate against Pseudomonas aeruginosa and Salmonella enteritidis. In mice model studies, aqueous extract at higher doses showed inhibition in antigen specific T cell proliferation and also declining in the level of IFN-gamma production but enhancement in IL-4 production. In addition, aqueous extract at higher concentration does not showed any hemolytic activity. Overall, this study provides evidence for the presence of secondary metabolites in aqueous extract that probably interferes with bacterial growth (antimicrobial) and also declining in antigenic specific proliferation (i.e. anti-inflammatory) which would prevent and inhibit initiation and progression of many diseases.

scholarly journals Opioid-induced hyperalgesia in a mice model of orthopaedic pain: preventive effect of ketamine †

2010 ◽  
Vol 104 (2) ◽  
pp. 231-238 ◽  
Author(s):  
V Minville ◽  
O Fourcade ◽  
J.-P. Girolami ◽  
I Tack
Keyword(s):  
Preventive Effect ◽  
Mice Model ◽  
Opioid Induced Hyperalgesia

Efficacy assessment of pomegranate peel aqueous extract for brown rot (Monilinia spp.) disease control

2020 ◽  
Vol 110 ◽  
pp. 101482 ◽  
Author(s):  
Assia El Khetabi ◽  
Rachid Lahlali ◽  
Latifa Askarne ◽  
Said Ezrari ◽  
Lahsen El Ghadaroui ◽  
...  
Keyword(s):  
Disease Control ◽  
Aqueous Extract ◽  
Brown Rot ◽  
Pomegranate Peel ◽  
Efficacy Assessment

scholarly journals In VitroAntioxidant andIn VivoLipid-Lowering Properties ofZingiber officinaleCrude Aqueous Extract and Methanolic Fraction: A Follow-Up Study

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Oussama Bekkouch ◽  
Mohamed Harnafi ◽  
Ilham Touiss ◽  
Saloua Khatib ◽  
Hicham Harnafi ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Zingiber Officinale ◽  
Cardiovascular Complications ◽  
The Body ◽  
High Density Lipoproteins ◽  
Dependent Manner ◽  
Mice Model

Over the past decades, cardiovascular diseases have become the leading cause of death all over the world, and among these diseases there is atherosclerosis caused mainly by an increase in plasmatic cholesterol levels and by strong oxidation caused by free radicals. For these reasons and others, we explored in this report the hypolipidemic and the antioxidant effects ofZingiber officinalecrude aqueous and methanolic extract. The hypolipidemic study was carried out in high-fat-fed mice model. Animals were subdivided into four groups and were orally treated with the aqueous extract once daily for twelve weeks at two doses: 250 and 500 mg/Kg. During the treatment, the body weight, total cholesterol, triglycerides, and high-density lipoproteins have been defined every four weeks. The antioxidant activity has been studied using radical scavenging activity,β-carotene bleaching, reducing power assay, and the TBARs tests. The daily oral administration of the extracts for twelve weeks significantly improved the lipid profile in a dose-dependent manner, from the first until the twelfth week, and also showed a significant antioxidant effect. These findings may be potentially contributive to the validation of the medicinal use ofZ. officinaleto treat hyperlipidemia and cardiovascular complications.

scholarly journals Comparison of hepatoprotective effect of aqueous and ethanolic extracts of Berberis lycium Royale (Sumbloo) in isoniazid induced hepatotoxicity in male mice model

2020 ◽  
Vol 9 (6) ◽  
pp. 835
Author(s):  
Saima Rafique ◽  
Khalida Ajmal ◽  
Uzma Naeem ◽  
Akbar Waheed ◽  
Ayesha Afzal ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Ethanolic Extract ◽  
Stem Bark ◽  
Hepatoprotective Effect ◽  
High Dose ◽  
Dependent Manner ◽  
Male Mice ◽  
Mice Model ◽  
Ethanolic Extracts ◽  
Berberis Lycium

Background: The objective of the study was to compare the hepatoprotective effect of aqueous and ethanolic extracts of stem bark of Berberis lycium Royle in isoniazid (INH) induced hepatotoxicity in mice model.Methods: This randomized controlled in-vivo study conducted in male mice model from 10th April 2014 till 10th May 2014 at National Institute of Health, Islamabad. Group (C) was given normal diet and water. Group (D) was given isoniazid (50 mg/kg BW) to produce hepatotoxicity. Group (LA) and (HA) were given isoniazid (INH) plus low and high dose of aqueous extract of stem bark of Berberis lycium Royle respectively. Group (L.E) and (H.E) were given INH plus low and high dose of ethanolic extract of stem bark of Berberis lycium Royle respectively.Results: Hepatotoxicity produced by INH was shown by raised serum liver function tests (LFT’s), marked hepatocytic ballooning, significant steatosis and inflammation. Mice receiving simultaneous treatment of INH, low and high dose of aqueous extract of Berberis lycium Royle showed decrease serum LFT’s and their liver sections showed improved histological picture but more significant reduction in hepatotoxic effects were observed in animals receiving low and high doses of ethanolic extract.Conclusions: Hepatotoxicity of INH can be more fully reversed by simultaneous use of INH with ethanolic extract as it has better hepatoprotective potential in dose dependent manner as compare to aqueous extract of stem bark of Berberis lycium Royle.

scholarly journals PROTECTIVE EFFECT OF AQUEOUS EXTRACT POMEGRANATE PEEL AGAINST STERIGMATOCYSTIN TOXICITY IN RAT

2015 ◽  
Vol 5 (5) ◽  
Author(s):  
T A El-Desouky ◽  
Mohamed R Sherif ◽  
Mohamed S Sherif ◽  
Naguib M Khayria
Keyword(s):  
Protective Effect ◽  
Aqueous Extract ◽  
Pomegranate Peel

scholarly journals In VitroandIn VivoEffects of Tamoxifen against Larval Stage Echinococcus granulosus

2014 ◽  
Vol 58 (9) ◽  
pp. 5146-5154 ◽  
Author(s):  
María Celeste Nicolao ◽  
María Celina Elissondo ◽  
Guillermo M. Denegri ◽  
Alejandra B. Goya ◽  
Andrea C. Cumino
Keyword(s):  
Echinococcus Granulosus ◽  
Larval Stage ◽  
Cystic Echinococcosis ◽  
Term Therapy ◽  
Content Type ◽  
Alternative Approach ◽  
Collateral Effects ◽  
Therapeutic Tools

ABSTRACTCystic echinococcosis is a zoonotic infection caused by the larval stage of the cestodeEchinococcus granulosus. Chemotherapy currently employs benzimidazoles; however, 40% of cases do not respond favorably. With regard to these difficulties, novel therapeutic tools are needed to optimize treatment in humans. The aim of this work was to explore thein vitroandin vivoeffects of tamoxifen (TAM) againstE. granulosus. In addition, possible mechanisms for the susceptibility of TAM are discussed in relation to calcium homeostasis, P-glycoprotein inhibition, and antagonist effects on a putative steroid receptor. After 24 h of treatment, TAM, at a low micromolar concentration range (10 to 50 μM), inhibited the survival ofE. granulosusprotoscoleces and metacestodes. Moreover, we demonstrated the chemotherapeutic and chemopreventive pharmacological effects of the drug. At a dose rate of 20 mg/kg of body weight, TAM induced protection against the infection in mice. In the clinical efficacy studies, a reduction in cyst weight was observed after the administration of 20 mg/kg in mice with cysts developed during 3 or 6 months, compared to that of those collected from control mice. Since the collateral effects of high TAM doses have been largely documented in clinical trials, the use of low doses of this drug as a short-term therapy may be a novel alternative approach for human cystic echinococcosis treatment.

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