Objective: In the present study, we have made an attempt to the developed formulation of nanoparticles (NPs) of eprosartan mesylate (EM) incorporated in carboxymethyl chitosan using reverse micelle technique for the better drug delivery by improving solubility.Methods: The NPs size and morphology were investigated by high-resolution transmission electron microscopy and field emission scanning electron microscopy, respectively. The physical and chemical aggregation state of eprosartan was analyzed using ultraviolet spectroscopy, and Fourier transforms infrared spectroscopy.Results: To increase the solubility of eprosartan by reverse micelle technique of the drug through polymeric NPs is an alternative efficient, option for increasing the solubility. Eprosartan nanosuspension was successfully formulated for dissolution and bioavailability enhancement of the drug. The percentage drug release pattern of both formulations was compared against that of pure drug. It shows that in 10 min 39% and 17% of drug was released from the NPs made by RM method and microemulsion method, respectively, as compared to that of 1.3% of the pure drug. In 50 min almost more than half 51% of the drug was released from NPs by microemulsion method whereas only 2.5% of the drug was released from NPs containing the pure drug. In 120 min 67% of the drug was released from NPs by microemulsion method whereas only 5.8% of drug release was shown by NPs with the pure drug. We are paying attention on evaluating the influence of particle size and crystalline state on the in vitro performance of eprosartan.Conclusion: In summary, we have developed a new approach toward the delivery of poorly water-soluble drug eprosartan by reverse micellar method. The particle size of NPs obtained by the reverse micellar method was significantly reduced as compared to the other method.
The Effect of Water Droplets on the Nano Particle Size Distribution using the SMPS System
