Effect of long-term aspartame (artificial sweetener) on anxiety, locomotor activity and emotionality behavior in Wistar Albino rats

2014 ◽  
Vol 4 (1) ◽  
pp. 39-43 ◽  
Author(s):  
Iyaswamy Ashok ◽  
Rathinasamy Sheeladevi ◽  
Dapkupar Wankhar
Keyword(s):  
Locomotor Activity ◽  
Albino Rats ◽  
Artificial Sweetener ◽  
Wistar Albino Rats

scholarly journals Sucralose induced pancreatic toxicity in albino rats: Histomorphological evidence

2014 ◽  
Vol 31 (02) ◽  
pp. 123-127 ◽  
Author(s):  
S. Gupta ◽  
S. Kalra ◽  
V. Bharihoke ◽  
D. Dhurandhar
Keyword(s):  
Lethal Dose ◽  
Nutrient Sensing ◽  
Albino Rats ◽  
Artificial Sweetener ◽  
Distilled Water ◽  
Obesity And Diabetes ◽  
Pancreatic Toxicity ◽  
Treatment Of Obesity ◽  
Wistar Albino Rats ◽  
And Control

AbstractIn the present world people have become conscious of the fact that sugar is one of the commonest culprits for gain in weight and blood sugar in diabetes. One of the artificial sweetener, sucralose is widely used by diabetics is still under strict scrutiny because of the contradictory feedbacks obtained from various studies, often discouraging its use. Therefore, there arises a need to check whether the use of sucralose is safe or not. The present study was designed to determine to evaluate and compare the histological changes of sucralose on the islets of pancreas in albino rats. Methods: The adult Wistar albino rats were given sucralose orally by gavage in the dose of 3gms/kg body weight/day dissolved in distilled water and only distilled water for 30 days to experimental and control groups respectively. The animals were weighed prior to and after the experiment. The animals were sacrificed on day 31. The pancreas was dissected and observed grossly. Tissue was processed; paraffin blocks were prepared and 8 micron thick sections were cut. Sections were stained with Haemotoxylin and Eosin and Gomori's stains. Results: Pancreatic toxicity was observed in the form of vaculation of islets, lymphocytic infilterate, degeneration of islets and acini of Pancreas. The commonly used non-lethal dose of sucralose induced damage to Pancreas is startling. Conclusion: The results obtained have wide implications for nutrient sensing and nutrition in the treatment of obesity and diabetes.

NEUROPROTECTIVE EFFECT OF POLYHERBAL FORMULATION IN PARKINSON’S ANIMAL MODEL

2020 ◽  
pp. 121-125
Author(s):  
ANITHA NANDAGOPAl ◽  
MIR AMJAD ALI KHAN
Keyword(s):  
Locomotor Activity ◽  
Methanolic Extract ◽  
Citrullus Lanatus ◽  
Neuroprotective Effect ◽  
Albino Rats ◽  
Prunus Amygdalus ◽  
Standard Drug ◽  
Polyherbal Formulation ◽  
Behavioral Assessments ◽  
Wistar Albino Rats

Objective: The study is aimed to evaluate the antiparkinsonian effect of polyherbal formulation containing methanolic extract of Prunus amygdalus, Arachis hypogaea, and Citrullus lanatus (MEPAC) in chlorpromazine (CPZ)-induced Parkinson’s disease in Wistar albino rats. Methods: The antiparkinsonian activity of polyherbal formulation was studied in CPZ (3 mg/kg i.p.) induced Parkinson rat model. Rats were subjected to treatment with MEPAC and standard drug for a period of 21 days. The behavioral assessments, i.e., catalepsy and locomotor activity were assessed during the treatment period. Then animals were sacrificed, brains were isolated and homogenized for the estimation of biochemical parameters such as dopamine (DA), lipid peroxidation (LPO), glutathione (GSH), and superoxide dismutase (SOD). Histopathology of the brains was also done. Results: The cataleptic score of MEPAC (200 mg/kg and 400 mg/kg) treated rats was significantly reduced. On the other hand, there was improved in the locomotor activity. MEPAC (200 mg/kg and 400 mg/kg) treated rats showed increase in the level of DA, reduced GSH, SOD, and decreased LPO significantly. Conclusion: It may be concluded that methanolic extract of polyherbal formulation consisting of P. amygdalus, A. hypogaea, and C. lanatus showed a good antioxidant and neuroprotective effect in CPZ-induced Parkinson rats.

scholarly journals Toxicity effect of sub-chronic oral administration of class bitters® - a polyherbal formula on serum electrolytes and hematological indices in male Wistar albino rats

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Kingsley C. Patrick-Iwuanyanwu ◽  
Kpobari W. Nkpaa
Keyword(s):  
Hematological Parameters ◽  
Albino Rats ◽  
Serum Electrolytes ◽  
Potential Health ◽  
Hematological Indices ◽  
Hydrogen Carbonate ◽  
Term Administration ◽  
Wistar Albino Rats ◽  
Herbal Formulations

The indiscriminate administration of readyto- use herbal formulations has become a major concern due to their potential health risk. The study investigated the effect of class bitters® (CB) - a polyherbal formula prepared with <em>Mondia whitei</em>, <em>Khaya</em> <em>senegalensis</em>, <em>Capparis</em> <em>erythrocarpus</em>, <em>Thoningia</em> <em>sanguinea</em> and <em>Xylopia</em> <em>aethiopica</em> on serum electrolytes and hematological parameters in male Wistar albino rats. Two doses (500 and 1000 mg kg<sup>–1</sup>) of the polyherbal drugs were administered orally to male Wistar albino rats for a period of 9 weeks. The results showed that administration of 500 and 1000 mg kg<sup>–1</sup> body weight of CB recorded a marked increase in the levels of sodium and chlorum when compared with control. However, there was a marked reduction in the levels of potassium and hydrogen carbonate. The results of the study also showed a significant (P≤0.05) decrease in the level of hematological parameters such as hemoglobin (Hb), packed cell volume (PCV), red blood cells (RBCs) and platelets levels in the male Wistar albino rats, when compared with control. The marked decrease in Hb, PCV, RBCs and platelets concentrations observed in experimental rats in this study suggest that CB may have an adverse effect on erythropoiesis. These observations therefore showed that long-term administration of CB might cause renal disease and anemia.

Long-term exposure to incense smoke alters metabolism in Wistar albino rats

2011 ◽  
Vol 29 (2) ◽  
pp. 96-101 ◽  
Author(s):  
Majed S. Alokail ◽  
Nasser M. Al-Daghri ◽  
Saud A. Alarifi ◽  
Hossam M. Draz ◽  
Tajamul Hussain ◽  
...  
Keyword(s):  
Albino Rats ◽  
Wistar Albino Rats

scholarly journals Atorvastatin Has no Effects on Kidney Tissues of Wistar Albino Rats in the Long-Term Intake: An Electron Microscopic Study

2011 ◽  
Vol 29 (1) ◽  
pp. 144-150 ◽  
Author(s):  
Ayfer Aktas ◽  
M Serhan Tasdemir ◽  
M Cudi Tuncer ◽  
Yusuf Nergiz ◽  
Murat Akkus ◽  
...  
Keyword(s):  
Microscopic Study ◽  
Electron Microscopic Study ◽  
Albino Rats ◽  
Electron Microscopic ◽  
Wistar Albino Rats

Long-term effect of aspartame on the liver antioxidant status and histopathology in Wistar albino rats

2014 ◽  
Vol 4 (2) ◽  
pp. 299-305 ◽  
Author(s):  
Iyaswamy Ashok ◽  
Dapkupar Wankhar ◽  
Rathinasamy Sheeladevi ◽  
Wankupar Wankhar
Keyword(s):  
Antioxidant Status ◽  
Term Effect ◽  
Albino Rats ◽  
Long Term Effect ◽  
Wistar Albino Rats

scholarly journals Comparison of the Hyperglycemic Control of M. oleifera Leaves Aqueous Extract and Glibenclamide Tablets in Alloxan Monohydrate Induced Diabetic Rats

2019 ◽  
pp. 1-9
Author(s):  
Josephine N. Kasolo ◽  
Agnes Namaganda ◽  
Joshua Nfambi ◽  
Ivan Kimuli ◽  
Haruna Muwonge ◽  
...  
Keyword(s):  
Blood Sugar ◽  
Aqueous Extract ◽  
Diabetic Rats ◽  
Fasting Blood Sugar ◽  
Albino Rats ◽  
Distilled Water ◽  
Moringa Oleifera Leaves ◽  
Wistar Albino Rats ◽  
Alloxan Monohydrate

Introduction: Diabetes being one of the commonest non-communicable diseases worldwide has no cure. The available hypoglycemic drugs are costly, and have associated long-term side effects.  M. oleifera leaves are used in many countries in Africa and Asia to treat diabetes. The study compared the hyperglycemic control of M. oleifera leaves aqueous extract and Glibenclamide tablet in alloxan monohydrate induced diabetic rats. Methods: Twenty-four female Wistar albino rats, made diabetic using alloxan monohydrate, received either M. oleifera extract, glibenclamide or distilled water were delivered intragastric. The mean body weight and mean fasting blood sugar were measured over a period of 28 days.  Results: Rats that received distilled water had a mean fasting blood sugar of 329.3+44.9 mg/dl at the beginning, which increased to 448.0+189.9 mg/dl on day 14; all   the rats were dead by day 21. The rats that received M. oleifera had blood sugar 443.4+134.7 mg/dl at the beginning, dropped to 166.5+162.79 mg/dl by day 14, and to 88.7+41.0 mg/dl by day 28. Rats that received glibenclamide had blood sugar 517.6+139.3mg/dl at the beginning, dropped to 209.0+201.9 mg/dl on day 14, and to 89.7+42.85 mg/dl on day 28.  The blood sugar of the M. oleifera and glibenclamide groups reached normal level by day 21 and remained within the normal range up to day 28. Conclusion: Moringa oleifera leaves aqueous extract has similar pattern to glibenclamide tablet in causing hypoglycemia to alloxan monohydrate induced diabetic rats.

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