P183 - Exposure to cadmium modulates the composition of short chain fatty acid-producing microbiota in an alzheimer’s disease mouse model

Propionate, a short-chain fatty acid, serves important roles in the human body. However, our review of the current literature suggests that under certain conditions, excess levels of propionate may play a role in Alzheimer’s disease (AD). The cause of the excessive levels of propionate may be related to the Bacteroidetes phylum, which are the primary producers of propionate in the human gut. Studies have shown that the relative abundance of the Bacteroidetes phylum is significantly increased in older adults. Other studies have shown that levels of the Bacteroidetes phylum are increased in persons with AD. Studies on the diet, medication use, and propionate metabolism offer additional potential causes. There are many different mechanisms by which excess levels of propionate may lead to AD, such as hyperammonemia. These mechanisms offer potential points for intervention.

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Pediococcus pentosaceus LI05 alleviates DSS‐induced colitis by modulating immunological profiles, the gut microbiota and short‐chain fatty acid levels in a mouse model

Microbial Biotechnology ◽

10.1111/1751-7915.13583 ◽

2020 ◽

Vol 13 (4) ◽

pp. 1228-1244 ◽

Cited By ~ 1

Author(s):

Xiaoyuan Bian ◽

Liya Yang ◽

Wenrui Wu ◽

Longxian Lv ◽

Xianwan Jiang ◽

...

Keyword(s):

Fatty Acid ◽

Mouse Model ◽

Gut Microbiota ◽

Short Chain Fatty Acid ◽

Chain Fatty Acid ◽

Short Chain ◽

Pediococcus Pentosaceus

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Deletion of atoR from Streptococcus pyogenes Results in Hypervirulence in a Mouse Model of Sepsis and is LuxS Independent

Polish Journal of Microbiology ◽

10.5604/17331331.1234989 ◽

2017 ◽

Vol 66 (1) ◽

pp. 17-24 ◽

Cited By ~ 2

Author(s):

Izabela Sitkiewicz ◽

James M. Musser

Keyword(s):

Gene Expression ◽

Fatty Acid ◽

Mouse Model ◽

Fatty Acid Metabolism ◽

Short Chain Fatty Acid ◽

Acid Metabolism ◽

Bacterial Species ◽

Chain Fatty Acid ◽

Short Chain ◽

Streptococcal Toxic Shock Syndrome

Group A Streptococcus (GAS) is a Gram-positive human pathogen that causes a variety of diseases ranging from pharyngitis to life-threatening streptococcal toxic shock syndrome. Recently, several global gene expression analyses have yielded extensive new information regarding the regulation of genes encoding known and putative virulence factors in GAS. A microarray analysis found that transcription of the GAS gene M5005_Spy_1343 was significantly increased in response to interaction with human polymorphonuclear leukocytes. M5005_Spy_1343 is predicted to encode a member of the LysR family of transcriptional regulators and is located upstream of a putative operon containing six genes. Five of these genes have sequence similarity to genes involved in short-chain fatty acid metabolism, whereas the sixth gene (luxS) is found in many bacterial species and is involved in quorum sensing. Unexpectedly, inactivation of the M5005_Spy_1343 gene resulted in hypervirulence in an intraperitoneal mouse model of infection. Increased virulence was not due to changes in luxS gene expression. We postulate that short-chain fatty acid metabolism is involved in GAS pathogenesis.

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