scholarly journals Propionate and Alzheimer’s Disease

2021 ◽  
Vol 12 ◽  
Author(s):  
Jessica Killingsworth ◽  
Darrell Sawmiller ◽  
R. Douglas Shytle
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Fatty Acid ◽  
Relative Abundance ◽  
Short Chain Fatty Acid ◽  
Medication Use ◽  
Chain Fatty Acid ◽  
Human Gut ◽  
Propionate Metabolism

Propionate, a short-chain fatty acid, serves important roles in the human body. However, our review of the current literature suggests that under certain conditions, excess levels of propionate may play a role in Alzheimer’s disease (AD). The cause of the excessive levels of propionate may be related to the Bacteroidetes phylum, which are the primary producers of propionate in the human gut. Studies have shown that the relative abundance of the Bacteroidetes phylum is significantly increased in older adults. Other studies have shown that levels of the Bacteroidetes phylum are increased in persons with AD. Studies on the diet, medication use, and propionate metabolism offer additional potential causes. There are many different mechanisms by which excess levels of propionate may lead to AD, such as hyperammonemia. These mechanisms offer potential points for intervention.

Wheat cell walls and constituent polysaccharides induce similar microbiota profiles upon in vitro fermentation despite different short chain fatty acid end-product levels.

2021 ◽  
Author(s):  
Shiyi Lu ◽  
Deirdre Mikkelsen ◽  
Hong Yao ◽  
Barbara Williams ◽  
Bernadine Flanagan ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Gut Microbiota ◽  
Plant Cell ◽  
Cell Walls ◽  
Short Chain Fatty Acid ◽  
Chain Fatty Acid ◽  
Plant Cell Walls ◽  
Human Gut ◽  
In Vitro Fermentation

Plant cell walls as well as their component polysaccharides in foods can be utilized to alter and maintain a beneficial human gut microbiota, but it is not known whether the...

scholarly journals Comparative analysis of the gut microbiota of mice fed a diet supplemented with raw and cooked beef loin powder

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hye-Jin Kim ◽  
Dongwook Kim ◽  
Kwan-Woo Kim ◽  
Sang-Hoon Lee ◽  
Aera Jang
Keyword(s):  
Fatty Acid ◽  
Comparative Analysis ◽  
Gut Microbiota ◽  
Ribosomal Rna ◽  
Relative Abundance ◽  
Short Chain Fatty Acid ◽  
Dietary Supplementation ◽  
Acid Synthesis ◽  
Chain Fatty Acid ◽  
Increasing Trend

AbstractWe used 16S ribosomal RNA sequencing to evaluate changes in the gut microbiota of mice fed a diet supplemented with either raw or cooked beef loin powder for 9 weeks. Male BALB/c mice (n = 60) were randomly allocated to five groups: mice fed AIN-93G chow (CON), chow containing 5% (5RB) and 10% (10RB) raw beef loin powder, and chow containing 5% (5CB) and 10% (10CB) cooked beef loin powder. Dietary supplementation with both RB and CB increased the relative abundance of Clostridiales compared to the CON diet (p < 0.05). Mice fed 10RB showed a significantly higher relative abundance of Firmicutes (p = 0.018) and Lactobacillus (p = 0.001) than CON mice, and the ratio of Firmicutes/Bacteroidetes showed an increasing trend in the 10RB mice (p > 0.05). Mice fed 10CB showed a higher abundance of Peptostreptococcaceae and a lower abundance of Desulfovibrionaceae compared with the CON mice (p < 0.05). Genes for glycan biosynthesis, which result in short-chain fatty acid synthesis, were enriched in the CB mice compared to the RB mice, which was correlated to a high abundance of Bacteroides. Overall, dietary RB and CB changed the gut microbiota of mice (p < 0.05).

scholarly journals Metformin Is Associated With Higher Relative Abundance of Mucin-DegradingAkkermansia muciniphilaand Several Short-Chain Fatty Acid–Producing Microbiota in the Gut

Diabetes Care ◽  
2016 ◽  
Vol 40 (1) ◽  
pp. 54-62 ◽  
Author(s):  
Jacobo de la Cuesta-Zuluaga ◽  
Noel T. Mueller ◽  
Vanessa Corrales-Agudelo ◽  
Eliana P. Velásquez-Mejía ◽  
Jenny A. Carmona ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Relative Abundance ◽  
Short Chain Fatty Acid ◽  
Chain Fatty Acid ◽  
Short Chain
Sign in / Sign up

Export Citation Format

Share Document