scholarly journals Alpha-hederin induces the apoptosis of oral cancer SCC-25 cells by regulating PI3K/Akt/mTOR signaling pathway

2019 ◽  
Vol 38 ◽  
pp. 27-31 ◽  
Author(s):  
Heyuan Wang ◽  
Bing Wu ◽  
Haotian Wang
Keyword(s):  
Oral Cancer ◽  
Signaling Pathway ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway

scholarly journals ANLN promotes carcinogenesis in oral cancer by regulating the PI3K/mTOR signaling pathway

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Bing Wang ◽  
Xiao-li Zhang ◽  
Chen-xi Li ◽  
Ning-ning Liu ◽  
Min Hu ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Signaling Pathway ◽  
Cell Cycle Progression ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway ◽  
Cell Behaviors ◽  
Rnai Technology ◽  
Tumor Tissues ◽  
Pi3k Signaling Pathway

Abstract Background Oral cancer is a malignant disease that threatenshuman life and greatly reducespatientquality of life. ANLN was reported to promote the progression of cancer. This study aims to investigate the role of ANLNin oral cancer and the underlying molecular mechanism. Methods ANLN expression was downregulated by RNAi technology. The effect of ANLN on cell behaviors, including proliferation, cell cycle progression, invasion, and apoptosis, was detected. Western blotting analysis was used to explore the mechanism by whichANLN functions in oral cancer. Results Data from TCGA database showed that ANLN was expressed at significantly higher levels in tumor tissues thanin normal control tissues. Patients with higher ANLN expression exhibitedshorter survivaltimes. ANLN was alsoabundantly expressedin the cancer cell lines CAL27 and HN30. When ANLN was knocked down in CAL27 and HN30 cells, cell proliferation and colony formation weredecreased. The cell invasion ability was also inhibited. However, the cell apoptosis rate was increased. In addition, the levels of critical members of the PI3K signaling pathway, includingPI3K, mTOR, Akt, and PDK-1, were significantlyreducedafter ANLN was knocked down in CAL27 cells. Conclusions ANLN contributes to oral cancerprogressionand affects activation ofthe PI3K/mTOR signaling pathway. This study providesa new potential targetfor drug development and treatment in oral cancer.

scholarly journals NRSF/REST regulates the mTOR signaling pathway in oral cancer cells

2014 ◽  
Vol 33 (3) ◽  
pp. 1459-1464 ◽  
Author(s):  
EUGENE CHO ◽  
SUNG-MIN MOON ◽  
BO RAM PARK ◽  
DO KYUNG KIM ◽  
BYUNG-KWON LEE ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway ◽  
Oral Cancer Cells

Vietnamese coriander inhibits cell proliferation, survival and migration via suppression of Akt/mTOR pathway in oral squamous cell carcinoma

2019 ◽  
Vol 31 (3) ◽  
Author(s):  
Amrita Devi Khwairakpam ◽  
Javadi Monisha ◽  
Nand Kishor Roy ◽  
Devivasha Bordoloi ◽  
Ganesan Padmavathi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Signaling Pathway ◽  
Squamous Cell ◽  
Mtor Signaling ◽  
Dependent Manner ◽  
Mtor Signaling Pathway ◽  
Anticancer Properties

AbstractBackgroundAccording to GLOBOCAN 2018, oral cancer was reported as the second highest cancer prevalent in India. Despite the several therapies available for oral cancer treatment, tumor recurrence and distant metastasis persist. This study investigates the anticancer potential of Persicaria odorata, commonly known as Vietnamese coriander, used widely in traditional systems of medicine for the treatment of inflammation, stomach ailments, tumors, etc.MethodsThe crude methanolic extract of P. odorata (MPo) was prepared. The anticancer properties of MPo on SAS cells and other human oral squamous cell carcinoma cell line were evaluated using in vitro experimental conditions. The phytochemical constituents present in the MPo were also determined.ResultsPersicaria odorata possesses antiproliferative, antisurvival, antimetastatic activities, and induced cell cycle arrest in the G2 phase. It inhibited Akt-mammalian target of rapamycin (mTOR) signaling pathway and also downregulated the expression of essential proteins that are involved in tumorigenesis such as cyclin D1, cyclooxygenase 2 (COX2), survivin, matrix metalloproteinase-9 (MMP-9), and vascular endothelial growth factor-A (VEGF-A). Moreover, the presence of flavonoids and quinones also revealed the anticancer activity of the plant.ConclusionOverall, our study concludes that P. odorata exhibits its anticancer properties through the downregulation of Akt/mTOR signaling pathway in a dose-dependent manner.

ANLN promotes carcinogenesis in oral cancer by regulating PI3K/mTOR signaling pathway

2020 ◽  
Author(s):  
Bing Wang ◽  
Xiaoli Zhang ◽  
Chenxi Li ◽  
Ningning Liu ◽  
Min Hu ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Signaling Pathway ◽  
Malignant Disease ◽  
Life Quality ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway ◽  
Cell Behaviors ◽  
Rnai Technology ◽  
Tumor Tissues

Abstract Background: Oral cancer is a malignant disease threatening human’s life and severely reduces human’s life-quality. Gene ANLN was reported to promote progression in cancer. This study aims at investigating the role of ANLN and molecular mechanism in oral cancer. Methods: ANLN was down-regulated by RNAi technology. The effect of ANLN on cell behaviors including proliferation, cycle distribution, invasion, and apoptosis was detected. Western blotting analysis was used to disclose the mechanism of ANLN in oral cancer. Results: ANLN was shown to express significantly higher in tumor tissues compared to the normal control tissues based on TCGA data. Patients with higher expression of ANLN displayed worse survival rate. Then ANLN was shown to express abundantly in cancer cell lines CA127 and HN30. When ANLN was reduced in CA127 and HN30 cells, cell proliferation and colony formation ability was inhibited. Cell invasion ability was suppressed. But cell apoptosis was induced reversely. In addition, expression of critical molecules including PI3K, mTOR, Akt, and PDK-1 were reduced after ANLN knockdown in CA127 cells. Conclusions: ANLN contributes to the progression in oral cancer and regulates activation of PI3K/mTOR signaling pathway. This study will provide guidance and new drug target for oral cancer.

scholarly journals [6]-Gingerol Suppresses Oral Cancer Cell Growth by Inducing the Activation of AMPK and Suppressing the AKT/mTOR Signaling Pathway

In Vivo ◽  
2021 ◽  
Vol 35 (6) ◽  
pp. 3193-3201
Author(s):  
HAIBO ZHANG ◽  
EUNGYUNG KIM ◽  
JUNKOO YI ◽  
HUANG HAI ◽  
HYEONJIN KIM ◽  
...  
Keyword(s):  
Cell Growth ◽  
Oral Cancer ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway ◽  
Cancer Cell Growth ◽  
Oral Cancer Cell

UPF1 Impacts on mTOR Signaling Pathway and Autophagy in Endometrioid Endometrial Carcinoma

2020 ◽  
Author(s):  
Minfen Zhang ◽  
Hui Chen ◽  
Ping Qin ◽  
Tonghui Cai ◽  
Lingjun Li ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway

Targeting mammalian target of rapamycin: prospects for the treatment of inflammatory bowel diseases

2020 ◽  
Vol 27 ◽  
Author(s):  
Naser-Aldin Lashgari ◽  
Nazanin Momeni Roudsari ◽  
Saeideh Momtaz ◽  
Negar Ghanaatian ◽  
Parichehr Kohansal ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Mammalian Target Of Rapamycin ◽  
Mtor Pathway ◽  
Mtor Signaling ◽  
Target Of Rapamycin ◽  
In Vivo Studies ◽  
Cochrane Library ◽  
Mtor Signaling Pathway ◽  
Inflammatory Bowel

: Inflammatory bowel disease (IBD) is a general term for a group of chronic and progressive disorders. Several cellular and biomolecular pathways are implicated in the pathogenesis of IBD, yet the etiology is unclear. Activation of the mammalian target of rapamycin (mTOR) pathway in the intestinal epithelial cells was also shown to induce inflammation. This review focuses on the inhibition of the mTOR signaling pathway and its potential application in treating IBD. We also provide an overview on plant-derived compounds that are beneficial for the IBD management through modulation of the mTOR pathway. Data were extracted from clinical, in vitro and in vivo studies published in English between 1995 and May 2019, which were collected from PubMed, Google Scholar, Scopus and Cochrane library databases. Results of various studies implied that inhibition of the mTOR signaling pathway downregulates the inflammatory processes and cytokines involved in IBD. In this context, a number of natural products might reverse the pathological features of the disease. Furthermore, mTOR provides a novel drug target for IBD. Comprehensive clinical studies are required to confirm the efficacy of mTOR inhibitors in treating IBD.

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