P.0070 The associations of thyroid axis hormones with suicidal ideation in individuals with anxiety and mood disorders

2021 ◽  
Vol 53 ◽  
pp. S50
Author(s):  
V. Liaugaudaite ◽  
A. Podlipskyte ◽  
N. Mickuviene ◽  
V. Steibliene ◽  
J. Burkauskas
Crisis ◽  
2014 ◽  
Vol 35 (4) ◽  
pp. 278-282 ◽  
Author(s):  
Karen M. Davison ◽  
Bonnie J. Kaplan

Background: Mood disorders are associated with a high risk of suicide. Statin therapy has been implicated in this relationship. Aims: To further clarify reported associations between suicide and cholesterol in mental health conditions, we conducted an analysis of dietary, clinical, and suicidal ideation measures in community-living adults with mood disorders. Method: Data were used from a cross-sectional study of a randomly selected community-based sample (> 18 years; n = 97) with verified mood disorders. Dietary (e.g., fat, iron, vitamin intakes), clinical (e.g., current depression and mania symptoms, medications), and sociodemographic (age, sex, and income) measures were analyzed using bivariate statistics and Poisson regression with robust variance. Results: Participants were predominantly female (71.1%) with bipolar disorder (59.8%); almost one-third (28.9%) were taking lipophilic statins. The prevalence of suicidal ideation was more than 2.5 times in those taking statins, PR = 2.59, 95% CI 1.27–5.31, p < .05. The prevalence ratio for suicidal ideation was 1.10, 95% CI 1.06–1.15, p < .001, for each unit increase in mania symptom scores. No associations between suicidal ideation and dietary intake measures were identified. Conclusion: Individuals with mood disorders may be susceptible to neuropsychiatric effects of cholesterol-lowering drugs, which warrants further research.


2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Pengshuo Wang ◽  
Ran Zhang ◽  
Xiaowei Jiang ◽  
Shengnan Wei ◽  
Fei Wang ◽  
...  

Abstract Background Mood disorders are severe mental disorders related to increased suicidal behavior. Finding neural features for suicidal behavior, including suicide attempts (SAs) and suicidal ideation (SI), in mood disorders may be helpful in preventing suicidal behavior. Methods Subjects consisted of 70 patients with mood disorders and suicidal behavior, 128 patients with mood disorders without suicidal behavior (mood disorders control, MC), and 145 health control (HC) individuals. All participants underwent structural magnetic resonance imaging (MRI). We used voxel-based morphometry (VBM) techniques to examine gray matter volumes (GMVs). Results Significant differences were found in GMVs of the left and right middle frontal gyrus among the patients with mood disorders and suicidal behavior, MC, and HC. Post hoc comparisons showed significant differences in the GMVs of the above regions across all three groups (P < 0.01): HC > MC > mood disorders with suicidal behavior. However, there were no significant differences in the GMVs of the left and right middle frontal gyrus between the mood disorders with SI and mood disorders with SAs groups. Conclusions These findings provide evidence that abnormal regional GMV in the middle frontal gyrus is associated with suicidal behavior in mood disorders. Further investigation is warranted to determine whether the GMV alterations in mood disorders with SI are different from these in mood disorders with SAs.


2012 ◽  
Vol 201 (6) ◽  
pp. 466-472 ◽  
Author(s):  
Osvaldo P. Almeida ◽  
Brian Draper ◽  
John Snowdon ◽  
Nicola T. Lautenschlager ◽  
Jane Pirkis ◽  
...  

BackgroundThoughts about death and self-harm in old age have been commonly associated with the presence of depression, but other risk factors may also be important.AimsTo determine the independent association between suicidal ideation in later life and demographic, lifestyle, socioeconomic, psychiatric and medical factors.MethodA cross-sectional study was conducted of a community-derived sample of 21290 adults aged 60-101 years enrolled from Australian primary care practices. We considered that participants endorsing any of the four items of the Depressive Symptom Inventory - Suicidality Subscale were experiencing suicidal thoughts. We used standard procedures to collect demographic, lifestyle, psychosocial and clinical data. Anxiety and depressive symptoms were assessed with the Hospital Anxiety and Depression Scale.ResultsThe 2-week prevalence of suicidal ideation was 4.8%. Male gender, higher education, current smoking, living alone, poor social support, no religious practice, financial strain, childhood physical abuse, history of suicide in the family, past depression, current anxiety, depression or comorbid anxiety and depression, past suicide attempt, pain, poor self-perceived health and current use of antidepressants were independently associated with suicidal ideation. Poor social support was associated with a population attributable fraction of 38.0%, followed by history of depression (23.6%), concurrent anxiety and depression (19.7%), prevalent anxiety (15.1%), pain (13.7%) and no religious practice (11.4%).ConclusionsPrevalent and past mood disorders seem to be valid targets for indicated interventions designed to reduce suicidal thoughts and behaviour. However, our data indicate that social disconnectedness and stress account for a larger proportion of cases than mood disorders. Should these associations prove to be causal, then interventions that succeeded in addressing these issues would contribute the most to reducing suicidal ideation and, possibly, suicidal behaviour in later life.


2015 ◽  
Vol 226 (1) ◽  
pp. 38-44 ◽  
Author(s):  
Laura Mandelli ◽  
Finiki A. Nearchou ◽  
Chrysostomos Vaiopoulos ◽  
Costas N. Stefanis ◽  
Silia Vitoratou ◽  
...  

2020 ◽  
pp. 008124632097775
Author(s):  
Kim-Louise Rousseau ◽  
Sabrina Thompson ◽  
Lea-Ann Pileggi ◽  
Michelle Henry ◽  
Kevin GF Thomas

University students are particularly vulnerable to mood disorders. This vulnerability may be increasing, with recent investigations reporting sharp rises in the prevalence of depression and other psychiatric disorders. Moreover, previous studies indicate that first-year undergraduates tend to show more depression and suicidal ideation than students in subsequent years. However, most studies in the extant literature emerge from high-income countries in the global north; relatively few focus on university students in low- and middle-income countries such as South Africa. Because students in low- and middle-income countries are more likely to be exposed to crime and trauma, and less likely to have easily accessible mental health services, they might be at even higher risk for developing mood disorders than their counterparts in high-income countries. Furthermore, most previous studies of mental health in university students analyse cross-sectional data and therefore cannot comment on longitudinal patterns in the data. To fill these knowledge gaps, the current study aimed to describe recent trends in depression and suicidal ideation among South African university students. We analysed both archival ( n = 2593) and original ( n = 499) Beck Depression Inventory-Second Edition reports, sampled between 2016 and 2019. As expected, depression and suicidal ideation scores increased significantly over time, and first-year students reported significantly more depression and suicidal ideation than students in subsequent years of study. These findings suggest that preventive interventions during sensitive periods of undergraduate study are imperative and provide a foundation for treatment strategies tailored to the needs of the most vulnerable South African students.


2012 ◽  
Vol 49 (S1) ◽  
pp. 227-234 ◽  
Author(s):  
Luciane B. Ceretta ◽  
Gislaine Z. Réus ◽  
Helena M. Abelaira ◽  
Luciano K. Jornada ◽  
Magada T. Schwalm ◽  
...  

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