scholarly journals Simplex lattice design for optimization of the mass ratio of Curcuma longa L., Curcuma zedoaria (Christm.) Roscoe and Curcuma aromatica Salisb. to maximize curcuminoids content and antioxidant activity

2021 ◽  
Vol 71 (3) ◽  
pp. 445-457
Author(s):  
Chaowalit Monton ◽  
Panupong Chuanchom ◽  
Puwadon Popanit ◽  
Sukanya Settharaksa ◽  
Pathamaporn Pathompak
Keyword(s):  
Antioxidant Activity ◽  
High Performance Liquid Chromatography ◽  
High Performance ◽  
Curcuma Longa ◽  
Mass Ratio ◽  
Curcuma Zedoaria ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Simplex Lattice ◽  
The Individual

AbstractThe aim of this work was to optimize the mass ratio of three Curcuma plants’ rhizomes to obtain the highest curcuminoid content and antioxidant activity using the simplex lattice design. The selected Curcuma plants were C. longa, C. zedoaria and C. aromatica. The simplex lattice design was applied in the work. The individual curcuminoids (curcumin, demethoxycurcumin and bis-demethoxycurcumin) and total curcuminoid content were determined using high-performance liquid chromatography. Curcuma longa alone provided the highest content of bis-demethoxycurcumin and demethoxycurcumin. A mixture of C. longa and C. aromatica in the mass ratio of 72:28 % provided the highest curcumin content. The results showed that C. longa alone exhibited the highest antioxidant activity.

scholarly journals Optimasi Formula Gel Antioksidan Ekstrak Etanol Buah Bligo (Benincasa hispida) dengan Metode Simplex Lattice Design (SLD)

2017 ◽  
Vol 3 (2) ◽  
pp. 150-156
Author(s):  
Suryani Suryani ◽  
Andi Nafisah ◽  
Syahrir Mana'an
Keyword(s):  
Antioxidant Activity ◽  
Laboratory Experiments ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Benincasa Hispida ◽  
Dpph Method ◽  
Simplex Lattice ◽  
Dispersive Power ◽  
Carbomer 940 ◽  
Optimal Formula

Benincasa hispida has many benefits including as antioxidant. This study aims to evaluate the effect of Carbomer 940, HPMC and NaOH concentrations in antioxidant gel formula and to determine Carbomer 940, HPMC and NaOH concentrations that could produce the optimal antioxidant gel formula. Benincasa hispida was extracted by maceration method and antioxidant activity was tested by DPPH method. The antioxidant gels were formulated with variety combinations of Carbomer 940, HPMC and NaOH. The optimal gel formula was obtained by Design Expert 7.1.5 with Simplex Lattice Design method. The physical characteristic of optimal gel formula was retested and compared with the results of Simplex Lattice Design .The results showed that antioxidant activity of Benincasa hispida ethanolic extract has potent activity with the IC50 40,28 μg/mL. The increasing concentration of Carbomer 940, HPMC and NaOH possessed the high coefficients viscosity (cPs) with the value of 4366, 4133 and 3750 respectively. The increasing concentration of NaOH possessed pH and dispersive power of the gel with coefficients of 11,0 and 5,21 respectively. The desirability values suggested by Simplex Lattice Design were 1,000 with component variation of the optimal formula were Carbomer 940 1,5%, HPMC 0,5% and NaOH 0,4%. The significance test of the optimal formula  compared to the results of laboratory experiments showed the significance of viscosity of 0,130, the dispersive power of 0,348 and pH of 0,184 that means there was no significant difference between the prediction values by using Simplex Lattice Design and results of laboratory experiments. It was indicated that significance values of each responses were over 0,05 (p>0.05).

The Optimization of Maltodextrin and Arabic Gum in the Microencapsulation of Aqueous Fraction of Clinacanthus nutans Using Simplex Lattice Design

2018 ◽  
Vol 8 (2) ◽  
Author(s):  
Intan Martha Cahyani ◽  
Ebta Narasukma Anggraeny ◽  
Bekti Nugraheni ◽  
Christiana Retnaningsih ◽  
V Kristina Ananingsih
Keyword(s):  
Antioxidant Activity ◽  
Moisture Content ◽  
Flow Rate ◽  
Aqueous Fraction ◽  
Arabic Gum ◽  
Design Expert ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Clinacanthus Nutans ◽  
Simplex Lattice

The aqueous fraction of Clinacanthus nutans leaf extracts contains flavonoids which known had antioxidative properties. To improve acceptability, this viscous and bitter aqueous fraction was microencapsulated using maltodextrin and Arabic gum. This research aims to discover the effectivity of maltodextrin and Arabic gum and the concentrations for optimum microencapsulation. Optimization design was done using Design Expert with simplex lattice design with ratios of 1:0; 0.75:0.25; 0.5:0.5; 0.25:0.75 and 0:1. The evaluations done to the results were microcapsule yield, moisture content, flow rate, and antioxidant activity. The optimum ratio of maltodextrin and Arabic gum was obtained at 0.806:0.194 with 1.49% moisture content, flow rate 4.375 g/s and antioxidant activity at the value of 842,499 ppm. The result of one-sample T-test showed that the prediction result of Design Expert did not differ significantly from the experiment result. From the data, it was concluded that the resulting equation was valid

scholarly journals Evaluation of the synergistic effects of antioxidant activity on mixtures of the essential oil from Apium graveolens L., Thymus vulgaris L. and Coriandrum sativum L. using simplex-lattice design

Heliyon ◽  
2019 ◽  
Vol 5 (6) ◽  
pp. e01942 ◽  
Author(s):  
Yasiel Arteaga Crespo ◽  
Luis Ramón Bravo Sánchez ◽  
Yudel García Quintana ◽  
Andrea Silvana Tapuy Cabrera ◽  
Abdel Bermúdez del Sol ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Essential Oil ◽  
Synergistic Effects ◽  
Coriandrum Sativum ◽  
Apium Graveolens ◽  
Thymus Vulgaris ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Simplex Lattice

scholarly journals Optimization Formula of Turmeric (Curcuma longa L.) Extract Chewable with Combination of Mannitol-Lactose as Filler Based on Simplex Lattice Design

2017 ◽  
Vol 2 (01) ◽  
pp. 53 ◽  
Author(s):  
Dian Eka Ermawati ◽  
Saifullah Sulaiman ◽  
Indah Purwantini
Keyword(s):  
Physical Properties ◽  
Curcuma Longa ◽  
Water Extract ◽  
Hydroalcoholic Extract ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Simplex Lattice ◽  
Student’S T ◽  
Optimum Formula ◽  
Prevention Of Atherosclerosis

<div class="WordSection1"><p>Hydroalcoholic extract of turmeric (<em>Curcuma longa</em> L.) doses of 1.66 mg/kg containing 10% of curcuminoid was recommended as a supplement for prevention of atherosclerosis. This study aimed to formulate hydroalcoholic extract of turmeric into chewable which are more acceptable and practical. Mannitol-Lactose selected as a filler to make the chewable in this study. Optimum composition of filler of the mixture obtained by the <em>Simplex Lattice Design</em> method.</p><p>Identification of turmeric rhizome has been done at Departemen of Plant Taxonomy, Faculty of Biology, Gadjah Mada University, Yogyakarta, Indonesia. The rhizome extraction carried out as re to research carried out by Quiles. The mixture between curcuminoid, ethanol and water extract made up to 25% level of curcuminoid level. Then, Extract was granulated with combination of filler mannitol-lactose to be five formulas, there are: FI (mannitol 100%), FII (mannitol-lactose 75%:25%), FIII (mannitol-lactose 50%:50%), FIV (mannitol-lactose 25%:75%), FV (lactose 100%). The granules then tested their physical properties such as flowability, compactibility, and water content. Furthermore, the granules tableted and physical tested including : weight uniformity, hardness, friability, absorption, flavor acceptance and soluble time. Determining the optimum formulation obtained from the physical properties of the granules and chewable physical properties based on SLD methods. Optimum formula of chewable then tested with kurkuminoid levels. The physical properties data of granules and chewable were analyzed statistically using student’s t-test.</p><p>The result of this study was the optimum formula obtained from the mixture of mannitol-lactose fillers with a ratio of 90% mannitol: 10% lactose. The optimum formula of turmeric extract chewable produced meets the physical properties of the granules and chewable. Acceptance of flavor chewable optimum formula appreciation in the range of sweet and sour taste to sour. Percentage kurkuminoid levels in chewable after manufacture process was 76.42%.</p></div>

Compositional Analysis of Organosolv Poplar Lignin by Using High-Performance Liquid Chromatography/High-resolution Multi-stage Tandem Mass Spectrometry

2021 ◽  
Author(s):  
Jifa Zhang ◽  
Yuan Jiang ◽  
Leah F Easterling ◽  
Anton Anster ◽  
Wanru Li ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Compositional Analysis ◽  
Complex Mixtures ◽  
Tandem Mass ◽  
Multi Stage ◽  
The Individual ◽  
Environmentally Friendly Process

Organosolv treatment is an efficient and environmentally friendly process to degrade lignin into small compounds. The capability of characterizing the individual compounds in the complex mixtures formed upon organosolv treatment...

scholarly journals PHYTOCHEMICAL AND ANTIOXIDANT COMPOSITION IN ACCESSIONS OF THE MANGABA ACTIVE GERMPLASM BANK

2021 ◽  
Vol 34 (1) ◽  
pp. 228-235
Author(s):  
PRISCILLA SANTANA SANTOS ◽  
LISIANE DOS SANTOS FREITAS ◽  
EVANDRO NEVES MUNIZ ◽  
JOSEFA GRASIELA SILVA SANTANA ◽  
ANA VERUSKA CRUZ DA SILVA
Keyword(s):  
Principal Component Analysis ◽  
Antioxidant Activity ◽  
High Performance Liquid Chromatography ◽  
High Performance ◽  
Antioxidant Properties ◽  
Principal Component ◽  
Total Phenols ◽  
Germplasm Bank ◽  
Fruit Species ◽  
Hancornia Speciosa

ABSTRACT Mangaba (Hancornia speciosa Gomes) is a fruit species native to Brazil, belonging to the Apocynaceae family. Its cultivation is predominantly extractivist and its antioxidant properties have been recently reported. The objective of this study was to evaluate the bioactive compounds and antioxidant activity in fruits of accession from the Active Germplasm Bank of Embrapa Coastal Tablelands (BI, CA, LG, PR, PT and TC). The extracts were analyzed by high-performance liquid chromatography (HPLC), which identified chlorogenic acid (93.71 - 131.66 mg.100g-1), ferulic acid (0.85 - 2.27 mg.100g-1) and rutin (238.59 -442.94 mg.100g-1). The accessions CA and PR showed the highest values of total phenols (1179.39 and 1167.05 mg GAE.100g-1, respectively). The accessions CA and TC had the highest concentration of the major compound rutin (436.78 and 442.94 mg.100g-1, respectively). Antioxidant activity values ranged from 125.95 to 158.67 g.g-1 DPPH. Principal component analysis grouped the accessions into four groups, due to the genetic variability verified in previous studies. The results will be useful to guide actions of selection and future breeding program of the species.

scholarly journals BAYESIAN APPROACH TO THE D-OPTIMAL FOR MIXTURE EXPERIMENTAL DESIGN

2019 ◽  
Vol 3 (2) ◽  
pp. 109
Author(s):  
Uqwatul Alma Wizsa
Keyword(s):  
Optimal Design ◽  
Quadratic Model ◽  
Model Parameters ◽  
Potential Term ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Simplex Lattice ◽  
Mixture Experimental Design ◽  
Special Case ◽  
Experimental Region

A mixture experiment is a special case of response surface methodology in which the value of the components are proportions. In case there are constraints on the proportions, the experimental region can be not a simplex. The classical designs such as a simplex-lattice design or a simplex-centroid design, in some cases, cannot fit to the problem. In this case, optimal design come up as a solution. A D-optimal design is seeking a design in which minimizing the covariance of the model parameter.  Some model parameters are important and some of them are less important. As the priority of the parameters, the prior information of parameters is needed in advance. This brings to a Bayesian D-optimal design. This research was focus on a baking experiment in which consisted of three ingredients with lower bounds on the proportion of the ingredients. The assumption model was a quadratic model. Due to the priority of the model parameters, the Bayesian D-optimal design was used to solve the problem. A point-exchange algorithm was developed to find the optimal design. Nineteen candidates is used to choose twelve design points. It found that the potential term is feasible to the actual model and design points represent overall points in the design area.

Sign in / Sign up

Export Citation Format

Share Document