Influence of sodium caseinate, maltodextrin, pectin and their Maillard conjugate on the stability, in vitro release, anti-oxidant property and cell viability of eugenol-olive oil nanoemulsions

2021 ◽  
Vol 183 ◽  
pp. 158-170
Author(s):  
Pramod G. Nagaraju ◽  
Sindhu P. ◽  
Tushar Dubey ◽  
Subashchandrabose Chinnathambi ◽  
Poornima Priyadarshini C. G. ◽  
...  
Keyword(s):  
Cell Viability ◽  
Olive Oil ◽  
In Vitro Release ◽  
Sodium Caseinate ◽  
Anti Oxidant ◽  
The Stability ◽  
Vitro Release

scholarly journals Design and evaluation of Pulsatile drug delivery of Losartan Potassium

2014 ◽  
Vol 12 (2) ◽  
pp. 119-123
Author(s):  
MS Ashwini ◽  
Mohammed Gulzar Ahmed
Keyword(s):  
In Vitro Release ◽  
Losartan Potassium ◽  
Stability Studies ◽  
In Vitro Drug Release ◽  
Drug Content ◽  
Weight Variation ◽  
Release Studies ◽  
The Stability ◽  
Vitro Release

The study was designed for the investigation of pulsatile device to achieve time or site specific release of Losartan potassium based on chronopharmaceutical considerations. The basic design involves the preparation of cross linked hard gelatin capsules by using formaldehyde, then the drug diluent mixture were prepared and loaded in, which was separated by using hydrogel plugs of different polymers of different viscosities. Prepared formulations were subjected to evaluation of various parameters like weight variation, percentage drug content, in vitro drug release and stability studies. Weight variation and percentage drug content results showed that they were within the limits of official standards. The in-vitro release studies revealed that the capsules plugged with polymer HPMC showed better pulsatile or sustained release property as compared to the other formulations. The stability studies were carried out for all the formulations and formulations F1 & F2 were found to be stable. Dhaka Univ. J. Pharm. Sci. 12(2): 119-123, 2013 (December) DOI: http://dx.doi.org/10.3329/dujps.v12i2.17610

scholarly journals Permeability Enhancement of Methotrexate Transdermal Gel using Eucalyptus oil, Peppermint Oil and Olive Oil(Conference Paper )#

2022 ◽  
Vol 30 (Suppl.) ◽  
pp. 16-21
Author(s):  
Jamal Ali Ashoor ◽  
Jinan M. Mohsin ◽  
Hussein Mohammed Mohsin ◽  
Basam W. Mahde ◽  
Mowafaq M. Gareeb
Keyword(s):  
Olive Oil ◽  
In Vitro Release ◽  
Peppermint Oil ◽  
Physiochemical Properties ◽  
Eucalyptus Oil ◽  
Permeability Enhancement ◽  
Permeability Studies ◽  
Vitro Release ◽  
Transdermal Permeability

Abstract Objective: the idea of this study to improve transdermal permeability of Methotrexate using eucalyptus oil, olive oil and peppermint oil as enhancers.Method: eucalyptus oil (2% and 4%), peppermint oil (2% and 4%) and olive oil (2% and 4%) all used as natural enhancers to develop transdermal permeability of Methotrexate via gel formulation. The gel was subjected to many physiochemical properties tests. In-vitro release and permeability studies for the drug were done by Franz cell diffusion across synthetic membrane, kinetic model was studied via korsmeyer- peppas equation.Result: the results demonstrate that safe, nonirritant or cause necrosis to rats' skin and stable till 60 days gel was successfully formulated.Methotrexate penetration alone without enhancer is only about 20%, while using enhancers reach to 85%, 99% and 90% with eucalyptus oil 4%, peppermint oil 4% and olive oil 4% respectively after 24 hours.Conclusion: Methotrexate transdermal gel was prepared and evaluated fruitfully in-vitro with a good permeation across semipermeable membrane. The results indicated that using of peppermint oil as enhancer have superiority to enhance the transdermal permeation of the Methotrexate.

scholarly journals 75 Evaluating the in vitro release of essential oils from microparticles in simulated swine gastric and intestinal fluids and the essential oil stability in microparticles during feed pelleting process

2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 70-70
Author(s):  
Janghan Choi ◽  
Lucy Wang ◽  
Joshua Gong ◽  
Ludovic Lahaye ◽  
Song Liu ◽  
...  
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
In Vitro Release ◽  
Oil Stability ◽  
Positive Effects ◽  
Intestinal Fluids ◽  
Gastric Fluids ◽  
The Stability ◽  
Vitro Release

Abstract Essential oils are defined as plant-derived natural bioactive compounds with positive effects on animal growth and health due to their antimicrobial and antioxidative properties. However, essential oils are very volatile, can evaporate rapidly and be rapidly absorbed in the upper gastrointestinal tract. In addition, due to their labile nature, the stability of essential oils during feed processing is often questionable, leading to variable final concentrations in feeds. Micro-encapsulation has become one of the most popular methods to deliver essential oils into the lower gut. The objective of the present study was double: 1) to validate and demonstrate the slow release of essential oils, such as thymol, micro-encapsulated in combination with organic acids in a matrix of triglycerides, in simulated swine gastric and intestinal fluids and 2) to evaluate the essential oil stability in the microparticles during feed pelleting process. In the in vitro release experiments, the microparticles were incubated in simulated gastric fluids for 2 hours and then the samples were incubated in simulated intestinal fluids for 0, 1, 2, 3, 4, 6, 8, 10, and 24 hours at 39°C. In the pelleting experiment, a wheat-corn basal diet with 2 kg of micro-encapsulated product was formulated and pelleted. The thymol content in the samples was analyzed by gas chromatography with flame-ionization detection. The results showed that 27.65% thymol was released in simulated gastric fluids and the rest of thymol was progressively released in intestinal fluids until completion, which was achieved by 24 hours. The thymol concentration was not significantly different between the mash feeds and pelleted feeds (P > 0.05). In conclusion, the micro-encapsulated organic acid and essential oil product was able to maintain the stability of thymol under a commercial pelleting process and allow a slow and progressive release of its active ingredients as thymol in simulated digestive fluids.

scholarly journals Host-guest interaction and properties of cucurbit[8]uril with chloramphenicol

2021 ◽  
Author(s):  
Lin Zhang ◽  
Jun Zheng ◽  
Guangyan Luo ◽  
Xiaoyue Li ◽  
Yunqian Zhang ◽  
...  
Keyword(s):  
Inhibitory Concentration ◽  
Slow Release ◽  
In Vitro Release ◽  
Titration Calorimetry ◽  
X Ray Diffraction ◽  
X Ray ◽  
E Coli ◽  
The Stability ◽  
Vitro Release

The interaction between cucurbit[8]uril (Q[8]) and chloramphenicol (CPE) was investigated using single-crystal X-ray diffraction, spectroscopy, isothermal titration calorimetry (ITC) and UV-Vis, NMR and IR spectroscopy. The effects of Q[8] on the stability, in vitro release performance and antibacterial activity of CPE were also studied. The results showed that CPE and Q[8] formed a 1:1 inclusion complex (CPE@Q[8]) with an inclusion constant of 5.4736 × 105 L/mol. The intervention of Q[8] did not affect the stability of CPE, but obviously reduced the release rate of CPE in artificial gastric and intestinal juice; Q[8] has a slow-release effect on CPE. The antibacterial results showed that the minimum inhibitory concentration (MIC) of CPE and CPE@Q[8] toward Escherichia coli (E. coli) was 1.5 × 10–3 and 1.0 × 10–3 mol/L, respectively, and toward Staphylococcus aureus (SA), the MIC was 2.0 × 10–3 mol/L for both CPE and CPE@Q[8]. Therefore, Q[8] enhanced the inhibitory activity of CPE against E. coli.

Fabrication of zein and rhamnolipid complex nanoparticles to enhance the stability and in vitro release of curcumin

2018 ◽  
Vol 77 ◽  
pp. 617-628 ◽  
Author(s):  
Lei Dai ◽  
Ruirui Li ◽  
Yang Wei ◽  
Cuixia Sun ◽  
Like Mao ◽  
...  
Keyword(s):  
In Vitro Release ◽  
The Stability ◽  
Vitro Release

Preparation and Characterization of Zein/Sodium Caseinate/Xanthan Gum Complex for Encapsulation of Piperine and its In Vitro Release Study

2021 ◽  
Author(s):  
Farzaneh Shirmohammadli ◽  
Maryam Nikzad ◽  
Ali Asghar Ghoreyshi ◽  
Maedeh Mohammadi ◽  
Fatemeh Poureini
Keyword(s):  
Xanthan Gum ◽  
In Vitro Release ◽  
Sodium Caseinate ◽  
Release Study ◽  
Vitro Release

scholarly journals Development of Topical Niosomal Gel of Benzoyl Peroxide

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Jigar Vyas ◽  
Puja Vyas ◽  
Dhaval Raval ◽  
Paresh Paghdar
Keyword(s):  
Benzoyl Peroxide ◽  
In Vitro Release ◽  
Skin Penetration ◽  
Topical Gel ◽  
Different Temperatures ◽  
Skin Redness ◽  
The Stability ◽  
Niosomal Gel ◽  
Vitro Release

Benzoyl peroxide is macrolide antibiotic used commonly for the treatment of acne either alone or in combination. But it suffers from side effects like skin redness, irritation, itching, and edema. Niosomes, a nonionic surfactant vesicular formulation, have been explored extensively for topical application to enhance skin penetration as well as to improve skin retention of drugs. In the present study, Benzoyl peroxide was entrapped into niosomes by thin film hydration technique, and various process parameters were optimized by partial factorial design. The optimized niosomal formulation was incorporated into HPMC K15 gel and extensively characterized for percentage drug entrapment (PDE) and in vitro release performance. The stability of above formulation was studied at different temperatures. The present study demonstrated prolongation of drug release, increased drug retention into skin, and improved permeation across the skin after encapsulation of benzoyl peroxide into niosomal topical gel.

scholarly journals Nanoencapsulation of clove oil and study of physico-chemical properties, cytotoxic, haemolytic and antioxidant activities

2020 ◽  
Author(s):  
Pramod G Nagaraju ◽  
Parineeta Sengupta ◽  
C. G. Poornima Priyadarshini ◽  
Pooja J Rao
Keyword(s):  
Room Temperature ◽  
In Vitro Release ◽  
Radical Scavenging ◽  
Tween 80 ◽  
Tween 20 ◽  
Haemolytic Activity ◽  
Clove Oil ◽  
The Stability ◽  
Vitro Release

AbstractThe therapeutic properties of clove oil is known for centuries, however, the pungent nature, chemical instability and low water solubility impose limitations in harnessing its therapeutic potential. Hence, nanoencapsulation of clove oil was performed to overcome the above constraints and control its in-vitro release. The stability of nanoemulsion depends on various factors where the surfactant and its hydrophile/lipofile balance (HLB) play a key role. The non-ionic surfactants Tween 20, 40 and 80 with HLB of 16.7, 15.6 and 15, respectively, were used to study the stability of clove oil nanoemulsion (CON). The creaming index of CON prepared with Tween 20, 40 and 80 was 22.75 and 17.5 and 1.5%, respectively, after 8 days of storage at room temperature. Tween 20 and 40 produced particles > 300 nm while Tween 80 resulted in particles of size ∼150 nm. Transmission electron microscopic image of spray dried CON prepared with Tween 80 showed particle size in the range 150-190 nm after one month of storage at room temperature. The in vitro release studies showed 76% and 42% cumulative release of CON and native clove oil (NC), respectively at pH 7.4. The cellular toxicity of CON was significantly reduced by four fold compared to NC at a concentration of 60 µg/mL when tested on Caco2 cells. Similarly, haemolytic activity on red blood cells revealed less than 10% haemolysis signifying the compatibility of CON for its nutraceutical applications. In addition, CON also exhibited higher in-vitro antioxidant compared to NC as shown by DPPH and ABTS radical scavenging activity. Collectively, we have developed a unique method for NC nanoencapsulation using cost effective polysaccharide (maltodextrin) and surfactant for stabilizing the nanoemulsion for increased bioactivity.

Sign in / Sign up

Export Citation Format

Share Document